JP2002522780A - ポリマーの光学的な特性決定 - Google Patents
ポリマーの光学的な特性決定Info
- Publication number
- JP2002522780A JP2002522780A JP2000565191A JP2000565191A JP2002522780A JP 2002522780 A JP2002522780 A JP 2002522780A JP 2000565191 A JP2000565191 A JP 2000565191A JP 2000565191 A JP2000565191 A JP 2000565191A JP 2002522780 A JP2002522780 A JP 2002522780A
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-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9654498P | 1998-08-13 | 1998-08-13 | |
US12041499P | 1999-02-14 | 1999-02-14 | |
US60/120,414 | 1999-02-14 | ||
US60/096,544 | 1999-02-14 | ||
PCT/US1999/018438 WO2000009757A1 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
Publications (2)
Publication Number | Publication Date |
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JP2002522780A true JP2002522780A (ja) | 2002-07-23 |
JP2002522780A5 JP2002522780A5 (de) | 2006-10-05 |
Family
ID=26791804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000565191A Pending JP2002522780A (ja) | 1998-08-13 | 1999-08-13 | ポリマーの光学的な特性決定 |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1105535A1 (de) |
JP (1) | JP2002522780A (de) |
CN (1) | CN1323355A (de) |
AU (1) | AU5560699A (de) |
CA (1) | CA2340228A1 (de) |
IL (1) | IL141310A0 (de) |
WO (1) | WO2000009757A1 (de) |
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JP2007518107A (ja) * | 2004-01-13 | 2007-07-05 | ユー.エス. ジェノミクス, インコーポレイテッド | ポリマーを使用する溶液中の分析物の検出および定量化 |
JP2008546997A (ja) * | 2005-06-17 | 2008-12-25 | オーミック・アクチボラゲット | 光学式読取装置 |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08256755A (ja) * | 1995-03-16 | 1996-10-08 | Internatl Business Mach Corp <Ibm> | 生体分子のコード配列を確認する装置 |
WO1996031522A1 (en) * | 1995-04-03 | 1996-10-10 | New York University | Methods for measuring physical characteristics of nucleic acids by microscopic imaging |
JPH09503863A (ja) * | 1993-09-30 | 1997-04-15 | ニューヨークユニバーシティ | ポリマー分子などの特性を明らかにする方法 |
JP2001514739A (ja) * | 1997-02-12 | 2001-09-11 | ワイ. チャン,ユージーン | ポリマー分析のための方法および製品 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5538898A (en) * | 1995-03-16 | 1996-07-23 | International Business Machines Corporation | Method suitable for identifying a code sequence of a biomolecule |
WO1996030508A1 (en) * | 1995-03-24 | 1996-10-03 | Ely Michael Rabani | Assembly of complex molecular and supramolecular objects and devices and uses thereof |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
-
1999
- 1999-08-13 EP EP99942167A patent/EP1105535A1/de not_active Withdrawn
- 1999-08-13 CN CN99811963A patent/CN1323355A/zh active Pending
- 1999-08-13 AU AU55606/99A patent/AU5560699A/en not_active Abandoned
- 1999-08-13 WO PCT/US1999/018438 patent/WO2000009757A1/en active Application Filing
- 1999-08-13 CA CA002340228A patent/CA2340228A1/en not_active Abandoned
- 1999-08-13 JP JP2000565191A patent/JP2002522780A/ja active Pending
- 1999-08-13 IL IL14131099A patent/IL141310A0/xx unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH09503863A (ja) * | 1993-09-30 | 1997-04-15 | ニューヨークユニバーシティ | ポリマー分子などの特性を明らかにする方法 |
JPH08256755A (ja) * | 1995-03-16 | 1996-10-08 | Internatl Business Mach Corp <Ibm> | 生体分子のコード配列を確認する装置 |
WO1996031522A1 (en) * | 1995-04-03 | 1996-10-10 | New York University | Methods for measuring physical characteristics of nucleic acids by microscopic imaging |
JP2001514739A (ja) * | 1997-02-12 | 2001-09-11 | ワイ. チャン,ユージーン | ポリマー分析のための方法および製品 |
Cited By (9)
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JP2006522940A (ja) * | 2003-04-10 | 2006-10-05 | ユー.エス. ジェノミクス, インコーポレイテッド | マイクロチャネルにおけるポリマーの操作 |
JP2007518107A (ja) * | 2004-01-13 | 2007-07-05 | ユー.エス. ジェノミクス, インコーポレイテッド | ポリマーを使用する溶液中の分析物の検出および定量化 |
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JP2009520201A (ja) * | 2005-12-20 | 2009-05-21 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | グリッド及び偏光子で構成された一次元のサブ回折限界の開口を備えたバイオセンサー |
JP2009520981A (ja) * | 2005-12-22 | 2009-05-28 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 反射モードで動作するルミネス・センサ |
JP2014529082A (ja) * | 2011-09-28 | 2014-10-30 | コーニンクレッカ フィリップス エヌ ヴェ | 単一分子を処理するための装置 |
US10281453B2 (en) | 2011-09-28 | 2019-05-07 | Koninklijke Philips N.V. | Apparatus for the processing of single molecules |
Also Published As
Publication number | Publication date |
---|---|
EP1105535A1 (de) | 2001-06-13 |
CN1323355A (zh) | 2001-11-21 |
WO2000009757A1 (en) | 2000-02-24 |
IL141310A0 (en) | 2002-03-10 |
AU5560699A (en) | 2000-03-06 |
CA2340228A1 (en) | 2000-02-24 |
WO2000009757A9 (en) | 2000-10-12 |
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