JP2002538098A5 - - Google Patents
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- Publication number
- JP2002538098A5 JP2002538098A5 JP2000602039A JP2000602039A JP2002538098A5 JP 2002538098 A5 JP2002538098 A5 JP 2002538098A5 JP 2000602039 A JP2000602039 A JP 2000602039A JP 2000602039 A JP2000602039 A JP 2000602039A JP 2002538098 A5 JP2002538098 A5 JP 2002538098A5
- Authority
- JP
- Japan
- Prior art keywords
- capsule
- emulsifier
- capsule system
- active agent
- excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002775 capsule Substances 0.000 claims 36
- 239000013543 active substance Substances 0.000 claims 17
- 239000000546 pharmaceutical excipient Substances 0.000 claims 13
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims 13
- 239000003995 emulsifying agent Substances 0.000 claims 9
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 9
- 239000007788 liquid Substances 0.000 claims 8
- 239000007957 coemulsifier Substances 0.000 claims 7
- 150000004492 retinoid derivatives Chemical class 0.000 claims 7
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 claims 6
- OGQICQVSFDPSEI-UHFFFAOYSA-N Zorac Chemical group N1=CC(C(=O)OCC)=CC=C1C#CC1=CC=C(SCCC2(C)C)C2=C1 OGQICQVSFDPSEI-UHFFFAOYSA-N 0.000 claims 6
- 239000012190 activator Substances 0.000 claims 6
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 6
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 6
- 229920000053 polysorbate 80 Polymers 0.000 claims 6
- 229940068968 polysorbate 80 Drugs 0.000 claims 6
- 239000001593 sorbitan monooleate Substances 0.000 claims 6
- 235000011069 sorbitan monooleate Nutrition 0.000 claims 6
- 229940035049 sorbitan monooleate Drugs 0.000 claims 6
- 229960000565 tazarotene Drugs 0.000 claims 6
- 239000003963 antioxidant agent Substances 0.000 claims 5
- 230000003078 antioxidant effect Effects 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 238000004945 emulsification Methods 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000004255 Butylated hydroxyanisole Substances 0.000 claims 3
- 235000019282 butylated hydroxyanisole Nutrition 0.000 claims 3
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 claims 3
- 229940043253 butylated hydroxyanisole Drugs 0.000 claims 3
- 239000000049 pigment Substances 0.000 claims 3
- 239000008240 homogeneous mixture Substances 0.000 claims 2
- 230000001737 promoting effect Effects 0.000 claims 2
- 150000003626 triacylglycerols Chemical class 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- 235000019483 Peanut oil Nutrition 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 229920001219 Polysorbate 40 Polymers 0.000 claims 1
- 229920001214 Polysorbate 60 Polymers 0.000 claims 1
- 235000019485 Safflower oil Nutrition 0.000 claims 1
- IYFATESGLOUGBX-YVNJGZBMSA-N Sorbitan monopalmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O IYFATESGLOUGBX-YVNJGZBMSA-N 0.000 claims 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 1
- 239000002285 corn oil Substances 0.000 claims 1
- 235000005687 corn oil Nutrition 0.000 claims 1
- 235000012343 cottonseed oil Nutrition 0.000 claims 1
- 239000002385 cottonseed oil Substances 0.000 claims 1
- 238000004090 dissolution Methods 0.000 claims 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 1
- 229940093471 ethyl oleate Drugs 0.000 claims 1
- 230000037406 food intake Effects 0.000 claims 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000000312 peanut oil Substances 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000249 polyoxyethylene sorbitan monopalmitate Substances 0.000 claims 1
- 235000010483 polyoxyethylene sorbitan monopalmitate Nutrition 0.000 claims 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229940101027 polysorbate 40 Drugs 0.000 claims 1
- 229940113124 polysorbate 60 Drugs 0.000 claims 1
- 235000005713 safflower oil Nutrition 0.000 claims 1
- 239000003813 safflower oil Substances 0.000 claims 1
- 239000008159 sesame oil Substances 0.000 claims 1
- 235000011803 sesame oil Nutrition 0.000 claims 1
- 229940035044 sorbitan monolaurate Drugs 0.000 claims 1
- 239000001570 sorbitan monopalmitate Substances 0.000 claims 1
- 235000011071 sorbitan monopalmitate Nutrition 0.000 claims 1
- 229940031953 sorbitan monopalmitate Drugs 0.000 claims 1
- 239000001587 sorbitan monostearate Substances 0.000 claims 1
- 235000011076 sorbitan monostearate Nutrition 0.000 claims 1
- 229940035048 sorbitan monostearate Drugs 0.000 claims 1
- 239000003549 soybean oil Substances 0.000 claims 1
- 235000012424 soybean oil Nutrition 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/262,623 US6248354B1 (en) | 1999-03-04 | 1999-03-04 | Capsule system |
| US09/262,623 | 1999-03-04 | ||
| PCT/US2000/005811 WO2000051571A2 (en) | 1999-03-04 | 2000-03-03 | Capsule system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002538098A JP2002538098A (ja) | 2002-11-12 |
| JP2002538098A5 true JP2002538098A5 (https=) | 2005-09-15 |
Family
ID=22998308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000602039A Pending JP2002538098A (ja) | 1999-03-04 | 2000-03-03 | カプセルシステム |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US6248354B1 (https=) |
| EP (1) | EP1158965A2 (https=) |
| JP (1) | JP2002538098A (https=) |
| AU (1) | AU768796B2 (https=) |
| CA (1) | CA2363933C (https=) |
| HK (1) | HK1042241A1 (https=) |
| WO (1) | WO2000051571A2 (https=) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6248354B1 (en) * | 1999-03-04 | 2001-06-19 | Allergan Sales, Inc. | Capsule system |
| US7115277B2 (en) * | 1999-03-04 | 2006-10-03 | Allergan, Inc. | Method for enabling delivery of an active agent |
| US6457471B1 (en) | 2000-06-30 | 2002-10-01 | Medihale Ltd. | Dual-purpose medical device for upper airway treatment and methods for using same |
| KR100560092B1 (ko) * | 2000-12-15 | 2006-03-10 | 파트릭 프랑케 | 저알레르기성 및 비자극성 피부 보호 제제 |
| US6752953B2 (en) * | 2001-12-03 | 2004-06-22 | Yung Shin Pharmaceutical Co., Ltd. | Method for manufacturing hard non-gelatin pharmaceutical capsules |
| EP1547588B1 (en) * | 2002-08-20 | 2013-12-11 | Kowa Company, Ltd. | Soft capsule preparation |
| EP1527774A1 (en) * | 2003-11-03 | 2005-05-04 | Basilea Pharmaceutica AG | New formulation for retinoid-containing soft gelatin capsules |
| US20050026958A1 (en) * | 2003-07-30 | 2005-02-03 | Allergan, Inc. | Methods of therapeutic treatment using amounts of retinoid components |
| US20050026950A1 (en) * | 2003-07-30 | 2005-02-03 | Allergan, Inc. | Methods of therapeutic treatment using retinoids to achieve consistent bioavailability |
| CA2534008A1 (en) * | 2003-07-30 | 2005-02-10 | Allergan, Inc. | Methods of therapeutic treatment using amounts of retinoid components |
| US20050026949A1 (en) * | 2003-07-30 | 2005-02-03 | Allergan, Inc. | Methods of therapeutic treatment using amounts of retinoids without regard to body weight |
| US20060020037A1 (en) * | 2004-07-22 | 2006-01-26 | Allergan, Inc. | Tazarotenic acid and esters thereof for treating autism |
| US20060234948A1 (en) * | 2005-04-04 | 2006-10-19 | Empie Mark W | Lignan-containing compositions |
| US20070060620A1 (en) * | 2005-09-09 | 2007-03-15 | John Sefton | Use of RAR retinoid agonists to increase sperm count and sperm mobility in males |
| CN102438590B (zh) * | 2009-02-25 | 2013-07-10 | 施泰福研究澳大利亚有限公司 | 局部泡沫组合物 |
| US10022348B2 (en) | 2009-05-20 | 2018-07-17 | Sun Pharmaceutical Industries Limited | Topical solution of isotretinoin |
| EP3006021A1 (en) | 2009-05-20 | 2016-04-13 | Ranbaxy Laboratories Limited | Topical retinoid solutions |
| GB2488788B (en) * | 2011-03-07 | 2013-07-10 | Natco Pharma Ltd | Oral formulation of phenylaminopyrymidine compound with enhanced bioavailability and pharmacological response |
| BR112014032948A2 (pt) * | 2012-07-02 | 2017-06-27 | Dsm Ip Assets Bv | cápsulas contendo timoquinona |
| JP7728653B2 (ja) * | 2021-04-05 | 2025-08-25 | 真 小林 | 内視鏡用処置具 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2960M (fr) * | 1962-03-30 | 1964-11-30 | Pfizer & Co C | Compositions, facilement dispersibles dans l'eau, a base d'ester d'acide gras de vitamine a. |
| JPS58128141A (ja) * | 1982-01-26 | 1983-07-30 | Sumitomo Chem Co Ltd | 自己乳化分散型カロチノイド類含有ソフトカプセル剤の製法 |
| US4612194A (en) | 1984-02-15 | 1986-09-16 | Roshdy Ismail | Anti-rheumatic agents and their use |
| CA1282326C (en) | 1984-12-14 | 1991-04-02 | Paul J. Jarosz | Pharmaceutical composition containing 13-cis vitamin a acid as the active ingredient |
| GB8822857D0 (en) * | 1988-09-29 | 1988-11-02 | Patralan Ltd | Pharmaceutical formulations |
| JPH0426670A (ja) * | 1990-05-18 | 1992-01-29 | Nisshin Flour Milling Co Ltd | 安定化された油溶性ビタミン含有組成物 |
| JPH11504028A (ja) * | 1995-04-24 | 1999-04-06 | イースム リサーチ ディベロップメント カンパニー オブ ザ ヒーブル ユニバーシティ オブ エルサレム | 油／水エマルジョンを作り出す自己乳化性配合物 |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| US6248354B1 (en) * | 1999-03-04 | 2001-06-19 | Allergan Sales, Inc. | Capsule system |
-
1999
- 1999-03-04 US US09/262,623 patent/US6248354B1/en not_active Expired - Fee Related
-
2000
- 2000-03-03 WO PCT/US2000/005811 patent/WO2000051571A2/en not_active Ceased
- 2000-03-03 JP JP2000602039A patent/JP2002538098A/ja active Pending
- 2000-03-03 EP EP00916109A patent/EP1158965A2/en not_active Withdrawn
- 2000-03-03 HK HK02103939.6A patent/HK1042241A1/zh unknown
- 2000-03-03 AU AU37266/00A patent/AU768796B2/en not_active Ceased
- 2000-03-03 CA CA002363933A patent/CA2363933C/en not_active Expired - Fee Related
-
2001
- 2001-01-12 US US09/760,133 patent/US6656500B2/en not_active Expired - Fee Related
-
2003
- 2003-11-21 US US10/719,287 patent/US20040115257A1/en not_active Abandoned
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