JP2003113393A - Ceramide dispersion, method for producing the same, and application of the same - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a ceramide dispersion capable of being used in various fields, such as pharmaceutical, cosmetic, and dietary fields, by changing the ceramide slightly soluble in water into a water-soluble composition, scarcely causing isolation nor precipitation of the ceramide even when stored for a long period, capable of being kept in a uniformly and stably emulsified, dispersed or solubilized state, having excellent acid-resisting, salt-resisting and heat-resisting properties which are necessary when added to food and drink, capable of preventing the ceramide from depositing, precipitating, and floating in the food and drink and a cosmetic to which the dispersion is added, and having excellent transparency, to provide a method for producing the same, to provide the food and drink containing the same, and provide the cosmetic containing the same. SOLUTION: This ceramide dispersion is formed by dispersing the ceramide (A) in a water-based solvent, wherein an ester (B1) of a 8-10C fatty acid of a polyglycerol and another ester (B2) of a 12-18C fatty acid of the polyglycerol are combined to be used.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a ceramide dispersion, a method for producing the same, and foods and drinks and cosmetics containing the dispersion. More specifically, ceramide can maintain a homogeneous emulsified or dispersed or solubilized state without being precipitated or suspended even when stored for a long period of time, and further, it has heat resistance, acid resistance, and salt resistance required when added to foods and drinks. TECHNICAL FIELD The present invention relates to a ceramide dispersion having excellent properties, a method for producing the same, and a food or drink containing the dispersion, and a cosmetic.

[0002]

Ceramide is a sphingolipid that accounts for 50% or more of the lipid group existing between skin keratinocytes.
It has a known bioregulatory function such as a skin moisturizing effect, a surface protecting effect (barrier effect), and an effect of preventing and improving rough skin, and is widely used in the cosmetic field. In addition, it is known that ceramide is orally ingested as an edible substance and has an effect of protecting the skin and preventing rough skin (El
ian Lati, FRAGRANCE JOURNAL, 23 (1) 81 (1995)). As another technique, for example, Japanese Patent Application Laid-Open No. 60-183032 discloses an emulsion using a protein such as sodium casein, but it has problems such as poor acid resistance and heat resistance. Further, JP-A-1-13010 discloses a technique using sodium bentonite,
It is not suitable for foods and cannot be added to foods.
Furthermore, Japanese Patent Publication No. 6-504265 discloses an emulsion using polyoxyethylene lauryl ether as an emulsifier, but it is not permitted to be added to foods and cannot be applied to foods. In addition, JP-A-4-299
Japanese Patent No. 940 proposes to form a heat-resistant emulsion composition by using sucrose ricinoleic acid ester and polyhydric alcohol ester, but treatment under retort conditions under acidic conditions (generally 125 ° C.). When the heating conditions such as 20 minutes) are severe, there is a problem that there is no effect at all. In JP-A-8-256729, a polyglycerin fatty acid ester is used alone, but a water-soluble composition prepared alone has problems such as poor storage stability and ceramide precipitation. It was JP 2000-
Japanese Patent No. 139345 discloses an activator consisting of a fatty acid and an ester of glycerin having a degree of polymerization of 3 or less. The emulsion composition prepared with this activator has poor salt resistance and is dissolved in saline. At that time, there was a problem such as precipitation of ceramide. Therefore, the properties required when added to foods and beverages and cosmetics, transparency, acid resistance, salt resistance,
At present, there is no ceramide composition that has excellent heat resistance and that maintains a stable emulsified or dispersed or solubilized state, and there is a demand for it.

[0003]

The object of the present invention is to make it possible to use the sparingly soluble ceramide as a water-soluble composition in a wide range of fields such as pharmaceuticals, cosmetics and foods for a long period of time. Ceramide release or precipitation does not occur even when stored, maintaining a homogeneous and stable emulsification, dispersion, solubilized state, further, acid resistance of the properties required when added to food and drink, salt resistance, Excellent heat resistance, even in foods and drinks and cosmetics containing the composition, precipitation of ceramide, precipitation,
It is an object of the present invention to provide a ceramide dispersion liquid which does not float and is excellent in transparency, a method for producing the dispersion liquid, and foods and drinks and cosmetics containing the dispersion liquid.

[0004]

Means for Solving the Problems As a result of intensive studies for solving the above problems, the present inventors have found that ceramide is in a solubilized state when two specific types of polyglycerin fatty acid ester are used, The present invention has been completed. That is, the present invention includes the following [1]-

[9]. [1] A dispersion obtained by dispersing ceramide (A) in an aqueous solvent, which is an ester (B1) of a fatty acid having 8 to 10 carbon atoms and polyglycerin, an ester of a fatty acid having 12 to 18 carbon atoms and polyglycerin ( A ceramide dispersion characterized by being used in combination with B2). [2] B1; 0.1 to 20% by weight of ester of fatty acid having 8 to 10 carbon atoms and polyglycerin, B2; 12 carbon atoms
~ 18 fatty acid and polyglycerin ester, 0.1
30% by weight, the compounding ratio is B1 / B2 = 1/300 ~
The ceramide dispersion according to the above [1], which is 1 / 0.005.

[3] Ceramide / surfactant (the above B
The ceramide dispersion liquid according to the above [1] or [2], which has a compounding ratio of 1 + B2) = 1/100 to 1 / 0.004. [4] The ceramide dispersion according to the above [1] or [2], wherein the ceramide dispersion has an average particle diameter of 150 nm or less and is in a solubilized state. [5] A; 0.5 to 50% by weight of ceramide, B1; ester of fatty acid having 8 to 10 carbon atoms and polyglycerin 0.
1 to 20% by weight, B2; 0.1 to 30% by weight of an ester of a fatty acid having 12 to 18 carbon atoms and polyglycerin, and C;
Organic acid or its salt, 0 to 20% by weight, and D; alcohol, or one or more of water 0.01 to 99.3
A ceramide dispersion liquid, characterized in that

[6] A: Ceramide 0.5 to 50% by weight
And B1; 0.1 to 20% by weight of an ester of a fatty acid having 8 to 10 carbon atoms and polyglycerin, and B2; 12 to 1 carbon atoms.
0.1 to 30% by weight of fatty acid ester of 8 and polyglycerin, C; organic acid or salt thereof, 0 to 20% by weight,
D; one or more of alcohol or water 0.0
A method for producing a ceramide dispersion, wherein 1 to 99.3% by weight is weighed out as a raw material and uniformly mixed.

[7] A predetermined amount of ceramide and alcohol,
Water is added, and then an ester of polyglycerin with a fatty acid having 8 to 10 carbon atoms of B1 and an ester of fatty acid having 12 to 18 carbon atoms of B2 and polyglycerin are added and dispersed,
A method for producing a ceramide dispersion, which is characterized in that a homogenization treatment is then performed to obtain a solubilized state having an average particle diameter of 150 nm or less. [8] A food or drink comprising the ceramide dispersion according to any one of [1] to [6].

[9] A cosmetic comprising the ceramide dispersion according to any one of [1] to [6].

[0008]

BEST MODE FOR CARRYING OUT THE INVENTION The ceramide used in the present invention is
It refers to ceramide and ceramide-related substances having a similar structure, and is not limited to sources of animal origin, plant origin, or microorganism origin, and is also limited to extracts from natural products or synthetic products. Not even a thing. Examples of natural products include those extracted from beef brain, wheat, rice,
Examples include those extracted from plants such as rice bran, soybeans, black mold and spinach. Among them, the ceramide dispersion of the present invention is preferably a plant-derived ceramide because it is mainly used in foods and drinks and cosmetics. Above all, extracts from wheat and rice bran are preferable from the viewpoint of availability.
The purity of the ceramide used is not particularly limited, but a highly pure one is preferable, but preferably 1% to 50%,
From the availability, 3 to 10% is desirable. In the ceramide dispersion of the present invention, the ceramide is 0.5 to 50 relative to the dispersion.
% By weight, preferably 1 to 30% by weight, more preferably 5
It is suitable to mix it so as to be about 20% by weight. If the content of ceramide is less than 0.5% by weight, a water-soluble composition having practical value cannot be obtained,
If it exceeds 5% by weight, the emulsion stability of the ceramide dispersion is poor, which is not preferable.

As the ester of a fatty acid having 8 to 10 carbon atoms and polyglycerin (referred to as B1) used in the present invention, a normal polyglycerin having a degree of polymerization of 4 or more and an ester having 8 to 1 carbon atoms are used.
It is an ester with 0 fatty acid, and one or more of the above can be used. Further, an ester of a fatty acid having 12 to 18 carbon atoms and polyglycerin used in the present invention (B2
As the ester), an ester of an ordinary polyglycerin having a degree of polymerization of 4 or more and a fatty acid having 12 to 18 carbon atoms, and one or more of the above can be used. The polyglycerin ester emulsifier does not necessarily have to be highly purified by distillation or the like, and may be a reaction mixture. The total amount of polyglycerin fatty acid esters B1 and B2 used in the present invention is usually 0.2.
-50% by weight, preferably 1-30% by weight, more preferably 5-20% by weight. When the total content of the polyglycerin fatty acid esters B1 and B2 exceeds 50% by weight, when the ceramide dispersion is added to the food or drink, the taste peculiar to the hydrophilic emulsifier affects the taste of the food or drink, which is not preferable. Examples of commercially available activators corresponding to the above B1 and B2 include, for example, B1 equivalent to monoglyceryl dicaprylate [trade name: Sunsoft Q-81F Taiyo Kagaku Co., Ltd.
Manufactured by Sakamoto Yakuhin Kogyo Co., Ltd., and the like. Further, as B2 equivalent, decaglycerin monooleate [trade name: Sunsoft Q-17UL Taiyo Kagaku Co., Ltd.], hexaglycerin monooleate [trade name: SY Glister MO-50
0 Sakamoto Yakuhin Kogyo Co., Ltd., tetraglycerin monostearate [trade name: Poem J-4081 Riken Vitamin Co., Ltd.] and the like.

In the present invention, in addition to the above-mentioned polyglycerin ester emulsifier, other surfactants may be mixed and used as long as the effects of the present invention are not impaired. As these surfactants, specifically, for example,
Sorbitan fatty acid ester, glycerin fatty acid ester, propylene glycol fatty acid ester, sucrose fatty acid ester, lecithin, saponin, sterol, cholic acid, deoxycholic acid, yucca extract, cationic surfactant, anionic surfactant, amphoteric There are surfactants.

As the organic acid used in the present invention, any organic acid that can be used in foods can be used. Examples thereof include citric acid, malic acid, tartaric acid, acetic acid, L-ascorbic acid, and the salts thereof.
More preferably, citric acid, trisodium citrate, L
-Sodium ascorbate. The amount of the organic acid used in the present invention is usually 0 to 20% by weight, preferably 0.1 to 10% by weight, more preferably 1 to 5% by weight.
Is. If the content of the organic acid exceeds 20% by weight, the dispersion will not be stable, which is not preferable.

As the alcohol used in the present invention, any alcohol can be used as long as it can be used in foods, and alcohol preparations and the like can also be used. The amount of the alcohol used in the present invention is 0.01 to 20% by weight,
Preferably 0.05 to 10% by weight, more preferably 0.
It is 1 to 5% by weight. When the amount of alcohol blended is less than 0.01% by weight, the dispersibility of ceramide is poor, which is not preferable.
If the amount of alcohol blended exceeds 20% by weight, emulsification becomes unstable, which is not preferable.

The water used in the present invention is not particularly limited as long as it can be mixed with foods and drinks, and may be water alone or water containing other food additives. Examples of food additives include emulsifiers, stabilizers, seasonings, acids and salts.

Further, a stabilizer may be added to the liquid of the present invention. Examples of the stabilizer used in the present invention include gums, sugar alcohols and sugars. Specifically, for example, gum arabic, xanthan gum, tragacanth gum, guar gum, gellan gum, locust bean gum, ethylene glycol, propylene glycol, glycerin, maltitol, reduced starch syrup, lactitol, palatinit, erythritol, sorbitol, mannitol, glucose fructose syrup, Examples thereof include dextrin and lactose. These stabilizers can be used alone or in combination of two or more.

In the method for producing a ceramide dispersion of the present invention, a colloid mill, a high-pressure homogenizer, an ultra-high pressure homogenizer, an ultrasonic emulsifier, etc. are used in order to weigh the above-mentioned various components and enhance the stability of emulsification, dispersion or solubilization. Using a homogenizer and a homomixer, it is possible to obtain a uniform liquid ceramide dispersion. In particular, ceramide, alcohol, and water are blended to make the mixture uniform, and further the above-mentioned fatty acid having 8 to 10 carbon atoms and polyglycerin ester (B1) and fatty acid having 12 to 18 carbon atoms and polyglycerin ester (B2) are added. It is desirable to disperse and homogenize. This homogenization treatment may be performed twice or more in order to further stabilize the ceramide dispersion. Further, the homogenization treatment may use a phase inversion emulsification method, a liquid crystal emulsification method, a D phase emulsification method, a PIT emulsification method, or the like, in addition to the above homogenization treatment machine.

The ceramide dispersion of the present invention is taken as it is, or is mainly used for beverages such as sports drinks, carbonated drinks and nutritional drinks and foods such as bread, noodles, confectionery, dairy products and seasonings. It can be used as a compounding raw material for addition. The use is not particularly limited and can be applied to all kinds of food and drink.

Examples of foods containing the ceramide dispersion of the present invention include breads and confectioneries such as bread, biscuits, candies and jellies, processed meat products such as yogurt and ham, and miso, sauces, sauces and dressings. Health foods such as seasonings, processed foods such as tofu and noodles, processed oils such as margarine, fat spread, shortening, powdered beverages such as powdered soup, powdered foods such as soups, capsules, tablets, powders and granules Foods etc. can be mentioned.

Beverages containing the ceramide dispersion of the present invention include beverages containing at least one of minerals such as salt, acidulants, sweeteners, alcohols, vitamins, flavors and fruit juices, such as sports drinks and fruit juice drinks. , Lactic acid bacteria drinks, alcoholic drinks, vitamin / mineral drinks, and the like. Furthermore, processed milk, soy milk, beverages for improving physical constitution, beverages in which natural materials expected to have physiological effects are combined with ceramide, and the like can be mentioned.

The ceramide dispersion of the present invention can be used for cosmetics and pharmaceuticals as well as foods. As cosmetics,
For example, cosmetics such as creams, lotions, shampoos, etc. can be used as a blending raw material for adding ceramide to pharmaceuticals and the like, and the range is not particularly limited, and it can be used for all types of cosmetics and pharmaceuticals. Can be applied.

[0020]

The ceramide dispersion of the present invention can maintain a homogeneous and stable state without precipitation or suspension of ceramide even when stored for a long period of time. In addition, it has excellent acid resistance, salt resistance, and heat resistance, and can maintain stability even if it is mixed with acids and salts used in foods and food additives.
Sterilization at 100 ° C or 100 to 150 as required
It can be sterilized at a high temperature of ℃ or sterilized, is stable against heating at this time, and can maintain a uniform state even after being stored for a long period of time. Furthermore, the method for producing a ceramide dispersion liquid of the present invention is a method which can uniformly disperse ceramide and easily bring the ceramide into a solubilized state of 150 nm or less. This ceramide dispersion can be ingested as a food as it is, and by further mixing it in the production of various foods and drinks, foods and drinks containing ceramide can be obtained.
Furthermore, the ceramide dispersion of the present invention is useful because it can be incorporated into cosmetics and is stable even when used in combination with salt or acid or when heat-treated.

[0021]

EXAMPLES Next, the present invention will be described in more detail based on examples. The test methods and evaluation methods used are shown below. 1. Storage stability test Using the ceramide dispersions obtained in Examples and Comparative Examples as a sample, put in a 100 mL sample bottle, immediately after preparation, and 4
The appearance state after 30-day static storage at 0 ° C. was visually evaluated. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured. 2. Heat resistance test 1% of a ceramide dispersion was added to purified water, and the appearance state of an aqueous solution of the ceramide dispersion at room temperature was visually evaluated. Further, in order to confirm the heat resistance of this aqueous solution, this aqueous solution was placed in a hot water bath and heat-treated for 30 minutes from the time when the liquid temperature reached 85 ° C. After cooling these aqueous solutions at room temperature, the appearance state was visually evaluated to confirm the heat resistance of the aqueous solution of the ceramide dispersion. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured. 3. Measurement of Average Particle Size of Emulsified Dispersion A submicron particle analyzer (COULTER N4SD) was used to measure the average particle size of the emulsified dispersion. 4.1 Acid resistance / heat resistance test 1% of a ceramide dispersion was added to purified water whose pH was adjusted to 3 or less with citric acid, and the appearance state at room temperature was visually evaluated to confirm the acid resistance of the ceramide dispersion. . Further, in order to confirm the heat resistance under this acidic condition, this dispersion-containing acidic aqueous solution was placed in a hot water bath and heat-treated for 30 minutes from the time when the liquid temperature reached 85 ° C. After cooling the acidic aqueous solution containing these dispersions at room temperature, the appearance state was visually evaluated to confirm the acid resistance and heat resistance of the ceramide dispersion. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured. 4.2 Acid-resistant storage stability test A 40 ° C static storage test of the test solution subjected to the acid resistance / heat resistance test was carried out, and the appearance state after static storage for 30 days was visually evaluated. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured. 5.1 Salt Resistance / Heat Resistance Test Similar to the salt resistance / heat resistance test, 1% of the ceramide dispersion was added to purified water containing 3% of salt, and the appearance state at room temperature was visually evaluated to confirm the salt resistance of the ceramide dispersion. Further, in order to confirm the heat resistance under this high salt concentration condition, the salt solution containing this dispersion liquid was put in a hot water bath and the liquid temperature was changed to 85 ° C.
Heat treatment was performed for 30 minutes after reaching the temperature. The appearance state of the saline solution containing these dispersion liquids was visually evaluated to confirm the salt resistance and heat resistance of the ceramide dispersion liquid. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured. 5.2 Salt-Resistant Storage Stability Test A 40 ° C. static storage test of the test solution subjected to the salt resistance / heat resistance test was carried out, and the appearance state after static storage for 30 days was visually evaluated. Evaluation ◯: Good condition, Δ: Slightly bad condition, X: Bad condition, floating / precipitates were generated, −: Not measured.

Example 1 In a 2000 mL stainless steel beaker, 100 g of ceramide [trade name: Nissan N-Ceramide Nippon Oil & Fats Co., Ltd., ceramide purity 4%], food alcohol preparation [trade name: KOCHELSIN Mitsubishi Kagaku Foods Co., Ltd. 5) and 745 g of water were added in this order, and the mixture was heated to 80 ° C. with stirring. Furthermore, 50 g of ascorbic acid, monooleic acid (C18) decaglycerin (G10) [trade name: Sunsoft Q-17S Taiyo Kagaku Co., Ltd.] 50 g, mono-dicaprylic acid (C8) hexaglycerin (G6) [ Product name: Sunsoft Q-81F Taiyo Kagaku Co., Ltd.] 50
g was added to completely disperse the ceramide. Then, homogenize with a high pressure homogenizer to obtain an average particle size of 90.
A ceramide dispersion liquid of nm was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 1
/ 1, ceramide / surfactant = 1/1)

COMPARATIVE EXAMPLE 1 The procedure of Example 1 was repeated except that the total amount of decaglycerin monooleate and hexaglycerin mono-dicaprylate was 100 g, and the total amount of hexaglycerin mono-dicaprylate was 100 g. A ceramide dispersion was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 1/0, ceramide /
Surfactant = 1/1)

Comparative Example 2 Ceramide having an average particle size of 170 nm was carried out in the same manner as in Example 1 except that 100 g of decaglycerin monooleate and hexaglycerin mono-dicaprylate was changed to 100 g. A dispersion was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 1/0, ceramide / surfactant = 1/1)

Comparative Example 3 Ceramide having an average particle size of 168 nm was carried out in the same manner as in Example 1 except that 100 g of decaglycerin monooleate and hexaglycerin mono-dicaprylate were changed to 100 g of triglycerin monomyristate. A dispersion was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 0/1, ceramide / surfactant = 1/1)

[0026]

[Table 1]

From the above results, Comparative Example 1 is inferior in the stability of the salt / heat resistance test solution and the acid / heat resistance test solution in storage at 40 ° C. for 30 days, and Comparative Example 2 is inferior in heat resistance, salt resistance and acid resistance. Both are inferior, 40 ° C of ceramide dispersion
Floating of ceramide was observed after storage for 30 days, and storage stability was also inferior. Comparative Example 3 had markedly poor salt resistance, whereas Example 1 had both heat resistance, salt resistance and acid resistance. It can be seen that each of the test solutions is excellent and stable even after being stored at 40 ° C. for 30 days.

Example 2 Ceramide 10 was added to a 2000 mL stainless beaker.
0 g, absolute ethanol 5 g, and water 245 g were added in that order, and the mixture was heated to 70 ° C. with stirring. Furthermore, 30 g of sodium L-ascorbate and monooleic acid (C1
8) Decaglycerin (G10) [trade name: Poem J-0
381 manufactured by Riken Vitamin Co., Ltd.] 70 g, monocaprylic acid (8) decaglycerin (G10) [trade name: SY Glister MCA-750 manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.] 30 g,
Reduced water candy [Product name: S58 Nikken Chemical Co., Ltd.]
[Production] 520 g was added and completely dispersed. Then, homogenize with a high pressure homogenizer to obtain an average particle size of 75n.
A ceramide dispersion of m was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 3 /
7, ceramide / surfactant = 1/1)

Comparative Example 4 Average particle size was the same as in Example 2 except that monocaprylic decaglycerin was changed to hexaglycerin monolaurate [trade name: SY Glister ML-500 manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.]. A ceramide dispersion liquid having a diameter of 180 nm was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 0/1, ceramide / surfactant = 1/1)

Comparative Example 5 Average particle size was the same as in Example 2 except that monocaprylic acid decaglycerin was changed to pentaglycerin monooleate [trade name: Sunsoft A-171E manufactured by Taiyo Kagaku Co., Ltd.]. A ceramide dispersion having a diameter of 165 nm was obtained.
(Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 0/1, ceramide / surfactant =
1/1)

[0031]

[Table 2]

From the above results, Comparative Example 4 is inferior in storage stability in salt resistance / heat resistance test and acid resistance / heat resistance test, and Comparative Example 5 is inferior in storage stability in salt resistance / heat resistance test. On the other hand, in Example 2, slight precipitation of ceramide was observed after the salt / heat resistance test solution was stored at 40 ° C. for 30 days, but the stability against heat and acid was the same as in Example 1. It turns out to be excellent.

Example 3 Ceramide 20 was added to a 2000 mL stainless steel beaker.
0g, absolute ethanol 10g, water 350g in this order,
The mixture was heated to 70 ° C with stirring. In addition to this, 100 g of citric acid and hexaglycerin monooleate [trade name: SY Glister MO500 Sakamoto Yakuhin Kogyo Co., Ltd.]
Made] 70 g, monocaprylic acid decaglycerin [Product name:
SY Glister MCA-750 Sakamoto Yakuhin Kogyo Co., Ltd.
Made] 30 g, glycerin [trade name: glycerin for food additives]
240 g of Nippon Oil & Fats Co., Ltd. was added to completely disperse the ceramide. Then, homogenization treatment was performed with a high pressure homogenizer to obtain a uniform ceramide dispersion liquid having an average particle diameter of 80 nm. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 3/7, ceramide / surfactant = 2/1)

Example 4 350 g of the water of Example 3 and 240 g of glycerin were added to 59 parts of water.
The same operation as in Example 3 was carried out except that the amount was 0 g to obtain a uniform ceramide dispersion liquid having an average particle diameter of 92 nm. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 3/7, ceramide / surfactant = 2 /
1)

Example 5 A total of 360 g of water and absolute ethanol of Example 3 was added to water 3
Except for 60 g, the same operation as in Example 3 was carried out,
A ceramide dispersion liquid having an average particle diameter of 85 nm was obtained. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 3/7, ceramide / surfactant = 2/1)

Example 6 The same operation as in Example 3 was carried out except that 340 g of citric acid and glycerin in Example 3 was replaced with 340 g of glycerin, to obtain a ceramide dispersion liquid having an average particle size of 96 nm. (Polyglycerin fatty acid ester B1 / Polyglycerin fatty acid ester B2 = 3/7, ceramide / surfactant = 2/1)

Example 7 Example 3 was repeated except that the total of 700 g of water, anhydrous ethanol, citric acid and glycerin of Example 3 was changed to 700 g of water.
The same operation as above was performed to obtain a ceramide dispersion liquid having an average particle diameter of 110 nm. (Polyglycerin fatty acid ester B1
/ Polyglycerin fatty acid ester B2 = 3/7, ceramide / surfactant = 2/1)

[0038]

[Table 3]

From the above results, Example 3 has both excellent salt resistance and acid resistance, and is stable even after standing at 40 ° C. for 30 days, and Examples 4 to 7 show ceramide dispersion, salt resistance and heat resistance. When the test solution and the acid / heat resistance test solution were allowed to stand at 40 ° C. for 30 days, the stability was slightly inferior, but it was not unusable.

Example 8 Using the ceramide dispersion of Example 2, a beverage having the composition shown in Table 7 was prepared, filled in a 100 mL bottle and sealed. This beverage was heat-sterilized at 95 ° C. for 15 minutes to prepare a beverage.
The beverage thus obtained was allowed to stand for 30 days in a constant temperature bath at 40 ° C., and the dispersion stability was evaluated. As a result, precipitation of ceramide was not observed at all, and the dispersion state was stable.

Comparative Example 6 A beverage was prepared in the same manner as in Example 5 except that the ceramide dispersion liquid of Example 2 was replaced with the ceramide dispersion liquid of Comparative Example 5 in the ingredients shown in Table 7. 4 drinks thus obtained
After storage for 30 days in a constant temperature bath at 0 ° C., the dispersion stability was evaluated. Precipitation of ceramide was observed and the dispersion state was unstable.

[0042]

[Table 4]

The evaluation criteria for the results in Table 4 are as follows. Evaluation ◯: Good stability, ×: Poor stability.

From the above results, Example 8 of the present invention blended in an actual beverage is excellent in acid resistance, salt resistance, heat resistance, etc., while Comparative Example 6 has acid resistance, salt resistance, It can be seen that the heat resistance is inferior. From the above results, it can be seen that the examples of the present invention are more excellent in acid resistance, salt resistance, heat resistance and the like than the comparative examples.

   ─────────────────────────────────────────────────── ─── Continued front page    F-term (reference) 4B018 MD07 ME14                 4C083 AC421 AC641 AD111 CC01                       DD39 EE01                 4H059 BA34 BA83 BA90 BB02 BB03                       DA24 EA11

Claims (9)

[Claims] 1. A dispersion obtained by dispersing ceramide (A) in an aqueous solvent, which comprises an ester (B1) of a fatty acid having 8 to 10 carbon atoms and polyglycerin, a fatty acid having 12 to 18 carbon atoms, and polyglycerin. A ceramide dispersion characterized by being used in combination with an ester (B2). 2. B1; 0.1 to 20% by weight of an ester of a fatty acid having 8 to 10 carbon atoms and polyglycerin; B2; an ester of a fatty acid having 12 to 18 carbon atoms and polyglycerin;
1 to 30% by weight, and the compounding ratio is B1 / B2 = 1/30
The ceramide dispersion liquid according to claim 1, which is 0 to 1 / 0.005. 3. A ceramide / surfactant (the above B1 + B
2) The ceramide dispersion liquid according to claim 1 or 2, which has a compounding ratio of 1/100 to 1 / 0.004. 4. The ceramide dispersion according to claim 1, which is in a solubilized state having an average particle diameter of 150 nm or less. 5. A; 0.5 to 50% by weight of ceramide, and B
1; 0.1 to 20% by weight of a fatty acid having 8 to 10 carbon atoms and polyglycerin; and B2: 0.1 to 30% by weight of an ester of fatty acid having 12 to 18 carbon atoms and polyglycerin.
And C; organic acid or salt thereof, 0 to 20% by weight, D;
Alcohol or water 1 type or 2 types or more 0.01-
A ceramide dispersion liquid comprising 99.3% by weight. 6. A; 0.5 to 50% by weight of ceramide, and B
1; 0.1 to 20% by weight of a fatty acid having 8 to 10 carbon atoms and polyglycerin; and B2: 0.1 to 30% by weight of an ester of fatty acid having 12 to 18 carbon atoms and polyglycerin.
And C; organic acid or salt thereof, 0 to 20% by weight, D;
Alcohol or water 1 type or 2 types or more 0.01-
A method for producing a ceramide dispersion, which comprises weighing 99.3% by weight as a raw material and uniformly mixing them. 7. A predetermined amount of ceramide, alcohol, and water are blended, and then an ester of B1 fatty acid having 8 to 10 carbon atoms and polyglycerin and an ester of B2 fatty acid having 12 to 18 carbon atoms and polyglycerin are added. And a homogenizing treatment to obtain a solubilized state having an average particle diameter of 150 nm or less. 8. A food or drink comprising the ceramide dispersion liquid according to any one of claims 1 to 6. 9. A cosmetic comprising the ceramide dispersion according to any one of claims 1 to 6.