JP2002516853A5 - - Google Patents

Download PDF

Info

Publication number
JP2002516853A5
JP2002516853A5 JP2000551761A JP2000551761A JP2002516853A5 JP 2002516853 A5 JP2002516853 A5 JP 2002516853A5 JP 2000551761 A JP2000551761 A JP 2000551761A JP 2000551761 A JP2000551761 A JP 2000551761A JP 2002516853 A5 JP2002516853 A5 JP 2002516853A5
Authority
JP
Japan
Prior art keywords
alkyl
disease
hydrogen
aralkyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2000551761A
Other languages
English (en)
Japanese (ja)
Other versions
JP4637351B2 (ja
JP2002516853A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1999/011702 external-priority patent/WO1999062505A2/en
Publication of JP2002516853A publication Critical patent/JP2002516853A/ja
Publication of JP2002516853A5 publication Critical patent/JP2002516853A5/ja
Application granted granted Critical
Publication of JP4637351B2 publication Critical patent/JP4637351B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2000551761A 1998-06-01 1999-05-27 神経変性疾患の処置法 Expired - Fee Related JP4637351B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8757798P 1998-06-01 1998-06-01
US60/087,577 1998-06-01
PCT/US1999/011702 WO1999062505A2 (en) 1998-06-01 1999-05-27 Method for treating neurodegenerative disorders

Publications (3)

Publication Number Publication Date
JP2002516853A JP2002516853A (ja) 2002-06-11
JP2002516853A5 true JP2002516853A5 (https=) 2006-07-20
JP4637351B2 JP4637351B2 (ja) 2011-02-23

Family

ID=22206004

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000551761A Expired - Fee Related JP4637351B2 (ja) 1998-06-01 1999-05-27 神経変性疾患の処置法

Country Status (12)

Country Link
US (2) US6441049B2 (https=)
EP (1) EP1083889B1 (https=)
JP (1) JP4637351B2 (https=)
AR (1) AR018431A1 (https=)
AT (1) ATE255888T1 (https=)
AU (1) AU765142B2 (https=)
CA (1) CA2333951C (https=)
DE (1) DE69913520T2 (https=)
DK (1) DK1083889T3 (https=)
ES (1) ES2212570T3 (https=)
PT (1) PT1083889E (https=)
WO (1) WO1999062505A2 (https=)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214686B2 (en) 1997-06-30 2007-05-08 Targacept, Inc. Pharmaceutical compositions and methods for effecting dopamine release
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
US8188043B2 (en) 1999-07-28 2012-05-29 The Board Of Trustees Of The Leland Stanford Jr. University Nicotine in therapeutic angiogenesis and vasculogenesis
US6380224B1 (en) * 1999-07-28 2002-04-30 Ortho-Mcneil Pharmaceutical, Inc. Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders
IL150374A0 (en) 1999-12-23 2002-12-01 Neurochem Inc Compounds and methods for modulating cerebral amyloid angiopathy
JP2001261652A (ja) * 2000-03-21 2001-09-26 Suntory Ltd 二置換イミノヘテロサイクリック化合物
EP1269201A1 (en) * 2000-03-29 2003-01-02 Synaptica Limited Alpha 7 nicotinic receptor screening assays
WO2001089453A2 (en) * 2000-05-19 2001-11-29 Wayne State University Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential cns receptor activity and behavior
US20030092613A1 (en) * 2000-08-14 2003-05-15 Lee Daniel H. S. Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
HUP0402289A2 (hu) 2001-10-02 2005-02-28 Pharmacia & Upjohn Company Gyógyhatású azabiciklusos csoporttal helyettesített kondenzált heteroaril-származékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
US6951868B2 (en) 2001-11-09 2005-10-04 Pfizer Inc. Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease
EP1463481A4 (en) 2001-12-14 2008-06-25 Targacept Inc METHOD AND COMPOSITIONS FOR TREATING DISORDERS OF THE CENTRAL NERVOUS SYSTEM
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
US7045534B2 (en) * 2002-02-12 2006-05-16 The Board Of Trustees Of The Leland Stanford Junior University Methods of reducing angiogenesis
AU2003217275A1 (en) * 2002-02-19 2003-09-09 Pharmacia And Upjohn Company Azabicyclic compounds for the treatment of disease
JP2005523288A (ja) * 2002-02-19 2005-08-04 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 疾病治療用の縮合した二環式−n−架橋−複素環式芳香族カルボキサミド
JP2006501246A (ja) 2002-08-30 2006-01-12 メモリー・ファーマシューティカルズ・コーポレイション 神経変性疾患の治療において有用なアナバセイン誘導体
MXPA05003317A (es) 2002-09-25 2005-07-05 Memory Pharm Corp Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
WO2004039815A2 (en) * 2002-11-01 2004-05-13 Pharmacia & Upjohn Company Llc Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
WO2004052365A2 (en) * 2002-12-06 2004-06-24 North Shore-Long Island Jewish Research Institute Inhibition of inflamation using alpha 7 receptor-binding cholinergic agonists
US7238715B2 (en) * 2002-12-06 2007-07-03 The Feinstein Institute For Medical Research Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
WO2004074973A2 (en) * 2003-02-19 2004-09-02 Balin Advertising Ltd. A system for providing private offers to customers of web sites
EP1635823A1 (en) * 2003-05-20 2006-03-22 TransTech Pharma Inc. Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
WO2005013910A2 (en) * 2003-08-07 2005-02-17 University Of South Florida Cholinergic modulation of microglial activation via alpha-7 nicotinic receptors
AU2004282201A1 (en) 2003-10-15 2005-04-28 Targacept, Inc. Azabicycyclic compounds for relieving pain and treating central nervous system disorders
EP1541547A1 (en) 2003-12-11 2005-06-15 Newron Pharmaceuticals S.p.A. Hydroxylamine derivatives
US20050170360A1 (en) * 2004-01-30 2005-08-04 Papke Roger L. Variant neuronal nicotinic alpha-7 receptor and methods of use
DE102004014841B4 (de) * 2004-03-24 2006-07-06 Schwarz Pharma Ag Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
NZ550534A (en) 2004-03-25 2009-07-31 Memory Pharm Corp Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
US7678823B2 (en) 2004-10-04 2010-03-16 Myriad Pharmaceticals, Inc. Compounds for alzheimer's disease
US9216966B2 (en) 2004-10-04 2015-12-22 John Manfredi Compounds for Alzheimer's disease
BRPI0614874A2 (pt) 2005-08-22 2011-04-19 Targacept Inc diazatricicloalcanos substituìdos com heteroarila, métodos para sua preparação e uso dos mesmos
KR20080064956A (ko) * 2005-09-27 2008-07-10 미리어드 제네틱스, 인크. 치료학적 화합물로서의 피롤 유도체
US8316104B2 (en) 2005-11-15 2012-11-20 California Institute Of Technology Method and apparatus for collaborative system
RU2432362C2 (ru) 2005-11-30 2011-10-27 Эбботт Лэборетриз Моноклональные антитела и их применения
PL2289909T3 (pl) 2005-11-30 2015-04-30 Abbvie Inc Sposób przeszukiwania, proces oczyszczania niedyfundujących oligomerów Abeta, selektywne przeciwciała przeciw niedyfundującym oligomerom Abeta i sposób wytwarzania tych przeciwciał
CA2633655A1 (en) * 2005-12-19 2007-07-05 Comentis, Inc. Topical mecamylamine formulations for ocular administration and uses therof
WO2007149392A1 (en) * 2006-06-16 2007-12-27 University Of Kentucky Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
FR2905009A1 (fr) * 2006-08-18 2008-02-22 Servier Lab Methode de criblage de composes aux proprietes anti-amyloide
CA2662870A1 (en) * 2006-09-07 2008-03-13 Myriad Genetics, Inc. Therapeutic compounds for diseases and disorders
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
TW200901974A (en) 2007-01-16 2009-01-16 Wyeth Corp Compounds, compositions, and methods of making and using them
EP2124952A2 (en) 2007-02-27 2009-12-02 Abbott GmbH & Co. KG Method for the treatment of amyloidoses
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
DK2217597T3 (da) 2007-10-01 2011-06-20 Comentis Inc Quinuclidin-4-ylmethyl-1h-indol-3-carboxylatderivater som alpha-7-nicotin-acetylcholin-receptor-ligander til behandling af Alzheimers sygdom
JP2011511845A (ja) 2008-02-13 2011-04-14 ターガセプト,インコーポレイテッド アルファ7(α7)ニコチン作動薬と抗精神病薬との組合せ物
RU2372355C1 (ru) * 2008-06-27 2009-11-10 Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН Пептид, обладающий защитным действием против болезни альцгеймера
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
ES2467923T3 (es) 2009-09-30 2014-06-13 Transtech Pharma, Llc Derivados de imidazol substituidos para el tratamiento de la enfermedad de Alzheimer
ES2684475T3 (es) 2010-04-15 2018-10-03 Abbvie Inc. Proteínas que se unen a beta amiloide
DE102010020553A1 (de) 2010-05-14 2011-11-17 Bayer Schering Pharma Aktiengesellschaft Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung
AR081402A1 (es) 2010-05-17 2012-08-29 Envivo Pharmaceuticals Inc Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida monohidrato
CN103298833B (zh) 2010-08-14 2015-12-16 Abbvie公司 β淀粉样蛋白结合蛋白
CN103180321A (zh) 2010-09-23 2013-06-26 Abbvie公司 氮杂金刚烷衍生物的一水合物
FR2966827B1 (fr) 2010-10-27 2014-08-22 Kimonella Ventures Ltd Compose peptidique utile pour l'inhibition de la formation de plaques amyloides
JP5850374B2 (ja) * 2012-01-27 2016-02-03 パナソニックヘルスケア株式会社 アルツハイマー病の診断補助方法、及び診断システム
CA2872005A1 (en) 2012-05-08 2013-11-14 Forum Pharmaceuticals, Inc. Methods of maintaining, treating or improving cognitive function
ES2716049T3 (es) * 2012-07-13 2019-06-07 Pain Therapeutics Inc Un método para inhibir la fosforilación de tau
JP6566867B2 (ja) * 2012-07-13 2019-08-28 ペイン セラピューティクス インコーポレイテッド 生きている患者でのアルツハイマー病アッセイ
ES2603262T3 (es) 2012-07-20 2017-02-24 Bayer Pharma Aktiengesellschaft Ácidos aminoindano-carboxílicos y aminotetralin-carboxílicos sustituidos y su uso
KR102137517B1 (ko) 2012-07-20 2020-07-24 바이엘 파마 악티엔게젤샤프트 신규 5-아미노테트라히드로퀴놀린-2-카르복실산 및 그의 용도
US9717710B2 (en) 2012-10-05 2017-08-01 Vtv Therapeutics Llc Treatment of mild and moderate Alzheimer's disease
GB201303507D0 (en) * 2013-02-27 2013-04-10 Hollfelder Florian Assays
US20170166561A1 (en) 2014-07-11 2017-06-15 Alpharmagen, Llc Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity
US9724340B2 (en) 2015-07-31 2017-08-08 Attenua, Inc. Antitussive compositions and methods
WO2018067662A1 (en) * 2016-10-04 2018-04-12 University Of Miami Protein amyloidogenesis and related methods
WO2019084365A1 (en) * 2017-10-27 2019-05-02 St. Jude Children's Research Hospital, Inc. METHODS AND FORMULATIONS FOR THE TREATMENT OF SPINOBULAR MUSCLE ATROPHY
WO2019190822A1 (en) 2018-03-28 2019-10-03 Vtv Therapeutics Llc Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
WO2019190823A1 (en) 2018-03-28 2019-10-03 Vtv Therapeutics Llc Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
JP7464591B2 (ja) 2018-10-10 2024-04-09 ブイティーブイ・セラピューティクス・エルエルシー [3-(4-{2-ブチル-1-[4-(4-クロロ-フェノキシ)-フェニル]-1h-イミダゾール-4-イル}-フェノキシ)-プロピル]-ジエチル-アミンの代謝産物
CU24626B1 (es) 2019-12-26 2022-11-07 Centro Nac De Biopreparados Composición farmacéutica a base de proteínas con actividad neuroprotectora, inmunomoduladora, antiinflamatoria y antimicrobiana
CN118765199A (zh) 2021-12-29 2024-10-11 拜耳股份公司 心肺病症的治疗
TW202342012A (zh) 2021-12-29 2023-11-01 德商拜耳廠股份有限公司 製備用作醫藥活性化合物的(5s)-{[2-(4-羧基苯基)乙基][2-(2-{[3-氯-4'-(三氟甲基)聯苯-4-基]甲氧基}苯基)乙基]胺基}-5,6,7,8-四氫喹啉-2-羧酸及其結晶形式之方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH637363A5 (en) * 1977-11-24 1983-07-29 Sandoz Ag Process for preparing novel 2-aminotetralins
DE3831888A1 (de) 1988-09-20 1990-03-29 Troponwerke Gmbh & Co Kg Arzneimittel zur behandlung von apoplexia cerebri
US5554601A (en) 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
US6689574B1 (en) * 1997-10-07 2004-02-10 Merck & Co., Inc. Assays for nuclear receptor agonists and antagonists using fluorescence resonance energy transfer
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6689578B2 (en) * 2001-12-06 2004-02-10 Paradigm Genetics, Inc. Methods for the identification of inhibitors of 5-aminolevulinate synthase as antibiotics

Similar Documents

Publication Publication Date Title
JP2002516853A5 (https=)
Di Lazzaro et al. Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia
Bilikiewicz et al. Colostrinin (a naturally occurring, proline-rich, polypeptide mixture) in the treatment of Alzheimer's disease
CA2333951A1 (en) Method for treating neurodegenerative disorders
Spagnoli et al. Long‐term acetyl‐L‐carnitine treatment in Alzheimer's disease
Mantovani et al. Repetitive transcranial magnetic stimulation (rTMS) in the treatment of obsessive–compulsive disorder (OCD) and Tourette's syndrome (TS)
Strafella et al. Therapeutic application of transcranial magnetic stimulation in Parkinson's disease: the contribution of expectation
Arya et al. Long-term outcomes of resective epilepsy surgery after invasive presurgical evaluation in children with tuberous sclerosis complex and bilateral multiple lesions
Hamidi et al. Brain responses evoked by high-frequency repetitive transcranial magnetic stimulation: an event-related potential study
US20080139517A1 (en) Methods of treating age associated memory impairment (AAMI), mild cognitive impairment (MCI), and dementias with cell cycle inhibitors
AU2023208107B2 (en) Composition comprising an anti-Αβ protofibril antibody and a beta- secretase BACE1 inhibitor for the treatment of Alzheimer's disease
Aylward et al. Caudate volume as an outcome measure in clinical trials for Huntington’s disease: a pilot study
Heinen et al. Absence of transcallosal inhibition in adolescents with diplegic cerebral palsy
Ryding SPECT measurements of brain function in dementia; a review
Fuchs et al. Dementia in idiopathic Parkinson’s syndrome
Arendt et al. Clinicopathologic correlations and the brain—behaviour relationship in Alzheimer's disease
Yoshikawa et al. Giant somatosensory evoked potentials in the Rett syndrome
Blagoveschenskiy et al. Characteristics of electrophysiological activity of the cerebral cortex in children with arthrogryposis
Rissanen et al. Carbon monoxide poisoning-induced nigrostriatal dopaminergic dysfunction detected using positron emission tomography (PET)
Matousek et al. EEG abnormalities in dementia reflect the parietal lobe syndrome
Akbostancı et al. Cavernous angioma presenting with hemidystonia
Machii et al. Somatosensory evoked potential recovery in Kii amyotrophic lateral sclerosis/parkinsonism–dementia complex (Kii ALS/PDC)
Kwon et al. A case of Bickerstaff's brainstem encephalitis; the evidence of cerebellum involvement by SPM analysis using PET
Alexandre et al. Sleep alterations during post-traumatic coma as a possible predictor of cognitive defects
Conca et al. Simultaneous pattern of rCBF and rCMRGlu in continuation ECT