JP2002533701A - 細胞発現プロファイルの統計的組合せ - Google Patents
細胞発現プロファイルの統計的組合せInfo
- Publication number
- JP2002533701A JP2002533701A JP2000591227A JP2000591227A JP2002533701A JP 2002533701 A JP2002533701 A JP 2002533701A JP 2000591227 A JP2000591227 A JP 2000591227A JP 2000591227 A JP2000591227 A JP 2000591227A JP 2002533701 A JP2002533701 A JP 2002533701A
- Authority
- JP
- Japan
- Prior art keywords
- microarray
- fluorophore
- pool
- genetic material
- experiment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
- G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/222,596 US6351712B1 (en) | 1998-12-28 | 1998-12-28 | Statistical combining of cell expression profiles |
US09/222,596 | 1998-12-28 | ||
PCT/US1999/030837 WO2000039339A1 (en) | 1998-12-28 | 1999-12-27 | Statistical combining of cell expression profiles |
Publications (2)
Publication Number | Publication Date |
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JP2002533701A true JP2002533701A (ja) | 2002-10-08 |
JP2002533701A5 JP2002533701A5 (US20020128781A1-20020912-P00012.png) | 2007-03-22 |
Family
ID=22832874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000591227A Pending JP2002533701A (ja) | 1998-12-28 | 1999-12-27 | 細胞発現プロファイルの統計的組合せ |
Country Status (7)
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005034003A1 (ja) * | 2003-10-01 | 2005-04-14 | Japan As Represented By The President Of National Institute Of Genetics | マイクロアレイ実験等から得られるデータの新規解析方法 |
JP4833495B2 (ja) * | 2000-08-03 | 2011-12-07 | アレイジェット リミテッド | インクジェットプリントヘッドによるマイクロアレイの高度平行構成体 |
Families Citing this family (112)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6456942B1 (en) * | 1998-01-25 | 2002-09-24 | Combimatrix Corporation | Network infrastructure for custom microarray synthesis and analysis |
US6990221B2 (en) * | 1998-02-07 | 2006-01-24 | Biodiscovery, Inc. | Automated DNA array image segmentation and analysis |
SE9801420D0 (sv) * | 1998-04-22 | 1998-04-22 | Mikael Kubista | Metod för karakterisering av enstaka testprover |
US6351712B1 (en) * | 1998-12-28 | 2002-02-26 | Rosetta Inpharmatics, Inc. | Statistical combining of cell expression profiles |
EP1147229A2 (en) * | 1999-02-02 | 2001-10-24 | Bernhard O. Palsson | Methods for identifying drug targets based on genomic sequence data |
US6136541A (en) | 1999-02-22 | 2000-10-24 | Vialogy Corporation | Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions |
US6142681A (en) | 1999-02-22 | 2000-11-07 | Vialogy Corporation | Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics |
US6731781B1 (en) * | 1999-09-30 | 2004-05-04 | Biodiscovery, Inc. | System and method for automatically processing microarrays |
US7099502B2 (en) * | 1999-10-12 | 2006-08-29 | Biodiscovery, Inc. | System and method for automatically processing microarrays |
US6607885B1 (en) | 1999-10-15 | 2003-08-19 | E. I. Du Pont De Nemours And Company | Method for high-density microarray medicated gene expression profiling |
WO2003042780A2 (en) * | 2001-11-09 | 2003-05-22 | Gene Logic Inc. | System and method for storage and analysis of gene expression data |
US6424921B1 (en) * | 2000-07-10 | 2002-07-23 | Incyte Genomics, Inc. | Averaging multiple hybridization arrays |
JP2002065259A (ja) * | 2000-08-24 | 2002-03-05 | Shinya Watanabe | 核酸標識方法および核酸標識用キット |
US6713257B2 (en) | 2000-08-25 | 2004-03-30 | Rosetta Inpharmatics Llc | Gene discovery using microarrays |
US20020107640A1 (en) * | 2000-11-14 | 2002-08-08 | Ideker Trey E. | Methods for determining the true signal of an analyte |
US20030130798A1 (en) * | 2000-11-14 | 2003-07-10 | The Institute For Systems Biology | Multiparameter integration methods for the analysis of biological networks |
CA2327527A1 (en) * | 2000-12-27 | 2002-06-27 | Geneka Biotechnologie Inc. | Method for the normalization of the relative fluorescence intensities of two rna samples in hybridization arrays |
US7127379B2 (en) * | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
CA2439260C (en) * | 2001-03-01 | 2012-10-23 | The Regents Of The University Of California | Models and methods for determining systemic properties of regulated reaction networks |
US7146062B2 (en) * | 2001-03-08 | 2006-12-05 | Clarient, Inc. | Apparatus and method for labeling rows and columns in an irregular array |
US7219016B2 (en) * | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
AU2002307486A1 (en) * | 2001-04-26 | 2002-11-11 | Rosetta Inpharmatics, Inc. | Methods and compositions for utilizing changes of hybridization signals during approach to equilibrium |
WO2002095654A1 (en) * | 2001-05-22 | 2002-11-28 | Entelos, Inc. | Methods for predicting the activities of cellular constituents |
US20030104426A1 (en) * | 2001-06-18 | 2003-06-05 | Linsley Peter S. | Signature genes in chronic myelogenous leukemia |
US6691042B2 (en) * | 2001-07-02 | 2004-02-10 | Rosetta Inpharmatics Llc | Methods for generating differential profiles by combining data obtained in separate measurements |
US6768961B2 (en) * | 2001-09-14 | 2004-07-27 | Yield Dyamics, Inc. | System and method for analyzing error information from a semiconductor fabrication process |
US20030073085A1 (en) * | 2001-10-05 | 2003-04-17 | Fang Lai | Amplifying expressed sequences from genomic DNA of higher-order eukaryotic organisms for DNA arrays |
WO2003035865A1 (fr) * | 2001-10-22 | 2003-05-01 | Takara Bio Inc. | Procede de marquage d'acides nucleiques |
US7751981B2 (en) | 2001-10-26 | 2010-07-06 | The Regents Of The University Of California | Articles of manufacture and methods for modeling Saccharomyces cerevisiae metabolism |
US7418351B2 (en) * | 2002-01-31 | 2008-08-26 | Rosetta Inpharmatics Llc | Methods for analysis of measurement errors in measured signals |
AU2003216257A1 (en) * | 2002-02-11 | 2003-09-04 | Syngenta Participations Ag | Gene function inferring using gene expression data |
JP4438414B2 (ja) * | 2002-02-21 | 2010-03-24 | 味の素株式会社 | 遺伝子発現情報解析装置、遺伝子発現情報解析方法、プログラム、および、記録媒体 |
WO2003076928A1 (en) * | 2002-03-07 | 2003-09-18 | University Of Utah Research Foundation | Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data analysis |
US20030224363A1 (en) * | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
AU2003222128A1 (en) * | 2002-03-29 | 2003-10-13 | Genomatica, Inc. | Human metabolic models and methods |
US8949032B2 (en) * | 2002-03-29 | 2015-02-03 | Genomatica, Inc. | Multicellular metabolic models and methods |
US7856317B2 (en) * | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
AU2003294211A1 (en) * | 2002-08-01 | 2004-04-23 | Gene Logic Inc. | Method and system for managing and querying gene expression data according to quality |
US7512496B2 (en) * | 2002-09-25 | 2009-03-31 | Soheil Shams | Apparatus, method, and computer program product for determining confidence measures and combined confidence measures for assessing the quality of microarrays |
US7869957B2 (en) * | 2002-10-15 | 2011-01-11 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
CA2500761C (en) * | 2002-10-15 | 2012-11-20 | Bernhard O. Palsson | Methods and systems to identify operational reaction pathways |
US7996155B2 (en) | 2003-01-22 | 2011-08-09 | Microsoft Corporation | ANOVA method for data analysis |
JP2004254298A (ja) * | 2003-01-30 | 2004-09-09 | Ricoh Co Ltd | 画像処理装置、プログラム及び記憶媒体 |
EP1625394A4 (en) * | 2003-04-23 | 2008-02-06 | Bioseek Inc | METHOD FOR ANALYZING BIOLOGICAL DATA PROFILES |
US8301388B2 (en) * | 2003-05-05 | 2012-10-30 | Amplicon Express, Inc. | Pool and superpool matrix coding and decoding designs and methods |
US20040229226A1 (en) * | 2003-05-16 | 2004-11-18 | Reddy M. Parameswara | Reducing microarray variation with internal reference spots |
EP1628993A4 (en) * | 2003-05-16 | 2010-04-07 | Rosetta Inpharmatics Llc | METHOD AND COMPOSITIONS FOR RNA INTERFERENCE |
JP2004348674A (ja) * | 2003-05-26 | 2004-12-09 | Noritsu Koki Co Ltd | 領域検出方法及びその装置 |
US20050143628A1 (en) * | 2003-06-18 | 2005-06-30 | Xudong Dai | Methods for characterizing tissue or organ condition or status |
US8321137B2 (en) * | 2003-09-29 | 2012-11-27 | Pathwork Diagnostics, Inc. | Knowledge-based storage of diagnostic models |
US20050069863A1 (en) * | 2003-09-29 | 2005-03-31 | Jorge Moraleda | Systems and methods for analyzing gene expression data for clinical diagnostics |
EP2469439A2 (en) | 2003-09-29 | 2012-06-27 | Pathwork Diagnostics, Inc. | Systems and methods for detecting biological features |
US7519565B2 (en) * | 2003-11-03 | 2009-04-14 | Cloudmark, Inc. | Methods and apparatuses for classifying electronic documents |
US20050149546A1 (en) * | 2003-11-03 | 2005-07-07 | Prakash Vipul V. | Methods and apparatuses for determining and designating classifications of electronic documents |
US20050094807A1 (en) * | 2003-11-04 | 2005-05-05 | John Silzel | Accuracy array assay system and method |
KR20070000438A (ko) * | 2003-12-23 | 2007-01-02 | 게노믹 헬쓰, 인코포레이티드 | 단편화 rna의 범용적 증폭 |
WO2005067640A2 (en) * | 2004-01-07 | 2005-07-28 | University Of Hawaii | Methods for enhanced detection & analysis of differentially expressed genes using gene chip microarrays |
EP1719051A4 (en) * | 2004-02-27 | 2009-06-17 | Bioseek Inc | BIOLOGICAL RECORDING OF ASTHMA AND ATOPY |
CA2558808A1 (en) | 2004-03-05 | 2005-09-22 | Rosetta Inpharmatics Llc | Classification of breast cancer patients using a combination of clinical criteria and informative genesets |
US7881872B2 (en) * | 2004-03-12 | 2011-02-01 | Microsoft Corporation | Methods of analyzing multi-channel profiles |
US7660709B2 (en) * | 2004-03-18 | 2010-02-09 | Van Andel Research Institute | Bioinformatics research and analysis system and methods associated therewith |
US7653260B2 (en) * | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
US8582924B2 (en) * | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
US7542854B2 (en) * | 2004-07-22 | 2009-06-02 | International Business Machines Corporation | Method for discovering gene regulatory models and genetic networks using relational fuzzy models |
US8484000B2 (en) | 2004-09-02 | 2013-07-09 | Vialogy Llc | Detecting events of interest using quantum resonance interferometry |
BRPI0615980A2 (pt) * | 2005-07-26 | 2011-05-31 | Council Scient Ind Res | método de identificação de genes que aumentam a toleráncia ao stress na levedura para melhorar a eficiência da levedura |
US7437249B2 (en) * | 2006-06-30 | 2008-10-14 | Agilent Technologies, Inc. | Methods and systems for detrending signal intensity data from chemical arrays |
CN101790731B (zh) * | 2007-03-16 | 2013-11-06 | 纳特拉公司 | 用于清除遗传数据干扰并确定染色体拷贝数的系统和方法 |
US20090023182A1 (en) * | 2007-07-18 | 2009-01-22 | Schilling Christophe H | Complementary metabolizing organisms and methods of making same |
WO2009052417A2 (en) * | 2007-10-18 | 2009-04-23 | Rubinstein Wendy S | Breast cancer profiles and methods of use thereof |
US8105777B1 (en) | 2008-02-13 | 2012-01-31 | Nederlands Kanker Instituut | Methods for diagnosis and/or prognosis of colon cancer |
CN101250584B (zh) * | 2008-03-19 | 2012-06-13 | 南京大学 | 一种识别显著差异表达基因集合的方法 |
US8086502B2 (en) | 2008-03-31 | 2011-12-27 | Ebay Inc. | Method and system for mobile publication |
US7991646B2 (en) | 2008-10-30 | 2011-08-02 | Ebay Inc. | Systems and methods for marketplace listings using a camera enabled mobile device |
CA2755784C (en) | 2009-03-16 | 2020-03-24 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
US8825660B2 (en) * | 2009-03-17 | 2014-09-02 | Ebay Inc. | Image-based indexing in a network-based marketplace |
EP2414513B1 (en) | 2009-03-31 | 2015-10-28 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
US9405773B2 (en) * | 2010-03-29 | 2016-08-02 | Ebay Inc. | Searching for more products like a specified product |
US9792638B2 (en) | 2010-03-29 | 2017-10-17 | Ebay Inc. | Using silhouette images to reduce product selection error in an e-commerce environment |
US8819052B2 (en) * | 2010-03-29 | 2014-08-26 | Ebay Inc. | Traffic driver for suggesting stores |
US8861844B2 (en) * | 2010-03-29 | 2014-10-14 | Ebay Inc. | Pre-computing digests for image similarity searching of image-based listings in a network-based publication system |
US8949252B2 (en) | 2010-03-29 | 2015-02-03 | Ebay Inc. | Product category optimization for image similarity searching of image-based listings in a network-based publication system |
AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
JP6294074B2 (ja) | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
US9068177B2 (en) | 2010-04-29 | 2015-06-30 | Atyr Pharma, Inc | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutaminyl-tRNA synthetases |
CA2797393C (en) | 2010-04-29 | 2020-03-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of valyl trna synthetases |
WO2011135459A2 (en) | 2010-04-29 | 2011-11-03 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy |
CA2797374C (en) | 2010-04-29 | 2021-02-16 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of asparaginyl trna synthetases |
CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN103096912A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与苯丙氨酰-α-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CA2797978C (en) | 2010-05-03 | 2019-12-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-trna synthetases |
CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
JP6396656B2 (ja) | 2010-05-14 | 2018-09-26 | エータイアー ファーマ, インコーポレイテッド | フェニルアラニルβtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
JP6027965B2 (ja) | 2010-05-17 | 2016-11-16 | エータイアー ファーマ, インコーポレイテッド | ロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
US8962560B2 (en) | 2010-06-01 | 2015-02-24 | Atyr Pharma Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Lysyl-tRNA synthetases |
US8407221B2 (en) | 2010-07-09 | 2013-03-26 | International Business Machines Corporation | Generalized notion of similarities between uncertain time series |
CA2804416C (en) | 2010-07-12 | 2020-04-28 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-trna synthetases |
AU2011293294B2 (en) | 2010-08-25 | 2016-03-24 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases |
US8412594B2 (en) | 2010-08-28 | 2013-04-02 | Ebay Inc. | Multilevel silhouettes in an online shopping environment |
EP2694963B1 (en) | 2011-04-01 | 2017-08-02 | Qiagen | Gene expression signature for wnt/b-catenin signaling pathway and use thereof |
CA2836836A1 (en) | 2011-06-01 | 2012-12-06 | Medical Prognosis Institute A/S | Methods and devices for prognosis of cancer relapse |
RU2659423C2 (ru) | 2012-02-16 | 2018-07-02 | ЭйТИР ФАРМА, ИНК. | ГИСТИДИЛ-тРНК-СИНТЕТАЗЫ ДЛЯ ЛЕЧЕНИЯ АУТОИММУННЫХ И ВОСПАЛИТЕЛЬНЫХ ЗАБОЛЕВАНИЙ |
US9934522B2 (en) | 2012-03-22 | 2018-04-03 | Ebay Inc. | Systems and methods for batch- listing items stored offline on a mobile device |
US9336302B1 (en) | 2012-07-20 | 2016-05-10 | Zuci Realty Llc | Insight and algorithmic clustering for automated synthesis |
US10260103B2 (en) | 2012-11-27 | 2019-04-16 | Pontificia Universidad Catolica De Chile | Compositions and methods for diagnosing thyroid tumors |
EP2986326B1 (en) | 2013-04-15 | 2018-09-05 | Cedars-Sinai Medical Center | Methods for detecting cancer metastasis |
US10392667B2 (en) | 2013-06-07 | 2019-08-27 | Medical Prognosis Institute A/S | Methods and devices for predicting treatment efficacy of fulvestrant in cancer patients |
EP3074039A4 (en) | 2013-11-26 | 2017-10-11 | The Brigham and Women's Hospital, Inc. | Compositions and methods for modulating an immune response |
DK3169815T3 (da) | 2014-07-15 | 2021-02-15 | Ontario Institute For Cancer Res | Fremgangsmåder og indretninger til forudsigelse af anthracyclinbehandlingseffektivitet |
US11205103B2 (en) | 2016-12-09 | 2021-12-21 | The Research Foundation for the State University | Semisupervised autoencoder for sentiment analysis |
US20180165424A1 (en) * | 2016-12-14 | 2018-06-14 | Exxonmobil Research And Engineering Company | Method for dynamic bias management between online process analyzers and referee tests |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552270A (en) * | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
JPH10503384A (ja) * | 1995-12-22 | 1998-03-31 | エグザクト ラボラトリーズ, インコーポレイテッド | ゲノム上不均一な細胞サンプルにおける形質転換細胞のクローン集団検出のための方法 |
WO1999054724A1 (en) * | 1998-04-22 | 1999-10-28 | Imaging Research Inc. | Process for evaluating chemical and biological assays |
WO1999058708A1 (en) * | 1998-05-08 | 1999-11-18 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US130215A (en) * | 1872-08-06 | Improvement in steam and air brakes | ||
US164273A (en) * | 1875-06-08 | Improvement in hand-stamps | ||
US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
US5155916A (en) * | 1991-03-21 | 1992-10-20 | Scientific Drilling International | Error reduction in compensation of drill string interference for magnetic survey tools |
US5807522A (en) * | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
US5777888A (en) | 1995-08-09 | 1998-07-07 | Regents Of The University Of California | Systems for generating and analyzing stimulus-response output signal matrices |
AU2253397A (en) * | 1996-01-23 | 1997-08-20 | Affymetrix, Inc. | Nucleic acid analysis techniques |
US6165709A (en) * | 1997-02-28 | 2000-12-26 | Fred Hutchinson Cancer Research Center | Methods for drug target screening |
US6218122B1 (en) * | 1998-06-19 | 2001-04-17 | Rosetta Inpharmatics, Inc. | Methods of monitoring disease states and therapies using gene expression profiles |
US6171794B1 (en) * | 1998-07-13 | 2001-01-09 | Rosetta Inpharmatics, Inc. | Methods for determining cross-hybridization |
US6174794B1 (en) | 1998-08-20 | 2001-01-16 | Advanced Micro Devices, Inc. | Method of making high performance MOSFET with polished gate and source/drain feature |
US6146830A (en) | 1998-09-23 | 2000-11-14 | Rosetta Inpharmatics, Inc. | Method for determining the presence of a number of primary targets of a drug |
US6245517B1 (en) | 1998-09-29 | 2001-06-12 | The United States Of America As Represented By The Department Of Health And Human Services | Ratio-based decisions and the quantitative analysis of cDNA micro-array images |
US6203987B1 (en) * | 1998-10-27 | 2001-03-20 | Rosetta Inpharmatics, Inc. | Methods for using co-regulated genesets to enhance detection and classification of gene expression patterns |
US6950752B1 (en) | 1998-10-27 | 2005-09-27 | Rosetta Inpharmatics Llc | Methods for removing artifact from biological profiles |
US6453241B1 (en) * | 1998-12-23 | 2002-09-17 | Rosetta Inpharmatics, Inc. | Method and system for analyzing biological response signal data |
US6351712B1 (en) | 1998-12-28 | 2002-02-26 | Rosetta Inpharmatics, Inc. | Statistical combining of cell expression profiles |
US6230987B1 (en) * | 2000-05-23 | 2001-05-15 | Hai Quang Truong | Applicators for allowing a predetermined fluid flow for dissolving and distributing soluble substances |
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1998
- 1998-12-28 US US09/222,596 patent/US6351712B1/en not_active Expired - Fee Related
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1999
- 1999-12-27 CA CA2356696A patent/CA2356696C/en not_active Expired - Fee Related
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5552270A (en) * | 1991-03-18 | 1996-09-03 | Institut Molekulyarnoi Biologii Imeni V.A. | Methods of DNA sequencing by hybridization based on optimizing concentration of matrix-bound oligonucleotide and device for carrying out same |
JPH10503384A (ja) * | 1995-12-22 | 1998-03-31 | エグザクト ラボラトリーズ, インコーポレイテッド | ゲノム上不均一な細胞サンプルにおける形質転換細胞のクローン集団検出のための方法 |
WO1999054724A1 (en) * | 1998-04-22 | 1999-10-28 | Imaging Research Inc. | Process for evaluating chemical and biological assays |
WO1999058708A1 (en) * | 1998-05-08 | 1999-11-18 | Rosetta Inpharmatics, Inc. | Methods for identifying pathways of drug action |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4833495B2 (ja) * | 2000-08-03 | 2011-12-07 | アレイジェット リミテッド | インクジェットプリントヘッドによるマイクロアレイの高度平行構成体 |
WO2005034003A1 (ja) * | 2003-10-01 | 2005-04-14 | Japan As Represented By The President Of National Institute Of Genetics | マイクロアレイ実験等から得られるデータの新規解析方法 |
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EP1141411A4 (en) | 2007-05-02 |
US20020128781A1 (en) | 2002-09-12 |
CA2356696A1 (en) | 2000-07-06 |
AU774830B2 (en) | 2004-07-08 |
US8521441B2 (en) | 2013-08-27 |
US20050130215A1 (en) | 2005-06-16 |
US20050164273A1 (en) | 2005-07-28 |
EP1141411A1 (en) | 2001-10-10 |
US7966130B2 (en) | 2011-06-21 |
US6351712B1 (en) | 2002-02-26 |
AU2385500A (en) | 2000-07-31 |
WO2000039339A1 (en) | 2000-07-06 |
CA2356696C (en) | 2011-08-02 |
US7565251B2 (en) | 2009-07-21 |
US20060190191A1 (en) | 2006-08-24 |
CN1335893A (zh) | 2002-02-13 |
US20030093227A1 (en) | 2003-05-15 |
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