|
US7214686B2
(en)
|
1997-06-30 |
2007-05-08 |
Targacept, Inc. |
Pharmaceutical compositions and methods for effecting dopamine release
|
|
GB9923078D0
(en)
*
|
1999-09-29 |
1999-12-01 |
Phytopharm Plc |
Sapogenin derivatives and their use
|
|
US8188043B2
(en)
|
1999-07-28 |
2012-05-29 |
The Board Of Trustees Of The Leland Stanford Jr. University |
Nicotine in therapeutic angiogenesis and vasculogenesis
|
|
WO2001009120A1
(en)
*
|
1999-07-28 |
2001-02-08 |
Ortho-Mcneil Pharmaceutical, Inc. |
Amine and amide derivatives as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders
|
|
EP1251837A2
(en)
|
1999-12-23 |
2002-10-30 |
Neurochem, Inc. |
Compounds and methods for modulating cerebral amyloid angiopathy
|
|
JP2001261652A
(ja)
*
|
2000-03-21 |
2001-09-26 |
Suntory Ltd |
二置換イミノヘテロサイクリック化合物
|
|
US20040038875A1
(en)
*
|
2000-03-29 |
2004-02-26 |
Greenfield Susan Adele |
Alpha 7nicotinic receptor screening assays
|
|
US7049337B2
(en)
*
|
2000-05-19 |
2006-05-23 |
Wayne State University |
Derivatives of 2-aminotetralins and pharmaceutical analogs thereof exhibiting differential CNS receptor activity and behavior
|
|
US20030092613A1
(en)
*
|
2000-08-14 |
2003-05-15 |
Lee Daniel H. S. |
Alpha7 nicotinic receptor peptides as ligands for beta amyloid peptides
|
|
CA2462453C
(en)
|
2001-10-02 |
2009-07-28 |
Pharmacia & Upjohn Company |
Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
|
|
MXPA04004373A
(es)
|
2001-11-09 |
2004-08-11 |
Upjohn Co |
Compuestos heterociclicos condensados con fenilo azabiciclo para el tratamiento de enfermedades.
|
|
HUP0501017A3
(en)
|
2001-12-14 |
2010-06-28 |
Targacept |
Methods and compositions for treatment of central nervous system disorders
|
|
DE10164139A1
(de)
|
2001-12-27 |
2003-07-10 |
Bayer Ag |
2-Heteroarylcarbonsäureamide
|
|
US7045534B2
(en)
*
|
2002-02-12 |
2006-05-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of reducing angiogenesis
|
|
CA2476681A1
(en)
*
|
2002-02-19 |
2003-08-28 |
Bruce N. Rogers |
Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
|
|
CA2476624A1
(en)
*
|
2002-02-19 |
2003-08-28 |
Pharmacia & Upjohn Company |
Azabicyclic compounds for the treatment of disease
|
|
US7244745B2
(en)
|
2002-08-30 |
2007-07-17 |
Memory Pharmaceuticals Corp. |
Heterocyclic compounds, methods for the preparation thereof, and uses thereof
|
|
MXPA05003317A
(es)
|
2002-09-25 |
2005-07-05 |
Memory Pharm Corp |
Indazoles, benzotiazoles y benzoisotiazoles asi como preparacion y usos de los mismos.
|
|
WO2004039815A2
(en)
*
|
2002-11-01 |
2004-05-13 |
Pharmacia & Upjohn Company Llc |
Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
|
|
JP4750421B2
(ja)
*
|
2002-12-06 |
2011-08-17 |
ノース ショア−ロング アイランド ジュ−イッシュ リサ−チ インスティチュ−ト |
α７受容体結合コリン作動性アゴニストを用いる炎症の阻害
|
|
US7238715B2
(en)
*
|
2002-12-06 |
2007-07-03 |
The Feinstein Institute For Medical Research |
Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists
|
|
DE10303974A1
(de)
|
2003-01-31 |
2004-08-05 |
Abbott Gmbh & Co. Kg |
Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
|
|
WO2004074973A2
(en)
*
|
2003-02-19 |
2004-09-02 |
Balin Advertising Ltd. |
A system for providing private offers to customers of web sites
|
|
WO2005000295A1
(en)
*
|
2003-05-20 |
2005-01-06 |
Transtech Pharma, Inc. |
Rage antagonists as agents to reverse amyloidosis and diseases associated therewith
|
|
WO2005013910A2
(en)
*
|
2003-08-07 |
2005-02-17 |
University Of South Florida |
Cholinergic modulation of microglial activation via alpha-7 nicotinic receptors
|
|
WO2005037832A2
(en)
|
2003-10-15 |
2005-04-28 |
Targacept, Inc. |
Azabicycyclic compounds for relieving pain and treating central nervous system disorders
|
|
EP1541547A1
(en)
*
|
2003-12-11 |
2005-06-15 |
Newron Pharmaceuticals S.p.A. |
Hydroxylamine derivatives
|
|
US20050170360A1
(en)
*
|
2004-01-30 |
2005-08-04 |
Papke Roger L. |
Variant neuronal nicotinic alpha-7 receptor and methods of use
|
|
DE102004014841B4
(de)
*
|
2004-03-24 |
2006-07-06 |
Schwarz Pharma Ag |
Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
|
|
EP1735306A2
(en)
|
2004-03-25 |
2006-12-27 |
Memory Pharmaceuticals Corporation |
Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
|
|
US9216966B2
(en)
|
2004-10-04 |
2015-12-22 |
John Manfredi |
Compounds for Alzheimer's disease
|
|
US7678823B2
(en)
|
2004-10-04 |
2010-03-16 |
Myriad Pharmaceticals, Inc. |
Compounds for alzheimer's disease
|
|
US7732607B2
(en)
|
2005-08-22 |
2010-06-08 |
Anatoly Mazurov |
Heteroaryl-substituted diazatricycloalkanes and methods of use thereof
|
|
JP2009510090A
(ja)
|
2005-09-27 |
2009-03-12 |
ミリアド ジェネティックス インコーポレーティッド |
治療化合物としてのピロール誘導体
|
|
US8316104B2
(en)
|
2005-11-15 |
2012-11-20 |
California Institute Of Technology |
Method and apparatus for collaborative system
|
|
US8691224B2
(en)
|
2005-11-30 |
2014-04-08 |
Abbvie Inc. |
Anti-Aβ globulomer 5F7 antibodies
|
|
HRP20140240T4
(hr)
|
2005-11-30 |
2017-02-24 |
Abbvie Inc. |
Monoklonalna antitijela protiv amiloidnih beta proteina i njihova upotreba
|
|
AU2006331790A1
(en)
*
|
2005-12-19 |
2007-07-05 |
Comentis, Inc. |
Topical mecamylamine formulations for ocular administration and uses therof
|
|
WO2007149392A1
(en)
*
|
2006-06-16 |
2007-12-27 |
University Of Kentucky |
Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors
|
|
FR2905009A1
(fr)
*
|
2006-08-18 |
2008-02-22 |
Servier Lab |
Methode de criblage de composes aux proprietes anti-amyloide
|
|
CA2662870A1
(en)
*
|
2006-09-07 |
2008-03-13 |
Myriad Genetics, Inc. |
Therapeutic compounds for diseases and disorders
|
|
US8314119B2
(en)
*
|
2006-11-06 |
2012-11-20 |
Abbvie Inc. |
Azaadamantane derivatives and methods of use
|
|
US8455626B2
(en)
|
2006-11-30 |
2013-06-04 |
Abbott Laboratories |
Aβ conformer selective anti-aβ globulomer monoclonal antibodies
|
|
TW200901974A
(en)
|
2007-01-16 |
2009-01-16 |
Wyeth Corp |
Compounds, compositions, and methods of making and using them
|
|
US8895004B2
(en)
|
2007-02-27 |
2014-11-25 |
AbbVie Deutschland GmbH & Co. KG |
Method for the treatment of amyloidoses
|
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
|
WO2009046025A1
(en)
|
2007-10-01 |
2009-04-09 |
Comentis, Inc. |
Quinuclidin-4-ylmethyl 1h-indole-3-carboxylate derivatives as alpha 7 nicotinic acetylcholine receptor ligands for the treatment of alzheimer's disease
|
|
KR20100113163A
(ko)
|
2008-02-13 |
2010-10-20 |
타가셉트 인코포레이티드 |
알파 ７ 니코틴 작용제 및 항정신병제의 조합
|
|
RU2372355C1
(ru)
*
|
2008-06-27 |
2009-11-10 |
Учреждение Российской академии наук Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова РАН |
Пептид, обладающий защитным действием против болезни альцгеймера
|
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
|
JP5805646B2
(ja)
|
2009-09-30 |
2015-11-04 |
ブイティーブイ・セラピューティクス・エルエルシー |
アルツハイマー病の治療のための置換イミダゾール誘導体
|
|
US8987419B2
(en)
|
2010-04-15 |
2015-03-24 |
AbbVie Deutschland GmbH & Co. KG |
Amyloid-beta binding proteins
|
|
DE102010020553A1
(de)
|
2010-05-14 |
2011-11-17 |
Bayer Schering Pharma Aktiengesellschaft |
Substituierte 8-Alkoxy-2-aminotetralin-Derivate und ihre Verwendung
|
|
PE20170923A1
(es)
|
2010-05-17 |
2017-07-12 |
Forum Pharmaceuticals Inc |
Una forma cristalina de clorhidrato de (r)-7-cloro-n-(quinuclidin-3-il)benzo[b]tiofeno-2-carboxamida monohidratado
|
|
EP3533803B1
(en)
|
2010-08-14 |
2021-10-27 |
AbbVie Inc. |
Anti-amyloid-beta antibodies
|
|
PE20131394A1
(es)
|
2010-09-23 |
2014-01-11 |
Abbvie Inc |
Monohidrato de derivados de aza-adamantano
|
|
FR2966827B1
(fr)
|
2010-10-27 |
2014-08-22 |
Kimonella Ventures Ltd |
Compose peptidique utile pour l'inhibition de la formation de plaques amyloides
|
|
EP2808679A4
(en)
*
|
2012-01-27 |
2015-01-14 |
Panasonic Healthcare Co Ltd |
DIAGNOSTIC PROCESS AND DIAGNOSIS SYSTEM FOR MORBUS ALZHEIMER
|
|
EP3461481A1
(en)
|
2012-05-08 |
2019-04-03 |
Forum Pharmaceuticals Inc. |
Methods of maintaining, treating or improving cognitive function
|
|
EP2882428B1
(en)
*
|
2012-07-13 |
2019-01-16 |
Pain Therapeutics, Inc. |
A method of inhibiting tau phosphorylation
|
|
WO2014012054A1
(en)
|
2012-07-13 |
2014-01-16 |
Pain Therapeutics, Inc. |
Alzheimer's disease assay in a living patent
|
|
CA2879456A1
(en)
|
2012-07-20 |
2014-01-23 |
Bayer Pharma Aktiengesellschaft |
Substituted aminoindane- and aminotetralincarboxylic acids and use thereof
|
|
RS55651B1
(sr)
|
2012-07-20 |
2017-06-30 |
Bayer Pharma AG |
Nove 5-aminotetrahidrohinolin-2-karbonske kiseline i njihova upotreba
|
|
US9717710B2
(en)
|
2012-10-05 |
2017-08-01 |
Vtv Therapeutics Llc |
Treatment of mild and moderate Alzheimer's disease
|
|
GB201303507D0
(en)
*
|
2013-02-27 |
2013-04-10 |
Hollfelder Florian |
Assays
|
|
JP2017524736A
(ja)
|
2014-07-11 |
2017-08-31 |
アルファーマゲン，エルエルシー |
アルファ７−ニコチン性アセチルコリン受容体活性を調節するためのキヌクリジン化合物
|
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
|
WO2018067662A1
(en)
*
|
2016-10-04 |
2018-04-12 |
University Of Miami |
Protein amyloidogenesis and related methods
|
|
WO2019084365A1
(en)
*
|
2017-10-27 |
2019-05-02 |
St. Jude Children's Research Hospital, Inc. |
METHODS AND FORMULATIONS FOR THE TREATMENT OF SPINOBULAR MUSCLE ATROPHY
|
|
WO2019190822A1
(en)
|
2018-03-28 |
2019-10-03 |
Vtv Therapeutics Llc |
Crystalline forms of [3-(4- {2-butyl-1-[4-(4-chloro-phenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
|
|
WO2019190823A1
(en)
|
2018-03-28 |
2019-10-03 |
Vtv Therapeutics Llc |
Pharmaceutically acceptable salts of [3-(4- {2-butyl-1-[4-(4-chlorophenoxy)-phenyl]-1h-imidazol-4-yl} -phenoxy)-propyl]-diethyl-amine
|
|
WO2020076668A1
(en)
|
2018-10-10 |
2020-04-16 |
Vtv Therapeutics Llc |
Metabolites of [3-(4-{2-butyl-l-[4-(4-chloro-phenoxy)-phenyl]-lh-imidazol-4-yl } -phen ox y)-prop yl] -diethyl-amine
|
|
CU24626B1
(es)
|
2019-12-26 |
2022-11-07 |
Centro Nac De Biopreparados |
Composición farmacéutica a base de proteínas con actividad neuroprotectora, inmunomoduladora, antiinflamatoria y antimicrobiana
|
|
KR20240144177A
(ko)
|
2021-12-29 |
2024-10-02 |
바이엘 악티엔게젤샤프트 |
(5s)-{[2-(4-카르복시페닐)에틸][2-(2-{[3-클로로-4'-(트리플루오로메틸)비페닐-4-일]메톡시}페닐)에틸]아미노}-5,6,7,8-테트라히드로퀴놀린-2-카르복실산및 약학적 활성 화합물로서 사용하기 위한 이의 결정질 형태를 제조하는 방법
|
|
EP4456896A1
(en)
|
2021-12-29 |
2024-11-06 |
Bayer Aktiengesellschaft |
Treatment of cardiopulmonary disorders
|