JP2002520008A - Ｄｎａ配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法 - Google Patents
Ｄｎａ配列ハイブリッド形成を最適化するための改良されたペプチド核酸汎用ライブラリーの使用法Info
- Publication number
- JP2002520008A JP2002520008A JP2000559128A JP2000559128A JP2002520008A JP 2002520008 A JP2002520008 A JP 2002520008A JP 2000559128 A JP2000559128 A JP 2000559128A JP 2000559128 A JP2000559128 A JP 2000559128A JP 2002520008 A JP2002520008 A JP 2002520008A
- Authority
- JP
- Japan
- Prior art keywords
- library
- pna
- sequence
- nucleic acid
- peptide nucleic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
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- 150000002513 isocyanates Chemical class 0.000 description 1
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- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 description 1
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- 230000004044 response Effects 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
- C07K14/003—Peptide-nucleic acids (PNAs)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11321198A | 1998-07-09 | 1998-07-09 | |
| US09/113,211 | 1998-07-09 | ||
| PCT/US1999/014969 WO2000002899A1 (en) | 1998-07-09 | 1999-07-01 | Method of using an improved peptide nucleic acid universal library to optimize dna sequence hybridation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002520008A true JP2002520008A (ja) | 2002-07-09 |
| JP2002520008A5 JP2002520008A5 (enExample) | 2006-08-17 |
Family
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| Country | Link |
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| US (1) | US6433134B1 (enExample) |
| EP (1) | EP1095054B1 (enExample) |
| JP (1) | JP2002520008A (enExample) |
| KR (1) | KR100694914B1 (enExample) |
| AT (1) | ATE343586T1 (enExample) |
| AU (1) | AU4965499A (enExample) |
| DE (1) | DE69933770D1 (enExample) |
| WO (1) | WO2000002899A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023508440A (ja) * | 2019-12-24 | 2023-03-02 | シーサンバイオ マテリアルズ | 溶液工程でのｐｎａオリゴマーの製造方法 |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| ATE496139T1 (de) | 2001-03-09 | 2011-02-15 | Boston Probes Inc | Kombinationsoligomere betreffende verfahren, kits und zusammensetzungen |
| EP1373472B1 (en) * | 2001-04-03 | 2007-06-27 | Biocept, Inc. | Methods and gel compositions for encapsulating living cells and organic molecules |
| WO2003020978A1 (en) | 2001-09-01 | 2003-03-13 | Samsung Electronics Co., Ltd. | Method for manufacturing hydrogel biochip by using star-like polyethylene glycol derivative having epoxy group |
| AU2002347981A1 (en) | 2001-11-07 | 2003-05-19 | Applera Corporation | Universal nucleotides for nucleic acid analysis |
| WO2003046144A2 (en) * | 2001-11-26 | 2003-06-05 | Molecular Reflections, Inc. | Microscale immobilization of molecules using a hydrogel and methods of use thereof |
| KR100464261B1 (ko) | 2002-01-24 | 2005-01-03 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| US20030175828A1 (en) * | 2002-03-15 | 2003-09-18 | Lazar James G. | Signal amplification by Hybrid Capture |
| KR20030084444A (ko) | 2002-04-26 | 2003-11-01 | 주식회사 파나진 | Ｐｎａ 올리고머를 합성하기 위한 신규한 단량체 및 그의제조방법 |
| AU2003273298B2 (en) * | 2002-09-08 | 2008-03-06 | Applera Corporation | Methods, compositions and libraries pertaining PNA dimer and PNA oligomer synthesis |
| EP1641942A2 (en) * | 2003-06-12 | 2006-04-05 | Applera Corporation | Combinatorial nucleobase oligomers comprising universal base analogues and methods for making and using same |
| US7211668B2 (en) * | 2003-07-28 | 2007-05-01 | Panagene, Inc. | PNA monomer and precursor |
| WO2006076650A2 (en) * | 2005-01-12 | 2006-07-20 | Applera Corporation | Compositions, methods, and kits for selective amplification of nucleic acids |
| US7482353B2 (en) | 2005-06-15 | 2009-01-27 | Applied Biosystems Inc. | Compositions and methods pertaining to PNA synthons and oligomers comprising a universal base |
| CN101321877B (zh) | 2005-10-03 | 2013-04-10 | 应用生物系统有限责任公司 | 用于扩增核酸的组合物、方法和试剂盒 |
| US20070172842A1 (en) * | 2006-01-25 | 2007-07-26 | Andreas Braun | Methods for isolating and identifying novel target-specific structuremers for use in the biological sciences |
| US9404864B2 (en) | 2013-03-13 | 2016-08-02 | Denovo Sciences, Inc. | System for imaging captured cells |
| US10466160B2 (en) | 2011-08-01 | 2019-11-05 | Celsee Diagnostics, Inc. | System and method for retrieving and analyzing particles |
| US9174216B2 (en) | 2013-03-13 | 2015-11-03 | DeNovo Science, Inc. | System for capturing and analyzing cells |
| EP2739587B1 (en) | 2011-08-01 | 2020-05-27 | Denovo Sciences | Cell capture system |
| US9752181B2 (en) | 2013-01-26 | 2017-09-05 | Denovo Sciences, Inc. | System and method for capturing and analyzing cells |
| US9707562B2 (en) | 2013-03-13 | 2017-07-18 | Denovo Sciences, Inc. | System for capturing and analyzing cells |
| US10391490B2 (en) | 2013-05-31 | 2019-08-27 | Celsee Diagnostics, Inc. | System and method for isolating and analyzing cells |
| US9856535B2 (en) | 2013-05-31 | 2018-01-02 | Denovo Sciences, Inc. | System for isolating cells |
| CA2927358C (en) | 2013-10-16 | 2021-12-21 | The University Of British Columbia | Device for formulating particles at small volumes |
| JP6764870B2 (ja) | 2015-02-24 | 2020-10-07 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 連続フローマイクロ流体システム |
| JP7349788B2 (ja) | 2016-01-06 | 2023-09-25 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | 分岐ミキサー並びにその使用及び製造方法 |
| CN106117153B (zh) * | 2016-07-05 | 2018-11-23 | 淮阴师范学院 | 2-哌嗪酮的制备方法 |
| WO2018189214A1 (en) * | 2017-04-12 | 2018-10-18 | F. Hoffmann-La Roche Ag | A method for labeling of aldehyde containing target molecules |
| WO2019046307A1 (en) | 2017-08-29 | 2019-03-07 | Celsee Diagnostics, Inc. | SYSTEM AND METHOD FOR ISOLATING AND ANALYZING CELLS |
| US11419947B2 (en) | 2017-10-30 | 2022-08-23 | Massachusetts Institute Of Technology | Layer-by-layer nanoparticles for cytokine therapy in cancer treatment |
| US10633693B1 (en) | 2019-04-16 | 2020-04-28 | Celsee Diagnostics, Inc. | System and method for leakage control in a particle capture system |
| US11578322B2 (en) | 2019-05-07 | 2023-02-14 | Bio-Rad Laboratories, Inc. | System and method for automated single cell processing |
| US11273439B2 (en) | 2019-05-07 | 2022-03-15 | Bio-Rad Laboratories, Inc. | System and method for target material retrieval from microwells |
| EP3975841A1 (en) | 2019-05-30 | 2022-04-06 | Massachusetts Institute of Technology | Peptide nucleic acid functionalized hydrogel microneedles for sampling and detection of interstitial fluid nucleic acids |
| CN118291246A (zh) | 2019-06-14 | 2024-07-05 | 伯乐实验室有限公司 | 用于自动化单细胞处理和分析的系统和方法 |
| CN110511973B (zh) * | 2019-07-16 | 2021-05-07 | 杭州原合生物科技有限公司 | 一种用于核酸原位合成的固相载体及其制备方法 |
| US11504719B2 (en) | 2020-03-12 | 2022-11-22 | Bio-Rad Laboratories, Inc. | System and method for receiving and delivering a fluid for sample processing |
| KR20220057138A (ko) | 2020-10-29 | 2022-05-09 | 엘지전자 주식회사 | 청소기 |
| US12465910B2 (en) | 2021-12-10 | 2025-11-11 | Bio-Rad Laboratories, Inc. | Compositions, methods, and systems for sample processing with morphology-adjustable functionalized particles |
| KR102804687B1 (ko) | 2023-02-10 | 2025-05-12 | 엘지전자 주식회사 | 청소기 및 청소기 제어 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3687030T2 (de) | 1985-03-15 | 1993-03-11 | Eugene Stirchak | Stereoregulare polynukleotiden bindende polymere. |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| US5766855A (en) | 1991-05-24 | 1998-06-16 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity and sequence specificity |
| DK51092D0 (da) | 1991-05-24 | 1992-04-15 | Ole Buchardt | Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf |
| US5641625A (en) | 1992-05-22 | 1997-06-24 | Isis Pharmaceuticals, Inc. | Cleaving double-stranded DNA with peptide nucleic acids |
| US5714331A (en) | 1991-05-24 | 1998-02-03 | Buchardt, Deceased; Ole | Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility |
| US5700922A (en) * | 1991-12-24 | 1997-12-23 | Isis Pharmaceuticals, Inc. | PNA-DNA-PNA chimeric macromolecules |
| US5438131A (en) | 1992-09-16 | 1995-08-01 | Bergstrom; Donald E. | 3-nitropyrrole nucleoside |
| US5539083A (en) * | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5738996A (en) | 1994-06-15 | 1998-04-14 | Pence, Inc. | Combinational library composition and method |
| JP3307945B2 (ja) | 1994-10-06 | 2002-07-29 | アイシス・ファーマシューティカルス・インコーポレーテッド | ペプチド核酸コンジュゲート |
| WO1996015143A1 (en) | 1994-11-14 | 1996-05-23 | Chiron Corporation | SYNTHESIS OF PEPTIDE NUCLEIC ACIDS (PNAs) AND ANALOGUES VIA SUBMONOMER APPROACH |
| AU4729796A (en) * | 1994-12-28 | 1996-07-19 | Peter E. Nielsen | Peptide nucleic acid incorporating a chiral backbone |
| DE19532553A1 (de) | 1995-09-04 | 1997-03-06 | Hoechst Ag | Verfahren zur Herstellung substituierter N-Ethyl-Glycinderivate |
| DE19627898A1 (de) | 1996-07-11 | 1998-01-15 | Hoechst Ag | Festphasensynthese von Oligonucleotiden |
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1999
- 1999-07-01 KR KR1020017000159A patent/KR100694914B1/ko not_active Expired - Fee Related
- 1999-07-01 WO PCT/US1999/014969 patent/WO2000002899A1/en not_active Ceased
- 1999-07-01 JP JP2000559128A patent/JP2002520008A/ja active Pending
- 1999-07-01 EP EP99933646A patent/EP1095054B1/en not_active Expired - Lifetime
- 1999-07-01 AT AT99933646T patent/ATE343586T1/de not_active IP Right Cessation
- 1999-07-01 DE DE69933770T patent/DE69933770D1/de not_active Expired - Lifetime
- 1999-07-01 AU AU49654/99A patent/AU4965499A/en not_active Abandoned
-
2000
- 2000-01-05 US US09/479,320 patent/US6433134B1/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023508440A (ja) * | 2019-12-24 | 2023-03-02 | シーサンバイオ マテリアルズ | 溶液工程でのｐｎａオリゴマーの製造方法 |
| JP7550225B2 (ja) | 2019-12-24 | 2024-09-12 | シーサンバイオ マテリアルズ | 溶液工程でのｐｎａオリゴマーの製造方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ATE343586T1 (de) | 2006-11-15 |
| KR100694914B1 (ko) | 2007-03-14 |
| AU4965499A (en) | 2000-02-01 |
| WO2000002899A9 (en) | 2000-07-27 |
| KR20010074672A (ko) | 2001-08-08 |
| US6433134B1 (en) | 2002-08-13 |
| WO2000002899A1 (en) | 2000-01-20 |
| DE69933770D1 (de) | 2006-12-07 |
| EP1095054A1 (en) | 2001-05-02 |
| EP1095054B1 (en) | 2006-10-25 |
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