JP2002518016A5 - - Google Patents
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- Publication number
- JP2002518016A5 JP2002518016A5 JP2000554860A JP2000554860A JP2002518016A5 JP 2002518016 A5 JP2002518016 A5 JP 2002518016A5 JP 2000554860 A JP2000554860 A JP 2000554860A JP 2000554860 A JP2000554860 A JP 2000554860A JP 2002518016 A5 JP2002518016 A5 JP 2002518016A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- polypeptide
- amino acid
- kinase polypeptide
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 229920001184 polypeptide Polymers 0.000 description 87
- 108090000765 processed proteins & peptides Proteins 0.000 description 87
- 102000004196 processed proteins & peptides Human genes 0.000 description 87
- 125000003275 alpha amino acid group Chemical group 0.000 description 54
- 238000000034 method Methods 0.000 description 54
- 108091000080 Phosphotransferase Proteins 0.000 description 53
- 102000020233 phosphotransferase Human genes 0.000 description 53
- 108020004707 nucleic acids Proteins 0.000 description 45
- 102000039446 nucleic acids Human genes 0.000 description 45
- 239000002773 nucleotide Substances 0.000 description 45
- 125000003729 nucleotide group Chemical group 0.000 description 45
- 150000007523 nucleic acids Chemical class 0.000 description 43
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 37
- 239000000126 substance Substances 0.000 description 30
- 201000010099 disease Diseases 0.000 description 28
- 239000000523 sample Substances 0.000 description 27
- 241000124008 Mammalia Species 0.000 description 26
- 210000004027 cell Anatomy 0.000 description 25
- 230000000694 effects Effects 0.000 description 23
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 19
- 206010028980 Neoplasm Diseases 0.000 description 18
- 201000011510 cancer Diseases 0.000 description 18
- 230000000295 complement effect Effects 0.000 description 17
- 150000001413 amino acids Chemical class 0.000 description 15
- 101000896657 Homo sapiens Mitotic checkpoint serine/threonine-protein kinase BUB1 Proteins 0.000 description 14
- -1 Amino Chemical group 0.000 description 13
- 210000004899 c-terminal region Anatomy 0.000 description 12
- 101000601467 Homo sapiens Serine/threonine-protein kinase Nek5 Proteins 0.000 description 9
- 101000588540 Homo sapiens Serine/threonine-protein kinase Nek6 Proteins 0.000 description 9
- 208000035475 disorder Diseases 0.000 description 9
- 239000002253 acid Substances 0.000 description 8
- 230000003197 catalytic effect Effects 0.000 description 8
- 239000012634 fragment Substances 0.000 description 7
- 108091034117 Oligonucleotide Proteins 0.000 description 6
- 238000012217 deletion Methods 0.000 description 6
- 208000026278 immune system disease Diseases 0.000 description 6
- 208000015122 neurodegenerative disease Diseases 0.000 description 6
- 108020004711 Nucleic Acid Probes Proteins 0.000 description 5
- 108091028043 Nucleic acid sequence Proteins 0.000 description 5
- 239000000074 antisense oligonucleotide Substances 0.000 description 5
- 238000012230 antisense oligonucleotides Methods 0.000 description 5
- 238000003556 assay Methods 0.000 description 5
- 230000027455 binding Effects 0.000 description 5
- 230000001413 cellular effect Effects 0.000 description 5
- 238000009396 hybridization Methods 0.000 description 5
- 230000003993 interaction Effects 0.000 description 5
- 239000002853 nucleic acid probe Substances 0.000 description 5
- 238000013518 transcription Methods 0.000 description 5
- 230000035897 transcription Effects 0.000 description 5
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 4
- 125000000539 amino acid group Chemical group 0.000 description 4
- 230000037430 deletion Effects 0.000 description 4
- 230000009870 specific binding Effects 0.000 description 4
- LYOKOJQBUZRTMX-UHFFFAOYSA-N 1,3-bis[[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxy]-2,2-bis[[1,1,1,3,3,3-hexafluoro-2-(trifluoromethyl)propan-2-yl]oxymethyl]propane Chemical group FC(F)(F)C(C(F)(F)F)(C(F)(F)F)OCC(COC(C(F)(F)F)(C(F)(F)F)C(F)(F)F)(COC(C(F)(F)F)(C(F)(F)F)C(F)(F)F)COC(C(F)(F)F)(C(F)(F)F)C(F)(F)F LYOKOJQBUZRTMX-UHFFFAOYSA-N 0.000 description 3
- 206010006187 Breast cancer Diseases 0.000 description 3
- 208000026310 Breast neoplasm Diseases 0.000 description 3
- 206010008342 Cervix carcinoma Diseases 0.000 description 3
- 206010009944 Colon cancer Diseases 0.000 description 3
- 208000008839 Kidney Neoplasms Diseases 0.000 description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 3
- 206010025323 Lymphomas Diseases 0.000 description 3
- 206010033128 Ovarian cancer Diseases 0.000 description 3
- 206010061535 Ovarian neoplasm Diseases 0.000 description 3
- 206010060862 Prostate cancer Diseases 0.000 description 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
- 206010038389 Renal cancer Diseases 0.000 description 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 3
- 201000007455 central nervous system cancer Diseases 0.000 description 3
- 201000010881 cervical cancer Diseases 0.000 description 3
- 208000029742 colonic neoplasm Diseases 0.000 description 3
- 201000010982 kidney cancer Diseases 0.000 description 3
- 208000032839 leukemia Diseases 0.000 description 3
- 201000005202 lung cancer Diseases 0.000 description 3
- 208000020816 lung neoplasm Diseases 0.000 description 3
- 201000001441 melanoma Diseases 0.000 description 3
- 210000004408 hybridoma Anatomy 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- 102100021691 Mitotic checkpoint serine/threonine-protein kinase BUB1 Human genes 0.000 description 1
- 101150076596 bub-1 gene Proteins 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8952098P | 1998-06-16 | 1998-06-16 | |
| US60/089,520 | 1998-06-16 | ||
| US9826598P | 1998-08-28 | 1998-08-28 | |
| US60/098,265 | 1998-08-28 | ||
| PCT/US1999/013533 WO1999066051A2 (en) | 1998-06-16 | 1999-06-15 | Nek-related and bub1-related protein kinases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002518016A JP2002518016A (ja) | 2002-06-25 |
| JP2002518016A5 true JP2002518016A5 (https=) | 2006-07-20 |
Family
ID=26780662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000554860A Withdrawn JP2002518016A (ja) | 1998-06-16 | 1999-06-15 | Ｎｅｋ関連及びｂｕｂ１関連プロテインキナーゼ |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1088079A2 (https=) |
| JP (1) | JP2002518016A (https=) |
| AU (1) | AU4686299A (https=) |
| CA (1) | CA2331889A1 (https=) |
| WO (1) | WO1999066051A2 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183962B1 (en) * | 1998-09-09 | 2001-02-06 | Millennium Pharmaceuticals, Inc. | Protein kinase molecules and uses therefor |
| DE10011530A1 (de) * | 2000-03-13 | 2001-09-27 | Robert Elez | Hochwirksame Antisense-Oligodesoxynucleotide gegen Polio-like Kinasel |
| AU2001266954A1 (en) * | 2000-06-15 | 2001-12-24 | Millennium Pharmaceuticals, Inc. | 53070, a novel human protein kinase family member and uses thereof |
| WO2002003790A2 (en) * | 2000-07-11 | 2002-01-17 | Deltagen, Inc. | Transgenic mice containing targeted kinase gene disruptions |
| AU2002214576A1 (en) * | 2000-10-13 | 2002-04-22 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Genes related to development of refractory prostate cancer |
| US7033790B2 (en) | 2001-04-03 | 2006-04-25 | Curagen Corporation | Proteins and nucleic acids encoding same |
| US20040097441A1 (en) * | 2002-11-16 | 2004-05-20 | Isis Pharmaceuticals Inc. | Modulation of NIMA-related kinase 6 expression |
| JP2006512048A (ja) * | 2002-06-11 | 2006-04-13 | ザ・ジェネラル・ホスピタル・コーポレイション | 有糸分裂の阻害剤の同定 |
| EP2976334A1 (en) * | 2013-03-21 | 2016-01-27 | Bayer Pharma Aktiengesellschaft | Diaminoheteroaryl substituted indazoles |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5863780A (en) * | 1996-09-12 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | Human Protein Kinases |
| US6489137B2 (en) * | 1997-06-11 | 2002-12-03 | Chiron Corporation | Detection of loss of the wild-type huBUB1 gene |
| AU1614099A (en) * | 1997-12-01 | 1999-06-16 | Fox Chase Cancer Center | Novel genes encoding proteins involved in mitotic checkpoint control and methodsof use thereof |
| AU3187399A (en) * | 1998-03-16 | 1999-10-11 | Johns Hopkins University School Of Medicine, The | Mutations in mitotic check point genes and methods of diagnosis |
| US5928874A (en) * | 1998-03-27 | 1999-07-27 | Incyte Pharmaceuticals, Inc. | Nek1-related protein kinase |
| AU758074B2 (en) * | 1998-04-29 | 2003-03-13 | Genesis Research And Development Corporation Limited | Polynucleotides isolated from skin cells and methods for their use |
| EP1027441A2 (en) * | 1998-08-04 | 2000-08-16 | Immunex Corporation | Murine dna molecules encoding polypeptides having kinase functions |
-
1999
- 1999-06-15 AU AU46862/99A patent/AU4686299A/en not_active Abandoned
- 1999-06-15 EP EP99930298A patent/EP1088079A2/en not_active Ceased
- 1999-06-15 CA CA002331889A patent/CA2331889A1/en not_active Abandoned
- 1999-06-15 WO PCT/US1999/013533 patent/WO1999066051A2/en not_active Ceased
- 1999-06-15 JP JP2000554860A patent/JP2002518016A/ja not_active Withdrawn
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