JP2002538181A5 - - Google Patents
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- JP2002538181A5 JP2002538181A5 JP2000602761A JP2000602761A JP2002538181A5 JP 2002538181 A5 JP2002538181 A5 JP 2002538181A5 JP 2000602761 A JP2000602761 A JP 2000602761A JP 2000602761 A JP2000602761 A JP 2000602761A JP 2002538181 A5 JP2002538181 A5 JP 2002538181A5
- Authority
- JP
- Japan
- Prior art keywords
- patient
- heparanase
- pharmaceutical composition
- bone
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100003684 HPSE Human genes 0.000 claims 10
- 108010037536 heparanase Proteins 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 210000000988 Bone and Bones Anatomy 0.000 claims 7
- 210000004027 cells Anatomy 0.000 claims 6
- 210000001519 tissues Anatomy 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 4
- 102000004190 Enzymes Human genes 0.000 claims 4
- 229920002683 Glycosaminoglycan Polymers 0.000 claims 4
- 230000000593 degrading Effects 0.000 claims 4
- 230000011164 ossification Effects 0.000 claims 4
- 229940088598 Enzyme Drugs 0.000 claims 3
- 101710010421 BN863_22020 Proteins 0.000 claims 2
- 101710010411 BN863_22030 Proteins 0.000 claims 2
- 206010065687 Bone loss Diseases 0.000 claims 2
- 101700032815 GALNS Proteins 0.000 claims 2
- 102100020232 GALNS Human genes 0.000 claims 2
- 101700063555 HYAL Proteins 0.000 claims 2
- 108010022901 Heparin Lyase Proteins 0.000 claims 2
- 102000001974 Hyaluronidase Human genes 0.000 claims 2
- 108010074224 Hyaluronoglucosaminidase Proteins 0.000 claims 2
- 206010028093 Mucopolysaccharidosis Diseases 0.000 claims 2
- 208000002678 Mucopolysaccharidosis Diseases 0.000 claims 2
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 2
- 208000001132 Osteoporosis Diseases 0.000 claims 2
- 238000011087 biopharmaceutical technology Methods 0.000 claims 2
- 229960002773 hyaluronidase Drugs 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 201000008838 periodontal disease Diseases 0.000 claims 2
- 238000002054 transplantation Methods 0.000 claims 2
- 239000011800 void material Substances 0.000 claims 2
- 210000001130 Astrocytes Anatomy 0.000 claims 1
- 210000002459 Blastocyst Anatomy 0.000 claims 1
- 210000001161 Embryo, Mammalian Anatomy 0.000 claims 1
- 210000002510 Keratinocytes Anatomy 0.000 claims 1
- 210000003491 Skin Anatomy 0.000 claims 1
- 210000002536 Stromal Cells Anatomy 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 229960000074 biopharmaceuticals Drugs 0.000 claims 1
- 230000003247 decreasing Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 230000003394 haemopoietic Effects 0.000 claims 1
- 229940020899 hematological Enzymes Drugs 0.000 claims 1
- 238000001764 infiltration Methods 0.000 claims 1
- 230000005012 migration Effects 0.000 claims 1
- 210000003757 neuroblast Anatomy 0.000 claims 1
Claims (24)
- 細胞と、その細胞の外側に付着されている精製された天然のまたは組換え体のグリコサミノグリカン類分解酵素とを生体外で含有し、かくして生体内での前記細胞の血管外滲出、移植、浸潤および／または移動を増大させる、生体内で使用するための生体製剤。
- 前記細胞が造血細胞、間質細胞、角化細胞、胚盤胞、神経芽細胞、星状膠細胞、線維芽細胞および遺伝的に修飾された細胞からなる群から選択される請求項１に記載の生体製剤。
- 前記グリコサミノグリカン類分解酵素が、ヘパラナーゼ、ヘパリナーゼ、グルコロニダーゼ、ヘパリチナーゼ、ヒアルロニダーゼ、スルファターゼおよびコンドロイチナーゼからなる群から選択される請求項１に記載の生体製剤。
- 組織または組織の一部と、それらの外側に付着されている精製された天然のまたは組換え体のグリコサミノグリカン類分解酵素とを生体外で含有し、かくして生体内での前記組織または前記組織の一部の移植を増大させる、生体内で使用するための生体製剤。
- 前記組織または前記組織の一部が胚、皮膚移植片および骨スクラップからなる群から選択される請求項４に記載の生体製剤。
- 前記グリコサミノグリカン類分解酵素が、ヘパラナーゼ、ヘパリナーゼ、グルコロニダーゼ、ヘパリチナーゼ、ヒアルロニダーゼ、スルファターゼおよびコンドロイチナーゼからなる群から選択される請求項４に記載の生体製剤。
- 骨形成を必要とする患者に骨形成を誘導する方法であって、治療的に有効な量のヘパラナーゼを患者に投与することを含む方法。
- 前記ヘパラナーゼがプロヘパラナーゼである請求項７に記載の方法。
- 前記ヘパラナーゼが加工されたヘパラナーゼである請求項７に記載の方法。
- 患者が骨損失、減少した骨質量又は骨折により特徴付けられる医学的症状を有する請求項７に記載の方法。
- 患者が骨形成不全症を有する請求項７に記載の方法。
- 患者が骨粗しょう症を有する請求項７に記載の方法。
- 患者が骨欠損に関連したムコ多糖症又は歯周疾患を有する請求項７に記載の方法。
- 患者が骨空隙を有する請求項７に記載の方法。
- 投与が骨内注射である請求項７に記載の方法。
- 骨形成を必要とする患者に骨形成を誘導するための医薬組成物であって、有効成分として治療的に有効な量のヘパラナーゼ及び医薬的に許容可能なキャリアーを含む医薬組成物。
- 前記ヘパラナーゼがプロへパラナーゼである請求項１６に記載の医薬組成物。
- 前記ヘパラナーゼが加工されたへパラナーゼである請求項１６に記載の医薬組成物。
- 容器に入れられ、骨損失、減少した骨質量又は骨折により特徴付けられる医学的症状を有する患者において使用するために印刷により識別された請求項１６に記載の医薬組成物。
- 容器に入れられ、骨形成不全症を有する患者において使用するために印刷により識別された請求項１６に記載の医薬組成物。
- 容器に入れられ、骨粗しょう症を有する患者において使用するために印刷により識別された請求項１６に記載の医薬組成物。
- 容器に入れられ、骨欠損に関連したムコ多糖症又は歯周疾患を有する患者において使用するために印刷により識別された請求項１６に記載の医薬組成物。
- 容器に入れられ、骨空隙を有する患者において使用するために印刷により識別された請求項１６に記載の医薬組成物。
- 骨内注射を介した投与のために処方される請求項１６に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/260,037 US20010006630A1 (en) | 1997-09-02 | 1999-03-02 | Introducing a biological material into a patient |
| US09/260,037 | 1999-03-02 | ||
| PCT/US2000/003353 WO2000052149A1 (en) | 1999-03-02 | 2000-02-10 | Introducing a biological material into a patient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538181A JP2002538181A (ja) | 2002-11-12 |
| JP2002538181A5 true JP2002538181A5 (ja) | 2005-06-23 |
Family
ID=22987561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000602761A Pending JP2002538181A (ja) | 1999-03-02 | 2000-02-10 | 生体材料の患者への導入 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20010006630A1 (ja) |
| EP (1) | EP1159409A4 (ja) |
| JP (1) | JP2002538181A (ja) |
| AU (1) | AU761592B2 (ja) |
| CA (1) | CA2364463A1 (ja) |
| IL (1) | IL144932A0 (ja) |
| NO (1) | NO20014218L (ja) |
| WO (1) | WO2000052149A1 (ja) |
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| US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
| US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
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| EP1333862A4 (en) * | 2000-10-17 | 2004-08-18 | Insight Strategy & Marketing | PHARMACEUTICAL METHODS AND COMPOSITIONS FOR IMPROVING THE ESTABLISHMENT OF EMBRYOS |
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| JP5189985B2 (ja) | 2005-09-26 | 2013-04-24 | アコーダ セラピューティクス、インク． | コンドロイチナーゼａｂｃｉ変異体を用いた組成物およびその使用方法 |
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| JP7252211B2 (ja) * | 2017-09-08 | 2023-04-04 | ザ ヌムール ファウンデーション | リソソーム蓄積症を治療するための薬剤、デバイス、および血液循環システム、ならびにリソソーム蓄積症を治療するための方法 |
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-
1999
- 1999-03-02 US US09/260,037 patent/US20010006630A1/en not_active Abandoned
-
2000
- 2000-02-10 WO PCT/US2000/003353 patent/WO2000052149A1/en not_active Application Discontinuation
- 2000-02-10 AU AU29881/00A patent/AU761592B2/en not_active Ceased
- 2000-02-10 JP JP2000602761A patent/JP2002538181A/ja active Pending
- 2000-02-10 EP EP00908565A patent/EP1159409A4/en not_active Ceased
- 2000-02-10 CA CA002364463A patent/CA2364463A1/en not_active Abandoned
- 2000-02-10 IL IL14493200A patent/IL144932A0/xx unknown
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2001
- 2001-08-31 NO NO20014218A patent/NO20014218L/no not_active Application Discontinuation
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2002
- 2002-06-07 US US10/163,993 patent/US20030031660A1/en not_active Abandoned
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2004
- 2004-03-15 US US10/799,701 patent/US20040175371A1/en not_active Abandoned
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