JP2002541088A5 - - Google Patents
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- JP2002541088A5 JP2002541088A5 JP2000609037A JP2000609037A JP2002541088A5 JP 2002541088 A5 JP2002541088 A5 JP 2002541088A5 JP 2000609037 A JP2000609037 A JP 2000609037A JP 2000609037 A JP2000609037 A JP 2000609037A JP 2002541088 A5 JP2002541088 A5 JP 2002541088A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- lymphoma
- liposome
- vincristine
- mol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 description 72
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 50
- 229960004528 vincristine Drugs 0.000 description 37
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 37
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 37
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 32
- 239000002502 liposome Substances 0.000 description 26
- 235000012000 cholesterol Nutrition 0.000 description 25
- 206010025323 Lymphomas Diseases 0.000 description 24
- 239000000243 solution Substances 0.000 description 16
- 206010028980 Neoplasm Diseases 0.000 description 14
- 208000032839 leukemia Diseases 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 13
- 238000000034 method Methods 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 241000124008 Mammalia Species 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 7
- 229940122803 Vinca alkaloid Drugs 0.000 description 7
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 6
- 206010035226 Plasma cell myeloma Diseases 0.000 description 6
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- 208000017604 Hodgkin disease Diseases 0.000 description 4
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- 229940123237 Taxane Drugs 0.000 description 4
- 239000002246 antineoplastic agent Substances 0.000 description 4
- 230000000973 chemotherapeutic effect Effects 0.000 description 4
- 208000011691 Burkitt lymphomas Diseases 0.000 description 3
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 3
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 3
- 230000001154 acute effect Effects 0.000 description 3
- 230000000259 anti-tumor effect Effects 0.000 description 3
- 239000007979 citrate buffer Substances 0.000 description 3
- 229960004679 doxorubicin Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 201000003444 follicular lymphoma Diseases 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 238000001959 radiotherapy Methods 0.000 description 3
- 201000006845 reticulosarcoma Diseases 0.000 description 3
- 208000029922 reticulum cell sarcoma Diseases 0.000 description 3
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 description 3
- AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical group OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 3
- 229960002110 vincristine sulfate Drugs 0.000 description 3
- 206010000830 Acute leukaemia Diseases 0.000 description 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 2
- 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
- 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 2
- 229940045799 anthracyclines and related substance Drugs 0.000 description 2
- 230000000692 anti-sense effect Effects 0.000 description 2
- 239000007853 buffer solution Substances 0.000 description 2
- 238000002512 chemotherapy Methods 0.000 description 2
- 201000002797 childhood leukemia Diseases 0.000 description 2
- 208000024207 chronic leukemia Diseases 0.000 description 2
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 229940052354 dibasic sodium phosphate heptahydrate Drugs 0.000 description 2
- PYLIXCKOHOHGKQ-UHFFFAOYSA-L disodium;hydrogen phosphate;heptahydrate Chemical compound O.O.O.O.O.O.O.[Na+].[Na+].OP([O-])([O-])=O PYLIXCKOHOHGKQ-UHFFFAOYSA-L 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000003325 follicular Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 201000011649 lymphoblastic lymphoma Diseases 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 2
- 229960004618 prednisone Drugs 0.000 description 2
- NRJAVPSFFCBXDT-HUESYALOSA-N 1,2-distearoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCCCCCCCCCCC NRJAVPSFFCBXDT-HUESYALOSA-N 0.000 description 1
- NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 1
- 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
- 101710197836 HLA class I histocompatibility antigen, alpha chain G Proteins 0.000 description 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
- 206010029350 Neurotoxicity Diseases 0.000 description 1
- 206010044221 Toxic encephalopathy Diseases 0.000 description 1
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 238000011319 anticancer therapy Methods 0.000 description 1
- 238000010322 bone marrow transplantation Methods 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 1
- 229940127093 camptothecin Drugs 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000009096 combination chemotherapy Methods 0.000 description 1
- 238000002648 combination therapy Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 1
- 238000009093 first-line therapy Methods 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 230000009826 neoplastic cell growth Effects 0.000 description 1
- 230000007135 neurotoxicity Effects 0.000 description 1
- 231100000228 neurotoxicity Toxicity 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000011275 oncology therapy Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 238000011255 standard chemotherapy Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- 229960004355 vindesine Drugs 0.000 description 1
- UGGWPQSBPIFKDZ-KOTLKJBCSA-N vindesine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(N)=O)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1N=C1[C]2C=CC=C1 UGGWPQSBPIFKDZ-KOTLKJBCSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
Images
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12744499P | 1999-04-01 | 1999-04-01 | |
| US60/127,444 | 1999-04-01 | ||
| US13719499P | 1999-06-02 | 1999-06-02 | |
| US60/137,194 | 1999-06-02 | ||
| PCT/US2000/008669 WO2000059473A1 (en) | 1999-04-01 | 2000-03-31 | Compositions and methods for treating lymphoma |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104769A Division JP5981214B2 (ja) | 1999-04-01 | 2012-05-01 | リンパ腫の治療のための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541088A JP2002541088A (ja) | 2002-12-03 |
| JP2002541088A5 true JP2002541088A5 (https=) | 2011-03-17 |
Family
ID=26825635
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000609037A Pending JP2002541088A (ja) | 1999-04-01 | 2000-03-31 | リンパ腫の治療のための組成物および方法 |
| JP2012104769A Expired - Lifetime JP5981214B2 (ja) | 1999-04-01 | 2012-05-01 | リンパ腫の治療のための組成物および方法 |
| JP2014246221A Pending JP2015071631A (ja) | 1999-04-01 | 2014-12-04 | リンパ腫の治療のための組成物および方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012104769A Expired - Lifetime JP5981214B2 (ja) | 1999-04-01 | 2012-05-01 | リンパ腫の治療のための組成物および方法 |
| JP2014246221A Pending JP2015071631A (ja) | 1999-04-01 | 2014-12-04 | リンパ腫の治療のための組成物および方法 |
Country Status (13)
| Country | Link |
|---|---|
| EP (3) | EP1985285A3 (https=) |
| JP (3) | JP2002541088A (https=) |
| AT (1) | ATE442839T1 (https=) |
| AU (1) | AU777572B2 (https=) |
| BR (1) | BRPI0009448B8 (https=) |
| CA (1) | CA2366787C (https=) |
| CY (1) | CY1109641T1 (https=) |
| DE (1) | DE60042968D1 (https=) |
| DK (2) | DK2266537T3 (https=) |
| ES (2) | ES2524141T3 (https=) |
| IL (4) | IL145720A0 (https=) |
| PT (1) | PT1169021E (https=) |
| WO (1) | WO2000059473A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6723338B1 (en) | 1999-04-01 | 2004-04-20 | Inex Pharmaceuticals Corporation | Compositions and methods for treating lymphoma |
| WO2000059473A1 (en) * | 1999-04-01 | 2000-10-12 | Inex Pharmaceuticals Corp. | Compositions and methods for treating lymphoma |
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| US7303749B1 (en) | 1999-10-01 | 2007-12-04 | Immunogen Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| GB0000313D0 (en) | 2000-01-10 | 2000-03-01 | Astrazeneca Uk Ltd | Formulation |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| ATE440593T1 (de) * | 2001-03-27 | 2009-09-15 | Phares Pharm Res Nv | Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlíslichkeit |
| CA2752124A1 (en) * | 2002-05-17 | 2003-11-27 | Celgene Corporation | Methods and compositions using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for treatment and management of head and neck cancer |
| FR2840203B1 (fr) * | 2002-05-31 | 2004-08-27 | Scherer Technologies Inc R P | Composition pharmaceutique orale pour capsules molles contenant vinorelbine et methode de traitement |
| US6890558B2 (en) | 2002-05-31 | 2005-05-10 | R.P. Scherer Technologies, Inc. | Oral pharmaceutical composition for soft capsules containing vinorelbine and method of treatment |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| RU2252764C2 (ru) * | 2003-03-04 | 2005-05-27 | Российский научный центр рентгенорадиологии МЗ РФ | Способ комплексного лечения лимфогранулематоза |
| US8088387B2 (en) | 2003-10-10 | 2012-01-03 | Immunogen Inc. | Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates |
| WO2005011698A1 (en) * | 2003-07-28 | 2005-02-10 | Inex Pharmaceuticals Corporation | Combination comprising a liposome-encapsulated vinca alkaloid and a topoisomerase ii inhibitor and the use thereof for treating neoplasia |
| WO2006005477A1 (en) * | 2004-07-09 | 2006-01-19 | Schering Ag | Combination therapywith radiolabeled anti-cd20 antibody in the treatment of b-cell lymphoma |
| JP5199666B2 (ja) * | 2004-08-10 | 2013-05-15 | タロン セラピューティクス インコーポレイテッド | 白血病を治療するための組成物および方法 |
| HRP20160625T1 (hr) * | 2007-09-10 | 2016-08-12 | Boston Biomedical, Inc. | Novi inhibitori stat3 signalnog puta i inhibitori matičnih stanica raka |
| DK2644194T3 (en) | 2008-03-18 | 2017-07-03 | Genentech Inc | Combinations of an anti-HER2 antibody-drug conjugate and docetaxel |
| WO2010047714A1 (en) * | 2008-10-24 | 2010-04-29 | Gloucester Pharmaceuticals | Cancer therapy |
| MX2015005992A (es) | 2012-11-20 | 2016-03-07 | Spectrum Pharmaceuticals Inc | Metodo mejorado para la preparacion de la vincristina liposomal encapsulada para el uso terapeutico. |
| WO2014116866A1 (en) * | 2013-01-24 | 2014-07-31 | Memorial Sloan Kettering Cancer Center | Method for diagnosing or treating tumors using sphingomyelin containing liposomes |
| CA2908380A1 (en) | 2013-04-09 | 2014-10-16 | Boston Biomedical, Inc. | Methods for treating cancer |
| TWI678213B (zh) * | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| WO2018102427A1 (en) | 2016-11-29 | 2018-06-07 | Boston Biomedical, Inc. | Naphthofuran derivatives, preparation, and methods of use thereof |
| WO2018213424A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| SI26542A (sl) | 2023-09-12 | 2025-03-31 | Univerza V Ljubljani | Nove liposomske formulacije in postopek za njihovo pripravo |
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| US5837282A (en) | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
| US6320017B1 (en) | 1997-12-23 | 2001-11-20 | Inex Pharmaceuticals Corp. | Polyamide oligomers |
| WO2000059473A1 (en) * | 1999-04-01 | 2000-10-12 | Inex Pharmaceuticals Corp. | Compositions and methods for treating lymphoma |
-
2000
- 2000-03-31 WO PCT/US2000/008669 patent/WO2000059473A1/en not_active Ceased
- 2000-03-31 EP EP08003804A patent/EP1985285A3/en not_active Withdrawn
- 2000-03-31 DK DK10011105.3T patent/DK2266537T3/en active
- 2000-03-31 AU AU40606/00A patent/AU777572B2/en not_active Expired
- 2000-03-31 DK DK00920004T patent/DK1169021T3/da active
- 2000-03-31 IL IL14572000A patent/IL145720A0/xx unknown
- 2000-03-31 ES ES10011105.3T patent/ES2524141T3/es not_active Expired - Lifetime
- 2000-03-31 DE DE60042968T patent/DE60042968D1/de not_active Expired - Lifetime
- 2000-03-31 CA CA2366787A patent/CA2366787C/en not_active Expired - Lifetime
- 2000-03-31 JP JP2000609037A patent/JP2002541088A/ja active Pending
- 2000-03-31 EP EP10011105.3A patent/EP2266537B1/en not_active Expired - Lifetime
- 2000-03-31 AT AT00920004T patent/ATE442839T1/de active
- 2000-03-31 EP EP00920004A patent/EP1169021B1/en not_active Expired - Lifetime
- 2000-03-31 PT PT00920004T patent/PT1169021E/pt unknown
- 2000-03-31 ES ES00920004T patent/ES2333400T3/es not_active Expired - Lifetime
- 2000-03-31 BR BRPI0009448A patent/BRPI0009448B8/pt not_active IP Right Cessation
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2001
- 2001-09-30 IL IL145720A patent/IL145720A/en not_active IP Right Cessation
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2009
- 2009-11-17 CY CY20091101201T patent/CY1109641T1/el unknown
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2011
- 2011-04-14 IL IL212390A patent/IL212390A/en not_active IP Right Cessation
- 2011-04-14 IL IL212389A patent/IL212389A/en not_active IP Right Cessation
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2012
- 2012-05-01 JP JP2012104769A patent/JP5981214B2/ja not_active Expired - Lifetime
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2014
- 2014-12-04 JP JP2014246221A patent/JP2015071631A/ja active Pending
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