JP2004501608A5 - - Google Patents
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- JP2004501608A5 JP2004501608A5 JP2001568372A JP2001568372A JP2004501608A5 JP 2004501608 A5 JP2004501608 A5 JP 2004501608A5 JP 2001568372 A JP2001568372 A JP 2001568372A JP 2001568372 A JP2001568372 A JP 2001568372A JP 2004501608 A5 JP2004501608 A5 JP 2004501608A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- protein
- activity
- vegf
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 description 36
- 229920001184 polypeptide Polymers 0.000 description 34
- 102000004196 processed proteins & peptides Human genes 0.000 description 34
- 108090000623 proteins and genes Proteins 0.000 description 32
- 238000000034 method Methods 0.000 description 31
- 230000000694 effects Effects 0.000 description 23
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 21
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 21
- 239000003814 drug Substances 0.000 description 19
- 230000001105 regulatory effect Effects 0.000 description 18
- 101710155665 Mesencephalic astrocyte-derived neurotrophic factor Proteins 0.000 description 14
- 102100021833 Mesencephalic astrocyte-derived neurotrophic factor Human genes 0.000 description 14
- 206010028980 Neoplasm Diseases 0.000 description 13
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 12
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 12
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 12
- 102100021506 NADH-ubiquinone oxidoreductase chain 4 Human genes 0.000 description 12
- 101710106576 NADH-ubiquinone oxidoreductase chain 4 Proteins 0.000 description 12
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 12
- 102000055046 tissue-factor-pathway inhibitor 2 Human genes 0.000 description 12
- 108010016054 tissue-factor-pathway inhibitor 2 Proteins 0.000 description 12
- 101001076680 Homo sapiens Insulin-induced gene 1 protein Proteins 0.000 description 11
- 102100025887 Insulin-induced gene 1 protein Human genes 0.000 description 11
- 101710106575 NADH-ubiquinone oxidoreductase chain 1 Proteins 0.000 description 11
- 102100038625 NADH-ubiquinone oxidoreductase chain 1 Human genes 0.000 description 11
- -1 hVPS41p Proteins 0.000 description 11
- 102100027557 Calcipressin-1 Human genes 0.000 description 10
- 101000580357 Homo sapiens Calcipressin-1 Proteins 0.000 description 10
- 102100033824 A-kinase anchor protein 12 Human genes 0.000 description 9
- 102100030878 Cytochrome c oxidase subunit 1 Human genes 0.000 description 9
- 102100037567 Dual specificity protein phosphatase 14 Human genes 0.000 description 9
- 101000779382 Homo sapiens A-kinase anchor protein 12 Proteins 0.000 description 9
- 101000919849 Homo sapiens Cytochrome c oxidase subunit 1 Proteins 0.000 description 9
- 101000881116 Homo sapiens Dual specificity protein phosphatase 14 Proteins 0.000 description 9
- 101000806511 Homo sapiens Protein DEPP1 Proteins 0.000 description 9
- 102100037469 Protein DEPP1 Human genes 0.000 description 9
- 102100037415 Regulator of G-protein signaling 3 Human genes 0.000 description 9
- 101710140411 Regulator of G-protein signaling 3 Proteins 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- 101000601048 Homo sapiens Nidogen-2 Proteins 0.000 description 8
- 102100037371 Nidogen-2 Human genes 0.000 description 8
- 201000011510 cancer Diseases 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 108091033319 polynucleotide Proteins 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 108010039419 Connective Tissue Growth Factor Proteins 0.000 description 6
- 102000015225 Connective Tissue Growth Factor Human genes 0.000 description 6
- 102100033299 Glia-derived nexin Human genes 0.000 description 6
- 101800001649 Heparin-binding EGF-like growth factor Proteins 0.000 description 6
- 101000997803 Homo sapiens Glia-derived nexin Proteins 0.000 description 6
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 description 6
- 102100033762 Proheparin-binding EGF-like growth factor Human genes 0.000 description 6
- 230000033115 angiogenesis Effects 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 102000004169 proteins and genes Human genes 0.000 description 6
- 239000000523 sample Substances 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 108700005075 Regulator Genes Proteins 0.000 description 4
- 239000005557 antagonist Substances 0.000 description 4
- 230000033228 biological regulation Effects 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 201000010374 Down Syndrome Diseases 0.000 description 3
- 108091006027 G proteins Proteins 0.000 description 3
- 102000030782 GTP binding Human genes 0.000 description 3
- 108091000058 GTP-Binding Proteins 0.000 description 3
- 101000921808 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Probable cytochrome oxidase subunit 1 Proteins 0.000 description 3
- 101000771974 Homo sapiens Vacuolar protein sorting-associated protein 41 homolog Proteins 0.000 description 3
- 101000668058 Infectious salmon anemia virus (isolate Atlantic salmon/Norway/810/9/99) RNA-directed RNA polymerase catalytic subunit Proteins 0.000 description 3
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
- 102100029496 Vacuolar protein sorting-associated protein 41 homolog Human genes 0.000 description 3
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 108020004999 messenger RNA Proteins 0.000 description 3
- 229960003387 progesterone Drugs 0.000 description 3
- 239000000186 progesterone Substances 0.000 description 3
- 230000006884 regulation of angiogenesis Effects 0.000 description 3
- 230000011664 signaling Effects 0.000 description 3
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 2
- 108090000312 Calcium Channels Proteins 0.000 description 2
- 102000003922 Calcium Channels Human genes 0.000 description 2
- 201000009030 Carcinoma Diseases 0.000 description 2
- 208000005243 Chondrosarcoma Diseases 0.000 description 2
- 208000007571 Ovarian Epithelial Carcinoma Diseases 0.000 description 2
- 206010061535 Ovarian neoplasm Diseases 0.000 description 2
- 239000000556 agonist Substances 0.000 description 2
- 239000012472 biological sample Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 230000003828 downregulation Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 201000008968 osteosarcoma Diseases 0.000 description 2
- 206010041823 squamous cell carcinoma Diseases 0.000 description 2
- 230000035897 transcription Effects 0.000 description 2
- 238000013518 transcription Methods 0.000 description 2
- 238000013519 translation Methods 0.000 description 2
- 230000003827 upregulation Effects 0.000 description 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
- SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 description 1
- 102100026112 60S acidic ribosomal protein P2 Human genes 0.000 description 1
- 108020004491 Antisense DNA Proteins 0.000 description 1
- 108020005544 Antisense RNA Proteins 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 108090000994 Catalytic RNA Proteins 0.000 description 1
- 102000053642 Catalytic RNA Human genes 0.000 description 1
- 101000691878 Homo sapiens 60S acidic ribosomal protein P2 Proteins 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 108091061763 Triple-stranded DNA Proteins 0.000 description 1
- 206010073104 Tubular breast carcinoma Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 230000000692 anti-sense effect Effects 0.000 description 1
- 239000003816 antisense DNA Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000003184 complementary RNA Substances 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 description 1
- 229960004166 diltiazem Drugs 0.000 description 1
- 201000002696 invasive tubular breast carcinoma Diseases 0.000 description 1
- HYIMSNHJOBLJNT-UHFFFAOYSA-N nifedipine Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1C1=CC=CC=C1[N+]([O-])=O HYIMSNHJOBLJNT-UHFFFAOYSA-N 0.000 description 1
- 229960001597 nifedipine Drugs 0.000 description 1
- 108091008104 nucleic acid aptamers Proteins 0.000 description 1
- 229920000768 polyamine Polymers 0.000 description 1
- 108091092562 ribozyme Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 230000005748 tumor development Effects 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19120100P | 2000-03-21 | 2000-03-21 | |
| PCT/US2001/009043 WO2001070174A2 (en) | 2000-03-21 | 2001-03-21 | Vegf-modulated genes and methods employing them |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004501608A JP2004501608A (ja) | 2004-01-22 |
| JP2004501608A5 true JP2004501608A5 (https=) | 2008-05-08 |
Family
ID=22704517
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001568372A Pending JP2004501608A (ja) | 2000-03-21 | 2001-03-21 | Ｖｅｇｆ調節遺伝子及びそれらを利用する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US20020132978A1 (https=) |
| EP (1) | EP1290005A4 (https=) |
| JP (1) | JP2004501608A (https=) |
| AU (2) | AU2001250912B2 (https=) |
| CA (1) | CA2403804A1 (https=) |
| WO (1) | WO2001070174A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002013819A1 (en) * | 2000-08-16 | 2002-02-21 | Chugai Seiyaku Kabushiki Kaisha | Seamless soft capsule preparations containing dihydrobenzofuran derivatives |
| WO2002074956A2 (en) * | 2001-03-20 | 2002-09-26 | Prescient Neuropharma Inc. | Dopaminergic neuronal survival-promoting factors and uses thereof |
| US7452969B2 (en) | 2002-08-30 | 2008-11-18 | Licentia Ltd | Neurotrophic factor protein and uses thereof |
| EP1644406B1 (en) | 2003-07-11 | 2012-08-15 | DeveloGen Aktiengesellschaft | Use of dg153 secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome |
| JPWO2005082412A1 (ja) * | 2004-02-26 | 2007-10-25 | 株式会社ペルセウスプロテオミクス | 癌の治療および予防薬 |
| JP5048323B2 (ja) * | 2004-03-31 | 2012-10-17 | 株式会社ツーセル | 損傷組織の治療剤と治療方法 |
| ZA200707490B (en) * | 2005-03-10 | 2008-12-31 | Genentech Inc | Methods and compositions for modulatiing vascular integrity |
| AU2005339101B2 (en) | 2005-12-14 | 2013-01-10 | Herantis Pharma Plc. | Novel neurotrophic factor protein and uses thereof |
| EP2271358B1 (en) * | 2008-03-25 | 2018-11-21 | Amarantus Therapeutics, Inc. | use of mesencephalic astrocyte-derived neurotrophic factor for treating Parkinson's disease |
| CN102066404B (zh) | 2008-04-23 | 2013-11-13 | 诺娃细胞科技公司 | 血管生成肽 |
| FI20080326A0 (fi) | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
| EP2310534B1 (en) | 2008-07-07 | 2018-09-05 | Oxford Nanopore Technologies Limited | Base-detecting pore |
| US20110229877A1 (en) | 2008-07-07 | 2011-09-22 | Oxford Nanopore Technologies Limited | Enzyme-pore constructs |
| US9132168B2 (en) | 2008-08-05 | 2015-09-15 | University Of South Florida | Methods of treating cognitive impairment |
| CA2733126A1 (en) * | 2008-08-05 | 2010-02-11 | University Of South Florida | Methods of treating cognitive impairment |
| US8848606B2 (en) | 2008-08-06 | 2014-09-30 | Sharp Kabushiki Kaisha | Communication system, mobile station device, and communication method |
| GB0820927D0 (en) | 2008-11-14 | 2008-12-24 | Isis Innovation | Method |
| EP2391732B1 (en) | 2009-01-30 | 2015-05-27 | Oxford Nanopore Technologies Limited | Methods using adaptors for nucleic acid constructs in transmembrane sequencing |
| KR20110125226A (ko) * | 2009-01-30 | 2011-11-18 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 혼성화 링커 |
| GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
| WO2012094600A1 (en) * | 2011-01-06 | 2012-07-12 | William Marsh Rice University | Methods for treating lysosomal storage diseases using l-type ca2+ channel blockers with a 1,4 dihydropyridine structure and inhibitors of er-associated degradation |
| KR101939420B1 (ko) | 2011-02-11 | 2019-01-16 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 세공 |
| EA201400002A1 (ru) * | 2011-06-09 | 2014-08-29 | Юниверсити Оф Майами | Способы лечения заболеваний сетчатки |
| JP6298404B2 (ja) | 2011-07-25 | 2018-03-20 | オックスフォード ナノポール テクノロジーズ リミテッド | 膜貫通ポアを用いる二重鎖ポリヌクレオチド配列決定のためのヘアピンループ方法 |
| KR102083695B1 (ko) | 2012-04-10 | 2020-03-02 | 옥스포드 나노포어 테크놀로지즈 리미티드 | 돌연변이체 리세닌 기공 |
| US11155860B2 (en) | 2012-07-19 | 2021-10-26 | Oxford Nanopore Technologies Ltd. | SSB method |
| GB201314695D0 (en) | 2013-08-16 | 2013-10-02 | Oxford Nanopore Tech Ltd | Method |
| CA2901545C (en) | 2013-03-08 | 2019-10-08 | Oxford Nanopore Technologies Limited | Use of spacer elements in a nucleic acid to control movement of a helicase |
| GB201313477D0 (en) | 2013-07-29 | 2013-09-11 | Univ Leuven Kath | Nanopore biosensors for detection of proteins and nucleic acids |
| GB201403096D0 (en) | 2014-02-21 | 2014-04-09 | Oxford Nanopore Tech Ltd | Sample preparation method |
| EP3137490B1 (en) | 2014-05-02 | 2021-01-27 | Oxford Nanopore Technologies Limited | Mutant pores |
| CA2959220A1 (en) | 2014-09-01 | 2016-03-10 | Vib Vzw | Mutant csgg pores |
| EP3204511B1 (en) | 2014-10-07 | 2021-07-28 | Oxford Nanopore Technologies Limited | Mutant pores |
| GB201418159D0 (en) | 2014-10-14 | 2014-11-26 | Oxford Nanopore Tech Ltd | Method |
| GB201609220D0 (en) | 2016-05-25 | 2016-07-06 | Oxford Nanopore Tech Ltd | Method |
| CA3077518C (en) * | 2016-09-07 | 2021-10-19 | Frederic Fellouse | Synthetic antibodies against vegf and their uses |
| EP4678236A3 (en) * | 2018-03-29 | 2026-04-08 | MyNeuroCure Oy | C-terminal cdnf and manf fragments, pharmaceutical compositions comprising same and uses thereof |
| GB201807793D0 (en) | 2018-05-14 | 2018-06-27 | Oxford Nanopore Tech Ltd | Method |
| CN113528510A (zh) | 2018-06-29 | 2021-10-22 | 武汉纽福斯生物科技有限公司 | 治疗遗传性视神经病变的组合物和方法 |
| SG11202101032VA (en) * | 2018-08-20 | 2021-02-25 | Wuhan Neurophth Biotechnology Ltd Company | Compositions and methods for treating leber's hereditary optic neuropathy |
| CN113025633B (zh) | 2019-12-09 | 2024-08-27 | 武汉纽福斯生物科技有限公司 | 编码人nadh脱氢酶亚单位1蛋白的核酸及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT374041B (de) * | 1982-03-25 | 1984-03-12 | Naimer H L | Stern-dreieck-schalter mit nullspannungsausloesung |
| US4758195A (en) * | 1986-09-08 | 1988-07-19 | 3 W Designers, Inc. | Elastomeric foam building units |
| FR2626254B1 (fr) * | 1988-01-27 | 1990-07-06 | Valois Sa | Poussoir-etui avec systeme de garantie |
| US5174392A (en) * | 1991-11-21 | 1992-12-29 | Reinhardt Paul A | Mechanically actuated fluid control device for downhole fluid motor |
| US5455338A (en) * | 1993-11-05 | 1995-10-03 | Zymogenetics, Inc. | DNA encoding novel human kunitz-type inhibitors and methods relating thereto |
| DE4340891A1 (de) * | 1993-12-01 | 1995-06-08 | Mahle Gmbh | Hubkolben für Verbrennungsmotoren aus insbesondere Leichtmetall |
| US5856103A (en) * | 1994-10-07 | 1999-01-05 | Board Of Regents The University Of Texas | Method for selectively ranking sequences for antisense targeting |
| US6410046B1 (en) * | 1996-11-19 | 2002-06-25 | Intrabrain International Nv | Administering pharmaceuticals to the mammalian central nervous system |
| CA2383076A1 (en) * | 1999-09-16 | 2001-03-22 | Neurotrophic Bioscience, Inc. | Dopaminergic neuronal survival-promoting factors and uses thereof |
| AU7452300A (en) * | 1999-10-01 | 2001-05-10 | Kyowa Hakko Kogyo Co. Ltd. | Shear stress-response dna |
| ZA200707490B (en) * | 2005-03-10 | 2008-12-31 | Genentech Inc | Methods and compositions for modulatiing vascular integrity |
-
2001
- 2001-03-21 US US09/815,153 patent/US20020132978A1/en not_active Abandoned
- 2001-03-21 EP EP01924240A patent/EP1290005A4/en not_active Withdrawn
- 2001-03-21 WO PCT/US2001/009043 patent/WO2001070174A2/en not_active Ceased
- 2001-03-21 CA CA002403804A patent/CA2403804A1/en not_active Abandoned
- 2001-03-21 AU AU2001250912A patent/AU2001250912B2/en not_active Expired
- 2001-03-21 AU AU5091201A patent/AU5091201A/xx active Pending
- 2001-03-21 JP JP2001568372A patent/JP2004501608A/ja active Pending
-
2003
- 2003-05-02 US US10/428,487 patent/US20040006780A1/en not_active Abandoned
-
2007
- 2007-10-31 US US11/932,133 patent/US20080166724A1/en not_active Abandoned
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