JP2002522780A - ポリマーの光学的な特性決定 - Google Patents

ポリマーの光学的な特性決定

Info

Publication number
JP2002522780A
JP2002522780A JP2000565191A JP2000565191A JP2002522780A JP 2002522780 A JP2002522780 A JP 2002522780A JP 2000565191 A JP2000565191 A JP 2000565191A JP 2000565191 A JP2000565191 A JP 2000565191A JP 2002522780 A JP2002522780 A JP 2002522780A
Authority
JP
Japan
Prior art keywords
polymer
radiation
radiation spot
microchannel
wavelength
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000565191A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002522780A5 (de
Inventor
ジョナス・オー.・テゲンフェルト
ロバート・エイチ.・オースチン
ユージーン・ワイ.・チャン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Princeton University
Original Assignee
Princeton University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Princeton University filed Critical Princeton University
Publication of JP2002522780A publication Critical patent/JP2002522780A/ja
Publication of JP2002522780A5 publication Critical patent/JP2002522780A5/ja
Pending legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/645Specially adapted constructive features of fluorimeters
    • G01N21/648Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/44Resins; Plastics; Rubber; Leather
    • G01N33/442Resins; Plastics
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y20/00Nanooptics, e.g. quantum optics or photonic crystals
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64Fluorescence; Phosphorescence
    • G01N21/6428Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
JP2000565191A 1998-08-13 1999-08-13 ポリマーの光学的な特性決定 Pending JP2002522780A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9654498P 1998-08-13 1998-08-13
US12041499P 1999-02-14 1999-02-14
US60/120,414 1999-02-14
US60/096,544 1999-02-14
PCT/US1999/018438 WO2000009757A1 (en) 1998-08-13 1999-08-13 Optically characterizing polymers

Publications (2)

Publication Number Publication Date
JP2002522780A true JP2002522780A (ja) 2002-07-23
JP2002522780A5 JP2002522780A5 (de) 2006-10-05

Family

ID=26791804

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000565191A Pending JP2002522780A (ja) 1998-08-13 1999-08-13 ポリマーの光学的な特性決定

Country Status (7)

Country Link
EP (1) EP1105535A1 (de)
JP (1) JP2002522780A (de)
CN (1) CN1323355A (de)
AU (1) AU5560699A (de)
CA (1) CA2340228A1 (de)
IL (1) IL141310A0 (de)
WO (1) WO2000009757A1 (de)

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー.エス. ジェノミクス, インコーポレイテッド マイクロチャネルにおけるポリマーの操作
JP2006313151A (ja) * 2005-04-07 2006-11-16 Sysmex Corp 血液分析装置、試料分析装置及びフローサイトメータ
JP2007518107A (ja) * 2004-01-13 2007-07-05 ユー.エス. ジェノミクス, インコーポレイテッド ポリマーを使用する溶液中の分析物の検出および定量化
JP2008546997A (ja) * 2005-06-17 2008-12-25 オーミック・アクチボラゲット 光学式読取装置
JP2009520201A (ja) * 2005-12-20 2009-05-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ グリッド及び偏光子で構成された一次元のサブ回折限界の開口を備えたバイオセンサー
JP2009520981A (ja) * 2005-12-22 2009-05-28 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 反射モードで動作するルミネス・センサ
JP2014529082A (ja) * 2011-09-28 2014-10-30 コーニンクレッカ フィリップス エヌ ヴェ 単一分子を処理するための装置

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US20120160687A1 (en) 1995-03-17 2012-06-28 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US8142708B2 (en) 1995-04-03 2012-03-27 Wisconsin Alumni Research Foundation Micro fluidic system for single molecule imaging
US7775368B2 (en) 1995-04-03 2010-08-17 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
CA2281205A1 (en) 1997-02-12 1998-08-13 Eugene Y. Chan Methods and products for analyzing polymers
US6263286B1 (en) 1998-08-13 2001-07-17 U.S. Genomics, Inc. Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer
US7056661B2 (en) 1999-05-19 2006-06-06 Cornell Research Foundation, Inc. Method for sequencing nucleic acid molecules
WO2000079257A1 (en) 1999-06-22 2000-12-28 President And Fellows Of Harvard College Molecular and atomic scale evaluation of biopolymers
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6927065B2 (en) 1999-08-13 2005-08-09 U.S. Genomics, Inc. Methods and apparatus for characterization of single polymers
US6762059B2 (en) 1999-08-13 2004-07-13 U.S. Genomics, Inc. Methods and apparatuses for characterization of single polymers
WO2001013088A1 (en) * 1999-08-13 2001-02-22 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
AU7105300A (en) 1999-09-03 2001-04-10 Lifebeam Technologies, Inc. Optical system for rapid polymer analysis
GB9923644D0 (en) 1999-10-06 1999-12-08 Medical Biosystems Ltd DNA sequencing
US6908736B1 (en) 1999-10-06 2005-06-21 Medical Biosystems, Ltd. DNA sequencing method
AU2001261094A1 (en) 2000-04-28 2001-11-12 Edgelight Biosciences, Inc. Micro-array evanescent wave fluorescence detection device
JP2002048765A (ja) * 2000-08-03 2002-02-15 Masabumi Youda 水平面型ゲル電気泳動装置用試料導入装置、水平面型ゲル電気泳動システム、その試料導入方法およびその試料採取方法
EP1354064A2 (de) 2000-12-01 2003-10-22 Visigen Biotechnologies, Inc. Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen
EP2465943A3 (de) 2001-03-16 2012-10-03 Kalim Mir Lineare Polymeranzeige
EP1417474B1 (de) 2001-07-25 2021-12-29 The Trustees Of Princeton University Nanokanal-arrays sowie ihre herstellung und verwendung zur makromolekularen analyse mit hohem durchsatz
US9678038B2 (en) 2001-07-25 2017-06-13 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US8423294B2 (en) 2001-09-18 2013-04-16 Pathogenetix, Inc. High resolution linear analysis of polymers
JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
CA2482566C (en) 2002-04-16 2010-07-20 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US7282330B2 (en) 2002-05-28 2007-10-16 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
US7371520B2 (en) 2002-05-28 2008-05-13 U.S. Genomics, Inc. Methods and apparati using single polymer analysis
US20040053399A1 (en) * 2002-07-17 2004-03-18 Rudolf Gilmanshin Methods and compositions for analyzing polymers using chimeric tags
AU2003301262A1 (en) * 2002-10-18 2004-05-04 Wisconsin Alumni Research Foundation Micro-channel long molecule manipulation system
DE10297995D2 (de) * 2002-11-20 2005-10-06 Richard Fritz Sauter Analyseverfahren für Moleküle, zur Sequenzierung von Molekülen und Spektrometer hierfür
US7141801B2 (en) * 2002-12-26 2006-11-28 Applied Precision, Llc System and method of illuminating living cells for imaging
WO2004066185A1 (en) * 2003-01-23 2004-08-05 U.S. Genomics, Inc. Methods for analyzing polymer populations
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
WO2005085849A2 (en) * 2003-10-24 2005-09-15 U S. Genomics, Inc Biohazard identification by fluorescent immunoassay and single molecule detection
US7595160B2 (en) 2004-01-13 2009-09-29 U.S. Genomics, Inc. Analyte detection using barcoded polymers
US7238485B2 (en) 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US7351538B2 (en) 2004-08-23 2008-04-01 U.S. Genomics Systems and methods for detecting and analyzing polymers
US7315019B2 (en) 2004-09-17 2008-01-01 Pacific Biosciences Of California, Inc. Arrays of optical confinements and uses thereof
US7170050B2 (en) 2004-09-17 2007-01-30 Pacific Biosciences Of California, Inc. Apparatus and methods for optical analysis of molecules
WO2006098772A2 (en) 2004-10-13 2006-09-21 U.S. Genomics, Inc. Systems and methods for measurement optimization
US7888011B2 (en) 2004-10-18 2011-02-15 U.S. Genomics, Inc. Methods for isolation of nucleic acids from prokaryotic spores
LT2949668T (lt) 2005-05-18 2019-11-11 Ablynx Nv Pagerinti nanokūnai tm prieš navikų nekrozės faktorių alfa
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
US9410889B2 (en) * 2005-06-10 2016-08-09 Applied Biosystem, Llc Method and system for multiplex genetic analysis
CN101203743B (zh) * 2005-06-23 2011-04-06 皇家飞利浦电子股份有限公司 使用亚波长孔径或狭缝的发光传感器
CN101223425B (zh) * 2005-07-18 2011-03-30 皇家飞利浦电子股份有限公司 使用多层衬底结构的发光传感器
EP1936340A1 (de) * 2006-12-21 2008-06-25 Koninklijke Philips Electronics N.V. Subwellenlängen-Apertur
WO2008078263A1 (en) 2006-12-21 2008-07-03 Koninklijke Philips Electronics N.V. Aperture biosensor with trenches
CA2964611C (en) 2007-03-28 2021-06-01 Bionano Genomics, Inc. Methods of macromolecular analysis using nanochannel arrays
EP2201136B1 (de) 2007-10-01 2017-12-06 Nabsys 2.0 LLC Sequenzierung mittels nanoporen und hybridisierung von sonden zur bildung ternärer komplexe und ausrichtung mit variablem bereich
EP3045542B1 (de) 2008-03-28 2016-11-16 Pacific Biosciences of California, Inc. Verfahren zur nukleinsäuresequenzierung
US9650668B2 (en) 2008-09-03 2017-05-16 Nabsys 2.0 Llc Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
US8262879B2 (en) 2008-09-03 2012-09-11 Nabsys, Inc. Devices and methods for determining the length of biopolymers and distances between probes bound thereto
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WO2012005857A1 (en) 2010-06-08 2012-01-12 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
US8715933B2 (en) 2010-09-27 2014-05-06 Nabsys, Inc. Assay methods using nicking endonucleases
JP5998148B2 (ja) 2010-11-16 2016-09-28 ナブシス 2.0 エルエルシー ハイブリダイズされたプローブの相対位置を検出することによる生体分子のシークエンシングのための方法
US11274341B2 (en) 2011-02-11 2022-03-15 NABsys, 2.0 LLC Assay methods using DNA binding proteins
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JPH08256755A (ja) * 1995-03-16 1996-10-08 Internatl Business Mach Corp <Ibm> 生体分子のコード配列を確認する装置
WO1996031522A1 (en) * 1995-04-03 1996-10-10 New York University Methods for measuring physical characteristics of nucleic acids by microscopic imaging
JPH09503863A (ja) * 1993-09-30 1997-04-15 ニューヨークユニバーシティ ポリマー分子などの特性を明らかにする方法
JP2001514739A (ja) * 1997-02-12 2001-09-11 ワイ. チャン,ユージーン ポリマー分析のための方法および製品

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US5538898A (en) * 1995-03-16 1996-07-23 International Business Machines Corporation Method suitable for identifying a code sequence of a biomolecule
WO1996030508A1 (en) * 1995-03-24 1996-10-03 Ely Michael Rabani Assembly of complex molecular and supramolecular objects and devices and uses thereof
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JPH09503863A (ja) * 1993-09-30 1997-04-15 ニューヨークユニバーシティ ポリマー分子などの特性を明らかにする方法
JPH08256755A (ja) * 1995-03-16 1996-10-08 Internatl Business Mach Corp <Ibm> 生体分子のコード配列を確認する装置
WO1996031522A1 (en) * 1995-04-03 1996-10-10 New York University Methods for measuring physical characteristics of nucleic acids by microscopic imaging
JP2001514739A (ja) * 1997-02-12 2001-09-11 ワイ. チャン,ユージーン ポリマー分析のための方法および製品

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006522940A (ja) * 2003-04-10 2006-10-05 ユー.エス. ジェノミクス, インコーポレイテッド マイクロチャネルにおけるポリマーの操作
JP2007518107A (ja) * 2004-01-13 2007-07-05 ユー.エス. ジェノミクス, インコーポレイテッド ポリマーを使用する溶液中の分析物の検出および定量化
JP2006313151A (ja) * 2005-04-07 2006-11-16 Sysmex Corp 血液分析装置、試料分析装置及びフローサイトメータ
JP2008546997A (ja) * 2005-06-17 2008-12-25 オーミック・アクチボラゲット 光学式読取装置
JP2013019907A (ja) * 2005-06-17 2013-01-31 Aemic Ab ポリマー試料基板およびそれを用いた光学式分析試験装置
JP2009520201A (ja) * 2005-12-20 2009-05-21 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ グリッド及び偏光子で構成された一次元のサブ回折限界の開口を備えたバイオセンサー
JP2009520981A (ja) * 2005-12-22 2009-05-28 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 反射モードで動作するルミネス・センサ
JP2014529082A (ja) * 2011-09-28 2014-10-30 コーニンクレッカ フィリップス エヌ ヴェ 単一分子を処理するための装置
US10281453B2 (en) 2011-09-28 2019-05-07 Koninklijke Philips N.V. Apparatus for the processing of single molecules

Also Published As

Publication number Publication date
EP1105535A1 (de) 2001-06-13
CN1323355A (zh) 2001-11-21
WO2000009757A1 (en) 2000-02-24
IL141310A0 (en) 2002-03-10
AU5560699A (en) 2000-03-06
CA2340228A1 (en) 2000-02-24
WO2000009757A9 (en) 2000-10-12

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