JP2002531090A5 - - Google Patents
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- Publication number
- JP2002531090A5 JP2002531090A5 JP2000585404A JP2000585404A JP2002531090A5 JP 2002531090 A5 JP2002531090 A5 JP 2002531090A5 JP 2000585404 A JP2000585404 A JP 2000585404A JP 2000585404 A JP2000585404 A JP 2000585404A JP 2002531090 A5 JP2002531090 A5 JP 2002531090A5
- Authority
- JP
- Japan
- Prior art keywords
- tgf
- antibodies
- binding
- binding protein
- inhibit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000014914 Carrier Proteins Human genes 0.000 description 4
- 102000004887 Transforming Growth Factor beta Human genes 0.000 description 4
- 108090001012 Transforming Growth Factor beta Proteins 0.000 description 4
- 108091008324 binding proteins Proteins 0.000 description 4
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 description 4
- 102000043168 TGF-beta family Human genes 0.000 description 3
- 108091085018 TGF-beta family Proteins 0.000 description 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 230000003302 anti-idiotype Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11028398P | 1998-11-27 | 1998-11-27 | |
| US60/110,283 | 1998-11-27 | ||
| PCT/US1999/027990 WO2000032773A1 (en) | 1998-11-27 | 1999-11-24 | Compositions and methods for increasing bone mineralization |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011145326A Division JP5691036B2 (ja) | 1998-11-27 | 2011-06-30 | 骨鉱化作用を増加するための組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002531090A JP2002531090A (ja) | 2002-09-24 |
| JP2002531090A5 true JP2002531090A5 (https=) | 2006-12-07 |
| JP4813660B2 JP4813660B2 (ja) | 2011-11-09 |
Family
ID=22332193
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000585404A Expired - Lifetime JP4813660B2 (ja) | 1998-11-27 | 1999-11-24 | 骨鉱化作用を増加するための組成物および方法 |
| JP2011145326A Expired - Lifetime JP5691036B2 (ja) | 1998-11-27 | 2011-06-30 | 骨鉱化作用を増加するための組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011145326A Expired - Lifetime JP5691036B2 (ja) | 1998-11-27 | 2011-06-30 | 骨鉱化作用を増加するための組成物および方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (12) | US6395511B1 (https=) |
| EP (3) | EP1721979B1 (https=) |
| JP (2) | JP4813660B2 (https=) |
| CN (2) | CN1333828B (https=) |
| AT (2) | ATE481487T1 (https=) |
| BR (1) | BRPI9915679B8 (https=) |
| CA (1) | CA2352532C (https=) |
| CY (3) | CY1106260T1 (https=) |
| DE (2) | DE69933044T3 (https=) |
| DK (3) | DK2261335T3 (https=) |
| ES (3) | ES2350454T3 (https=) |
| HK (1) | HK1044171B (https=) |
| IL (3) | IL143266A0 (https=) |
| MX (2) | MX343200B (https=) |
| NZ (3) | NZ512122A (https=) |
| PT (3) | PT1721979E (https=) |
| WO (1) | WO2000032773A1 (https=) |
| ZA (1) | ZA200104234B (https=) |
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