AU770920C - Phenylalanine derivatives - Google Patents
Phenylalanine derivativesInfo
- Publication number
- AU770920C AU770920C AU39276/00A AU3927600A AU770920C AU 770920 C AU770920 C AU 770920C AU 39276/00 A AU39276/00 A AU 39276/00A AU 3927600 A AU3927600 A AU 3927600A AU 770920 C AU770920 C AU 770920C
- Authority
- AU
- Australia
- Prior art keywords
- compound
- alkyl
- formula
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- 150000001875 compounds Chemical class 0.000 claims abstract description 236
- -1 e.g. Chemical group 0.000 claims abstract description 89
- 238000000034 method Methods 0.000 claims abstract description 78
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 43
- 125000001424 substituent group Chemical group 0.000 claims abstract description 41
- 102000014400 SH2 domains Human genes 0.000 claims abstract description 33
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 28
- 150000001413 amino acids Chemical class 0.000 claims abstract description 26
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims abstract description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 24
- 150000001412 amines Chemical class 0.000 claims abstract description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 15
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 8
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims abstract description 6
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- 125000000405 phenylalanyl group Chemical group 0.000 claims abstract description 5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 10
- VVXVKSLTODWZAJ-UHFFFAOYSA-N 2-(4-methylphenyl)propanedioic acid Chemical compound CC1=CC=C(C(C(O)=O)C(O)=O)C=C1 VVXVKSLTODWZAJ-UHFFFAOYSA-N 0.000 claims description 9
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
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Classifications
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
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- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Landscapes
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- Chemical & Material Sciences (AREA)
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- Endocrinology (AREA)
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- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
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| US12604799P | 1999-03-23 | 1999-03-23 | |
| US60/126047 | 1999-03-23 | ||
| PCT/US2000/008231 WO2000056760A1 (en) | 1999-03-23 | 2000-03-23 | Phenylalanine derivatives |
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| AU3927600A AU3927600A (en) | 2000-10-09 |
| AU770920B2 AU770920B2 (en) | 2004-03-11 |
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| AU39276/00A Ceased AU770920C (en) | 1999-03-23 | 2000-03-23 | Phenylalanine derivatives |
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|---|---|
| US (1) | US7825216B2 (https=) |
| EP (1) | EP1163262B1 (https=) |
| JP (1) | JP4604161B2 (https=) |
| AT (1) | ATE509026T1 (https=) |
| AU (1) | AU770920C (https=) |
| CA (2) | CA2368733C (https=) |
| WO (1) | WO2000056760A1 (https=) |
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| US7871981B2 (en) * | 1999-10-22 | 2011-01-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of cell motility, angiogenesis, and metastasis |
| JP2003512334A (ja) * | 1999-10-22 | 2003-04-02 | アメリカ合衆国 | Ｇｒｂ−２ｓｈ−２ドメインの阻害剤による細胞運動性及び脈管形成の阻害 |
| AU2001285133A1 (en) * | 2000-08-22 | 2002-03-04 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | SH2 domain binding inhibitors |
| US7425537B2 (en) | 2000-08-22 | 2008-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SH2 domain binding inhibitors |
| US6821979B2 (en) | 2002-03-07 | 2004-11-23 | Blanchette Rockefeller Neurosciences Institute | Synergistic enhancement of cognitive ability |
| TW201206425A (en) | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| CN115192564B (zh) * | 2022-05-23 | 2023-11-17 | 四川大学华西医院 | 一种苯丙氨酸衍生物、药物组合物及其在肿瘤治疗中的应用 |
| CN117603075B (zh) * | 2024-01-18 | 2024-04-12 | 深圳创元生物医药科技有限公司 | 一种碳13标记的3-羧酸苯丙氨酸的制备方法 |
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| US4879398A (en) * | 1987-12-31 | 1989-11-07 | Monsanto Company | Process for producing 2,6-disubstituted tyrosine |
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| US5272268A (en) * | 1990-06-28 | 1993-12-21 | Shionogi & Co., Ltd. | Dipeptide derivatives |
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| AU657498B2 (en) * | 1990-12-14 | 1995-03-16 | Novartis Ag | Biphenylyl compounds |
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| US5587372A (en) * | 1991-12-12 | 1996-12-24 | Roussel Uclaf | Cephalosporins |
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| US5981569A (en) * | 1992-11-13 | 1999-11-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Substituted phenylacrylonitrile compounds and compositions thereof for the treatment of disease |
| EP0672059A1 (en) * | 1992-11-18 | 1995-09-20 | The Du Pont Merck Pharmaceutical Company | CYCLIC COMPOUNDS LINKED BY A HETEROCYCLIC RING USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa |
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| PL179628B1 (pl) * | 1993-06-30 | 2000-10-31 | Pharmacia Spa | Peptydy b ed ace inhibitorami m itogenezy i m otogenezy, sp o só b ich wytwarzania, i zawierajacy je srodek farm aceutyczny PL PL PL PL PL PL |
| US5824862A (en) * | 1993-08-19 | 1998-10-20 | Japan Tobacco Inc. | DNA encoding ATP-dependent fructose 6-phosphate 1-phosphotransferase originating from plant, recombinant vector containing the same and method for changing sugar content in plant cells under low temperature |
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- 2000-03-23 CA CA2368733A patent/CA2368733C/en not_active Expired - Fee Related
- 2000-03-23 CA CA2855415A patent/CA2855415A1/en not_active Abandoned
- 2000-03-23 WO PCT/US2000/008231 patent/WO2000056760A1/en not_active Ceased
- 2000-03-23 AU AU39276/00A patent/AU770920C/en not_active Ceased
- 2000-03-23 EP EP00918474A patent/EP1163262B1/en not_active Expired - Lifetime
- 2000-03-23 JP JP2000606620A patent/JP4604161B2/ja not_active Expired - Fee Related
- 2000-03-23 AT AT00918474T patent/ATE509026T1/de not_active IP Right Cessation
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| Title |
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| BIORG MED. CHEM. LETTERS VOL. 9 PAGES 347352 (1999) * |
| TETRAHEDRON LETTERS VOL. 38 NO. 8, 1389-1392 (1993) * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000056760A1 (en) | 2000-09-28 |
| AU3927600A (en) | 2000-10-09 |
| JP2002544119A (ja) | 2002-12-24 |
| ATE509026T1 (de) | 2011-05-15 |
| US20070219194A1 (en) | 2007-09-20 |
| CA2368733A1 (en) | 2000-09-28 |
| CA2855415A1 (en) | 2000-09-28 |
| JP4604161B2 (ja) | 2010-12-22 |
| US7825216B2 (en) | 2010-11-02 |
| EP1163262A1 (en) | 2001-12-19 |
| AU770920B2 (en) | 2004-03-11 |
| EP1163262B1 (en) | 2011-05-11 |
| CA2368733C (en) | 2014-10-07 |
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