JP2002538814A5 - - Google Patents
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- JP2002538814A5 JP2002538814A5 JP2000605633A JP2000605633A JP2002538814A5 JP 2002538814 A5 JP2002538814 A5 JP 2002538814A5 JP 2000605633 A JP2000605633 A JP 2000605633A JP 2000605633 A JP2000605633 A JP 2000605633A JP 2002538814 A5 JP2002538814 A5 JP 2002538814A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- binding domain
- binding
- linker
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 102000004169 proteins and genes Human genes 0.000 description 59
- 108090000623 proteins and genes Proteins 0.000 description 59
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 241000725303 Human immunodeficiency virus Species 0.000 description 7
- 210000003527 eukaryotic cell Anatomy 0.000 description 7
- 230000003472 neutralizing effect Effects 0.000 description 7
- 108020004707 nucleic acids Proteins 0.000 description 7
- 102000039446 nucleic acids Human genes 0.000 description 7
- 108020001507 fusion proteins Proteins 0.000 description 6
- 102000037865 fusion proteins Human genes 0.000 description 6
- 230000006698 induction Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 102000008300 Mutant Proteins Human genes 0.000 description 4
- 108010021466 Mutant Proteins Proteins 0.000 description 4
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 239000003795 chemical substances by application Substances 0.000 description 4
- 230000001939 inductive effect Effects 0.000 description 4
- 102000009410 Chemokine receptor Human genes 0.000 description 3
- 108050000299 Chemokine receptor Proteins 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- -1 CCR2B Proteins 0.000 description 2
- 108010041397 CD4 Antigens Proteins 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 230000004071 biological effect Effects 0.000 description 2
- 102100030949 Apelin receptor Human genes 0.000 description 1
- 102100022718 Atypical chemokine receptor 2 Human genes 0.000 description 1
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 description 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 description 1
- 102100035875 C-C chemokine receptor type 5 Human genes 0.000 description 1
- 101710149870 C-C chemokine receptor type 5 Proteins 0.000 description 1
- 102100036305 C-C chemokine receptor type 8 Human genes 0.000 description 1
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 1
- 102100025618 C-X-C chemokine receptor type 6 Human genes 0.000 description 1
- 101150018759 CG10 gene Proteins 0.000 description 1
- 108010061304 CXCR6 Receptors Proteins 0.000 description 1
- 102100023416 G-protein coupled receptor 15 Human genes 0.000 description 1
- 208000031886 HIV Infections Diseases 0.000 description 1
- 208000037357 HIV infectious disease Diseases 0.000 description 1
- 101000793362 Homo sapiens Apelin receptor Proteins 0.000 description 1
- 101000678892 Homo sapiens Atypical chemokine receptor 2 Proteins 0.000 description 1
- 101000716063 Homo sapiens C-C chemokine receptor type 8 Proteins 0.000 description 1
- 101000716070 Homo sapiens C-C chemokine receptor type 9 Proteins 0.000 description 1
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 1
- 101000727061 Homo sapiens Complement receptor type 1 Proteins 0.000 description 1
- 101000829794 Homo sapiens G-protein coupled receptor 15 Proteins 0.000 description 1
- 101001017968 Homo sapiens Leukotriene B4 receptor 1 Proteins 0.000 description 1
- 102100033374 Leukotriene B4 receptor 1 Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 101150044134 US28 gene Proteins 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 230000003302 anti-idiotype Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 108010043277 recombinant soluble CD4 Proteins 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12468199P | 1999-03-16 | 1999-03-16 | |
| US60/124,681 | 1999-03-16 | ||
| PCT/US2000/006946 WO2000055207A1 (en) | 1999-03-16 | 2000-03-16 | A novel chimeric protein for prevention and treatment of hiv infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538814A JP2002538814A (ja) | 2002-11-19 |
| JP2002538814A5 true JP2002538814A5 (https=) | 2007-04-12 |
Family
ID=22416252
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000605633A Ceased JP2002538814A (ja) | 1999-03-16 | 2000-03-16 | Ｈｉｖ感染の予防および治療のための新規キメラタンパク質 |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1161455B1 (https=) |
| JP (1) | JP2002538814A (https=) |
| AT (1) | ATE407146T1 (https=) |
| AU (1) | AU765218B2 (https=) |
| CA (1) | CA2361292C (https=) |
| DE (1) | DE60040136D1 (https=) |
| ES (1) | ES2313886T3 (https=) |
| WO (1) | WO2000055207A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9925966D0 (en) | 1999-11-02 | 1999-12-29 | Petrik Juraj | Threapeutic vaccines against variable viruses and other targets |
| IL141023A0 (en) * | 2001-01-22 | 2002-02-10 | Gavish Galilee Bio Appl Ltd | Recombinant polypeptides for effective hiv neutralization |
| DK1390535T3 (da) * | 2001-04-26 | 2010-12-06 | Amgen Mountain View Inc | Kombinatoriske biblioteker af monomer-domæner |
| ATE481109T1 (de) | 2001-10-16 | 2010-10-15 | Us Gov Health & Human Serv | Neutralisierende antikörper gegen hiv mit breiter kreuzreaktion, die mit hilfe von env-cd4-co- rezeptorkomplexen selektiert werden |
| US7368114B2 (en) | 2001-10-25 | 2008-05-06 | The United States Of America As Represented By The Department Of Health And Human Services | Fusion protein including of CD4 |
| US7566451B2 (en) | 2002-05-06 | 2009-07-28 | The United States Of America As Represented By The Department Of Health And Human Services | Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency |
| US7803913B2 (en) | 2002-05-06 | 2010-09-28 | The United States Of America As Represented By The Department Of Health And Human Services | Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries |
| WO2004110359A2 (en) * | 2003-05-16 | 2004-12-23 | Acorda Therapeutics, Inc. | Fusion proteins for the treatment of cns |
| ES2319838B1 (es) * | 2006-09-29 | 2010-02-11 | Consejo Superior Investig. Cientificas | Uso de inhibidores de la actividad de la proteina filamina a, para la elaboracion de composiciones farmaceuticas, compuestos inhibidores de dicha actividad, composiciones farmaceuticas y sus aplicaciones terapeuticas y procedimiento identificacion de dichos compuestos inhibidores. |
| WO2010070394A1 (en) * | 2008-12-17 | 2010-06-24 | Universite Pierre Et Marie Curie-Paris Vi | Modulators of the cx3cr1 receptor and therapeutic uses thereof |
| CN111909278B (zh) | 2014-01-27 | 2024-04-09 | 分子模板公司 | Mhc i类表位递送多肽 |
| AU2016271124C1 (en) * | 2015-05-30 | 2020-05-14 | Molecular Templates, Inc. | De-immunized, Shiga toxin a subunit scaffolds and cell-targeting molecules comprising the same |
| MX2022000896A (es) * | 2019-07-24 | 2022-02-14 | Regeneron Pharma | Receptores de antigenos quimericos con especificidad por mage-a4 y usos de los mismos. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU735460B2 (en) * | 1996-06-14 | 2001-07-12 | Aaron Diamond Aids Research Center, The | Uses of a chemokine receptor for inhibiting HIV-1 infection |
| US6432699B1 (en) * | 1997-03-28 | 2002-08-13 | New York University | Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A |
-
2000
- 2000-03-16 DE DE60040136T patent/DE60040136D1/de not_active Expired - Lifetime
- 2000-03-16 CA CA2361292A patent/CA2361292C/en not_active Expired - Fee Related
- 2000-03-16 JP JP2000605633A patent/JP2002538814A/ja not_active Ceased
- 2000-03-16 EP EP00918015A patent/EP1161455B1/en not_active Expired - Lifetime
- 2000-03-16 ES ES00918015T patent/ES2313886T3/es not_active Expired - Lifetime
- 2000-03-16 AT AT00918015T patent/ATE407146T1/de not_active IP Right Cessation
- 2000-03-16 WO PCT/US2000/006946 patent/WO2000055207A1/en not_active Ceased
- 2000-03-16 AU AU38896/00A patent/AU765218B2/en not_active Ceased
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