WO2001066551A3 - Azole compounds as therapeutic agents for fungal infections - Google Patents

Azole compounds as therapeutic agents for fungal infections Download PDF

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Publication number
WO2001066551A3
WO2001066551A3 PCT/IB2001/000300 IB0100300W WO0166551A3 WO 2001066551 A3 WO2001066551 A3 WO 2001066551A3 IB 0100300 W IB0100300 W IB 0100300W WO 0166551 A3 WO0166551 A3 WO 0166551A3
Authority
WO
WIPO (PCT)
Prior art keywords
fungal infections
therapeutic agents
azole compounds
compounds
relates
Prior art date
Application number
PCT/IB2001/000300
Other languages
French (fr)
Other versions
WO2001066551A8 (en
WO2001066551A2 (en
Inventor
Ashwani Kumar Verma
Sudershan K Arora
Jasbir Singh Arora
Ashok Rattan
Original Assignee
Ranbaxy Lab Ltd
Ashwani Kumar Verma
Sudershan K Arora
Jasbir Singh Arora
Ashok Rattan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IN198DE2000 external-priority patent/IN191188B/en
Application filed by Ranbaxy Lab Ltd, Ashwani Kumar Verma, Sudershan K Arora, Jasbir Singh Arora, Ashok Rattan filed Critical Ranbaxy Lab Ltd
Priority to AU34023/01A priority Critical patent/AU3402301A/en
Priority to EP01906061A priority patent/EP1278755A2/en
Priority to CA002402345A priority patent/CA2402345A1/en
Priority to PL01365072A priority patent/PL365072A1/en
Priority to JP2001565367A priority patent/JP2004501867A/en
Priority to NZ521241A priority patent/NZ521241A/en
Publication of WO2001066551A2 publication Critical patent/WO2001066551A2/en
Publication of WO2001066551A3 publication Critical patent/WO2001066551A3/en
Publication of WO2001066551A8 publication Critical patent/WO2001066551A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared to known compounds such as fluconazole and itraconazole and the processes for the preparation thereof. This invention also relates to pharmaceutical compositions containing the compounds of the present invention and their use in treating and/or preventing fungal infections in mammals, preferably humans.
PCT/IB2001/000300 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections WO2001066551A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU34023/01A AU3402301A (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections
EP01906061A EP1278755A2 (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections
CA002402345A CA2402345A1 (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections
PL01365072A PL365072A1 (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections
JP2001565367A JP2004501867A (en) 2000-03-07 2001-03-01 Azole compounds as therapeutics for fungal infections
NZ521241A NZ521241A (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN198DE2000 IN191188B (en) 2000-03-07 2000-03-07
IN198/DEL/2000 2000-03-07
US09/575,578 US6670363B1 (en) 2000-03-07 2000-05-22 Azole compounds as therapeutic agents for fungal infections
US09/575,578 2000-05-22

Publications (3)

Publication Number Publication Date
WO2001066551A2 WO2001066551A2 (en) 2001-09-13
WO2001066551A3 true WO2001066551A3 (en) 2002-03-07
WO2001066551A8 WO2001066551A8 (en) 2003-06-26

Family

ID=26324879

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2001/000300 WO2001066551A2 (en) 2000-03-07 2001-03-01 Azole compounds as therapeutic agents for fungal infections

Country Status (8)

Country Link
EP (1) EP1278755A2 (en)
JP (1) JP2004501867A (en)
AU (1) AU3402301A (en)
CA (1) CA2402345A1 (en)
NZ (1) NZ521241A (en)
PL (1) PL365072A1 (en)
RU (1) RU2002126272A (en)
WO (1) WO2001066551A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044160A1 (en) * 2000-11-30 2002-06-06 Senju Pharmaceutical Co., Ltd. Pancreatitis remedies and medicines for prevention and therapy of reflux esophagitis
EP1347758A1 (en) 2000-12-26 2003-10-01 Ranbaxy Laboratories, Ltd. Azole compounds as anti-fungals agents
WO2002060446A1 (en) 2001-01-29 2002-08-08 Shionogi & Co., Ltd. Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient
HUP0303249A3 (en) 2001-02-22 2007-03-28 Sankyo Co Water-soluble triazole fungicide compounds and pharmaceutical compositions containing them
IN192526B (en) * 2001-09-25 2004-04-24 Ranbaxy Lab
AU2002328176A1 (en) * 2002-08-26 2004-03-11 Ranbaxy Laboratories Limited Azole derivatives as antifungal agents
EP1413301A1 (en) * 2002-10-24 2004-04-28 Bayer CropScience SA Antifungal medicaments comprising arylamidine derivatives
JPWO2007020888A1 (en) 2005-08-12 2009-02-26 武田薬品工業株式会社 Brain / nerve cell protective agent and sleep disorder therapeutic agent
US9156830B2 (en) 2011-05-17 2015-10-13 Shionogi & Co., Ltd. Heterocyclic compounds
AU2012272804B2 (en) 2011-06-22 2017-07-06 Vyome Therapeutics Limited Conjugate-based antifungal and antibacterial prodrugs
CN102617494B (en) * 2012-03-15 2014-10-29 南京工业大学 Triazole compound containing vinyl ether structure and preparation method and application thereof
MX2015016675A (en) 2013-06-04 2016-07-15 Vyome Biosciences Pvt Ltd Coated particles and compositions comprising same.
BR112016017690A2 (en) 2014-01-29 2017-08-08 Vyome Biosciences Pvt Ltd RESISTANT ACNE TREATMENTS
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
AR109545A1 (en) 2016-09-29 2018-12-19 Bayer Cropscience Ag TRIAZOL DERIVATIVES

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0567982A1 (en) * 1992-04-28 1993-11-03 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
EP0659751A1 (en) * 1993-12-22 1995-06-28 Takeda Chemical Industries, Ltd. Optically active azole derivatives, their production and use
US5811426A (en) * 1994-07-12 1998-09-22 Janssen Pharmaceutica, N.V. Urea and thiourea derivatives of azolones
WO1999058529A1 (en) * 1998-05-14 1999-11-18 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0567982A1 (en) * 1992-04-28 1993-11-03 Takeda Chemical Industries, Ltd. Azole compounds, their production and use
EP0659751A1 (en) * 1993-12-22 1995-06-28 Takeda Chemical Industries, Ltd. Optically active azole derivatives, their production and use
US5811426A (en) * 1994-07-12 1998-09-22 Janssen Pharmaceutica, N.V. Urea and thiourea derivatives of azolones
WO1999058529A1 (en) * 1998-05-14 1999-11-18 Janssen Pharmaceutica N.V. Water soluble azoles as broad-spectrum antifungals

Also Published As

Publication number Publication date
AU3402301A (en) 2001-09-17
PL365072A1 (en) 2004-12-27
WO2001066551A8 (en) 2003-06-26
WO2001066551A2 (en) 2001-09-13
RU2002126272A (en) 2004-08-10
CA2402345A1 (en) 2001-09-13
JP2004501867A (en) 2004-01-22
NZ521241A (en) 2004-02-27
EP1278755A2 (en) 2003-01-29

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Free format text: IN PCT GAZETTE 37/2001 UNDER (71) THE ADDRESS OF "RANBAXY LABORATORIES LIMITED" CORRECTED; UNDER (72, 75) THE ADDRESSES OF "VERMA, ASHWANI, KUMAR", "ARORA, JASBIR, SINGH" AND "RATTAN, ASHOK" CORRECTED

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