JP2002541849A - 血管内皮細胞増殖因子変異体とその用途 - Google Patents

血管内皮細胞増殖因子変異体とその用途

Info

Publication number
JP2002541849A
JP2002541849A JP2000612459A JP2000612459A JP2002541849A JP 2002541849 A JP2002541849 A JP 2002541849A JP 2000612459 A JP2000612459 A JP 2000612459A JP 2000612459 A JP2000612459 A JP 2000612459A JP 2002541849 A JP2002541849 A JP 2002541849A
Authority
JP
Japan
Prior art keywords
vegf
amino acid
flt
kdr
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000612459A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002541849A5 (https=
Inventor
カニンガム，ブライアン
デボス，アブラハム
リ，ビン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of JP2002541849A publication Critical patent/JP2002541849A/ja
Publication of JP2002541849A5 publication Critical patent/JP2002541849A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000612459A 1999-04-16 2000-04-10 血管内皮細胞増殖因子変異体とその用途 Pending JP2002541849A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12978899P 1999-04-16 1999-04-16
US60/129,788 1999-04-16
US18423500P 2000-02-23 2000-02-23
US60/184,235 2000-02-23
PCT/US2000/009483 WO2000063380A1 (en) 1999-04-16 2000-04-10 Vascular endothelial cell growth factor variants and uses thereof

Publications (2)

Publication Number Publication Date
JP2002541849A true JP2002541849A (ja) 2002-12-10
JP2002541849A5 JP2002541849A5 (https=) 2007-06-14

Family

ID=26827914

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000612459A Pending JP2002541849A (ja) 1999-04-16 2000-04-10 血管内皮細胞増殖因子変異体とその用途

Country Status (15)

Country Link
US (1) US20060063203A1 (https=)
EP (2) EP1655368B1 (https=)
JP (1) JP2002541849A (https=)
KR (1) KR100634926B1 (https=)
CN (1) CN1328376C (https=)
AT (2) ATE329024T1 (https=)
AU (1) AU771042B2 (https=)
CA (1) CA2370246C (https=)
DE (2) DE60041367D1 (https=)
ES (2) ES2265931T3 (https=)
HU (1) HU228898B1 (https=)
IL (2) IL145675A0 (https=)
MX (1) MXPA01010469A (https=)
NZ (1) NZ514488A (https=)
WO (1) WO2000063380A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6020473A (en) * 1995-08-25 2000-02-01 Genentech, Inc. Nucleic acids encoding variants of vascular endothelial cell growth factor
US7078382B1 (en) 1999-11-02 2006-07-18 Genentech, Inc. Modulation of eNOS activity and therapeutic uses thereof
IL148674A0 (en) * 1999-11-02 2002-09-12 Genentech Inc Modulation of enos activity and therapeutic uses thereof
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
SI1482987T1 (sl) * 2002-03-01 2014-12-31 Bracco Suisse Sa Večvalentni konstrukti za terapevtske in diagnostične aplikacije
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
CA2666005C (en) * 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
JP5111729B2 (ja) 2002-06-05 2013-01-09 ジェネンテック， インコーポレイテッド 肝成長及び肝保護のための組成物と方法
US7696320B2 (en) 2004-08-24 2010-04-13 Domantis Limited Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
JP4912144B2 (ja) 2003-03-12 2012-04-11 ジェネンテック， インコーポレイテッド 造血促進のためのｂｖ８及び／又はｅｇ−ｖｅｇｆの使用
WO2006014678A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Compositions and methods of using angiopoietin-like 4 protein
WO2006014729A2 (en) 2004-07-20 2006-02-09 Genentech, Inc. Inhibitors of angiopoietin-like 4 protein, combinations, and their use
CN102614134B (zh) 2005-03-25 2016-09-07 瑞泽恩制药公司 Vegf拮抗剂制剂
WO2007109183A2 (en) * 2006-03-20 2007-09-27 Novartis Ag Mutations and polymorphisms of fms-related tyrosine kinase 1
US7608261B2 (en) 2006-06-16 2009-10-27 Regeneron Pharmacuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998016551A2 (en) * 1996-10-17 1998-04-23 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties
JPH10511557A (ja) * 1995-08-25 1998-11-10 ジェネンテク・インコーポレイテッド 血管内皮細胞増殖因子の変種、それらの使用およびそれらの生産法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US169292A (en) * 1875-10-26 Improvement in butter-packages
ES2249762T3 (es) * 1994-03-08 2006-04-01 Human Genome Sciences, Inc. Factor de crecimiento del endotelio vascular 2.
CN1185159A (zh) * 1995-06-06 1998-06-17 人体基因组科学有限公司 人血管内皮生长因子3

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10511557A (ja) * 1995-08-25 1998-11-10 ジェネンテク・インコーポレイテッド 血管内皮細胞増殖因子の変種、それらの使用およびそれらの生産法
WO1998016551A2 (en) * 1996-10-17 1998-04-23 Genentech, Inc. Variants of vascular endothelial cell growth factor having antagonistic properties

Also Published As

Publication number Publication date
CA2370246A1 (en) 2000-10-26
EP1171594B1 (en) 2006-06-07
HK1093218A1 (en) 2007-02-23
DE60028565D1 (de) 2006-07-20
CN1352684A (zh) 2002-06-05
AU4222000A (en) 2000-11-02
ATE420177T1 (de) 2009-01-15
DE60041367D1 (de) 2009-02-26
HUP0200827A3 (en) 2004-11-29
US20060063203A1 (en) 2006-03-23
IL145675A (en) 2010-11-30
EP1655368B1 (en) 2009-01-07
CA2370246C (en) 2017-03-21
KR100634926B1 (ko) 2006-10-17
KR20020008151A (ko) 2002-01-29
ES2265931T3 (es) 2007-03-01
ES2320367T3 (es) 2009-05-21
WO2000063380A1 (en) 2000-10-26
HU228898B1 (en) 2013-06-28
HUP0200827A2 (en) 2002-06-29
AU771042B2 (en) 2004-03-11
DE60028565T2 (de) 2007-06-06
ATE329024T1 (de) 2006-06-15
MXPA01010469A (es) 2002-07-30
CN1328376C (zh) 2007-07-25
NZ514488A (en) 2004-01-30
IL145675A0 (en) 2002-06-30
EP1171594A1 (en) 2002-01-16
EP1655368A1 (en) 2006-05-10

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