JP2002527504A - システインプロテアーゼのＩＣＥ／ｃｅｄ−３系の置換アシルジペプチジル抑制剤 - Google Patents

システインプロテアーゼのＩＣＥ／ｃｅｄ−３系の置換アシルジペプチジル抑制剤

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Publication number
JP2002527504A
JP2002527504A JP2000577149A JP2000577149A JP2002527504A JP 2002527504 A JP2002527504 A JP 2002527504A JP 2000577149 A JP2000577149 A JP 2000577149A JP 2000577149 A JP2000577149 A JP 2000577149A JP 2002527504 A JP2002527504 A JP 2002527504A
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Prior art keywords
phenyl
naphthyl
substituted
cycloalkyl
mmol
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JP2000577149A
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JP2002527504A5 (enExample
Inventor
エス． カラニュースキー，ドナルド
ジェイ． カリッシュ，ビンセント
ディー． ロビンソン，エドワード
アール． ウルマン，ブレット
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アイドゥン ファーマシューティカルズ， インコーポレイテッド
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Publication of JP2002527504A publication Critical patent/JP2002527504A/ja
Publication of JP2002527504A5 publication Critical patent/JP2002527504A5/ja
Pending legal-status Critical Current

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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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JP2007506803A (ja) * 2003-05-27 2007-03-22 バーテックス　ファーマシューティカルズ　インコーポレイテッド カスパーゼ阻害剤およびそれらの用途
JP4791365B2 (ja) * 2003-05-27 2011-10-12 バーテックス ファーマシューティカルズ インコーポレイテッド カスパーゼ阻害剤およびそれらの用途
JP2012036206A (ja) * 2003-05-27 2012-02-23 Vertex Pharmaceuticals Inc カスパーゼ阻害剤およびそれらの用途
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US7803754B2 (en) 2005-01-10 2010-09-28 Arena Pharmaceuticals, Inc. Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
US7803753B2 (en) 2005-01-10 2010-09-28 Arena Pharmaceuticals, Inc. Combination therapy for the treatment of diabetes and conditions related thereto and for the treatment of conditions ameliorated by increasing a blood GLP-1 level
JP2008538205A (ja) * 2005-03-07 2008-10-16 ガンガ， ラジュ ゴカラジュ， ボスウェル酸及び選択的に濃縮したボスウェル酸の新規な塩、ならびにそのための方法
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US9241487B2 (en) 2010-11-30 2016-01-26 Bayer Intellectual Property Gmbh Pyrimidine derivatives and use thereof as pesticides
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US10555929B2 (en) 2015-03-09 2020-02-11 Coherus Biosciences, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
US10772865B2 (en) 2015-03-09 2020-09-15 Coherus Biosciences, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
US11400072B2 (en) 2015-03-09 2022-08-02 Coherus Biosciences, Inc. Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy
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