JP2002531474A - Deodorant cosmetic composition - Google Patents

Abstract

  (57) [Summary] The present invention relates to a deodorant cosmetic composition containing at least one selected amino acid converting enzyme inhibitor, the use of said composition for topical application to humans and the use of a selected amino acid converting enzyme inhibitor as an active deodorant. About.

Description

DETAILED DESCRIPTION OF THE INVENTION

The present invention relates to deodorant compositions, preferably cosmetic compositions, which contain at least one selected compound that inhibits enzymes for converting amino acids, these compositions for topical application to humans And the use of selective inhibitors of enzymes that convert amino acids as deodorants. The present invention also relates to a method of deodorizing using the above composition, and more particularly to a method of treating human armpit odor comprising applying an effective amount of the above composition to the armpit area.

It is well known in the cosmetics field to use deodorant products containing active substances of the antiperspirant or bactericide type, generally by topical application, to reduce or even eliminate the unpleasant armpit odor. Antiperspirant substances have the effect of restricting the flow of sweat. These generally consist of aluminum salts which are firstly irritating to the skin and secondly reduce the flow of sweat by altering the physiology of the skin, but this is not satisfactory.

[0003] Bactericidal substances inhibit the growth of skin microflora which causes body odor. The most frequently used antiseptic product is triclosan (5-chloro-2- (2,4-dichlorophenoxy) phenol), which greatly alters the biology of the skin flora, for example in the formulation of cosmetic compositions It has the disadvantage that it can be inhibited by certain compounds, such as commonly used nonionic surfactants. Due to the nature of triclosan, which is insoluble in water, it cannot be introduced into essentially aqueous formulations.

For the purpose of obtaining long-term effects, a novel product acting as a deodorant activator, namely body odor (this definition is defined in “Cosmetic Science and Technology Series-1988 / Volu
There is a need for a product that can modify, reduce, and / or eliminate or prevent the occurrence of "me 7 chapter 10-IIIc"). There is also a need for products that do not have the disadvantages of the active substances used in the prior art.

[0005] As a result of many studies performed in this regard, Applicants have surprisingly found that inhibitors of certain enzymes do not show the drawbacks of the active substances previously used in deodorant compositions. Has the advantage of having the property of preventing the development of unpleasant odors and of being more effective and easy to formulate into aqueous cosmetic compositions, especially for topical application to humans. discovered.

Accordingly, a first subject of the present invention comprises an effective amount of at least one compound which inhibits an enzyme which converts an amino acid which is not a β-lyase inhibitor, said enzyme comprising:-a hydrolase-an isomerase -A carboxylase-a linking enzyme-an amino acid dehydratase-an amino acid deoxygenase-an amino acid carbamoyltransferase-an amino acid amidinotransferase-an amino acid aminotransferase, wherein the enzyme is a novel deodorant composition having at least one amino acid as a substrate.

The subject of the present invention is also the use of at least one inhibitor of this type as a deodorant active in the manufacture of cosmetic or dermatological products, in particular as an agent for inhibiting the development of axillary odor in humans. Finally, the subject of the present invention is a method of deodorizing using said composition, more particularly a method for treating human armpit odor, comprising applying an effective amount of said composition to the armpit area. The expression "effective amount of an enzyme inhibitor" refers to an amount of an enzyme inhibitor sufficient to exert a satisfactory deodorant effect after application in the pharmaceutical form used. The expression "deodorant effect" means an activity which makes it possible to significantly reduce or even eliminate unpleasant odors, more particularly body odors.

The hydrolase according to the present invention includes, in particular, -asparaginase-citrullinase-arginase-arginine deiminase. Examples of the isomerase according to the present invention include amino acid racemase and amino acid aminomutase. Ligation enzymes according to the present invention particularly include-amino acid ammonia ligase,-amino acid t-RNA ligase-amino acid-amino acid ligase.

Examples of the enzymes according to the invention include the enzymes defined in the following table and in particular defined by the international classification published in the following two books: Enzymes Handbook Vol. -Thomas E. Barman.Editor Springer Verlag (1
969). − Enzyme Nomenclature: International Union of Biochemistry, Academic Pr
ess Inc. (1984).

[0010] Inhibitors of these enzymes are described in Helmward Zollner's book "Handbook of enzyme inhibitors" published by VCH, 1st edition (1989) and 2nd revised edition (1993).

Examples of inhibitors of these enzymes that can be used in the present invention include, inter alia, the following compounds:

In the deodorant composition of the present invention, the inhibitor of the amino acid converting enzyme is generally present in an amount of about 0.001% to about 20% by weight based on the total weight of the composition.
, Preferably in a weight percentage ranging from about 0.01% to about 5%.

[0013] The deodorant compositions of the present invention may also contain other common deodorant actives in addition to the compounds of the present invention. These deodorant activators include, for example, water-soluble zinc salts such as zinc pyrrolidonecarboxylate (more commonly zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, zinc gluconate and zinc phenolsulfonate; aluminum Salts, such as aluminum chloride and aluminum hydroxy halide; zirconium salts,
For example, it can be selected from zirconium oxide salts and hydroxyzirconyl salts; aluminum or zirconium-based metal complexes;

[0014] The deodorant composition of the present invention is conventionally formulated depending on the intended use. If cosmetic use is intended, they are more particularly formulated into a cosmetically acceptable vehicle, which may be essentially aqueous, in order to accelerate the evaporation of the product, to obtain a C ₁ -C ₄ monoalcohols, preferably containing ethanol. The monoalcohol is generally 15% to 50%, preferably 20%.
% To 45%, more preferably in an amount ranging from 25% to 35%.

The composition according to the invention may be a water-in-oil or oil-in-water emulsion or a water-in-oil-in-water three-phase emulsion (such emulsions are known, for example C. Fox's "Cosmetics and Toiletries" -1986). November-Volume 101-101-1
(Described on page 12).

The composition according to the present invention comprises a fatty substance, an organic solvent, a gelling agent, an emollient, a softener, an antioxidant, an opacifier, a stabilizer, silicone, an antifoaming agent, a humectant, vitamins, Fragrances, preservatives, surfactants, fillers, sequestering agents, polymers,
It may further contain a cosmetic adjuvant selected from propellants, basic or acidifying agents, dyes, pigments, thickeners or any other ingredients commonly used for this kind of use in cosmetics. Good. Surfactants are selected from anionic, amphoteric or non-ionic surfactants.

The fatty substances may consist of oils or waxes or mixtures thereof, petrolatum, paraffin, lanolin, hydrogenated lanolin or acetylated lanolin; they also include fatty acids, fatty alcohols such as lauryl alcohol, cetyl alcohol, myristyl alcohol, stearyl. Alcohol, palmityl alcohol, oleyl alcohol or 2-octyl dodecanol, fatty acid esters such as glyceryl monostearate, polyethylene glycol monostearate, isopropyl myristate, isopropyl adipate, isopropyl palmitate, octyl palmitate, C benzoate ₁₂ -C ₁₅ fatty alkyl (Finetex Inc. (Finetex Finsolve.RTM of) (Finsolv) TN), millimeters are polyoxypropylene with 3 moles of propylene oxide Still alcohol (Witco's Witcono
_{l) APM), C 6 -C} 18 fatty acid triglycerides, for example capric / caprylic triglyceride.

The oils are selected from animal, vegetable, mineral and synthetic oils, especially hydrogenated palm oil, hydrogenated castor oil, liquid petrolatum, liquid paraffin, prusserin oil (stearyl octanoate), silicone oil and isoparaffins. be able to. The waxes are selected from animals, fossils, plants, minerals and synthetic waxes. In particular, beeswax, carnauba wax, candelilla wax, sugarcane wax, mokuro, ozokerite, montan wax, microcrystalline wax, paraffin, silicone wax and resin can be mentioned.

The thickener is preferably nonionic or anionic. Nonionic thickeners are modified or unmodified guar gums and celluloses such as hydroxypropyl guar gum, cetyl hydroxyethyl cellulose, silicas,
For example, it can be selected from Bentone Gel MiO sold by NL Industries or Vegum Ultra sold by Polyplastics. The anionic thickener can be selected from crosslinked polyacrylic acid and acrylamidopropanesulfonic acid homopolymer or copolymer.

The composition may contain an emollient which contributes in giving a soft, dry and non-greasy sensation when the composition is applied to the skin. These emollients can be selected from products such as volatile silicones, non-volatile silicones and other non-volatile emollients. Generally, the emollient will be present in a proportion ranging from 20% to 80%, preferably 25% to 60%, more preferably 35% to 55%.

Volatile silicones are conventionally defined as compounds that are volatile at room temperature. Among these compounds, mention may be made of dimethylsiloxane-type cyclic and linear volatile silicones having a chain containing 3 to 9 silicone residues. Cyclomethicone D4 or D5 is preferably selected.

Non-volatile silicones are conventionally defined as compounds that exhibit low vapor pressure at room temperature. These compounds include polyalkylsiloxanes, especially linear polyalkylsiloxanes, such as polydimethylsiloxanes, or linear dimethicones, sold by Dow Corning under the name "Dow Corning 200 Fluid"; Polyalkylarylsiloxanes, such as from Dow Corning
Polymethylphenylsiloxane sold under the name "Dow Corning 556 Fluid"; and copolymers of polyethers and siloxanes, such as dimethicone copolyols.

[0023] The non-volatile emollient that can be used in the present invention, for example, hydrocarbon-based derivatives, mineral oils, fatty _alcohols, of _C 3 _{-C 18} alcohols with C 3 _{-C 18} acids esters, esters and mixtures thereof benzoic acids with C ₁₂ -C ₁₈ alcohols, glycerol, C ₂ -C ₆ polyols are preferably selected from propylene glycol and sorbitol, and may include polyalkylene glycols polymers it can.

The pH of the composition according to the invention is between 2 and 12, preferably between 4 and 10. When the deodorant composition according to the present invention is used for cosmetics, aerosol spray, a pump-type dispenser bottle or a liquid gel dispensed in a roll-on type, a cream or lotion form, a thickened cream form dispensed in a tube and It may be in the form of a stick or powder, and in this regard, may contain propellants and ingredients commonly used in such products and well known to those skilled in the art, provided that they do not interfere with the enzyme inhibitors described in the present invention. .

[0025]

【Example】

 Specific, non-limiting examples illustrating the invention are set forth below. The following three formulations (two aqueous lotions, aqueous sticks) were prepared. Example 1: Aqueous lotion D-cycloserine 2.0 g Triethanolamine Amount to make pH 7.5 Fragrance Appropriate amount Deionized water Amount to make the whole 100 g

Example 2: Aqueous lotion-3-1.0 g of indoleacetic acid-triethanolamine Amount to make pH 8.0-Fragrance appropriate amount-Demineralized water Amount to make the whole 100 g

Example 3: Aqueous stick-6.2 g of sodium stearate-3.0 g of succinic acid-15 g of glycerol-20 g of propylene glycol-appropriate amount of perfume-amount of demineralized water to make 100 g in total

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme court ゛ (Reference) A61K 31/19 A61K 31/19 31/192 31/192 31/194 31/194 31/198 31/198 31 / 405 31/405 31/4168 31/4168 31/42 31/42 31/519 31/519 31/52 31/52 31/661 31/661 31/7076 31/7076 33/06 33/06 A61P 17 / 00 A61P 17/00 (81) Designated countries EP (AT, BE, CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE), OA (BF, BJ, CF, CG, CI, CM, GA, GN, GW, ML, MR, NE, SN, TD, TG), AP (GH, GM, KE, LS, MW, SD, SL, SZ, TZ, UG, ZW), EA (AM, AZ, BY, KG, KZ, MD, RU, T , TM), AE, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, CA, CH, CN, CR, CU, CZ, DE, DK, DM, EE, ES, FI , GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TR, TT, TZ, UA , UG, US, UZ, VN, YU, ZA, ZWF terms (reference) CC05 CC17 DD08 DD11 DD23 DD31 DD41 EE07 EE10 EE18 4C086 AA01 AA02 BC13 B C38 BC69 CB07 CB09 DA34 EA18 HA04 MA01 MA02 MA03 MA04 MA63 NA14 ZA89 ZC20 4C206 AA01 CB12 DA21 DA36 DA37 FA01 FA53 HA31 HA32 KA01 MA01 MA02 MA03 MA04 MA83 NA09 NA14 ZA89 ZC20

Claims (15)

[Claims] Claims: 1. An effective amount of at least one compound that inhibits an enzyme that converts an amino acid that is not a β-lyase inhibitor, the enzyme comprising:-a hydrolase-an isomerase-a carboxylase-a linking enzyme-an amino acid dehydratase- A deodorant cosmetic composition selected from the group consisting of amino acid deoxygenase-amino acid carbamoyltransferase-amino acid amidinotransferase-amino acid aminotransferase, wherein the enzyme has at least one amino acid as a substrate. 2. The composition according to claim 1, wherein the hydrolase is selected from: -asparaginase-citrullinase-arginase-arginine deiminase. 3. The composition according to claim 1, wherein the isomerase is selected from:-amino acid racemase,-aminomutase. 4. The composition according to claim 1, wherein the ligation enzyme is selected from:-amino acid ammonia ligase,-amino acid t-RNA ligase. 5. A convertase inhibitor comprising: -diaminopropane, -caffeic acid, -indole-3acetyl-CoA, -Ca ⁺⁺ ion -guanidinoacetic acid, -D-cycloserine, -carbamoyl phosphate, -glutaric acid, -succinic acid. Acid, -biguanine, -choline, -riboflavin sulfate, -3-indoleacetic acid, -5'-para-fluorosulfonylbenzoyladenosine, -adenosine monophosphate, -pyrophosphate, -3-methylglutamic acid, -2,3-butanedione The composition according to any one of claims 1 to 4, wherein the composition is selected from the group consisting of:-adenine;-creatinine. 6. The method according to claim 1, wherein the converting enzyme inhibitor comprises 0.001% by weight of the total composition.
6. The composition according to claim 1, wherein the composition is present in a concentration of from about 20% to about 20%. 7. The composition according to claim 6, wherein the convertase inhibitor is present in a concentration of 0.01 to 5%, based on the total weight of the composition. 8. The composition according to claim 1, which further comprises another deodorant active. 9. The composition according to claim 1, wherein the composition is formulated in an essentially aqueous vehicle. 10. Fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, defoamers, humectants, vitamins, fragrances, preservatives, surfactants Agents, fillers, sequestering agents, polymers, spraying agents, acidifying or basifying agents, coloring agents, pigments and thickeners or any other components commonly used in cosmetics. The composition according to any one of claims 1 to 9, wherein 11. The composition according to claim 1, wherein the pH is between 2 and 12. 12. The composition according to claim 11, wherein the pH is between 4 and 10. 13. In the form of a lotion, cream or fluid gel dispensed as an aerosol spray, in a pump dispenser bottle, or as a roll-on, in the form of a thickened cream dispensed in a tube, or in the form of a stick. The composition according to any one of claims 1 to 12, characterized in that: 14. A method for treating human armpit odor, which comprises applying an effective amount of the composition according to any one of claims 1 to 13 to an underarm area. 15. The conversion of an amino acid according to any one of claims 1 to 5 as a deodorant activator in the manufacture of a cosmetic or dermatological product, in particular as an agent inhibiting the development of axillary odor in humans. Use of compounds that inhibit enzymes.