JP2002540152A5 - - Google Patents
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- Publication number
- JP2002540152A5 JP2002540152A5 JP2000607623A JP2000607623A JP2002540152A5 JP 2002540152 A5 JP2002540152 A5 JP 2002540152A5 JP 2000607623 A JP2000607623 A JP 2000607623A JP 2000607623 A JP2000607623 A JP 2000607623A JP 2002540152 A5 JP2002540152 A5 JP 2002540152A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrogen
- chloro
- group
- fluoro
- bromo
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229910052739 hydrogen Inorganic materials 0.000 description 32
- 239000001257 hydrogen Substances 0.000 description 32
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 17
- 150000001875 compounds Chemical class 0.000 description 15
- 150000002431 hydrogen Chemical class 0.000 description 15
- 125000001309 chloro group Chemical group Cl* 0.000 description 13
- 125000001153 fluoro group Chemical group F* 0.000 description 9
- 125000000217 alkyl group Chemical group 0.000 description 8
- -1 chloro, bromo, iodo Chemical group 0.000 description 8
- 125000003545 alkoxy group Chemical group 0.000 description 4
- 125000001246 bromo group Chemical group Br* 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 206010028980 Neoplasm Diseases 0.000 description 3
- 201000011510 cancer Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 230000002062 proliferating effect Effects 0.000 description 2
- JJSHRTVHJFKOFB-KTKRTIGZSA-N 1-[[(z)-2-(4-bromophenyl)ethenyl]sulfonylmethyl]-4-chlorobenzene Chemical compound C1=CC(Cl)=CC=C1CS(=O)(=O)\C=C/C1=CC=C(Br)C=C1 JJSHRTVHJFKOFB-KTKRTIGZSA-N 0.000 description 1
- URBLDUHDENNTET-KTKRTIGZSA-N 1-[[(z)-2-(4-bromophenyl)ethenyl]sulfonylmethyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1CS(=O)(=O)\C=C/C1=CC=C(Br)C=C1 URBLDUHDENNTET-KTKRTIGZSA-N 0.000 description 1
- XMPVUPXPMAUISH-KTKRTIGZSA-N 1-[[(z)-2-(4-chlorophenyl)ethenyl]sulfonylmethyl]-4-fluorobenzene Chemical compound C1=CC(F)=CC=C1CS(=O)(=O)\C=C/C1=CC=C(Cl)C=C1 XMPVUPXPMAUISH-KTKRTIGZSA-N 0.000 description 1
- WXVZZCHUAIGQKJ-KTKRTIGZSA-N 1-chloro-4-[[(z)-2-(4-chlorophenyl)ethenyl]sulfonylmethyl]benzene Chemical compound C1=CC(Cl)=CC=C1CS(=O)(=O)\C=C/C1=CC=C(Cl)C=C1 WXVZZCHUAIGQKJ-KTKRTIGZSA-N 0.000 description 1
- GMKXPTFOBQFAOD-KTKRTIGZSA-N 1-chloro-4-[[(z)-2-(4-fluorophenyl)ethenyl]sulfonylmethyl]benzene Chemical compound C1=CC(F)=CC=C1\C=C/S(=O)(=O)CC1=CC=C(Cl)C=C1 GMKXPTFOBQFAOD-KTKRTIGZSA-N 0.000 description 1
- 208000003174 Brain Neoplasms Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- AWHNUHMUCGRKRA-UHFFFAOYSA-N benzylsulfonylmethylbenzene Chemical compound C=1C=CC=CC=1CS(=O)(=O)CC1=CC=CC=C1 AWHNUHMUCGRKRA-UHFFFAOYSA-N 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000002346 iodo group Chemical group I* 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 230000002611 ovarian Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/282,855 | 1999-03-31 | ||
| US09/282,855 US6201154B1 (en) | 1999-03-31 | 1999-03-31 | Z-styryl sulfone anticancer agents |
| PCT/US2000/008350 WO2000057872A1 (en) | 1999-03-31 | 2000-03-30 | Z-styryl sulfone anticancer agents |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002540152A JP2002540152A (ja) | 2002-11-26 |
| JP2002540152A5 true JP2002540152A5 (enExample) | 2007-05-31 |
| JP4468593B2 JP4468593B2 (ja) | 2010-05-26 |
Family
ID=23083418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000607623A Expired - Fee Related JP4468593B2 (ja) | 1999-03-31 | 2000-03-30 | Ｚ−スチリルスルホン抗癌剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US6201154B1 (enExample) |
| EP (1) | EP1180024B1 (enExample) |
| JP (1) | JP4468593B2 (enExample) |
| AT (1) | ATE258790T1 (enExample) |
| AU (1) | AU771133B2 (enExample) |
| CA (1) | CA2368653C (enExample) |
| DE (1) | DE60008098T2 (enExample) |
| WO (1) | WO2000057872A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6762207B1 (en) * | 1999-04-02 | 2004-07-13 | Temple University - Of The Commonwealth System Of Higher Education | (E)-styryl sulfone anticancer agents |
| CA2366750C (en) * | 1999-04-02 | 2010-06-01 | Temple University - Of The Commonwealth System Of Higher Education | (e)-styryl sulfone anticancer agents |
| US6767926B1 (en) * | 1999-10-12 | 2004-07-27 | Temple University - Of The Commonwealth System Of Higher Education | Method for protecting normal cells from cytotoxicity of chemotherapeutic agents |
| US6541475B2 (en) * | 2000-04-14 | 2003-04-01 | Temple University - Of The Commonwealth System Of Higher Education | α, β-unsaturated sulfones for treating proliferative disorders |
| US6486210B2 (en) * | 2000-04-14 | 2002-11-26 | Temple University—Of the Commonwealth System of Higher Education | Substituted styryl benzylsulfones for treating proliferative disorders |
| CA2424884C (en) * | 2000-10-05 | 2009-12-15 | E. Premkumar Reddy | Substituted (e)-styryl benzylsulfones for treating proliferative disorders |
| US6833480B2 (en) * | 2001-02-27 | 2004-12-21 | Temple University - Of The Commonwealth System Of Higher Education | (Z)-styrylbenzylsulfones and pharmaceutical uses thereof |
| ATE406881T1 (de) * | 2001-02-28 | 2008-09-15 | Univ Temple | Verwendung von alpha, beta ungesättigten arylsulfonen zum schutz von zellen und geweben vor toxizität ionischer strahlung |
| WO2004041185A2 (en) * | 2002-10-31 | 2004-05-21 | University Of Rochester | Hyfroxyflutamide induced pathways related to androgen receptor negative prostate cancer cells |
| HUE032523T2 (en) * | 2003-11-14 | 2017-09-28 | Temple Univ - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfoxides for the treatment of proliferative disorders |
| ES2609084T3 (es) | 2004-03-16 | 2017-04-18 | Temple University - Of The Commonwealth System Of Higher Education | Derivados de fenoxi y feniltio sustituidos para tratar trastornos proliferativos |
| CA2577309C (en) | 2004-06-24 | 2013-10-22 | Temple University - Of The Commonwealth System Of Higher Education | Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof |
| PT1896401E (pt) * | 2005-02-25 | 2013-07-17 | Univ Temple | Síntese de sulfuretos, sulfonas, sulfóxidos e sulfonamidas não saturados |
| JP5278968B2 (ja) * | 2006-08-30 | 2013-09-04 | テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション | 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法 |
| US8308342B2 (en) * | 2008-11-24 | 2012-11-13 | Kraft Foods Global Brands Llc | Processing elements for mixing meat products |
| GB201010359D0 (en) | 2010-06-21 | 2010-08-04 | Univ Nottingham | Compounds for treating proliferative disorders |
| US10207989B2 (en) | 2012-09-20 | 2019-02-19 | Temple University—Of the Commonwealth System of Higher Education | Substituted alkyl diaryl derivatives, methods of preparation and uses |
| WO2014089483A1 (en) | 2012-12-07 | 2014-06-12 | Onconova Therapeutics, Inc. | Methods and compositions for treatment of cancer |
| US10383831B2 (en) | 2015-08-03 | 2019-08-20 | Temple University—Of the Commonwealth System of Higher Education | 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2532612A (en) | 1945-08-29 | 1950-12-05 | Union Oil Co | Preparation of unsaturated thio-ethers |
| US3185743A (en) * | 1960-08-24 | 1965-05-25 | Union Carbide Corp | Production of olefinic compounds from allyl sulfones |
| US3463774A (en) | 1963-03-18 | 1969-08-26 | Hoffmann La Roche | Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines |
| US3418101A (en) | 1965-12-15 | 1968-12-24 | Pennsalt Chemicals Corp | Process for plant desiccation |
| US3514386A (en) | 1967-12-11 | 1970-05-26 | Exxon Research Engineering Co | Stereoselective addition of thiols to acetylenic compounds |
| US3917714A (en) | 1972-09-06 | 1975-11-04 | American Cyanamid Co | Bis(alkylsulfonyl)vinylbenzenes |
| US4161407A (en) | 1977-10-06 | 1979-07-17 | Eastman Kodak Company | Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin |
| US4386221A (en) | 1981-10-28 | 1983-05-31 | Eastman Kodak Company | Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones |
| US4937388A (en) | 1985-08-09 | 1990-06-26 | Imperial Chemical Industries Plc | Insecticidal ethers |
| US5659087A (en) | 1995-06-07 | 1997-08-19 | Eli Lilly And Company | Diarylvinyl sulfoxides |
| US5733909A (en) * | 1996-02-01 | 1998-03-31 | Merck Frosst Canada, Inc. | Diphenyl stilbenes as prodrugs to COX-2 inhibitors |
-
1999
- 1999-03-31 US US09/282,855 patent/US6201154B1/en not_active Expired - Lifetime
-
2000
- 2000-03-30 DE DE60008098T patent/DE60008098T2/de not_active Expired - Lifetime
- 2000-03-30 EP EP00919829A patent/EP1180024B1/en not_active Expired - Lifetime
- 2000-03-30 AU AU40450/00A patent/AU771133B2/en not_active Ceased
- 2000-03-30 WO PCT/US2000/008350 patent/WO2000057872A1/en not_active Ceased
- 2000-03-30 JP JP2000607623A patent/JP4468593B2/ja not_active Expired - Fee Related
- 2000-03-30 US US09/937,805 patent/US6576675B1/en not_active Expired - Lifetime
- 2000-03-30 AT AT00919829T patent/ATE258790T1/de not_active IP Right Cessation
- 2000-03-30 CA CA002368653A patent/CA2368653C/en not_active Expired - Fee Related
- 2000-11-22 US US09/722,450 patent/US6414034B1/en not_active Expired - Lifetime
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