JP4468593B2 - Ｚ−スチリルスルホン抗癌剤 - Google Patents

Ｚ−スチリルスルホン抗癌剤 Download PDF

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Publication number
JP4468593B2
JP4468593B2 JP2000607623A JP2000607623A JP4468593B2 JP 4468593 B2 JP4468593 B2 JP 4468593B2 JP 2000607623 A JP2000607623 A JP 2000607623A JP 2000607623 A JP2000607623 A JP 2000607623A JP 4468593 B2 JP4468593 B2 JP 4468593B2
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JP
Japan
Prior art keywords
hydrogen
chloro
group
fluoro
bromo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000607623A
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English (en)
Japanese (ja)
Other versions
JP2002540152A (ja
JP2002540152A5 (enExample
Inventor
レディー，イー，プレムクマー
レディー，エム，ブイ，ラマナ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University
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Temple University
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Filing date
Publication date
Application filed by Temple University filed Critical Temple University
Publication of JP2002540152A publication Critical patent/JP2002540152A/ja
Publication of JP2002540152A5 publication Critical patent/JP2002540152A5/ja
Application granted granted Critical
Publication of JP4468593B2 publication Critical patent/JP4468593B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/20—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
JP2000607623A 1999-03-31 2000-03-30 Ｚ−スチリルスルホン抗癌剤 Expired - Fee Related JP4468593B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/282,855 US6201154B1 (en) 1999-03-31 1999-03-31 Z-styryl sulfone anticancer agents
US09/282,855 1999-03-31
PCT/US2000/008350 WO2000057872A1 (en) 1999-03-31 2000-03-30 Z-styryl sulfone anticancer agents

Publications (3)

Publication Number Publication Date
JP2002540152A JP2002540152A (ja) 2002-11-26
JP2002540152A5 JP2002540152A5 (enExample) 2007-05-31
JP4468593B2 true JP4468593B2 (ja) 2010-05-26

Family

ID=23083418

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000607623A Expired - Fee Related JP4468593B2 (ja) 1999-03-31 2000-03-30 Ｚ−スチリルスルホン抗癌剤

Country Status (8)

Country Link
US (3) US6201154B1 (enExample)
EP (1) EP1180024B1 (enExample)
JP (1) JP4468593B2 (enExample)
AT (1) ATE258790T1 (enExample)
AU (1) AU771133B2 (enExample)
CA (1) CA2368653C (enExample)
DE (1) DE60008098T2 (enExample)
WO (1) WO2000057872A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000059495A1 (en) * 1999-04-02 2000-10-12 Temple University - Of The Commonwealth System Of Higher Education (e)-styryl sulfone anticancer agents
US6762207B1 (en) * 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
US6767926B1 (en) * 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6486210B2 (en) 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
US6541475B2 (en) * 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
CA2424884C (en) * 2000-10-05 2009-12-15 E. Premkumar Reddy Substituted (e)-styryl benzylsulfones for treating proliferative disorders
WO2002067913A1 (en) * 2001-02-27 2002-09-06 Temple University-Of The Commonwealth System Of Higher Education (z)-styrylbenzylsulfones and pharmaceutical uses thereof
US6667346B2 (en) 2001-02-28 2003-12-23 Temple University - Of The Commonwealth System Of Higher Education Method for protecting cells and tissues from ionizing radiation toxicity with α, β unsaturated aryl sulfones
US20060270643A1 (en) * 2002-10-31 2006-11-30 Chawnshang Chang Hyfroxyflutamide induced pathways related to androgen receptor negative prostate cancer cells
AU2004289281C1 (en) * 2003-11-14 2011-12-08 Onconova Therapeutics, Inc. Alpha, beta-Unsaturated sulfoxides for treating proliferative disorders
AU2005222947B2 (en) * 2004-03-16 2010-12-23 Onconova Therapeutics Inc. Substituted phenoxy- and phenylthio- derivatives for treating proliferative disorders
US8058313B2 (en) 2004-06-24 2011-11-15 Temple University—Of the Commonwealth System of Higher Education Alpha, beta-unsaturated sulfones, sulfoxides, sulfonimides, sulfinimides, acylsulfonamides and acylsulfinamides and therapeutic uses thereof
US8143453B2 (en) * 2005-02-25 2012-03-27 Temple University—Of the Commonwealth System of Higher Education Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
US8664272B2 (en) * 2006-08-30 2014-03-04 Temple University—Of the Commonwealth System of Higher Education Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia
US8308342B2 (en) * 2008-11-24 2012-11-13 Kraft Foods Global Brands Llc Processing elements for mixing meat products
GB201010359D0 (en) 2010-06-21 2010-08-04 Univ Nottingham Compounds for treating proliferative disorders
CA2885217C (en) 2012-09-20 2019-10-08 Temple University - Of The Commonwealth System Of Higher Education Substituted alkyl diaryl derivatives, methods of preparation and uses
ES2864681T3 (es) 2012-12-07 2021-10-14 Onconova Therapeutics Inc Tratamiento del cáncer hematológico refractario a un agente contra el cáncer
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532612A (en) 1945-08-29 1950-12-05 Union Oil Co Preparation of unsaturated thio-ethers
US3185743A (en) * 1960-08-24 1965-05-25 Union Carbide Corp Production of olefinic compounds from allyl sulfones
US3463774A (en) 1963-03-18 1969-08-26 Hoffmann La Roche Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
US3418101A (en) 1965-12-15 1968-12-24 Pennsalt Chemicals Corp Process for plant desiccation
US3514386A (en) 1967-12-11 1970-05-26 Exxon Research Engineering Co Stereoselective addition of thiols to acetylenic compounds
US3917714A (en) 1972-09-06 1975-11-04 American Cyanamid Co Bis(alkylsulfonyl)vinylbenzenes
US4161407A (en) 1977-10-06 1979-07-17 Eastman Kodak Company Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin
US4386221A (en) 1981-10-28 1983-05-31 Eastman Kodak Company Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones
US4937388A (en) 1985-08-09 1990-06-26 Imperial Chemical Industries Plc Insecticidal ethers
US5659087A (en) 1995-06-07 1997-08-19 Eli Lilly And Company Diarylvinyl sulfoxides
US5733909A (en) * 1996-02-01 1998-03-31 Merck Frosst Canada, Inc. Diphenyl stilbenes as prodrugs to COX-2 inhibitors

Also Published As

Publication number Publication date
AU771133B2 (en) 2004-03-11
DE60008098D1 (de) 2004-03-11
EP1180024B1 (en) 2004-02-04
ATE258790T1 (de) 2004-02-15
JP2002540152A (ja) 2002-11-26
EP1180024A4 (en) 2002-06-19
US6576675B1 (en) 2003-06-10
AU4045000A (en) 2000-10-16
US6414034B1 (en) 2002-07-02
EP1180024A1 (en) 2002-02-20
WO2000057872A1 (en) 2000-10-05
US6201154B1 (en) 2001-03-13
CA2368653C (en) 2010-01-12
DE60008098T2 (de) 2005-10-27
CA2368653A1 (en) 2000-10-05

Similar Documents

Publication Publication Date Title
JP4294217B2 (ja) スチリルスルホン抗癌剤
EP1180024B1 (en) Z-styryl sulfone anticancer agents
US6486210B2 (en) Substituted styryl benzylsulfones for treating proliferative disorders
AU2001251615A1 (en) Substituted styryl benzylsulfones for treating proliferative disorders
US6762207B1 (en) (E)-styryl sulfone anticancer agents
US6548553B2 (en) Styryl sulfone anticancer agents
US6541475B2 (en) α, β-unsaturated sulfones for treating proliferative disorders
JP4596651B2 (ja) （ｅ）−スチリルスルホン抗癌剤
US7053123B2 (en) Substituted (e)-styryl benzylsulfones for treating proliferative disorders
JP2002541101A (ja) スチリルスルホン抗癌剤

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