JP2002541255A5 - - Google Patents
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- Publication number
- JP2002541255A5 JP2002541255A5 JP2000610851A JP2000610851A JP2002541255A5 JP 2002541255 A5 JP2002541255 A5 JP 2002541255A5 JP 2000610851 A JP2000610851 A JP 2000610851A JP 2000610851 A JP2000610851 A JP 2000610851A JP 2002541255 A5 JP2002541255 A5 JP 2002541255A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibition
- binds
- tyrosine kinases
- family tyrosine
- kinases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 description 2
- 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 2
- 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 101100016370 Danio rerio hsp90a.1 gene Proteins 0.000 description 1
- 101100285708 Dictyostelium discoideum hspD gene Proteins 0.000 description 1
- JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 101100071627 Schizosaccharomyces pombe (strain 972 / ATCC 24843) swo1 gene Proteins 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical compound N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- ATEBXHFBFRCZMA-VXTBVIBXSA-N rifabutin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC(=C2N3)C(=O)C=4C(O)=C5C)C)OC)C5=C1C=4C2=NC13CCN(CC(C)C)CC1 ATEBXHFBFRCZMA-VXTBVIBXSA-N 0.000 description 1
- 229960000885 rifabutin Drugs 0.000 description 1
- 230000008684 selective degradation Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Images
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12859399P | 1999-04-09 | 1999-04-09 | |
| US60/128,593 | 1999-04-09 | ||
| PCT/US2000/009512 WO2000061578A1 (en) | 1999-04-09 | 2000-04-07 | Methods and compositions for degradation and/or inhibition of her-family tyrosine kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541255A JP2002541255A (ja) | 2002-12-03 |
| JP2002541255A5 true JP2002541255A5 (enExample) | 2007-07-05 |
Family
ID=22436066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000610851A Pending JP2002541255A (ja) | 1999-04-09 | 2000-04-07 | Ｈｅｒ族チロシンキナーゼの分解および／または阻害方法および組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7271160B2 (enExample) |
| EP (1) | EP1169319A4 (enExample) |
| JP (1) | JP2002541255A (enExample) |
| AU (1) | AU769235B2 (enExample) |
| CA (1) | CA2370007A1 (enExample) |
| WO (1) | WO2000061578A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1079859B1 (en) | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| US7220552B1 (en) | 1999-11-19 | 2007-05-22 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and their use in the disruption of protein-protein interactions |
| EP1229924A4 (en) | 1999-11-19 | 2004-12-15 | Univ Leland Stanford Junior | TARGETED BIFUNCTIONAL MOLECULES AND THERAPIES BASED THEREON |
| US6887842B1 (en) * | 1999-11-19 | 2005-05-03 | The Board Of Trustees Of The Leland Stanford Junior University | Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug |
| US20020002169A1 (en) | 1999-12-08 | 2002-01-03 | Griffin John H. | Protein kinase inhibitors |
| WO2002009696A1 (en) | 2000-07-28 | 2002-02-07 | Sloan-Kettering Institute For Cancer Research | Methods for treating cell proliferative disorders and viral infections |
| US7115651B2 (en) | 2000-08-25 | 2006-10-03 | Sloan-Kettering Institute For Cancer Research | Macrocycles and uses thereof |
| EP1335920B1 (en) | 2000-11-02 | 2013-04-03 | Sloan-Kettering Institute For Cancer Research | Compositions containing purine derivatives for binding to hsp90 |
| EP1404871A4 (en) * | 2001-05-23 | 2006-10-04 | Sloan Kettering Inst Cancer | METHOD OF TREATING CANCERS ASSOCIATED WITH LEVELS OF HER-2 STUDENTS |
| US6872715B2 (en) * | 2001-08-06 | 2005-03-29 | Kosan Biosciences, Inc. | Benzoquinone ansamycins |
| EP1923061A1 (en) | 2001-09-24 | 2008-05-21 | Conforma Therapeutic Corporation | Process for preparing 17-Allyl amino geldanamycin (17-AAG) and other ansamycins |
| DE60225307T2 (de) | 2001-09-24 | 2009-03-19 | Conforma Therapeutics Corp., San Diego | Verfahren zur herstellung von 17-allyl-amino-geldanamycin (17-aag) und anderer ansamycine |
| GB0202871D0 (en) * | 2002-02-07 | 2002-03-27 | Cancer Res Ventures Ltd | Assays,methods and means |
| US7259156B2 (en) | 2004-05-20 | 2007-08-21 | Kosan Biosciences Incorporated | Geldanamycin compounds and method of use |
| KR20070050918A (ko) * | 2004-07-02 | 2007-05-16 | 뉴텍 파마 피엘씨 | 암의 치료 |
| US20060105941A1 (en) * | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
| JP2008534609A (ja) | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Ｈｓｐ９０阻害剤としてのアルキニルピロロピリミジンおよび関連類似体 |
| WO2008005937A2 (en) | 2006-06-30 | 2008-01-10 | Sloan-Kettering Institute For Cancer Research | Treatment of neurodegenerative diseases through inhibiton of hsp90 |
| US20100113355A1 (en) | 2007-04-27 | 2010-05-06 | Naresh Chennamsetty | Novel antibody molecules and nucleic acids binding to fungal stress protein hsp90 |
| WO2010028389A1 (en) * | 2008-09-08 | 2010-03-11 | The Methodist Hospital Research Institute | Image-guided energy deposition for targeted drug delivery |
| NZ599138A (en) | 2009-10-07 | 2014-06-27 | Sloan Kettering Inst Cancer | Purine derivatives useful as hsp90 inhibitors |
| CN103596955B (zh) | 2011-04-05 | 2016-11-16 | 索隆-基特林癌症研究协会 | Hsp90抑制剂 |
| CA2832530C (en) | 2011-04-05 | 2021-02-16 | Sloan-Kettering Institute For Cancer Research | Hsp90 inhibitors |
| WO2012167261A2 (en) | 2011-06-03 | 2012-12-06 | Yale University | Compositions and methods for treating and preventing neointimal stenosis |
| US20140079636A1 (en) | 2012-04-16 | 2014-03-20 | Dinesh U. Chimmanamada | Targeted therapeutics |
| WO2015038649A1 (en) | 2013-09-10 | 2015-03-19 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
| WO2015066053A2 (en) | 2013-10-28 | 2015-05-07 | Synta Pharmaceuticals Corp. | Targeted therapeutics |
| JP2017505777A (ja) | 2014-01-29 | 2017-02-23 | シンタ ファーマスーティカルズ コーポレーション | 標的化治療薬 |
| JP6576942B6 (ja) | 2014-03-03 | 2019-11-27 | マドリガル ファーマシューティカルズ インコーポレイテッド | 標的治療薬 |
| EP3131586A4 (en) | 2014-03-18 | 2017-10-25 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| CA3067572A1 (en) | 2017-06-20 | 2018-12-27 | Madrigal Pharmaceuticals, Inc. | Targeted therapeutics |
| US11491145B2 (en) | 2017-06-20 | 2022-11-08 | Madrigal Pharmaceuticals, Inc. | Combination therapies comprising targeted therapeutics |
| CN117700313B (zh) * | 2023-12-14 | 2025-02-14 | 怒江绿色香料产业研究院 | 一种羟基十四烯醛及其制备方法和应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55111469A (en) * | 1979-02-19 | 1980-08-28 | Kaken Pharmaceut Co Ltd | Novel geldanamycin derivative, its preparation, and antitumor drug comprising it as active ingredient |
| US4261989A (en) * | 1979-02-19 | 1981-04-14 | Kaken Chemical Co. Ltd. | Geldanamycin derivatives and antitumor drug |
| US5650430A (en) | 1990-06-06 | 1997-07-22 | Sankyo Company, Limited | Radicicol derivatives, their preparation and their anti-tumor activity |
| CA2052907A1 (en) * | 1990-10-11 | 1992-04-12 | Joseph P. Vacca | Hiv protease inhibitors having symmetrical structure |
| JP2794342B2 (ja) * | 1993-06-29 | 1998-09-03 | ファイザー・インク． | 抗癌遺伝子剤および抗癌剤としてのアンサマイシン誘導体 |
| US5932566A (en) * | 1994-06-16 | 1999-08-03 | Pfizer Inc. | Ansamycin derivatives as antioncogene and anticancer agents |
| CN1211244A (zh) | 1996-10-25 | 1999-03-17 | 协和发酵工业株式会社 | 根赤壳菌素衍生物 |
| DE69841549D1 (de) * | 1997-05-14 | 2010-04-22 | Sloan Kettering Inst Cancer | Verfahren und zubereitungen zur zerstörung bestimmter proteine |
| US5968921A (en) * | 1997-10-24 | 1999-10-19 | Orgegon Health Sciences University | Compositions and methods for promoting nerve regeneration |
-
2000
- 2000-04-07 WO PCT/US2000/009512 patent/WO2000061578A1/en not_active Ceased
- 2000-04-07 AU AU42235/00A patent/AU769235B2/en not_active Ceased
- 2000-04-07 CA CA002370007A patent/CA2370007A1/en not_active Abandoned
- 2000-04-07 JP JP2000610851A patent/JP2002541255A/ja active Pending
- 2000-04-07 EP EP00921985A patent/EP1169319A4/en not_active Withdrawn
-
2001
- 2001-09-21 US US09/960,665 patent/US7271160B2/en not_active Expired - Fee Related
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