ATE258790T1 - Z-styryl sulfonen als anti-krebsmittel - Google Patents

Z-styryl sulfonen als anti-krebsmittel

Info

Publication number
ATE258790T1
ATE258790T1 AT00919829T AT00919829T ATE258790T1 AT E258790 T1 ATE258790 T1 AT E258790T1 AT 00919829 T AT00919829 T AT 00919829T AT 00919829 T AT00919829 T AT 00919829T AT E258790 T1 ATE258790 T1 AT E258790T1
Authority
AT
Austria
Prior art keywords
hydrogen
styryl
chloro
group
cancer agents
Prior art date
Application number
AT00919829T
Other languages
English (en)
Inventor
E Premkumar Reddy
M V Ramana Reddy
Original Assignee
Univ Temple
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Temple filed Critical Univ Temple
Application granted granted Critical
Publication of ATE258790T1 publication Critical patent/ATE258790T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
    • C07C321/12—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms
    • C07C321/20—Sulfides, hydropolysulfides, or polysulfides having thio groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/10—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/07—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
AT00919829T 1999-03-31 2000-03-30 Z-styryl sulfonen als anti-krebsmittel ATE258790T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/282,855 US6201154B1 (en) 1999-03-31 1999-03-31 Z-styryl sulfone anticancer agents
PCT/US2000/008350 WO2000057872A1 (en) 1999-03-31 2000-03-30 Z-styryl sulfone anticancer agents

Publications (1)

Publication Number Publication Date
ATE258790T1 true ATE258790T1 (de) 2004-02-15

Family

ID=23083418

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00919829T ATE258790T1 (de) 1999-03-31 2000-03-30 Z-styryl sulfonen als anti-krebsmittel

Country Status (8)

Country Link
US (3) US6201154B1 (de)
EP (1) EP1180024B1 (de)
JP (1) JP4468593B2 (de)
AT (1) ATE258790T1 (de)
AU (1) AU771133B2 (de)
CA (1) CA2368653C (de)
DE (1) DE60008098T2 (de)
WO (1) WO2000057872A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6762207B1 (en) * 1999-04-02 2004-07-13 Temple University - Of The Commonwealth System Of Higher Education (E)-styryl sulfone anticancer agents
EP1173160B1 (de) * 1999-04-02 2005-06-22 Temple University of the Commonwealth System of Higher Education (e)-styrylsulfone als krebsbestreitende mittel
US6767926B1 (en) * 1999-10-12 2004-07-27 Temple University - Of The Commonwealth System Of Higher Education Method for protecting normal cells from cytotoxicity of chemotherapeutic agents
US6541475B2 (en) * 2000-04-14 2003-04-01 Temple University - Of The Commonwealth System Of Higher Education α, β-unsaturated sulfones for treating proliferative disorders
US6486210B2 (en) * 2000-04-14 2002-11-26 Temple University—Of the Commonwealth System of Higher Education Substituted styryl benzylsulfones for treating proliferative disorders
AU2001296677A1 (en) * 2000-10-05 2002-04-15 Temple University - Of The Commonwealth System Of Higher Education Substituted (e)-styryl benzylsulfones for treating proliferative disorders
EP1379228A4 (de) * 2001-02-27 2006-01-04 Univ Temple (z)-styrylbenzylsulfone und ihre pharmazeutischen anwendungen
JP4302986B2 (ja) * 2001-02-28 2009-07-29 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 細胞及び組織をα，β不飽和アリールスルホンにより電離放射線から防護する方法
AU2003287366A1 (en) * 2002-10-31 2004-06-07 University Of Rochester Hyfroxyflutamide induced pathways related to androgen receptor negative prostate cancer cells
HUE032523T2 (en) * 2003-11-14 2017-09-28 Temple Univ - Of The Commonwealth System Of Higher Education Alpha, beta-unsaturated sulfoxides for the treatment of proliferative disorders
EP1740530B8 (de) 2004-03-16 2017-03-01 Temple University - Of The Commonwealth System of Higher Education Substituierte phenoxy- und phenylthioderivate zur behandlung von proliferativen erkrankungen
EP1773310B9 (de) 2004-06-24 2012-04-25 Temple University - Of The Commonwealth System of Higher Education Alpha-, beta-ungesättigte sulfone, sulfonoxide, sulfonimide, sulfinimide, acylsulfonamide und acylsulfinamide und therapeutische verwendungen damit
US8143453B2 (en) * 2005-02-25 2012-03-27 Temple University—Of the Commonwealth System of Higher Education Unsaturated sulfides, sulfones, sulfoxides and sulfonamides synthesis
JP5278968B2 (ja) * 2006-08-30 2013-09-04 テンプル・ユニバーシティ−オブ・ザ・コモンウェルス・システム・オブ・ハイアー・エデュケイション 骨髄異形性症候群及び急性骨髄性白血病の治療のための組成物及び方法
US8308342B2 (en) * 2008-11-24 2012-11-13 Kraft Foods Global Brands Llc Processing elements for mixing meat products
GB201010359D0 (en) 2010-06-21 2010-08-04 Univ Nottingham Compounds for treating proliferative disorders
ES2863538T3 (es) 2012-09-20 2021-10-11 Univ Temple Derivados de alquil diarilo sustituidos, métodos de preparación y usos
EP2928456B1 (de) 2012-12-07 2021-02-03 Onconova Therapeutics, Inc. Behandlung einer gegenüber einem anti-krebsmittel refraktären hämatologischen krebserkrankung
US10383831B2 (en) 2015-08-03 2019-08-20 Temple University—Of the Commonwealth System of Higher Education 2,4,6-trialkoxystryl aryl sulfones, sulfonamides and carboxamides, and methods of preparation and use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2532612A (en) 1945-08-29 1950-12-05 Union Oil Co Preparation of unsaturated thio-ethers
US3185743A (en) * 1960-08-24 1965-05-25 Union Carbide Corp Production of olefinic compounds from allyl sulfones
US3463774A (en) 1963-03-18 1969-08-26 Hoffmann La Roche Novel 4,1-benzothiazepin-2-(1h)-ones and 4,1-benzothiazepines
US3418101A (en) 1965-12-15 1968-12-24 Pennsalt Chemicals Corp Process for plant desiccation
US3514386A (en) 1967-12-11 1970-05-26 Exxon Research Engineering Co Stereoselective addition of thiols to acetylenic compounds
US3917714A (en) 1972-09-06 1975-11-04 American Cyanamid Co Bis(alkylsulfonyl)vinylbenzenes
US4161407A (en) 1977-10-06 1979-07-17 Eastman Kodak Company Crosslinkable polymers having vinylsulfonyl groups or styrylsulfonyl groups and their use as hardeners for gelatin
US4386221A (en) 1981-10-28 1983-05-31 Eastman Kodak Company Process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones
US4937388A (en) 1985-08-09 1990-06-26 Imperial Chemical Industries Plc Insecticidal ethers
US5659087A (en) 1995-06-07 1997-08-19 Eli Lilly And Company Diarylvinyl sulfoxides
US5733909A (en) * 1996-02-01 1998-03-31 Merck Frosst Canada, Inc. Diphenyl stilbenes as prodrugs to COX-2 inhibitors

Also Published As

Publication number Publication date
EP1180024A4 (de) 2002-06-19
EP1180024A1 (de) 2002-02-20
US6414034B1 (en) 2002-07-02
JP4468593B2 (ja) 2010-05-26
WO2000057872A1 (en) 2000-10-05
AU771133B2 (en) 2004-03-11
CA2368653A1 (en) 2000-10-05
CA2368653C (en) 2010-01-12
US6201154B1 (en) 2001-03-13
DE60008098T2 (de) 2005-10-27
JP2002540152A (ja) 2002-11-26
DE60008098D1 (de) 2004-03-11
AU4045000A (en) 2000-10-16
EP1180024B1 (de) 2004-02-04
US6576675B1 (en) 2003-06-10

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Legal Events

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