JP2006524682A5 - - Google Patents

Download PDF

Info

Publication number
JP2006524682A5
JP2006524682A5 JP2006507414A JP2006507414A JP2006524682A5 JP 2006524682 A5 JP2006524682 A5 JP 2006524682A5 JP 2006507414 A JP2006507414 A JP 2006507414A JP 2006507414 A JP2006507414 A JP 2006507414A JP 2006524682 A5 JP2006524682 A5 JP 2006524682A5
Authority
JP
Japan
Prior art keywords
optionally substituted
compound according
compound
following formula
substituted lower
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2006507414A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006524682A (ja
JP4960085B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2004/008579 external-priority patent/WO2004083235A2/en
Publication of JP2006524682A publication Critical patent/JP2006524682A/ja
Publication of JP2006524682A5 publication Critical patent/JP2006524682A5/ja
Application granted granted Critical
Publication of JP4960085B2 publication Critical patent/JP4960085B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2006507414A 2003-03-19 2004-03-19 Ｔｉｅ−２モジュレータと使用方法 Expired - Fee Related JP4960085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45656503P 2003-03-19 2003-03-19
US60/456,565 2003-03-19
PCT/US2004/008579 WO2004083235A2 (en) 2003-03-19 2004-03-19 Tie-2 modulators and methods of use

Publications (3)

Publication Number Publication Date
JP2006524682A JP2006524682A (ja) 2006-11-02
JP2006524682A5 true JP2006524682A5 (https=) 2007-05-24
JP4960085B2 JP4960085B2 (ja) 2012-06-27

Family

ID=33030100

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006507414A Expired - Fee Related JP4960085B2 (ja) 2003-03-19 2004-03-19 Ｔｉｅ−２モジュレータと使用方法

Country Status (6)

Country Link
US (1) US8013156B2 (https=)
EP (1) EP1608373A4 (https=)
JP (1) JP4960085B2 (https=)
AU (1) AU2004221812B2 (https=)
CA (1) CA2517291C (https=)
WO (1) WO2004083235A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050124625A1 (en) * 2003-10-21 2005-06-09 Salvati Mark E. Piperazine derivatives and their use as modulators of nuclear hormone receptor function
MX2007006230A (es) 2004-11-30 2007-07-25 Amgen Inc Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer.
JO2787B1 (en) 2005-04-27 2014-03-15 امجين إنك, Alternative amide derivatives and methods of use
CN102743382B (zh) * 2005-09-19 2016-12-07 诺伊罗纳森特公司 刺激神经形成和抑制神经元变性的方法和组合物
AU2013211455B2 (en) * 2005-09-19 2017-12-07 Neuronascent, Inc. Methods and compositions for stimulating neurogenesis and inhibiting neuronal degeneration
WO2008040649A2 (en) * 2006-10-04 2008-04-10 F. Hoffmann-La Roche Ag Pyrazine-2-carboxamide derivatives as cb2 receptor modulators
EP2307456B1 (en) 2008-06-27 2014-10-15 Amgen Inc. Ang-2 inhibition to treat multiple sclerosis
GB0818241D0 (en) 2008-10-06 2008-11-12 Cancer Res Technology Compounds and their use
SG173014A1 (en) 2009-01-16 2011-08-29 Exelixis Inc Malate salt of n- (4- { [ 6, 7-bis (methyloxy) quin0lin-4-yl] oxy}phenyl)-n' - (4 -fluorophenyl) cyclopropane-1,1-dicarboxamide, and crystalline forms therof for the treatment of cancer
US8618111B2 (en) * 2010-01-26 2013-12-31 Boehringer Ingelheim International Gmbh 5-alkynyl-pyrimidines
WO2012061337A1 (en) 2010-11-02 2012-05-10 Exelixis, Inc. Fgfr2 modulators
JP6223563B2 (ja) 2013-10-14 2017-11-01 エーザイ・アール・アンド・ディー・マネジメント株式会社 選択的に置換されたキノリン化合物
CN105636945B (zh) 2013-10-14 2017-11-17 卫材R&D管理有限公司 选择性取代的喹啉化合物
AR104882A1 (es) 2015-06-05 2017-08-23 Orion Corp DERIVADOS DE 2-(1-HETEROARILPIPERAZIN-4-IL)METIL-1,4-BENZODIOXANO COMO ANTAGONISTAS DE a2C
EP4568951A1 (en) * 2022-08-08 2025-06-18 Ajax Therapeutics, Inc. Heterocyclic amide and urea compounds as jak2 inhibitors

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI193974A7 (https=) 1973-07-13 1975-01-14 Merck & Co Inc
DE2428030A1 (de) * 1974-06-11 1976-01-02 Merck Sharp & Dohme Substituierte thiadiazole und verfahren zu ihrer herstellung
EP0096006A3 (de) * 1982-05-28 1984-12-19 Ciba-Geigy Ag 3-(Ureidocyclohexylamino)-propan-1,2-diolderivate, Verfahren zu ihrer Herstellung, pharmazeutische Präparate enthaltend diese Verbindungen, sowie ihre therapeutische Verwendung
US4547505A (en) * 1983-03-25 1985-10-15 Degussa Aktiengesellschaft N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4994476A (en) * 1984-10-31 1991-02-19 Bristol-Myers Company Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties
IT1191845B (it) * 1986-01-20 1988-03-23 Dompe Farmaceutici Spa Alchiloli derivati farmacologicamente attivi
US4954502A (en) 1988-06-10 1990-09-04 Bristol-Myers Squibb Company 1-indolyalkyl-4-(substituted-pyridinyl)piperazines
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
SE9202265D0 (sv) 1992-07-31 1992-07-31 Kabi Pharmacia Ab Novel- pyridyl and pyrimidylpiperazine derivatives
TW279864B (https=) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
US5637592A (en) * 1994-07-12 1997-06-10 Janssen Pharmaceutica N.V. Acyl derivatives of azolones
US5571811A (en) * 1994-07-12 1996-11-05 Janssen Pharmaceutica N.V. Sulfonamide derivatives of azolones
US5639754A (en) * 1994-07-12 1997-06-17 Janssen Pharmaceutica N.V. Urea and thiourea derivatives of azolones
CZ288002B6 (cs) * 1995-01-11 2001-03-14 Samjin Pharmaceutical Co., Ltd. Piperazinové deriváty a farmaceutický prostředek s protinádorovou aktivitou je obsahující
ID19609A (id) * 1996-07-13 1998-07-23 Glaxo Group Ltd Senyawa-senyawa heterosiklik
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
JPH1180119A (ja) * 1997-07-15 1999-03-26 Sankyo Co Ltd ピペラジン誘導体
US6462036B1 (en) 1998-11-06 2002-10-08 Basf Aktiengesellschaft Tricyclic pyrazole derivatives
PT1161424E (pt) * 1999-03-03 2004-08-31 Wyeth Corp Novos derivados de diazole como agentes serotonergicos
SE9901884D0 (sv) * 1999-05-21 1999-05-21 Pharmacia & Upjohn Ab Novel compounds their use and preparation
ES2252004T3 (es) 1999-05-21 2006-05-16 Biovitrum Ab Nuevos compuestos, su uso y preparacion.
US6921763B2 (en) 1999-09-17 2005-07-26 Abbott Laboratories Pyrazolopyrimidines as therapeutic agents
EP1088821A1 (en) 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
JP2004525071A (ja) 2000-07-20 2004-08-19 ニューロジェン コーポレイション カプサイシン受容体リガンド
WO2002059117A1 (en) 2001-01-23 2002-08-01 Eli Lilly And Company Piperazine- and piperidine-derivatives as melanocortin receptor agonists
US20040102455A1 (en) 2001-01-30 2004-05-27 Burns Christopher John Method of inhibiting kinases
WO2002080928A1 (en) * 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
US7064215B2 (en) 2001-07-03 2006-06-20 Chiron Corporation Indazole benzimidazole compounds
DK1531822T3 (da) * 2002-06-12 2009-12-07 Chemocentryx Inc 1-aryl-4-substituerede piperazin derivater til anvendelse som CCR1 antagonister til behandlingen af inflammation og immunforstyrrelser
US7320979B2 (en) * 2003-04-14 2008-01-22 Abbott Gmbh & Co. Kg. N-[(piperazinyl)hetaryl]arylsulfonamide compounds

Similar Documents

Publication Publication Date Title
JP2006524682A5 (https=)
JP2022506887A5 (https=)
JP2002030084A5 (https=)
JP2006523238A5 (https=)
JPWO2020094104A5 (https=)
RU94030499A (ru) Тетрагидроизохинолиновые соединения, их о-ацилированные производные, способ получения, фармацевтическая композиция, способ лечения
RU2011152891A (ru) Диарилгидантоины
JP2009536620A5 (https=)
JP2010528089A5 (https=)
JP2010536887A5 (https=)
CA2407149A1 (en) Melanin-concentrating hormone antagonist
JP2015051999A (ja) 新しい治療用作用物質
AU2009273259B2 (en) Sphingosine 1 phosphate receptor modulators and their use to treat muscle inflammation
JP2002513793A5 (https=)
CA2668997A1 (en) 4-cyanophenylamino-substituted bicyclic heterocyclic compounds as hiv inhibitors
RU2010117156A (ru) Гетероциклические соединения в качестве антагонистов crth2 рецептора
JP2004535436A5 (https=)
CA2539349A1 (en) 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones
JP2018507899A5 (https=)
JP2013533253A5 (https=)
RU2007108415A (ru) Новое циклическое производное аминобензойной кислоты
RU2005137571A (ru) Новые производные диазабициклононена
JP2003513066A5 (https=)
JP2008534541A5 (https=)
Aboussafy et al. A Dieckmann cyclization route to piperazine-2, 5-diones