EP1137393A2 - Deodorant cosmetic composition - Google Patents

Deodorant cosmetic composition

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Publication number
EP1137393A2
EP1137393A2 EP99956129A EP99956129A EP1137393A2 EP 1137393 A2 EP1137393 A2 EP 1137393A2 EP 99956129 A EP99956129 A EP 99956129A EP 99956129 A EP99956129 A EP 99956129A EP 1137393 A2 EP1137393 A2 EP 1137393A2
Authority
EP
European Patent Office
Prior art keywords
composition according
amino acid
chosen
acid
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP99956129A
Other languages
German (de)
French (fr)
Inventor
Serge Forestier
Christophe Courbiere
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LOreal SA
Original Assignee
LOreal SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LOreal SA filed Critical LOreal SA
Publication of EP1137393A2 publication Critical patent/EP1137393A2/en
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/362—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Definitions

  • the present invention relates to a deodorant composition, preferably a cosmetic composition, comprising at least one selected inhibitor compound of amino acid transformation enzyme, the use of these compositions for topical human application and the use of an inhibitor.
  • selected amino acid transformation enzyme as deodorant active
  • the antiperspirant substances have the effect of limiting the sweat flow They generally consist of aluminum salts which, on the one hand, are irritating to the skin and which, on the other hand, reduce the sweat flow by modifying the physiology skin, which is not satisfactory
  • TRICLOSAN 5-chloro-2- (2,4-d ⁇ chlorophenoxy) phenol
  • inhibitors of certain enzymes have the property of preventing the development of bad odors, without the drawbacks of the active substances previously used in deodorant compositions, and with the advantage of being more effective and of being able to be selected to be easily formulated, in particular in cosmetic water-based compositions for human topical application
  • the present invention thus firstly relates to a new deodorant composition
  • a new deodorant composition comprising an effective amount of at least one inhibitor of an amino acid transformation enzyme which is not an inhibitor of ⁇ -lyase, said enzyme being chosen from the group formed by
  • It also relates to the use of at least one inhibitor of this type as a deodorant cosmetic active agent, in particular as an agent inhibiting the development of human axillary odors in the manufacture of cosmetic or dermatological products. It finally relates to a process for desodonsation using said composition, and more particularly a process for treating human axillary odors, consisting in applying to the axillary surface an effective amount of said composition
  • the term "effective amount of enzyme inhibitor” means a sufficient amount of enzyme inhibitor, in the dosage form used, to produce, after application, a satisfactory deodorant effect.
  • deodorant effect is intended to mean an activity which makes it possible to substantially reduce or even eliminate unpleasant odors and more particularly body odors.
  • hydrolases in accordance with the invention there may be mentioned in particular
  • inhibitors of these enzymes which can be used according to the invention, mention may be made, in particular of the following compounds
  • the amino acid transformation enzyme inhibitor is generally present in weight proportions, calculated by weight relative to the total weight of the composition, ranging from approximately 0.001 to approximately 20%, preferably ranging from approximately 0.01 to approximately 5%.
  • the deodorant compositions of the present invention may also comprise other conventional deodorant active agents in addition to the compounds of the invention.
  • deodorant active agents can be chosen, for example, from water-soluble zinc salts, such as for example zinc pyrrolidone carboxylate (more commonly called peeled zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, zinc gluconate and zinc phenolsulfonate; aluminum salts, such as for example aluminum chloride and aluminum hydroxyhalides; zirconium salts, such as, for example, zirconium oxide salts, hydroxyzirconyl salts; metal complexes based on Aluminum or Zirconium; bactericides.
  • water-soluble zinc salts such as for example zinc pyrrolidone carboxylate (more commonly called peeled zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, zinc gluconate and zinc phenolsulfonate
  • aluminum salts such as for example aluminum chloride and aluminum hydroxyhalides
  • zirconium salts such as, for example, zirconium oxide salts, hydroxyzircon
  • the deodorant compositions of the present invention are conventionally formulated according to the applications for which they are intended. When they are intended for cosmetic use, they are more particularly formulated in a cosmetically acceptable vehicle which can in particular be essentially aqueous, and contain monoalcohols in j-C preferably ethanol to accelerate the evaporation of the product.
  • the monoalcohols are generally present in amounts ranging from 15 to 50%, preferably from 20 to 45% and even more preferably from 25 to 35%.
  • compositions according to the invention can also be formulated in water-in-oil, oil-in-water emulsion, or in triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C FOX in “Cosmetics and Toi- letries” - November 1986 - Vol 101 - pages 101-1 12).
  • compositions of the invention may also comprise cosmetic adjuvants chosen from fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, anti-foaming agents, moisturizing agents, vitamins, perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, dyes, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics.
  • the surfactants are chosen from nonionic, amphoteric, canonical or anionic surfactants or their mixtures.
  • the fatty substances can consist of an oil or a wax or their mixture, petroleum jelly, paraffin, lanolin, hydrogenated lanolin, acetylated lanolin; they also include fatty acids, fatty alcohols such as lauric, cetyl, myoristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, esters of fatty acids such as glycerol monostearate, polyethylene glycol monostearate, isopropyl myististate, isopropyl adipate, isopropyl palmitate, octyl palmitate, C 12 -C 15 fatty alcohol benzoates (FINSOLV TN from FINETEX) , polyoxypropylenated myristic alcohol with 3 moles of propylene oxide (WITCONOL APM from WITCO), C 6 -C 18 fatty acid triglycerides such as caprylic / capric acid triglycerides.
  • oils are chosen from animal, vegetable, mineral or synthetic oils and in particular hydrogenated palm oil, hydrogenated castor oil, linseed oil, paraffin oil, Purcellin oil (stearyl octanoate), silicone oils and isoparaffins.
  • the waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. Mention may in particular bees beeswaxes, Camauba, Candlilla, sugar cane, Japanese waxes, ozokerites, Montan wax, microcrystalline waxes, paraffins, waxes and silicone resins.
  • the thickeners are preferably nonionic or anionic.
  • the nonionic thickeners can be chosen from guar gums and modified or unmodified celluloses such as hydroxypropylated guar gum. Cetylhydroxyethylcellulose, silicas such as, for example, Bentone Gel MiO sold by the company NL INDUSTRIES or Veegum Ultra, sold by the company POLYPLASTIC.
  • the anionic thickeners can be chosen from crosslinked polyacrylic acids or homo or copolymers of acrylamido propane sulfonic acid.
  • emollients which contribute to a soft, dry feeling, non-sticky when the composition is applied to the skin.
  • emollients can be chosen from products of the volatile silicone type, non-volatile silicones and other non-volatile emollients.
  • the emollients are present in proportions ranging from 20 to 80%, preferably from 25 to 60% and even more preferably from 35 to 55%.
  • Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type, the chains of which comprise from 3 to 9 silicone residues. Preferably, cyclomethicones D4 or D5 are chosen.
  • Non-volatile silicones are defined in a known manner as compounds with low vapor pressure at room temperature.
  • polyalkylsiloxanes in particular linear polyalkylsiloxanes such as, for example, linear polydimethylsiloxanes, or dimethicones, sold by the company Dow Corning under the name of "Dow Corning 200 Fluid”
  • polyalkylarylsiloxanes such as, for example, polymethylphenylsiloxanes, sold by the company Dow Corning under the name of "Dow Corning 556 Fluid”
  • polyether and siloxane copolymers such as, for example, dimethicone copolyols.
  • nonvolatile emollients useful in the present invention include for example: hydrocarbon-based derivatives, mineral oils, fatty alcohols, alcohol esters of C 3 -C 18 acids with C 3 -C 18 , esters of benzoic acid with C 12 -C 18 alcohols and their mixtures, C 2 -C 6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol.
  • the pH of the compositions of the invention is between 2 and 12 and preferably between 4 and 10.
  • the deodorant compositions according to the invention may be in the form of lotions, creams or of fluid gels distributed in aerosol spray, in pump bottle or in roll-on, in the form of thick creams distributed in tubes and in the form of sticks, and contain in this regard the ingredients and propellants generally used in this type of products and well known skilled in the art, provided that they do not interfere with the enzyme inhibitors described in the present invention.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention concerns a deodorant cosmetic composition comprising at least a selected amino acid transforming enzyme inhibitor, the use of said compositions for topical application for humans and the use of a selected amino acid transforming enzyme inhibitor as active deodorant.

Description

COMPOSITION COSMETIQUE DEODORANTE DEODORANT COSMETIC COMPOSITION
La présente invention concerne une composition déodorante, de préférence une composition cosmétique, comprenant au moins un composé inhibiteur sélectionné d'enzyme de transformation des acides aminés, l'utilisation de ces compositions pour l'application topique humaine et l'utilisation d'un inhibiteur sélectionné d'enzyme de transformation des acides aminés comme actif déodorantThe present invention relates to a deodorant composition, preferably a cosmetic composition, comprising at least one selected inhibitor compound of amino acid transformation enzyme, the use of these compositions for topical human application and the use of an inhibitor. selected amino acid transformation enzyme as deodorant active
Elle concerne également un procédé de désodonsation mettant en oeuvre ladite compo- sition et plus spécialement un procédé pour traiter les odeurs axillaires humaines consistant à appliquer sur la surface axillaire une quantité efficace de ladite compositionIt also relates to a deodonsation process using said composition and more particularly to a process for treating human axillary odors consisting in applying to the axillary surface an effective amount of said composition
Dans le domaine cosmétique, il est bien connu d'utiliser en application topique, des produits déodorants contenant des substances actives de type anti-transpirant ou de type bactéricide pour diminuer voire supprimer les odeurs axillaires généralement désagréablesIn the cosmetic field, it is well known to use, in topical application, deodorant products containing active substances of antiperspirant type or of bactericidal type to reduce or even eliminate generally unpleasant axillary odors.
Les substances anti-transpirantes ont pour effet de limiter le flux sudoral Elles sont généralement constituées de sels d'aluminium qui, d'une part, sont irritants pour la peau et qui, d'autre part, diminuent le flux sudoral en modifiant la physiologie cutanée, ce qui n'est pas satisfaisantThe antiperspirant substances have the effect of limiting the sweat flow They generally consist of aluminum salts which, on the one hand, are irritating to the skin and which, on the other hand, reduce the sweat flow by modifying the physiology skin, which is not satisfactory
Les substances bactéricides inhibent le développement de la flore cutanée responsable des odeurs axillaires Parmi les produits bactéricides, le plus couramment employé est le TRICLOSAN (5-chloro-2-(2,4-dιchlorophenoxy) phénol), qui présente l'inconvénient de modifier de façon importante l'écologie de la flore cutanée, d'être inhibé par certains composés, comme par exemple les tensioactifs non-ioniques, couramment utilisés dans la formulation de compositions cosmétiques Le caractère insoluble du TRICLOSAN dans l'eau ne permet pas son incorporation dans des formules essentiellement aqueu- sesBactericidal substances inhibit the development of the skin flora responsible for axillary odors. Among the bactericidal products, the most commonly used is TRICLOSAN (5-chloro-2- (2,4-dιchlorophenoxy) phenol), which has the disadvantage of modifying importantly the ecology of the skin flora, to be inhibited by certain compounds, such as non-ionic surfactants, commonly used in the formulation of cosmetic compositions The insoluble nature of TRICLOSAN in water does not allow its incorporation in essentially aqueous formulas
Dans le but d'obtenir une efficacité à long terme, on recherche de nouveaux produits exerçant une action d'actif déodorant c'est-a-dire des produits qui soient capables de modifier, de réduire et/ou d'ôter ou de prévenir le développement des odeurs corporelles (cette définition est donnée dans l'ouvrage «Cosmetic Science and Technology Séries» - 1988 / Volume 7 chap 10 - 11 le) En outre, on cherche des produits qui ne présentent pas les inconvénients des substances actives utilisées dans l'art antérieurIn order to obtain long-term efficacy, we are looking for new products that exert a deodorant active action, that is to say products that are capable of modifying, reducing and / or removing or preventing the development of body odors (this definition is given in the book “Cosmetic Science and Technology Series” - 1988 / Volume 7 chap 10 - 11 le) In addition, we are looking for products which do not have the drawbacks of the active substances used in prior art
Après de nombreuses recherches menées sur la question, la demanderesse a décou- vert, de façon étonnante, que les inhibiteurs de certaines enzymes présentent la propriété de prévenir le développement des mauvaises odeurs, sans les inconvénients des substances actives antérieurement employées dans les compositions déodorantes, et avec l'avantage d'être plus efficaces et de pouvoir être sélectionnes pour être aisément formulables, notamment dans les compositions cosmétiques a base d'eau pour l'application topique humaineAfter numerous researches carried out on the question, the applicant has discovered, surprisingly, that inhibitors of certain enzymes have the property of preventing the development of bad odors, without the drawbacks of the active substances previously used in deodorant compositions, and with the advantage of being more effective and of being able to be selected to be easily formulated, in particular in cosmetic water-based compositions for human topical application
La présente invention a ainsi pour premier objet une nouvelle composition déodorante comprenant une quantité efficace d'au moins un inhibiteur d'enzyme de transformation des acides aminés qui ne soit pas inhibiteur de la β-lyase, ladite enzyme étant choisie dans le groupe forme parThe present invention thus firstly relates to a new deodorant composition comprising an effective amount of at least one inhibitor of an amino acid transformation enzyme which is not an inhibitor of β-lyase, said enzyme being chosen from the group formed by
- les hydrolases- hydrolases
- les isomerases - les carboxylyases- isomerases - carboxylyases
- les ligases- ligases
- les amino acide déshydratases- amino acid dehydratases
- les amino acide déoxygénases- amino acid deoxygenases
- les amino acide carbamoyl transférases- amino acid carbamoyl transferases
- les amino acide amidmo transférases- amino acid amidmo transferases
- les amino acide amino transférases, lesdites enzymes ayant au moins un acide aminé naturel pour substrat- amino acid amino transferases, said enzymes having at least one natural amino acid for substrate
Elle a également pour objet l'utilisation d'au moins un inhibiteur de ce type comme actif cosmétique déodorant, en particulier comme agent inhibiteur du développement d'odeurs axillaires humaines dans la fabrication de produits cosmétiques ou dermatologiques Elle a enfin pour objet un procédé de desodonsation mettant en œuvre ladite composition, et plus particulièrement un procédé pour traiter les odeurs axillaires humaines, consistant à appliquer sur la surface axillaire une quantité efficace de ladite compositionIt also relates to the use of at least one inhibitor of this type as a deodorant cosmetic active agent, in particular as an agent inhibiting the development of human axillary odors in the manufacture of cosmetic or dermatological products. It finally relates to a process for desodonsation using said composition, and more particularly a process for treating human axillary odors, consisting in applying to the axillary surface an effective amount of said composition
On entend par «quantité efficace en inhibiteur d'enzyme» une quantité suffisante d'inhibiteur d'enzyme, dans la forme galenique utilisée, pour produire après application un effet déodorant satisfaisantThe term "effective amount of enzyme inhibitor" means a sufficient amount of enzyme inhibitor, in the dosage form used, to produce, after application, a satisfactory deodorant effect.
On entend par effet déodorant, une activité permettant de réduire sensiblement voire supprimer les mauvaises odeurs et plus particulièrement les odeurs corporellesThe term “deodorant effect” is intended to mean an activity which makes it possible to substantially reduce or even eliminate unpleasant odors and more particularly body odors.
Parmi les hydrolases conformes à l'invention, on peut citer en particulierAmong the hydrolases in accordance with the invention, there may be mentioned in particular
- l'asparaginase- asparaginase
- la citrullmase - l'arginase- citrullmase - arginase
- l'arginine déiminase- arginine deiminase
Parmi les isomérases conformes à l'invention, on peut citer en particulierAmong the isomerases in accordance with the invention, there may be mentioned in particular
- les amino acide racémases - les amino acide aminomutases- amino acid racemases - amino acid aminomutases
Parmi, les ligases conformes à l'invention, on peut citer en particulierAmong the ligases in accordance with the invention, there may be mentioned in particular
- les amino acide ammonia ligases- amino acid ammonia ligases
- les amino acide t-RNA ligases - les amino acide - amino acide ligases- amino acid t-RNA ligases - amino acid - amino acid ligases
A titre d'exemples d'enzymes de l'invention, on peut citer les enzymes mentionnées dans le tableau ci-après et définies selon la classification internationale publiée notamment dans les deux ouvrages suivantsAs examples of enzymes of the invention, mention may be made of the enzymes mentioned in the table below and defined according to the international classification published in particular in the following two works
- Enzymes Handbook Vol I -Thomas E BARMAN Editeur Springer Verlag (1969)- Enzymes Handbook Vol I -Thomas E BARMAN Publisher Springer Verlag (1969)
- Enzyme Nomenclature publiée pour l'Union Internationale de la Biochimie (IUB) Editeur Académie Press Inc (1984) - Enzyme Nomenclature published for the International Union of Biochemistry (IUB) Publisher Académie Press Inc (1984)
Les inhibiteurs de ces enzymes sont décrits dans l'ouvrage « Handbook of enzyme inhi- bitors » de Helmward ZOLLNER, éditeur VCH, première édition (année 1989) et seconde édition révisée (année 1993)The inhibitors of these enzymes are described in the book “Handbook of enzyme inhi- bitors” by Helmward ZOLLNER, VCH editor, first edition (year 1989) and second revised edition (year 1993)
A titre d'exemples d'inhibiteurs de ces enzymes utilisables selon l'invention, on peut citer, en particulier les composés suivantsAs examples of inhibitors of these enzymes which can be used according to the invention, mention may be made, in particular of the following compounds
Dans les compositions déodorantes selon la présente invention, l'inhibiteur d'enzyme de transformation d'acides aminés est généralement présent dans des proportions pondérales, calculées en poids par rapport au poids total de la composition, allant environ de 0,001 à environ 20%, de préférence allant environ de 0,01 a environ 5% Les compositions déodorantes de la présente invention peuvent comprendre en outre d'autres actifs déodorants classiques en plus des composés de l'invention In the deodorant compositions according to the present invention, the amino acid transformation enzyme inhibitor is generally present in weight proportions, calculated by weight relative to the total weight of the composition, ranging from approximately 0.001 to approximately 20%, preferably ranging from approximately 0.01 to approximately 5%. The deodorant compositions of the present invention may also comprise other conventional deodorant active agents in addition to the compounds of the invention.
Ces actifs déodorants peuvent être choisis par exemple parmi des sels hydrosolubles de zinc, comme par exemple le pyrrolidone carboxylate de zinc (plus communément ap- pelé pidolate de zinc), le sulfate de zinc, le chlorure de zinc, le lactate de zinc, le gluco- nate de zinc et le phénolsulfonate de zinc ; des sels d'aluminium, comme par exemple le chlorure d'aluminium et les hydroxyhalogénures d'aluminium ; des sels de zirconium, comme par exemple des sels d'oxyde de zirconium, des sels d'hydroxyzirconyle ; des complexes de métaux à base d'Aluminium ou de Zirconium ; des bactéricides.These deodorant active agents can be chosen, for example, from water-soluble zinc salts, such as for example zinc pyrrolidone carboxylate (more commonly called peeled zinc pidolate), zinc sulfate, zinc chloride, zinc lactate, zinc gluconate and zinc phenolsulfonate; aluminum salts, such as for example aluminum chloride and aluminum hydroxyhalides; zirconium salts, such as, for example, zirconium oxide salts, hydroxyzirconyl salts; metal complexes based on Aluminum or Zirconium; bactericides.
Les compositions déodorantes de la présente invention sont formulées classiquement selon les applications auxquelles elles sont destinées. Lorsqu'elles sont destinées à un usage cosmétique, elles sont plus particulièrement formulées dans un véhicule cosmétiquement acceptable qui peut être notamment essentiellement aqueux, et contenir des monoalcools en j-C de préférence de l'éthanol pour accélérer l'évaporation du produit. Les monoalcools sont généralement présents en quantités allant de 15 à 50%, préférentiellement de 20 à 45% et encore plus préféren- tiellement de 25 à 35%.The deodorant compositions of the present invention are conventionally formulated according to the applications for which they are intended. When they are intended for cosmetic use, they are more particularly formulated in a cosmetically acceptable vehicle which can in particular be essentially aqueous, and contain monoalcohols in j-C preferably ethanol to accelerate the evaporation of the product. The monoalcohols are generally present in amounts ranging from 15 to 50%, preferably from 20 to 45% and even more preferably from 25 to 35%.
Les compositions selon l'invention peuvent également être formulées en émuision eau- dans-huile, huile-dans-eau, ou en émuision triple eau-dans-huile-dans-eau, (de telles émulsions sont connues et décrites par exemple par C. FOX dans «Cosmetics and Toi- letries» - November 1986 - Vol 101 - pages 101-1 12).The compositions according to the invention can also be formulated in water-in-oil, oil-in-water emulsion, or in triple water-in-oil-in-water emulsion (such emulsions are known and described for example by C FOX in “Cosmetics and Toi- letries” - November 1986 - Vol 101 - pages 101-1 12).
Les compositions de l'invention peuvent comprendre en outre des adjuvants cosmétiques choisis parmi les corps gras, les sojvants organiques, les gélifiants, les émollients, les adoucissants, les antioxydants, les opacifiants, les stabilisants, les silicones, les agents anti-mousse, les agents hydratants, les vitamines, les parfums, les conservateurs, les tensioactifs, les charges, les séquestrants, les polymères, les propulseurs, les agents alcalinisants ou acidifiants, les colorants, les parfums, les colorants, les pigments, les agents épaississants, ou tout autre ingrédient habituellement utilisé en cosmétique. Les tensioactifs sont choisis parmi les tensioactifs non-ioniques, amphotères, canoniques, ou anioniques ou leurs mélanges.The compositions of the invention may also comprise cosmetic adjuvants chosen from fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, anti-foaming agents, moisturizing agents, vitamins, perfumes, preservatives, surfactants, fillers, sequestrants, polymers, propellants, basifying or acidifying agents, dyes, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics. The surfactants are chosen from nonionic, amphoteric, canonical or anionic surfactants or their mixtures.
Les corps gras peuvent être constitués par une huile ou une cire ou leur mélange, la vaseline, la paraffine, la lanoline, la lanoline hydrogénée, la lanoline acétylée ; ils compren- nent également les acides gras, les alcools gras tels que l'alcool laurique, cétylique, my- ristique, stéarique, palmitique, oléique ainsi que le 2-octyldodécanol, les esters d'acides gras tels que le monostéarate de glycérol, le monostéarate de polyéthylèneglycol, le my- ristate d'isopropyle, l'adipate d'isopropyle, le palmitate d'isopropyle, le palmitate d'octyle, les benzoates d'alcools gras en C12-C15 (FINSOLV TN de FINETEX), l'alcool myristique polyoxypropyléné à 3 moles d'oxyde de propylène (WITCONOL APM de WITCO), les triglycérides d'acides gras en C6-C18 tels que les triglycérides d'acide caprylique/caprique.The fatty substances can consist of an oil or a wax or their mixture, petroleum jelly, paraffin, lanolin, hydrogenated lanolin, acetylated lanolin; they also include fatty acids, fatty alcohols such as lauric, cetyl, myoristic, stearic, palmitic, oleic alcohol as well as 2-octyldodecanol, esters of fatty acids such as glycerol monostearate, polyethylene glycol monostearate, isopropyl myististate, isopropyl adipate, isopropyl palmitate, octyl palmitate, C 12 -C 15 fatty alcohol benzoates (FINSOLV TN from FINETEX) , polyoxypropylenated myristic alcohol with 3 moles of propylene oxide (WITCONOL APM from WITCO), C 6 -C 18 fatty acid triglycerides such as caprylic / capric acid triglycerides.
Les huiles sont choisies parmi les huiles animales, végétales, minérales ou de synthèse et notamment l'huile de palme hydrogénée, l'huile de ricin hydrogénée, l'huile de vase- line, l'huile de paraffine, l'huile de Purcellin (octanoate de stéaryle), les huiles de silicone et les isoparaffines.The oils are chosen from animal, vegetable, mineral or synthetic oils and in particular hydrogenated palm oil, hydrogenated castor oil, linseed oil, paraffin oil, Purcellin oil (stearyl octanoate), silicone oils and isoparaffins.
Les cires sont choisies parmi les cires animales, fossiles, végétales, minérales ou de synthèse. On peut citer notamment les cires d'abeille, les cires de Camauba, de Candlilla, de canne à sucre, du Japon, les ozokérites, la cire de Montan, les cires microcristallines, les paraffines, les cires et résines de silicone. Les épaississants sont de préférence non ioniques ou anioniques.The waxes are chosen from animal, fossil, vegetable, mineral or synthetic waxes. Mention may in particular bees beeswaxes, Camauba, Candlilla, sugar cane, Japanese waxes, ozokerites, Montan wax, microcrystalline waxes, paraffins, waxes and silicone resins. The thickeners are preferably nonionic or anionic.
Les épaississants non ioniques peuvent être choisis parmi les gommes de guar et celluloses modifiées ou non telles que la gomme de guar hydroxypropylée.la cétylhydroxy- éthylcellulose, les silices comme par exemple la Bentone Gel MiO vendue par la société NL INDUSTRIES ou la Veegum Ultra, vendue par la société POLYPLASTIC.The nonionic thickeners can be chosen from guar gums and modified or unmodified celluloses such as hydroxypropylated guar gum. Cetylhydroxyethylcellulose, silicas such as, for example, Bentone Gel MiO sold by the company NL INDUSTRIES or Veegum Ultra, sold by the company POLYPLASTIC.
Les épaississants anioniques peuvent être choisis parmi les acides polyacryliques réticulés ou les homo ou copolymères d'acide acrylamido propane sulfonique.The anionic thickeners can be chosen from crosslinked polyacrylic acids or homo or copolymers of acrylamido propane sulfonic acid.
Elles peuvent comprendre des émollients, qui contribuent à une sensation douce, sèche, non-collante à l'application de la composition sur la peau. Ces émollients peuvent être choisis parmi des produits du type silicone volatile, des silicones non-volatiles et d'autres émollients non-volatils. Généralement les émollients sont présents en proportions allant de 20 à 80%, de préférence de 25 à 60% et encore plus préférentiellement de 35 à 55%.They may include emollients, which contribute to a soft, dry feeling, non-sticky when the composition is applied to the skin. These emollients can be chosen from products of the volatile silicone type, non-volatile silicones and other non-volatile emollients. Generally the emollients are present in proportions ranging from 20 to 80%, preferably from 25 to 60% and even more preferably from 35 to 55%.
Les silicones volatiles sont définies de façon connue comme des composés volatils à température ambiante. On peut citer parmi ces composés les silicones volatiles cycliques et linéaires du type diméthylsiloxane dont les chaînes comprennent de 3 à 9 résidus sili- conés. De préférence on choisit les cyclométhicones D4 ou D5.Volatile silicones are defined in a known manner as volatile compounds at room temperature. Among these compounds, mention may be made of cyclic and linear volatile silicones of the dimethylsiloxane type, the chains of which comprise from 3 to 9 silicone residues. Preferably, cyclomethicones D4 or D5 are chosen.
Les silicones non-volatiles sont définies de façon connue comme des composés de pression de vapeur faible à température ambiante. Parmi ces composés sont inclus : les polyalkylsiloxanes, en particulier les polyalkylsiloxanes linéaires comme par exemple les polydiméthylsiloxanes, ou diméthicones, linéaires, commercialisés par la société Dow Corning sous le nom de «Dow Corning 200 Fluid» ; les polyalkylarylsiloxanes comme par exemple les polyméthylphénylsiloxanes, commercialisés par la société Dow Corning sous le nom de «Dow Corning 556 Fluid» ; les copolymères polyéther et siloxane, comme par exemple les diméthicone copolyols.Non-volatile silicones are defined in a known manner as compounds with low vapor pressure at room temperature. Among these compounds are included: polyalkylsiloxanes, in particular linear polyalkylsiloxanes such as, for example, linear polydimethylsiloxanes, or dimethicones, sold by the company Dow Corning under the name of "Dow Corning 200 Fluid"; polyalkylarylsiloxanes such as, for example, polymethylphenylsiloxanes, sold by the company Dow Corning under the name of "Dow Corning 556 Fluid"; polyether and siloxane copolymers, such as, for example, dimethicone copolyols.
Parmi les émollients non-volatils utilisables dans la présente invention, on peut citer par exemple : les dérivés hydrocarbonés, les huiles minérales, les alcools gras, les esters d'alcools en C3-C18 avec des acides en C3-C18, les esters de l'acide benzoïque avec des alcools en C12-C18 et leurs mélanges, des polyols en C2-C6 choisis de préférence parmi le glycérol, le propylèneglycol ou le sorbitol, les polymères de polalkylène glycol.Among the nonvolatile emollients useful in the present invention include for example: hydrocarbon-based derivatives, mineral oils, fatty alcohols, alcohol esters of C 3 -C 18 acids with C 3 -C 18 , esters of benzoic acid with C 12 -C 18 alcohols and their mixtures, C 2 -C 6 polyols preferably chosen from glycerol, propylene glycol or sorbitol, polymers of polalkylene glycol.
Le pH des compositions de l'invention est compris entre 2 et 12 et de préférence entre 4 et 10. Lorsque les compositions déodorantes selon l'invention sont destinées à l'usage cosmétique, elles peuvent se présenter sous forme de lotions, de crèmes ou de gels fluides distribués en spray aérosol, en flacon pompe ou en roll-on, sous forme de crèmes épaisses distribuées en tubes et sous forme de sticks, et contenir à cet égard les ingrédients et propulseurs généralement utilisés dans ce type de produits et bien connus de l'homme de l'art, sous réserve qu'ils n'interfèrent pas avec les inhibiteurs d'enzymes décrits dans la présente invention.The pH of the compositions of the invention is between 2 and 12 and preferably between 4 and 10. When the deodorant compositions according to the invention are intended for cosmetic use, they may be in the form of lotions, creams or of fluid gels distributed in aerosol spray, in pump bottle or in roll-on, in the form of thick creams distributed in tubes and in the form of sticks, and contain in this regard the ingredients and propellants generally used in this type of products and well known skilled in the art, provided that they do not interfere with the enzyme inhibitors described in the present invention.
Des exemples concrets, mais nullement limitatifs, illustrant l'invention vont maintenant être donnés. On a réalisé les trois formules suivantes (deux lotions aqueuses, un stick aqueux )Concrete, but in no way limiting, examples illustrating the invention will now be given. The following three formulas were made (two aqueous lotions, one aqueous stick)
Exemple 1 : Lotion aqueuseExample 1: Aqueous lotion
D-cyclosérine 2,0 g Triethanolamine q.s. pH 7,5D-cycloserine 2.0 g Triethanolamine q.s. pH 7.5
Parfum q.s.Perfume q.s.
Eau déminéralisée q.s. p. 100. gDemineralized water q.s. p. 100. g
Exemple 2 : Lotion aqueuseEXAMPLE 2 Aqueous Lotion
- Acide indole-3 acétique 1 ,0 g- Indole-3 acetic acid 1.0 g
- Triethanolamine q.s. pH 8.0- Triethanolamine q.s. pH 8.0
- Parfum qs - Eau déminéralisée qsp 100 g- Perfume qs - Demineralized water qs 100 g
Exemple 3 : Stick aqueux - Stéarate de Sodium 6,2 gExample 3 Aqueous Stick - Sodium Stearate 6 , 2 g
- Acide succinique 3.0 g- Succinic acid 3.0 g
- Glycérine 15. g- Glycerin 15. g
- Propylène glycol 20. g- Propylene glycol 20. g
- Parfum qs - Eau déminéralisée qsp 100. g - Perfume qs - Demineralized water qs 100. g

Claims

REVENDICATIONS
1 Composition cosmétique déodorante caractérisée par le fait qu'elle contient une quan- tité efficace d'au moins un composé inhibiteur d'enzyme de transformation des acides aminés qui ne soit pas inhibiteur de la β-lyase, ladite enzyme étant choisie dans le groupe formé par1 Deodorant cosmetic composition characterized by the fact that it contains an effective amount of at least one amino acid transformation enzyme inhibitor compound which is not an inhibitor of β-lyase, said enzyme being chosen from the group trained by
- les hydrolases- hydrolases
- les isomérases - les carboxylyases- isomerases - carboxylyases
- les ligases- ligases
- les amino acide déshydratases- amino acid dehydratases
- les amino acide déoxygénases- amino acid deoxygenases
- les amino acide carbamoyl transférases - les amino acide amidino transférases- amino acid carbamoyl transferases - amino acid amidino transferases
- les amino acide amino transférases, lesdites enzymes ayant au moins un acide aminé naturel pour substrat- amino acid amino transferases, said enzymes having at least one natural amino acid for substrate
2 Composition selon la revendication 1 , caractérisée par le fait que les hydrolases sont choisies parmi2 Composition according to Claim 1, characterized in that the hydrolases are chosen from
- l'asparaginase- asparaginase
- la citrullinase- citrullinase
- l'arginase - l'arginine déiminase- arginase - arginine deiminase
3 Composition selon la revendication 1 , caractérisée par le fait que les isomérases sont choisies parmi3 Composition according to Claim 1, characterized in that the isomerases are chosen from
- les amino acide racemases - les aminomutases- amino acid racemases - aminomutases
4 Composition selon la revendication 1 , caractérisée par le fait que les ligases sont choisies parmi - les amino acide ammonia ligases4 Composition according to Claim 1, characterized in that the ligases are chosen from - amino acids ammonia ligases
- les amino acide t-RNA ligases- amino acid t-RNA ligases
5 Composition selon l'une quelconque des revendications 1 à 4, caractérisée par le fait que l'inhibiteur d'enzyme de transformation est choisi dans le groupe constitue par - le diaminopropane5 Composition according to any one of claims 1 to 4, characterized in that the transformation enzyme inhibitor is chosen from the group consisting of - diaminopropane
- l'acide caféique- caffeic acid
- l'ιndole-3 acétyl CoA- indole-3 acetyl CoA
- l'ion Ca++ - the Ca ++ ion
- l'acide guanidinoacétique - la D-cycloséπne- guanidinoacetic acid - D-cyclosine
- le carbamoylphosphate- carbamoylphosphate
- l'acide glutanque- glutanic acid
- l'acide succinique- succinic acid
- la biguanine - la choline - le sulfate de Riboflavine- biguanine - choline - Riboflavin sulfate
- l'acide ιndole-3 acétique- indole-3 acetic acid
- la 5'-parafluorosulfonylbenzoyle adenosine- 5'-parafluorosulfonylbenzoyle adenosine
- l'adénosine monophosphate- adenosine monophosphate
- le pyrophosphate- pyrophosphate
- l'acιde-3 méthylglutamique- 3-methylglutamic acid
- la 2,3-butanedιone- 2,3-butanedιone
- l'adénine- adenine
- la créatinme- the creatinme
6 Composition selon l'une quelconque des revendications 1 à 5, caractérisée par le fait que l'inhibiteur d'enzyme de transformation est présent dans une concentration comprise entre 0,001 % et 20 % par rapport au poids total de la composition 7 Composition selon la revendication 6, caractérisée par le fait que l'inhibiteur d'enzyme de transformation est présent dans une concentration comprise entre 0 01 % et 5 % par rapport au poids total de la composition6 Composition according to any one of claims 1 to 5, characterized in that the transformation enzyme inhibitor is present in a concentration of between 0.001% and 20% relative to the total weight of the composition 7 Composition according to claim 6, characterized in that the transforming enzyme inhibitor is present in a concentration of between 0 01% and 5% relative to the total weight of the composition
8 Composition selon l'une quelconque des revendications 1 à 7, caractérisée par le fait qu'elle comprend en outre d'autres actifs déodorants8 Composition according to any one of claims 1 to 7, characterized in that it also comprises other deodorant active agents
9 Composition selon l'une quelconque des revendications 1 à 8, caractérisée par le fait qu'elle est formulée dans un véhicule essentiellement aqueux 10 Composition selon l'une quelconque des revendications 1 à 9, caractérisée par le fait qu'elle comprend en outre des adjuvants cosmétiques choisis parmi les corps gras, les solvants organiques, les gélifiants, les émollients, les adoucissants, les antioxydants, les opacifiants, les stabilisants, les silicones, les agents anti-mousse, les agents hydratants, les vitamines, les parfums, les conservateurs, les tensioactifs, les charges, les seques- trants, les polymères, les propulseurs, les agents alcalinisants ou acidifiants, les colorants, les parfums, les colorants, les pigments, les agents épaississants, ou tout autre ingrédient habituellement utilisé en cosmétique9 Composition according to any one of Claims 1 to 8, characterized in that it is formulated in an essentially aqueous vehicle 10 Composition according to any one of Claims 1 to 9, characterized in that it further comprises cosmetic adjuvants chosen from fatty substances, organic solvents, gelling agents, emollients, softeners, antioxidants, opacifiers, stabilizers, silicones, anti-foaming agents, moisturizing agents, vitamins, perfumes, preservatives, surfactants, fillers, sequencers, polymers, propellants, basifying or acidifying agents, dyes, perfumes, dyes, pigments, thickening agents, or any other ingredient usually used in cosmetics
11 Composition selon l'une quelconque des revendications 1 à 10, caractérisée par le fait que le pH est compris entre 2 et 1211 Composition according to any one of claims 1 to 10, characterized in that the pH is between 2 and 12
12 Composition selon la revendication 11 , caractérisée par le fait que le pH est compris entre 4 et 10 13 Composition selon l'une quelconque des revendications 1 à 12, caractérisée par le fait qu'elle se présente sous forme d'une lotion, d'une crème ou d'un gel fluide distribue en spray aérosol, en flacon pompe ou en roll-on sous forme d'une crème épaisse distribuée en tubes et sous forme de stick 14 Procédé pour traiter les odeurs axillaires humaines, consistant a appliquer sur la surface axillaire une quantité efficace d'une composition selon l'une quelconque des revendications 1 à 1312 Composition according to Claim 11, characterized in that the pH is between 4 and 10 13 Composition according to any one of Claims 1 to 12, characterized in that it is in the form of a lotion, d '' a cream or a fluid gel distributed in aerosol spray, in a pump bottle or in roll-on in the form of a thick cream distributed in tubes and in the form of stick 14 Method for treating human axillary odors, consisting in applying to the axillary surface an effective amount of a composition according to any one of claims 1 to 13
15 Utilisation d'un composé inhibiteur d'enzyme de transformation des acides aminés tel que défini dans les revendications 1 à 5, comme actif déodorant, en particulier comme agent inhibiteur du développement d'odeurs d'axillaires humaines dans la fabrication de produits cosmétiques ou dermatologiques Use of an amino acid transforming enzyme inhibitor compound as defined in claims 1 to 5 as a deodorant active agent, in particular as an agent inhibiting the development of human axillary odors in the manufacture of cosmetic products or dermatological
EP99956129A 1998-12-08 1999-11-23 Deodorant cosmetic composition Withdrawn EP1137393A2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9815477A FR2786690A1 (en) 1998-12-08 1998-12-08 COSMETIC DEODORANT COMPOSITION
FR9815477 1998-12-08
PCT/FR1999/002887 WO2000033787A2 (en) 1998-12-08 1999-11-23 Deodorant cosmetic composition

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AU (1) AU1279500A (en)
BR (1) BR9916947A (en)
CA (1) CA2353721A1 (en)
FR (1) FR2786690A1 (en)
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ZA (1) ZA200104481B (en)

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Publication number Priority date Publication date Assignee Title
US6060043A (en) * 1998-02-03 2000-05-09 The Gillette Company Deodorant composition containing D-amino acid
DE10136077A1 (en) * 2001-07-25 2003-02-13 Beiersdorf Ag Cosmetic or dermatological preparations containing creatinine and creatine, useful e.g. for combating skin aging symptoms or treating inflammatory conditions such as eczema or psoriasis
DE10136076A1 (en) * 2001-07-25 2003-02-13 Beiersdorf Ag Cosmetic or dermatological preparations containing creatinine or its derivative, useful e.g. for combating skin aging symptoms or treating inflammatory conditions such as eczema or psoriasis
DE10355714A1 (en) 2003-11-26 2005-06-30 Beiersdorf Ag Active ingredient combination of creatine and / or creatinine, phenoxyethanol and, if desired, glycerol
DE10355716A1 (en) 2003-11-26 2005-06-23 Beiersdorf Ag Cosmetic preparations containing creatine and / or creatine derivatives and / or creatinine and / or creatinine derivatives and organic thickeners
DE102005023636A1 (en) * 2005-05-19 2006-11-23 Beiersdorf Ag Active ingredient combinations of glucosylglycerides and creatine and / or creatinine
KR20090001013A (en) * 2007-06-29 2009-01-08 주식회사 웰스킨 Acne therapeutics and sebum secernent inhibitor which comprise indole-3-alkylcarboxylicacid, and kits for photodynamic therapy containing the same
BR112012008146A2 (en) * 2009-09-14 2019-09-24 Shiseido Co Ltd composition for relief of damage caused by ultraviolet irradiation

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US4089942A (en) * 1976-01-29 1978-05-16 L'oreal Deodorant composition and process
DE3716129C1 (en) * 1987-05-14 1988-12-15 Holger Meyer deodorant
MX173955B (en) * 1989-10-10 1994-04-11 Gillette Co DEODORATING COMPOSITION CONTAINING AMINO ACID BETA-LIASA ENZYME INHIBITORS
EP0483427A1 (en) * 1990-11-01 1992-05-06 The Procter & Gamble Company Amine deodorant composition and method of deodorization
US5643559A (en) * 1991-10-30 1997-07-01 Colgate-Palmolive Company Deodorant compositions comprising inhibitors of odor-producing axillary bacterial exoenzymes
US5516511A (en) * 1994-05-06 1996-05-14 The Procter & Gamble Company Antiperspirant gel compositions comprising chelators

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AU1279500A (en) 2000-06-26
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ZA200104481B (en) 2002-01-16
JP2002531474A (en) 2002-09-24
BR9916947A (en) 2002-02-19
WO2000033787A2 (en) 2000-06-15

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