JP2002542825A5 - - Google Patents
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- Publication number
- JP2002542825A5 JP2002542825A5 JP2000615760A JP2000615760A JP2002542825A5 JP 2002542825 A5 JP2002542825 A5 JP 2002542825A5 JP 2000615760 A JP2000615760 A JP 2000615760A JP 2000615760 A JP2000615760 A JP 2000615760A JP 2002542825 A5 JP2002542825 A5 JP 2002542825A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- residues
- protein
- polynucleotide
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 16
- 102000004169 proteins and genes Human genes 0.000 description 15
- 229920001184 polypeptide Polymers 0.000 description 11
- 102000004196 processed proteins & peptides Human genes 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 11
- 239000002157 polynucleotide Substances 0.000 description 8
- 102000040430 polynucleotide Human genes 0.000 description 8
- 108091033319 polynucleotide Proteins 0.000 description 8
- 238000000034 method Methods 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 5
- 239000013604 expression vector Substances 0.000 description 5
- 239000000203 mixture Substances 0.000 description 4
- 230000035897 transcription Effects 0.000 description 4
- 238000013518 transcription Methods 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- 108091008606 PDGF receptors Proteins 0.000 description 2
- 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 2
- 230000005856 abnormality Effects 0.000 description 2
- 239000012190 activator Substances 0.000 description 2
- 125000003275 alpha amino acid group Chemical group 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 230000002068 genetic effect Effects 0.000 description 2
- 238000013508 migration Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- -1 Amino Chemical group 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000018967 Platelet-Derived Growth Factor beta Receptor Human genes 0.000 description 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 description 1
- 108010076504 Protein Sorting Signals Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000006907 apoptotic process Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000002449 bone cell Anatomy 0.000 description 1
- 230000024245 cell differentiation Effects 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000012292 cell migration Effects 0.000 description 1
- 230000019522 cellular metabolic process Effects 0.000 description 1
- 230000033077 cellular process Effects 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30421699A | 1999-05-03 | 1999-05-03 | |
| US09/304,216 | 1999-05-03 | ||
| US16446399P | 1999-11-10 | 1999-11-10 | |
| US60/164,463 | 1999-11-10 | ||
| US18016900P | 2000-02-04 | 2000-02-04 | |
| US60/180,169 | 2000-02-04 | ||
| PCT/US2000/040047 WO2000066736A1 (en) | 1999-05-03 | 2000-05-03 | Growth factor homolog zvegf4 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002542825A JP2002542825A (ja) | 2002-12-17 |
| JP2002542825A5 true JP2002542825A5 (enExample) | 2007-04-26 |
Family
ID=27389018
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000615760A Pending JP2002542825A (ja) | 1999-05-03 | 2000-05-03 | 増殖因子同族体ｚｖｅｇｆ４ |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1177293A1 (enExample) |
| JP (1) | JP2002542825A (enExample) |
| AU (1) | AU4714500A (enExample) |
| CA (1) | CA2370948C (enExample) |
| MX (1) | MXPA01011158A (enExample) |
| WO (1) | WO2000066736A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999047677A2 (en) | 1998-03-17 | 1999-09-23 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
| US7148037B2 (en) | 1998-11-10 | 2006-12-12 | Ludwig Institute For Cancer Research | Platelet-derived growth factor D, DNA coding therefor, and uses thereof |
| EP2151454B1 (en) * | 1998-11-10 | 2012-05-02 | Ludwig Institute For Cancer Research | Truncated platelet-derived growth factor D, DNA coding therefor, and uses thereof |
| US7105481B2 (en) | 1998-11-10 | 2006-09-12 | Ludwig Institute For Cancer Research | Method for stimulating connective tissue growth or wound healing |
| US6630142B2 (en) | 1999-05-03 | 2003-10-07 | Zymogenetics, Inc. | Method of treating fibroproliferative disorders |
| EP1222279A2 (en) * | 1999-10-07 | 2002-07-17 | Curagen Corporation | Growth factor polypeptides and nucleic acids encoding same |
| WO2001089450A2 (en) * | 2000-05-19 | 2001-11-29 | Eli Lilly And Company | Treating musculoskeletal disorders using lp85 and analogs thereof |
| AU2003210996A1 (en) | 2002-02-11 | 2003-09-04 | Zymogenetics, Inc. | Materials and methods for preparing dimeric growth factors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998024811A2 (en) * | 1996-12-06 | 1998-06-11 | Zymogenetics, Inc. | Vascular endothelial growth factor |
| WO1999037671A1 (en) * | 1998-01-27 | 1999-07-29 | Eli Lilly And Company | Vegf related gene and protein |
| EP2151454B1 (en) * | 1998-11-10 | 2012-05-02 | Ludwig Institute For Cancer Research | Truncated platelet-derived growth factor D, DNA coding therefor, and uses thereof |
| ES2432053T3 (es) * | 1998-12-07 | 2013-11-29 | Zymogenetics, Inc. | Homólogo del factor del crecimiento ZVEGF3 |
-
2000
- 2000-05-03 CA CA2370948A patent/CA2370948C/en not_active Expired - Fee Related
- 2000-05-03 JP JP2000615760A patent/JP2002542825A/ja active Pending
- 2000-05-03 AU AU47145/00A patent/AU4714500A/en not_active Abandoned
- 2000-05-03 EP EP00928993A patent/EP1177293A1/en not_active Withdrawn
- 2000-05-03 MX MXPA01011158A patent/MXPA01011158A/es unknown
- 2000-05-03 WO PCT/US2000/040047 patent/WO2000066736A1/en not_active Ceased
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