IL141310A0 - Optically characterizing polymers - Google Patents
Optically characterizing polymersInfo
- Publication number
- IL141310A0 IL141310A0 IL14131099A IL14131099A IL141310A0 IL 141310 A0 IL141310 A0 IL 141310A0 IL 14131099 A IL14131099 A IL 14131099A IL 14131099 A IL14131099 A IL 14131099A IL 141310 A0 IL141310 A0 IL 141310A0
- Authority
- IL
- Israel
- Prior art keywords
- optically characterizing
- characterizing polymers
- polymers
- optically
- characterizing
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/44—Resins; Plastics; Rubber; Leather
- G01N33/442—Resins; Plastics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y20/00—Nanooptics, e.g. quantum optics or photonic crystals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9654498P | 1998-08-13 | 1998-08-13 | |
US12041499P | 1999-02-14 | 1999-02-14 | |
PCT/US1999/018438 WO2000009757A1 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
Publications (1)
Publication Number | Publication Date |
---|---|
IL141310A0 true IL141310A0 (en) | 2002-03-10 |
Family
ID=26791804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL14131099A IL141310A0 (en) | 1998-08-13 | 1999-08-13 | Optically characterizing polymers |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP1105535A1 (de) |
JP (1) | JP2002522780A (de) |
CN (1) | CN1323355A (de) |
AU (1) | AU5560699A (de) |
CA (1) | CA2340228A1 (de) |
IL (1) | IL141310A0 (de) |
WO (1) | WO2000009757A1 (de) |
Families Citing this family (71)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US20120160687A1 (en) | 1995-03-17 | 2012-06-28 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US8142708B2 (en) | 1995-04-03 | 2012-03-27 | Wisconsin Alumni Research Foundation | Micro fluidic system for single molecule imaging |
US7775368B2 (en) | 1995-04-03 | 2010-08-17 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
CA2281205A1 (en) | 1997-02-12 | 1998-08-13 | Eugene Y. Chan | Methods and products for analyzing polymers |
US6263286B1 (en) | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US7056661B2 (en) | 1999-05-19 | 2006-06-06 | Cornell Research Foundation, Inc. | Method for sequencing nucleic acid molecules |
WO2000079257A1 (en) | 1999-06-22 | 2000-12-28 | President And Fellows Of Harvard College | Molecular and atomic scale evaluation of biopolymers |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US6927065B2 (en) | 1999-08-13 | 2005-08-09 | U.S. Genomics, Inc. | Methods and apparatus for characterization of single polymers |
US6762059B2 (en) | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
WO2001013088A1 (en) * | 1999-08-13 | 2001-02-22 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
AU7105300A (en) | 1999-09-03 | 2001-04-10 | Lifebeam Technologies, Inc. | Optical system for rapid polymer analysis |
GB9923644D0 (en) | 1999-10-06 | 1999-12-08 | Medical Biosystems Ltd | DNA sequencing |
US6908736B1 (en) | 1999-10-06 | 2005-06-21 | Medical Biosystems, Ltd. | DNA sequencing method |
AU2001261094A1 (en) | 2000-04-28 | 2001-11-12 | Edgelight Biosciences, Inc. | Micro-array evanescent wave fluorescence detection device |
JP2002048765A (ja) * | 2000-08-03 | 2002-02-15 | Masabumi Youda | 水平面型ゲル電気泳動装置用試料導入装置、水平面型ゲル電気泳動システム、その試料導入方法およびその試料採取方法 |
EP1354064A2 (de) | 2000-12-01 | 2003-10-22 | Visigen Biotechnologies, Inc. | Enzymatische nukleinsäuresynthese: zusammensetzungen und verfahren, um die zuverlässigkeit des monomereinbaus zu erhöhen |
EP2465943A3 (de) | 2001-03-16 | 2012-10-03 | Kalim Mir | Lineare Polymeranzeige |
EP1417474B1 (de) | 2001-07-25 | 2021-12-29 | The Trustees Of Princeton University | Nanokanal-arrays sowie ihre herstellung und verwendung zur makromolekularen analyse mit hohem durchsatz |
US9678038B2 (en) | 2001-07-25 | 2017-06-13 | The Trustees Of Princeton University | Nanochannel arrays and their preparation and use for high throughput macromolecular analysis |
US8423294B2 (en) | 2001-09-18 | 2013-04-16 | Pathogenetix, Inc. | High resolution linear analysis of polymers |
JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
CA2482566C (en) | 2002-04-16 | 2010-07-20 | Princeton University | Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof |
US7282330B2 (en) | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
US7371520B2 (en) | 2002-05-28 | 2008-05-13 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
US20040053399A1 (en) * | 2002-07-17 | 2004-03-18 | Rudolf Gilmanshin | Methods and compositions for analyzing polymers using chimeric tags |
AU2003301262A1 (en) * | 2002-10-18 | 2004-05-04 | Wisconsin Alumni Research Foundation | Micro-channel long molecule manipulation system |
DE10297995D2 (de) * | 2002-11-20 | 2005-10-06 | Richard Fritz Sauter | Analyseverfahren für Moleküle, zur Sequenzierung von Molekülen und Spektrometer hierfür |
US7141801B2 (en) * | 2002-12-26 | 2006-11-28 | Applied Precision, Llc | System and method of illuminating living cells for imaging |
WO2004066185A1 (en) * | 2003-01-23 | 2004-08-05 | U.S. Genomics, Inc. | Methods for analyzing polymer populations |
EP1620203A2 (de) * | 2003-04-10 | 2006-02-01 | U.S. Genomics, Inc. | Handhabung von polymeren in mikrokanälen |
WO2005017025A2 (en) | 2003-08-15 | 2005-02-24 | The President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
WO2005085849A2 (en) * | 2003-10-24 | 2005-09-15 | U S. Genomics, Inc | Biohazard identification by fluorescent immunoassay and single molecule detection |
US7595160B2 (en) | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
EP1704256A4 (de) | 2004-01-13 | 2008-01-16 | Us Genomics Inc | Nachweis und quantifizierung von analyten in lösung unter verwendung von polymeren |
US7238485B2 (en) | 2004-03-23 | 2007-07-03 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
US7351538B2 (en) | 2004-08-23 | 2008-04-01 | U.S. Genomics | Systems and methods for detecting and analyzing polymers |
US7315019B2 (en) | 2004-09-17 | 2008-01-01 | Pacific Biosciences Of California, Inc. | Arrays of optical confinements and uses thereof |
US7170050B2 (en) | 2004-09-17 | 2007-01-30 | Pacific Biosciences Of California, Inc. | Apparatus and methods for optical analysis of molecules |
WO2006098772A2 (en) | 2004-10-13 | 2006-09-21 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
US7888011B2 (en) | 2004-10-18 | 2011-02-15 | U.S. Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
JP2006313151A (ja) * | 2005-04-07 | 2006-11-16 | Sysmex Corp | 血液分析装置、試料分析装置及びフローサイトメータ |
LT2949668T (lt) | 2005-05-18 | 2019-11-11 | Ablynx Nv | Pagerinti nanokūnai tm prieš navikų nekrozės faktorių alfa |
DE102005023617A1 (de) | 2005-05-21 | 2006-11-23 | Aspre Ag | Verfahren zum Mischen von Farben in einem Display |
US9410889B2 (en) * | 2005-06-10 | 2016-08-09 | Applied Biosystem, Llc | Method and system for multiplex genetic analysis |
SE529254C2 (sv) * | 2005-06-17 | 2007-06-12 | Aamic Ab | Optiskt testsystem |
CN101203743B (zh) * | 2005-06-23 | 2011-04-06 | 皇家飞利浦电子股份有限公司 | 使用亚波长孔径或狭缝的发光传感器 |
CN101223425B (zh) * | 2005-07-18 | 2011-03-30 | 皇家飞利浦电子股份有限公司 | 使用多层衬底结构的发光传感器 |
ATE479088T1 (de) * | 2005-12-20 | 2010-09-15 | Koninkl Philips Electronics Nv | Aus einem gitter und einem polarisator zusammengesetzter biosensor mit eindimensionalen sub-diffraktions-begrenzten öffnungen |
JP5199116B2 (ja) * | 2005-12-22 | 2013-05-15 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 反射モードで動作するルミネス・センサ |
EP1936340A1 (de) * | 2006-12-21 | 2008-06-25 | Koninklijke Philips Electronics N.V. | Subwellenlängen-Apertur |
WO2008078263A1 (en) | 2006-12-21 | 2008-07-03 | Koninklijke Philips Electronics N.V. | Aperture biosensor with trenches |
CA2964611C (en) | 2007-03-28 | 2021-06-01 | Bionano Genomics, Inc. | Methods of macromolecular analysis using nanochannel arrays |
EP2201136B1 (de) | 2007-10-01 | 2017-12-06 | Nabsys 2.0 LLC | Sequenzierung mittels nanoporen und hybridisierung von sonden zur bildung ternärer komplexe und ausrichtung mit variablem bereich |
EP3045542B1 (de) | 2008-03-28 | 2016-11-16 | Pacific Biosciences of California, Inc. | Verfahren zur nukleinsäuresequenzierung |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
CN102186989B (zh) | 2008-09-03 | 2021-06-29 | 纳伯塞斯2.0有限责任公司 | 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用 |
WO2012005857A1 (en) | 2010-06-08 | 2012-01-12 | President And Fellows Of Harvard College | Nanopore device with graphene supported artificial lipid membrane |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
JP5998148B2 (ja) | 2010-11-16 | 2016-09-28 | ナブシス 2.0 エルエルシー | ハイブリダイズされたプローブの相対位置を検出することによる生体分子のシークエンシングのための方法 |
US11274341B2 (en) | 2011-02-11 | 2022-03-15 | NABsys, 2.0 LLC | Assay methods using DNA binding proteins |
EP2574923A1 (de) | 2011-09-28 | 2013-04-03 | Koninklijke Philips Electronics N.V. | Vorrichtung zur Verarbeitung von Einzelmolekülen |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
US9028776B2 (en) | 2012-04-18 | 2015-05-12 | Toxic Report Llc | Device for stretching a polymer in a fluid sample |
WO2013158860A1 (en) * | 2012-04-18 | 2013-10-24 | Pathogenetix, Inc. | Devices and methods for nucleic acid preparation and analysis |
CN102923635B (zh) * | 2012-10-26 | 2015-06-03 | 中国科学院苏州纳米技术与纳米仿生研究所 | 纳米流体二极管及其制造方法 |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
US10294516B2 (en) | 2013-01-18 | 2019-05-21 | Nabsys 2.0 Llc | Enhanced probe binding |
LU100392B1 (en) * | 2017-07-27 | 2019-02-12 | Wisconsin Alumni Res Foundation Warf | A method to determine the throughput speed of a pore |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6150089A (en) * | 1988-09-15 | 2000-11-21 | New York University | Method and characterizing polymer molecules or the like |
US5624845A (en) * | 1995-03-16 | 1997-04-29 | International Business Machines Corporation | Assembly and a method suitable for identifying a code |
US5538898A (en) * | 1995-03-16 | 1996-07-23 | International Business Machines Corporation | Method suitable for identifying a code sequence of a biomolecule |
WO1996030508A1 (en) * | 1995-03-24 | 1996-10-03 | Ely Michael Rabani | Assembly of complex molecular and supramolecular objects and devices and uses thereof |
WO1996031522A1 (en) * | 1995-04-03 | 1996-10-10 | New York University | Methods for measuring physical characteristics of nucleic acids by microscopic imaging |
US5699157A (en) * | 1996-07-16 | 1997-12-16 | Caliper Technologies Corp. | Fourier detection of species migrating in a microchannel |
CA2281205A1 (en) * | 1997-02-12 | 1998-08-13 | Eugene Y. Chan | Methods and products for analyzing polymers |
-
1999
- 1999-08-13 EP EP99942167A patent/EP1105535A1/de not_active Withdrawn
- 1999-08-13 CN CN99811963A patent/CN1323355A/zh active Pending
- 1999-08-13 AU AU55606/99A patent/AU5560699A/en not_active Abandoned
- 1999-08-13 WO PCT/US1999/018438 patent/WO2000009757A1/en active Application Filing
- 1999-08-13 CA CA002340228A patent/CA2340228A1/en not_active Abandoned
- 1999-08-13 JP JP2000565191A patent/JP2002522780A/ja active Pending
- 1999-08-13 IL IL14131099A patent/IL141310A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EP1105535A1 (de) | 2001-06-13 |
CN1323355A (zh) | 2001-11-21 |
WO2000009757A1 (en) | 2000-02-24 |
AU5560699A (en) | 2000-03-06 |
CA2340228A1 (en) | 2000-02-24 |
JP2002522780A (ja) | 2002-07-23 |
WO2000009757A9 (en) | 2000-10-12 |
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