JP2002544119A5 - - Google Patents

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Publication number
JP2002544119A5
JP2002544119A5 JP2000606620A JP2000606620A JP2002544119A5 JP 2002544119 A5 JP2002544119 A5 JP 2002544119A5 JP 2000606620 A JP2000606620 A JP 2000606620A JP 2000606620 A JP2000606620 A JP 2000606620A JP 2002544119 A5 JP2002544119 A5 JP 2002544119A5
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JP
Japan
Prior art keywords
alkyl
group
carboxyl
aryl
alkylcarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000606620A
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English (en)
Japanese (ja)
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JP2002544119A (ja
JP4604161B2 (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2000/008231 external-priority patent/WO2000056760A1/en
Publication of JP2002544119A publication Critical patent/JP2002544119A/ja
Publication of JP2002544119A5 publication Critical patent/JP2002544119A5/ja
Application granted granted Critical
Publication of JP4604161B2 publication Critical patent/JP4604161B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2000606620A 1999-03-23 2000-03-23 フェニルアラニン誘導体 Expired - Fee Related JP4604161B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12604799P 1999-03-23 1999-03-23
US60/126,047 1999-03-23
PCT/US2000/008231 WO2000056760A1 (en) 1999-03-23 2000-03-23 Phenylalanine derivatives

Publications (3)

Publication Number Publication Date
JP2002544119A JP2002544119A (ja) 2002-12-24
JP2002544119A5 true JP2002544119A5 (https=) 2007-04-19
JP4604161B2 JP4604161B2 (ja) 2010-12-22

Family

ID=22422719

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000606620A Expired - Fee Related JP4604161B2 (ja) 1999-03-23 2000-03-23 フェニルアラニン誘導体

Country Status (7)

Country Link
US (1) US7825216B2 (https=)
EP (1) EP1163262B1 (https=)
JP (1) JP4604161B2 (https=)
AT (1) ATE509026T1 (https=)
AU (1) AU770920C (https=)
CA (2) CA2368733C (https=)
WO (1) WO2000056760A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7871981B2 (en) * 1999-10-22 2011-01-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of cell motility, angiogenesis, and metastasis
JP2003512334A (ja) * 1999-10-22 2003-04-02 アメリカ合衆国 Grb−2sh−2ドメインの阻害剤による細胞運動性及び脈管形成の阻害
AU2001285133A1 (en) * 2000-08-22 2002-03-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services SH2 domain binding inhibitors
US7425537B2 (en) 2000-08-22 2008-09-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services SH2 domain binding inhibitors
US6821979B2 (en) 2002-03-07 2004-11-23 Blanchette Rockefeller Neurosciences Institute Synergistic enhancement of cognitive ability
TW201206425A (en) 2004-05-18 2012-02-16 Brni Neurosciences Inst Treatment of depressive disorders
CN115192564B (zh) * 2022-05-23 2023-11-17 四川大学华西医院 一种苯丙氨酸衍生物、药物组合物及其在肿瘤治疗中的应用
CN117603075B (zh) * 2024-01-18 2024-04-12 深圳创元生物医药科技有限公司 一种碳13标记的3-羧酸苯丙氨酸的制备方法

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1883113A (en) * 1932-10-18 new yoek
US3906031A (en) * 1971-03-15 1975-09-16 Research Corp Novel 9-fluorenylmethoxycarbonyl compounds
US4394519A (en) * 1982-01-19 1983-07-19 Research Corporation Amino acid blocking agents
US4879398A (en) * 1987-12-31 1989-11-07 Monsanto Company Process for producing 2,6-disubstituted tyrosine
US5296608A (en) * 1988-04-25 1994-03-22 Hoffman-La Roche Inc. Intermediates for analogs of tyrosine sulfate or tyrosine phosphate containing peptides
US5182263A (en) * 1988-04-25 1993-01-26 Hoffmann-La Roche Inc. Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
US5272268A (en) * 1990-06-28 1993-12-21 Shionogi & Co., Ltd. Dipeptide derivatives
US5679842A (en) * 1990-08-17 1997-10-21 Hoechst Aktiengesellschaft Process for the preparation of aminomethanephosphonic acid and aminomethylphosphinic acids
AU657498B2 (en) * 1990-12-14 1995-03-16 Novartis Ag Biphenylyl compounds
DE4115468A1 (de) * 1991-05-11 1992-11-12 Behringwerke Ag Amidinophenylalaninderivate, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel als antikoagulantien
US5200546A (en) * 1991-09-30 1993-04-06 The United States Of America As Represented By The Department Of Health And Human Services Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
US5587372A (en) * 1991-12-12 1996-12-24 Roussel Uclaf Cephalosporins
EP0655055B1 (en) * 1992-08-13 2000-11-29 Warner-Lambert Company Tachykinin antagonists
TW399041B (en) * 1992-09-09 2000-07-21 Hoechst Ag Substituted cyclohexane derivatives, the preparation and the use for treating diseases
AU5136093A (en) 1992-09-25 1994-04-26 Warner-Lambert Company Peptide antagonists of sh2 binding and therapeutic uses thereof
US5712395A (en) * 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5792771A (en) * 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
US5981569A (en) * 1992-11-13 1999-11-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease
EP0672059A1 (en) * 1992-11-18 1995-09-20 The Du Pont Merck Pharmaceutical Company CYCLIC COMPOUNDS LINKED BY A HETEROCYCLIC RING USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa
GB9302331D0 (en) * 1993-02-05 1993-03-24 Smithkline Beecham Plc Process
PL179628B1 (pl) * 1993-06-30 2000-10-31 Pharmacia Spa Peptydy b ed ace inhibitorami m itogenezy i m otogenezy, sp o só b ich wytwarzania, i zawierajacy je srodek farm aceutyczny PL PL PL PL PL PL
US5824862A (en) * 1993-08-19 1998-10-20 Japan Tobacco Inc. DNA encoding ATP-dependent fructose 6-phosphate 1-phosphotransferase originating from plant, recombinant vector containing the same and method for changing sugar content in plant cells under low temperature
US5491253A (en) * 1993-10-22 1996-02-13 Abbott Laboratories Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane
ES2157994T3 (es) 1993-10-25 2001-09-01 Parke Davis & Co Inhibidores tetra y pentapeptidos sustituidos de la proteina farnesiltransferasa.
US5576323A (en) * 1993-12-03 1996-11-19 Eli Lilly And Company Excitatory amino acid receptor antagonists
WO1995024190A2 (en) * 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US6037134A (en) * 1994-03-07 2000-03-14 New York University Medical Center Methods that detect compounds that disrupt receptor tyrosine kinase/GRB-7 complexes
US5580979A (en) * 1994-03-15 1996-12-03 Trustees Of Tufts University Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
US5849510A (en) * 1994-04-26 1998-12-15 Selectide Corporation Factor Xa inhibitors
US5707624A (en) * 1994-06-03 1998-01-13 The Regents Of The University Of Michigan Treatment of Kaposi's sarcoma by inhibition of scatter factor
US5786454A (en) * 1994-09-16 1998-07-28 Washington University School Of Medicine Modified SH2 domains
WO1996023813A1 (en) * 1995-02-01 1996-08-08 Affymax Technologies N.V. Peptides and compounds that bind to sh2 domains
US5756817C1 (en) * 1995-02-11 2001-04-17 Sk Corp O-carbamoyl-phenylananinol compounds their pharmaceutically useful salts and process for preparing the same
US5710129A (en) * 1995-02-23 1998-01-20 Ariad Pharmaceuticals, Inc. Inhibitors of SH2-mediated processes
US5688992A (en) * 1995-03-31 1997-11-18 The United States Of America As Represented By The Department Of Health And Human Services O-malonyltryrosyl compounds, O-malonyltryrosyl compound-containing peptides, and use thereof
US5686292A (en) * 1995-06-02 1997-11-11 Genentech, Inc. Hepatocyte growth factor receptor antagonist antibodies and uses thereof
US5646036A (en) * 1995-06-02 1997-07-08 Genentech, Inc. Nucleic acids encoding hepatocyte growth factor receptor antagonist antibodies
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
WO1996040629A1 (en) * 1995-06-07 1996-12-19 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell proliferative disorders or cell differentiation disorders
US5710173A (en) * 1995-06-07 1998-01-20 Sugen, Inc. Thienyl compounds for inhibition of cell proliferative disorders
US5798374A (en) * 1995-06-07 1998-08-25 Sugen Inc. Methods of inhibiting phosphatase activity and treatment of disorders associated therewith
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
KR19990022369A (ko) * 1995-06-07 1999-03-25 스테판 이반스-프레크 어뎁터 단백질/티로신 카이나제 상호작용을 방해하는 조성물과그 방법
US5753687A (en) * 1995-06-19 1998-05-19 Ontogen Corporation Modulators of proteins with phosphotryrosine recognition units
US5965558A (en) * 1995-06-19 1999-10-12 Ontogen Corporation Modulators of proteins with phosphotyrosine recognition units
IT1282022B1 (it) * 1995-07-06 1998-03-06 Mini Ricerca Scient Tecnolog Procedimento per la produzione di carbammati aromatici
GB9517060D0 (en) 1995-08-17 1995-10-25 Ciba Geigy Ag Acylated oligopeptide derivatives
WO1997012903A1 (en) * 1995-10-04 1997-04-10 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an sh2 domain to cognate phosphorylated proteins
US5958957A (en) * 1996-04-19 1999-09-28 Novo Nordisk A/S Modulators of molecules with phosphotyrosine recognition units
US5948658A (en) * 1996-06-25 1999-09-07 The Trustees Of Columbia University In The City Of New York Anti-cocaine catalytic antibody
US5922697A (en) * 1996-10-02 1999-07-13 Warner-Lambert Company Compounds, compositions and methods for inhibiting the binding of proteins containing an SH2 domain to cognate phosphorylated proteins
SE9701718D0 (sv) 1997-05-07 1997-05-07 Astra Ab Analgesic peptidomimetic compounds
US6410585B1 (en) 1997-08-28 2002-06-25 Scott D. Larsen Inhibitors of protein tyrosine phosphatase
CA2298601A1 (en) 1997-08-28 1999-03-11 Pharmacia & Upjohn Company Inhibitors of protein tyrosine phosphatase
US6022696A (en) * 1998-04-02 2000-02-08 Washington State University Research Foundation Methods of identifying agonists or antagonists of angiotensin IV
US6228986B1 (en) * 1998-04-13 2001-05-08 Ortho-Mcneil Pharmaceutical, Inc. Solid-phase synthesis of novel 14-membered macroycles for high throughput screening
US6307090B1 (en) * 1999-01-22 2001-10-23 The United States Of America As Represented By The Department Of Health And Human Services Acylated oligopeptide derivatives having cell signal inhibiting activity
WO2000073326A2 (en) 1999-06-02 2000-12-07 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Redox-stable, non-phosphorylated cyclic peptide inhibitors of sh2 domain binding to target protein, conjugates thereof, compositions and methods of synthesis and use

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