JP2002523491A5 - - Google Patents

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Publication number
JP2002523491A5
JP2002523491A5 JP2000567508A JP2000567508A JP2002523491A5 JP 2002523491 A5 JP2002523491 A5 JP 2002523491A5 JP 2000567508 A JP2000567508 A JP 2000567508A JP 2000567508 A JP2000567508 A JP 2000567508A JP 2002523491 A5 JP2002523491 A5 JP 2002523491A5
Authority
JP
Japan
Prior art keywords
compound
propylamine
disorder
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000567508A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002523491A (ja
Filing date
Publication date
Priority claimed from GBGB9819033.3A external-priority patent/GB9819033D0/en
Application filed filed Critical
Publication of JP2002523491A publication Critical patent/JP2002523491A/ja
Publication of JP2002523491A5 publication Critical patent/JP2002523491A5/ja
Pending legal-status Critical Current

Links

JP2000567508A 1998-09-01 1999-09-01 5−ht2bおよび/または5−ht2cレセプターリガンドとしてのインドール誘導体 Pending JP2002523491A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9819033.3A GB9819033D0 (en) 1998-09-01 1998-09-01 Chemical compounds VI
GB9819033.3 1998-09-01
PCT/GB1999/002879 WO2000012475A1 (en) 1998-09-01 1999-09-01 Indoline derivatives as 5-ht2b and/or 5-ht2c receptor ligands

Publications (2)

Publication Number Publication Date
JP2002523491A JP2002523491A (ja) 2002-07-30
JP2002523491A5 true JP2002523491A5 (cg-RX-API-DMAC10.html) 2006-11-02

Family

ID=10838165

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000567508A Pending JP2002523491A (ja) 1998-09-01 1999-09-01 5−ht2bおよび/または5−ht2cレセプターリガンドとしてのインドール誘導体

Country Status (7)

Country Link
US (1) US6380238B1 (cg-RX-API-DMAC10.html)
EP (1) EP1109784A1 (cg-RX-API-DMAC10.html)
JP (1) JP2002523491A (cg-RX-API-DMAC10.html)
AU (1) AU5637199A (cg-RX-API-DMAC10.html)
CA (1) CA2341525A1 (cg-RX-API-DMAC10.html)
GB (1) GB9819033D0 (cg-RX-API-DMAC10.html)
WO (1) WO2000012475A1 (cg-RX-API-DMAC10.html)

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US6465467B1 (en) 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
GB9918965D0 (en) 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
WO2001040183A1 (en) * 1999-12-03 2001-06-07 Alcon Universal Ltd. 1-aminoalkyl-1h-indoles for treating glaucoma
US6806285B1 (en) 2000-03-17 2004-10-19 Alcon, Inc. 5-Hydroxyl indole derivatives for treating glaucoma
US7012090B1 (en) 2000-03-17 2006-03-14 Alcon, Inc. Pyranoindoles for treating glaucoma
WO2001070223A1 (en) * 2000-03-17 2001-09-27 Alcon, Inc. Compounds with 5-ht2 and 5-ht1a agonist activity for treating glaucoma
GB0019950D0 (en) * 2000-08-12 2000-09-27 Smithkline Beecham Plc Compounds
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
CN1227237C (zh) 2000-11-20 2005-11-16 比奥维特罗姆股份公司 作为五羟色胺5-ht2受体拮抗剂的哌嗪基吡嗪化合物
CA2432122A1 (en) 2000-12-20 2002-08-01 Bristol-Myers Squibb Pharma Company Aryl and aminoaryl substituted serotonin receptor agonist and antagonist ligands
AU2002305732B2 (en) 2001-06-01 2007-02-01 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
WO2002098860A1 (en) 2001-06-01 2002-12-12 Alcon, Inc. Novel fused indazoles and indoles and their use for the treatment of glaucoma
BR0210238A (pt) 2001-06-01 2004-07-20 Alcon Inc Novos análogos de aril-amino-propano e seu uso para o tratamento de glaucoma
US6884816B2 (en) 2001-08-31 2005-04-26 Alcon, Inc. Hydroxy substituted fused naphthyl-azoles and fused indeno-azoles and their use for the treatment of glaucoma
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
EA008148B1 (ru) 2002-06-19 2007-04-27 Биовитрум Аб Новые соединения, их применение и получение
MXPA05002259A (es) * 2002-08-30 2005-07-05 Alcon Inc Compuestos de 5-croman-5-il-etilamina sustituidos y uso para el tratamiento de glaucoma.
HRP20050396A2 (en) 2002-11-07 2005-06-30 Akzo Nobel N.V. Indoles useful in the treatment of androgen-receptor related diseases
EP1581209A4 (en) 2002-12-13 2009-03-11 Alcon Inc NEW BENZOPYRAN ANALOGUE AND ITS USE FOR THE TREATMENT OF GLAUKOM
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
GB0314967D0 (en) * 2003-06-26 2003-07-30 Hoffmann La Roche Piperazine derivatives
WO2005053688A1 (en) 2003-11-26 2005-06-16 Alcon, Inc. Substituted furo[2,3-g] indazoles for the treatment of glaucoma
TW200520760A (en) 2003-12-15 2005-07-01 Alcon Inc Substituted [1,4] oxazino [2,3-g] indazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
TW200602317A (en) 2004-04-23 2006-01-16 Akzo Nobel Nv Novel androgens
EP2248524A3 (en) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Preventives/remedies for stress urinary incontinence and method of screening the same
WO2006062839A1 (en) 2004-12-08 2006-06-15 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
EP1869000A1 (en) * 2005-03-31 2007-12-26 Pfizer Products Incorporated Cyclopentapyridine and tetrahydroquinoline derivatives
CN101151249B (zh) * 2005-03-31 2011-04-06 辉瑞产品公司 环戊吡啶及四氢喹啉衍生物
US8158617B2 (en) 2006-05-16 2012-04-17 Takeda Pharmaceutical Company Limited Fused heterocyclic compound and use thereof
CN101506172A (zh) * 2006-07-14 2009-08-12 辉瑞产品公司 (7S)-7-[(5-氟-2-甲基-苄基)氧基]-2-[(2R)-2-甲基哌嗪-1-基]-6,7-二氢-5H-环戊烷并[b]吡啶的酒石酸盐
GB0715047D0 (en) * 2007-08-02 2007-09-12 Glaxo Group Ltd Novel Compounds
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND ITS USE
KR101062376B1 (ko) 2008-04-10 2011-09-06 한국화학연구원 신규 인돌 카르복실산 비스피리딜 카르복사마이드 유도체,이의 제조방법 및 이를 유효성분으로 함유하는 조성물
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
US20210169850A1 (en) * 2016-01-21 2021-06-10 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Indoline derivatives, compositions comprising them and uses thereof
CA3029811A1 (en) * 2016-07-08 2018-01-11 Arizona Board Of Regents On Behalf Of The University Of Arizona Indoline derivatives and method for using and producing the same
WO2018064465A1 (en) 2016-09-29 2018-04-05 The Regents Of The University Of California Compounds for increasing neural plasticity
WO2019131902A1 (ja) 2017-12-27 2019-07-04 武田薬品工業株式会社 腹圧性尿失禁および便失禁の治療薬
AU2020229779B9 (en) 2019-02-27 2025-09-18 The Regents Of The University Of California Azepino-indoles and other heterocycles for treating brain disorders
CN113840600A (zh) 2019-02-27 2021-12-24 加利福尼亚大学董事会 用于治疗脑疾病的n-取代吲哚和其他杂环化合物
KR20230066543A (ko) * 2020-06-10 2023-05-16 델릭스 테라퓨틱스, 인크. 이소트립타민 사이코플라스토겐 및 이의 용도
WO2023114313A1 (en) 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Phenoxy and benzyloxy substituted psychoplastogens and uses thereof
CA3248170A1 (en) * 2022-04-19 2023-10-26 Mindset Pharma Inc. Indoline derivatives used as serotonergic agents useful for the treatment of disorders associated with them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW270114B (cg-RX-API-DMAC10.html) * 1993-10-22 1996-02-11 Hoffmann La Roche
JPH10500960A (ja) * 1994-05-28 1998-01-27 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 5ht1d−アンタゴニスト活性を有するアミド誘導体
FR2742047B1 (fr) 1995-12-06 1998-01-16 Oreal Compositions de teinture des fibres keratiniques contenant des derives n-substitues de la 4-hydroxy indoline, nouveaux derives, leur procede de synthese, leur utilisation pour la teinture, et procede de teinture

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