JP2002520008A5 - - Google Patents
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- Publication number
- JP2002520008A5 JP2002520008A5 JP2000559128A JP2000559128A JP2002520008A5 JP 2002520008 A5 JP2002520008 A5 JP 2002520008A5 JP 2000559128 A JP2000559128 A JP 2000559128A JP 2000559128 A JP2000559128 A JP 2000559128A JP 2002520008 A5 JP2002520008 A5 JP 2002520008A5
- Authority
- JP
- Japan
- Prior art keywords
- pna
- library
- oligomer
- nucleotide
- base
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108091093037 Peptide nucleic acid Proteins 0.000 description 27
- 125000003729 nucleotide group Chemical group 0.000 description 21
- 239000002773 nucleotide Substances 0.000 description 20
- 239000000539 dimer Substances 0.000 description 8
- 239000011347 resin Substances 0.000 description 8
- 229920005989 resin Polymers 0.000 description 8
- IWELDVXSEVIIGI-UHFFFAOYSA-N piperazin-2-one Chemical compound O=C1CNCCN1 IWELDVXSEVIIGI-UHFFFAOYSA-N 0.000 description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- 125000004122 cyclic group Chemical group 0.000 description 5
- 230000008878 coupling Effects 0.000 description 4
- 238000010168 coupling process Methods 0.000 description 4
- 238000005859 coupling reaction Methods 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 description 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
- LSTRKXWIZZZYAS-UHFFFAOYSA-N 2-bromoacetyl bromide Chemical compound BrCC(Br)=O LSTRKXWIZZZYAS-UHFFFAOYSA-N 0.000 description 1
- FTBBGQKRYUTLMP-UHFFFAOYSA-N 2-nitro-1h-pyrrole Chemical compound [O-][N+](=O)C1=CC=CN1 FTBBGQKRYUTLMP-UHFFFAOYSA-N 0.000 description 1
- OZFPSOBLQZPIAV-UHFFFAOYSA-N 5-nitro-1h-indole Chemical compound [O-][N+](=O)C1=CC=C2NC=CC2=C1 OZFPSOBLQZPIAV-UHFFFAOYSA-N 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 description 1
- 229930010555 Inosine Natural products 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- NHYXMAKLBXBVEO-UHFFFAOYSA-N bromomethyl acetate Chemical compound CC(=O)OCBr NHYXMAKLBXBVEO-UHFFFAOYSA-N 0.000 description 1
- 229940104302 cytosine Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N ethyl formate Chemical compound CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 238000009396 hybridization Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 229960003786 inosine Drugs 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11321198A | 1998-07-09 | 1998-07-09 | |
| US09/113,211 | 1998-07-09 | ||
| PCT/US1999/014969 WO2000002899A1 (en) | 1998-07-09 | 1999-07-01 | Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520008A JP2002520008A (ja) | 2002-07-09 |
| JP2002520008A5 true JP2002520008A5 (enExample) | 2006-08-17 |
Family
ID=22348188
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000559128A Pending JP2002520008A (ja) | 1998-07-09 | 1999-07-01 | Ｄｎａ配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6433134B1 (enExample) |
| EP (1) | EP1095054B1 (enExample) |
| JP (1) | JP2002520008A (enExample) |
| KR (1) | KR100694914B1 (enExample) |
| AT (1) | ATE343586T1 (enExample) |
| AU (1) | AU4965499A (enExample) |
| DE (1) | DE69933770D1 (enExample) |
| WO (1) | WO2000002899A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE496139T1 (de) | 2001-03-09 | 2011-02-15 | Boston Probes Inc | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
| EP1373472B1 (en) * | 2001-04-03 | 2007-06-27 | Biocept, Inc. | Methods and gel compositions for encapsulating living cells and organic molecules |
| WO2003020978A1 (en) | 2001-09-01 | 2003-03-13 | Samsung Electronics Co., Ltd. | Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group |
| AU2002347981A1 (en) | 2001-11-07 | 2003-05-19 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| WO2003046144A2 (en) * | 2001-11-26 | 2003-06-05 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
| KR100464261B1 (ko) | 2002-01-24 | 2005-01-03 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| US20030175828A1 (en) * | 2002-03-15 | 2003-09-18 | Lazar James G. | Signal amplification by Hybrid Capture |
| KR20030084444A (ko) | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| AU2003273298B2 (en) * | 2002-09-08 | 2008-03-06 | Applera Corporation | Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis |
| EP1641942A2 (en) * | 2003-06-12 | 2006-04-05 | Applera Corporation | Combinatorial nucleobase oligomers comprising universal base analogues and methods for making and using same |
| US7211668B2 (en) * | 2003-07-28 | 2007-05-01 | Panagene, Inc. | PNA monomer and precursor |
| WO2006076650A2 (en) * | 2005-01-12 | 2006-07-20 | Applera Corporation | Compositions, methods, and kits for selective amplification of nucleic acids |
| US7482353B2 (en) | 2005-06-15 | 2009-01-27 | Applied Biosystems Inc. | Compositions and methods pertaining to PNA synthons and oligomers comprising a universal base |
| CN101321877B (zh) | 2005-10-03 | 2013-04-10 | 应用生物系统有限责任公司 | 用于扩增核酸的组合物、方法和试剂盒 |
| US20070172842A1 (en) * | 2006-01-25 | 2007-07-26 | Andreas Braun | Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences |
| US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
| US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
| US9174216B2 (en) | 2013-03-13 | 2015-11-03 | DeNovo Science, Inc. | System for capturing and analyzing cells |
| EP2739587B1 (en) | 2011-08-01 | 2020-05-27 | Denovo Sciences | Cell capture system |
| US9752181B2 (en) | 2013-01-26 | 2017-09-05 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
| US9707562B2 (en) | 2013-03-13 | 2017-07-18 | Denovo Sciences, Inc. | System for capturing and analyzing cells |
| US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
| US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
| CA2927358C (en) | 2013-10-16 | 2021-12-21 | The University Of British Columbia | Device for formulating particles at small volumes |
| JP6764870B2 (ja) | 2015-02-24 | 2020-10-07 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 連続フローマイクロ流体システム |
| JP7349788B2 (ja) | 2016-01-06 | 2023-09-25 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 分岐ミキサー並びにその使用及び製造方法 |
| CN106117153B (zh) * | 2016-07-05 | 2018-11-23 | 淮阴师范学院 | 2-哌嗪酮的制备方法 |
| WO2018189214A1 (en) * | 2017-04-12 | 2018-10-18 | F. Hoffmann-La Roche Ag | A method for labeling of aldehyde containing target molecules |
| WO2019046307A1 (en) | 2017-08-29 | 2019-03-07 | Celsee Diagnostics, Inc. | SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS |
| US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
| US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
| US11578322B2 (en) | 2019-05-07 | 2023-02-14 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing |
| US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
| EP3975841A1 (en) | 2019-05-30 | 2022-04-06 | Massachusetts Institute of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
| CN118291246A (zh) | 2019-06-14 | 2024-07-05 | 伯乐实验室有限公司 | 用于自动化单细胞处理和分析的系统和方法 |
| CN110511973B (zh) * | 2019-07-16 | 2021-05-07 | 杭州原合生物科技有限公司 | 一种用于核酸原位合成的固相载体及其制备方法 |
| KR102403904B1 (ko) * | 2019-12-24 | 2022-06-02 | 주식회사 시선바이오머티리얼스 | 용액공정상 pna 올리고머의 제조방법 |
| US11504719B2 (en) | 2020-03-12 | 2022-11-22 | Bio-Rad Laboratories, Inc. | System and method for receiving and delivering a fluid for sample processing |
| KR20220057138A (ko) | 2020-10-29 | 2022-05-09 | 엘지전자 주식회사 | 청소기 |
| US12465910B2 (en) | 2021-12-10 | 2025-11-11 | Bio-Rad Laboratories, Inc. | Compositions, methods, and systems for sample processing with morphology-adjustable functionalized particles |
| KR102804687B1 (ko) | 2023-02-10 | 2025-05-12 | 엘지전자 주식회사 | 청소기 및 청소기 제어 방법 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687030T2 (de) | 1985-03-15 | 1993-03-11 | Eugene Stirchak | Stereoregulare polynukleotiden bindende polymere. |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5700922A (en) * | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| US5438131A (en) | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
| US5539083A (en) * | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5738996A (en) | 1994-06-15 | 1998-04-14 | Pence, Inc. | Combinational library composition and method |
| JP3307945B2 (ja) | 1994-10-06 | 2002-07-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ペプチド核酸コンジュゲート |
| WO1996015143A1 (en) | 1994-11-14 | 1996-05-23 | Chiron Corporation | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH |
| AU4729796A (en) * | 1994-12-28 | 1996-07-19 | Peter E. Nielsen | Peptide nucleic acid incorporating a chiral backbone |
| DE19532553A1 (de) | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
| DE19627898A1 (de) | 1996-07-11 | 1998-01-15 | Hoechst Ag | Festphasensynthese von Oligonucleotiden |
-
1999
- 1999-07-01 KR KR1020017000159A patent/KR100694914B1/ko not_active Expired - Fee Related
- 1999-07-01 WO PCT/US1999/014969 patent/WO2000002899A1/en not_active Ceased
- 1999-07-01 JP JP2000559128A patent/JP2002520008A/ja active Pending
- 1999-07-01 EP EP99933646A patent/EP1095054B1/en not_active Expired - Lifetime
- 1999-07-01 AT AT99933646T patent/ATE343586T1/de not_active IP Right Cessation
- 1999-07-01 DE DE69933770T patent/DE69933770D1/de not_active Expired - Lifetime
- 1999-07-01 AU AU49654/99A patent/AU4965499A/en not_active Abandoned
-
2000
- 2000-01-05 US US09/479,320 patent/US6433134B1/en not_active Expired - Fee Related
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