SI1482987T1 - Večvalentni konstrukti za terapevtske in diagnostične aplikacije - Google Patents

Večvalentni konstrukti za terapevtske in diagnostične aplikacije

Info

Publication number
SI1482987T1
SI1482987T1 SI200332395T SI200332395T SI1482987T1 SI 1482987 T1 SI1482987 T1 SI 1482987T1 SI 200332395 T SI200332395 T SI 200332395T SI 200332395 T SI200332395 T SI 200332395T SI 1482987 T1 SI1482987 T1 SI 1482987T1
Authority
SI
Slovenia
Prior art keywords
therapeutic
diagnostic applications
multivalent constructs
multivalent
constructs
Prior art date
Application number
SI200332395T
Other languages
English (en)
Inventor
Christophe Arbogast
Philippe Bussat
Daniel T. Dransfield
Hong Fan
Karen E. Linder
Edmund R. Marinelli
Palaniappa Nanjappan
Adrian D. Nunn
Radhakrishna K. Pillai
Sibylle Pochon
Kondareddiar Ramalingam
Aaron Sato
Ajay Shrivastava
Bo Song
Rolf E. Swenson
Wronski Mathew A. Von
Sharon Michele Walker
Feng Yan
Original Assignee
Bracco Suisse Sa
Dyax Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse Sa, Dyax Corp. filed Critical Bracco Suisse Sa
Publication of SI1482987T1 publication Critical patent/SI1482987T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
SI200332395T 2002-03-01 2003-03-03 Večvalentni konstrukti za terapevtske in diagnostične aplikacije SI1482987T1 (sl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US36082102P 2002-03-01 2002-03-01
US44020103P 2003-01-15 2003-01-15
EP03726024.7A EP1482987B1 (en) 2002-03-01 2003-03-03 Multivalent constructs for therapeutic and diagnostic applications
PCT/US2003/006656 WO2003084574A1 (en) 2002-03-01 2003-03-03 Multivalent constructs for therapeutic and diagnostic applications

Publications (1)

Publication Number Publication Date
SI1482987T1 true SI1482987T1 (sl) 2014-12-31

Family

ID=28794312

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200332395T SI1482987T1 (sl) 2002-03-01 2003-03-03 Večvalentni konstrukti za terapevtske in diagnostične aplikacije

Country Status (8)

Country Link
EP (1) EP1482987B1 (sl)
JP (1) JP2005519980A (sl)
AU (1) AU2003228276B8 (sl)
CA (1) CA2477935C (sl)
ES (1) ES2523654T3 (sl)
HK (1) HK1071999A1 (sl)
SI (1) SI1482987T1 (sl)
WO (1) WO2003084574A1 (sl)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US20050250700A1 (en) * 2002-03-01 2005-11-10 Sato Aaron K KDR and VEGF/KDR binding peptides
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7666979B2 (en) * 2002-03-01 2010-02-23 Bracco International B.V. Methods for preparing multivalent constructs for therapeutic and diagnostic applications and methods of preparing the same
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
MXPA05007730A (es) 2003-02-04 2006-01-31 Bracco Int Bv Agentes de contraste para ultrasonido y proceso para la preparacion de los mismos.
US9750821B2 (en) 2003-12-22 2017-09-05 Bracco Suisse S.A. Gas-filled microvesicle assembly for contrast imaging
ES2313352T3 (es) 2004-06-03 2009-03-01 Bracco Research S.A. Ensamblaje de liposomas para uso terapeutico y/o diagnostico.
WO2006018433A1 (en) 2004-08-18 2006-02-23 Bracco Research Sa Gas-filled microvesicles composition for contrast imaging
EP1714642A1 (en) 2005-04-18 2006-10-25 Bracco Research S.A. Pharmaceutical composition comprising gas-filled microcapsules for ultrasound mediated delivery
KR101323849B1 (ko) * 2005-12-09 2013-11-07 브라코 스위스 에스.에이. 표적화 벡터-포스포리피드 컨쥬게이트
WO2008028917A1 (en) 2006-09-05 2008-03-13 Bracco Research Sa Gas-filled microvesicles with polymer-modified lipids
EP2117603A2 (en) 2006-12-19 2009-11-18 Bracco International B.V. Targeting and therapeutic compounds and gas-filled microvesicles comprising said compounds
EP2346532B1 (en) 2008-10-07 2020-10-07 Bracco Suisse SA Targeting construct comprising anti-polymer antibody and microvesicles binding to the same
WO2011080401A1 (en) * 2009-12-31 2011-07-07 Licentia Ltd Receptor tyrosine kinase-binding compositions
JP6231263B2 (ja) * 2012-07-17 2017-11-15 株式会社島津製作所 アフィニティ支持体及びそれを用いた物質の捕捉方法
EP2934740B1 (en) 2012-12-21 2019-12-11 Bracco Suisse SA Gas-filled microvesicles
CA2968478C (en) 2014-12-18 2021-10-12 Bracco Suisse Sa Targeted gas-filled microvesicles formulation
US11717570B2 (en) 2019-05-15 2023-08-08 Bracco Suisse Sa Gas-filled microvesicles
US20200360289A1 (en) 2019-05-15 2020-11-19 Bracco Suisse Sa Freeze-dried product and gas-filled microvesicles suspension

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL139344A0 (en) * 1998-05-19 2001-11-25 Avidex Ltd Soluble t cell receptor
MXPA01010469A (es) * 1999-04-16 2002-07-30 Genentech Inc Variantes del factor de crecimiento celular endotelial vascular y usos de las mismas.
EP1248642A4 (en) * 2000-01-18 2005-05-18 Ludwig Inst Cancer Res PEPTIDOMIMETIC INHIBITOR OF VEGF AND VEGF-C AND -D
AU2003278807A1 (en) * 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7211240B2 (en) * 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
ES2506142T3 (es) * 2002-03-01 2014-10-13 Dyax Corp. Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico

Also Published As

Publication number Publication date
EP1482987B1 (en) 2014-08-13
HK1071999A1 (en) 2005-08-12
WO2003084574A1 (en) 2003-10-16
AU2003228276A1 (en) 2003-10-20
JP2005519980A (ja) 2005-07-07
AU2003228276B2 (en) 2009-09-03
CA2477935A1 (en) 2003-10-16
EP1482987A1 (en) 2004-12-08
CA2477935C (en) 2015-01-06
EP1482987A4 (en) 2007-03-07
ES2523654T3 (es) 2014-11-28
AU2003228276B8 (en) 2010-02-18

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