JP2002517227A5 - 造血幹細胞を試験管内で維持する方法と組成物 - Google Patents

造血幹細胞を試験管内で維持する方法と組成物 Download PDF

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JP2002517227A5
JP2002517227A5 JP2000553556A JP2000553556A JP2002517227A5 JP 2002517227 A5 JP2002517227 A5 JP 2002517227A5 JP 2000553556 A JP2000553556 A JP 2000553556A JP 2000553556 A JP2000553556 A JP 2000553556A JP 2002517227 A5 JP2002517227 A5 JP 2002517227A5
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stem cells
hematopoietic stem
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【特許請求の範囲】
【請求項１】 造血幹細胞がその幹細胞表現型を維持するようにヒト間葉幹細胞を造血幹細胞と共存培養することを含むことを特徴とする試験管内でヒト造血幹細胞を維持する方法。
【請求項２】 造血幹細胞がＣＤ３４＋細胞であることを特徴とする請求項１記載の方法。
【請求項３】 間葉幹細胞集団が造血幹細胞集団に対し同種異系あるいは自己由来であることを特徴とする請求項１記載の方法。
【請求項４】 造血幹細胞がその幹細胞表現型を維持するように脂肪細胞を造血幹細胞と共存培養することを含むことを特徴とする試験管内でヒト造血幹細胞を維持する方法。
【請求項５】 脂肪細胞がヒト間葉幹細胞から誘導されることを特徴とする請求項４記載の方法。
【請求項６】 造血幹細胞がＣＤ３４＋細胞であることを特徴とする請求項４記載の方法。
【請求項７】 脂肪細胞が造血幹細胞集団に対し同種異系あるいは自己由来であることを特徴とする請求項４記載の方法。
【請求項８】 造血幹細胞がヒト造血幹細胞とヒト間葉幹細胞を含む表現型を保持するようにヒト造血幹細胞を維持することを特徴とする組成物。
【請求項９】 造血幹細胞がヒト造血幹細胞と脂肪細胞を含む表現型を保持するようにヒト造血幹細胞を維持することを特徴とする組成物。
【請求項１０】 脂肪細胞がヒト間葉幹細胞から誘導されることを特徴とする請求項９記載の組成物。
【請求項１１】 造血幹細胞が遺伝的に修飾されることを特徴とする請求項９記載の組成物。
JP2000553556A 1998-06-08 1999-06-08 造血幹細胞を試験管内で維持する方法と組成物 Expired - Lifetime JP4526186B2 (ja)

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US8843198P 1998-06-08 1998-06-08
US60/088,431 1998-06-08
PCT/US1999/012851 WO1999064566A2 (en) 1998-06-08 1999-06-08 In vitro maintenance of hematopoietic stem cells

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JP2002517227A5 true JP2002517227A5 (ja) 2006-07-20
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