JP2002515869A - Hla―a2.1結合ペプチド及びその使用 - Google Patents
Hla―a2.1結合ペプチド及びその使用Info
- Publication number
- JP2002515869A JP2002515869A JP53380497A JP53380497A JP2002515869A JP 2002515869 A JP2002515869 A JP 2002515869A JP 53380497 A JP53380497 A JP 53380497A JP 53380497 A JP53380497 A JP 53380497A JP 2002515869 A JP2002515869 A JP 2002515869A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- immunogenic peptide
- hla
- cell
- residues
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00011—Details
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- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
- C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
- C12N2770/24222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.HLA−A2.1結合モチーフを有する免疫原性ペプチドを含む組成物であ って、該免疫原性ペプチドが9残基を有し、かつ以下に示す残基: I、V、A及びTからなる群より選ばれる、N末端から2番目の部位に存在 する第一の保存された残基及び、 V、L、I、A及びMからなる群より選ばれる、C末端に存在する第二の保 存された残基、 を有している組成物。 2.HLA−A2.1結合モチーフを有する免疫原性ペプチドを含む組成物であ って、該免疫原性ペプチドが9残基を有し、かつ以下に示す残基: L、M、I、V、A及びTからなる群より選ばれる、N末端から2番目の部 位に存在する第一の保存された残基及び、 A及びMからなる群より選ばれる、C末端に存在する第二の保存された残基 、 を有している組成物。 3.HLA−A2.1結合モチーフを有する免疫原性ペプチドを含む組成物であ って、該免疫原性ペプチドが10残基を有し、かつ以下に示す残基: L、M、I、V、A及びTからなる群より選ばれる、N末端から2番目の部 位に存在する第一の保存された残基及び、 V、I、L、A及びMからなる群より選ばれる、C末端に存在する第二の保 存された残基、 を有しており、第一及び第二の保存された残基が7残基離れている組成物。 4.HLA−A2.1結合モチーフを有する免疫原性ペプチドを含む組成物であ って、該免疫原性ペプチドが配列番号1〜48からなる群より選ばれる組成物 。 5.HLA−A2.1 MHC産物を発現している患者において、あらかじめ選 択した抗原に対する細胞障害性T細胞応答を誘導する方法であって、 患者由来の細胞障害性T細胞と、約5×10-7M未満の解離定数でHLA− A2.1 MHC産物に結合し、細胞障害性T細胞応答を誘導する免疫原性ペ プチドとを接触させる工程からなり、該免疫原性ペプチドが請求の範囲第1 項記載のモチーフを有していることを特徴とする方法。 6.免疫原性ペプチドと細胞障害性T細胞とをインビトロで接触させる、請求の 範囲第5項記載の方法。 7.細胞障害性T細胞と免疫原性ペプチドとの接触工程を、該ペプチドをコード する核酸を患者に投与することにより行う、請求の範囲第5項記載の方法。 8.免疫原性ペプチドがウイルス抗原に由来する、請求の範囲第5項記載の方法 。 9.免疫原性ペプチドがガン抗原に由来する、請求の範囲第5項記載の方法。 10.HLA−A2.1 MHC産物を発現している患者において、あらかじめ選 択した抗原に対する細胞障害性T細胞応答を誘導する方法であって、 患者由来の細胞障害性T細胞と、約5×10-7M未満の解離定数でHLA− A2.1 MHC産物に結合し、細胞障害性T細胞応答を誘導する免疫原性ペ プチドとを接触させる工程からなり、該免疫原性ペプチドが請求の範囲第2項 記載のモチーフを有していることを特徴とする方法。 11.免疫原性ペプチドと細胞障害性T細胞とをインビトロで接触させる、請求の 範囲第10項記載の方法。 12.細胞障害性T細胞と免疫原性ペプチドとの接触工程を、該ペプチドをコード する核酸を患者に投与することにより行う、請求の範囲第10項記載の方法。 13.免疫原性ペプチドがウイルス抗原に由来する、請求の範囲第10項記載の方 法。 14.免疫原性ペプチドがガン抗原に由来する、請求の範囲第10項記載の方法。 15.HLA−A2.1 MHC産物を発現している患者において、あらかじめ選 択した抗原に対する細胞障害性T細胞応答を誘導する方法であって、 患者由来の細胞障害性T細胞と、約5×10-7M未満の解離定数でHLA− A2.1 MHC産物に結合し、細胞障害性T細胞応答を誘導する免疫原性ペ プチドとを接触させる工程からなり、該免疫原性ペプチドが請求の範囲第3項 記載のモチーフを有していることを特徴とする方法。 16.免疫原性ペプチドと細胞障害性T細胞とをインビトロで接触させる、請求の 範囲第15項記載の方法。 17.細胞障害性T細胞と免疫原性ペプチドとの接触工程を、該ペプチドをコード する核酸を患者に投与することにより行う、請求の範囲第15項記載の方法。 18.免疫原性ペプチドがウイルス抗原に由来する、請求の範囲第15項記載の方法 。 19.免疫原性ペプチドがガン抗原に由来する、請求の範囲第15項記載の方法。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US1398096P | 1996-03-21 | 1996-03-21 | |
US60/013,980 | 1996-03-21 | ||
US82238297A | 1997-03-20 | 1997-03-20 | |
US08/822,382 | 1997-03-20 | ||
PCT/US1997/005348 WO1997034621A1 (en) | 1996-03-21 | 1997-03-21 | Hla-a2.1 binding peptides and their uses |
Publications (3)
Publication Number | Publication Date |
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JP2002515869A true JP2002515869A (ja) | 2002-05-28 |
JP2002515869A5 JP2002515869A5 (ja) | 2004-12-02 |
JP4210735B2 JP4210735B2 (ja) | 2009-01-21 |
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JP53380497A Expired - Lifetime JP4210735B2 (ja) | 1996-03-21 | 1997-03-21 | Hla―a2.1結合ペプチド及びその使用 |
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EP (1) | EP0907370B1 (ja) |
JP (1) | JP4210735B2 (ja) |
CN (1) | CN1218406A (ja) |
AT (1) | ATE296313T1 (ja) |
AU (1) | AU2658897A (ja) |
BR (1) | BR9708220A (ja) |
CA (1) | CA2248667C (ja) |
DE (1) | DE69733352T2 (ja) |
WO (1) | WO1997034621A1 (ja) |
Families Citing this family (25)
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US7611713B2 (en) | 1993-03-05 | 2009-11-03 | Pharmexa Inc. | Inducing cellular immune responses to hepatitis B virus using peptide compositions |
US9340577B2 (en) | 1992-08-07 | 2016-05-17 | Epimmune Inc. | HLA binding motifs and peptides and their uses |
US7585622B1 (en) | 1996-10-01 | 2009-09-08 | Geron Corporation | Increasing the proliferative capacity of cells using telomerase reverse transcriptase |
US6183746B1 (en) | 1997-10-09 | 2001-02-06 | Zycos Inc. | Immunogenic peptides from the HPV E7 protein |
WO1999045954A1 (en) * | 1998-03-13 | 1999-09-16 | Epimmune, Inc. | Hla-binding peptides and their uses |
AU1075001A (en) * | 1999-10-05 | 2001-05-10 | Epimmune, Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
EP1244693B1 (en) * | 1999-12-06 | 2005-06-22 | Hopital Sainte-Justine | Compositions for treating abnormalities in glomerular filtration, patent ductus arteriosus and osteoporosis |
US7462354B2 (en) | 1999-12-28 | 2008-12-09 | Pharmexa Inc. | Method and system for optimizing minigenes and peptides encoded thereby |
MXPA02008219A (es) * | 2000-02-23 | 2005-06-30 | Epimmune Inc | Peptidos que enlazan hla y sus usos. |
EP1619207A3 (en) * | 2000-09-01 | 2006-02-08 | Epimmune Inc. | HLA-A2.1 binding peptides derived from HCV and their uses |
US6974574B2 (en) | 2001-08-16 | 2005-12-13 | The General Hospital Corporation | Methods of inducing an HIV specific response using a Vpr-specific epitope |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
PT1562972E (pt) | 2002-10-15 | 2010-11-10 | Facet Biotech Corp | Alteração de afinidades de ligação ao fcrn ou semi-vidas séricas de anticorpos por mutagénese |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7365168B2 (en) | 2002-10-15 | 2008-04-29 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
CA2545539A1 (en) | 2003-10-15 | 2005-04-28 | Pdl Biopharma, Inc. | Alteration of fc-fusion protein serum half-lives by mutagenesis of positions 250, 314 and/or 428 of the heavy chain constant region of ig |
DE102005020911A1 (de) * | 2005-05-04 | 2006-11-16 | Carl Zeiss Meditec Ag | Verfahren zur Messung der Änderung des Polarisationszustands von polarisierter optischer Strahlung durch eine optisch aktive Schicht eines Körpers und/oder einer Konzentration eines optisch aktiven Stoffs in der Schicht und Vorrichtung zur Durchführung des Verfahrens |
CA2614893A1 (en) | 2005-07-06 | 2007-01-18 | Henry M. Jackson Foundation For The Advancement Of Military Medicine, In C. | Stable quantitation and detection of immune response levels with non-zero background peptides |
EP2565204B1 (en) * | 2007-07-27 | 2015-10-07 | immatics biotechnologies GmbH | Novel immunogenic epitopes for immunotherapy |
EP2391635B1 (en) | 2009-01-28 | 2017-04-26 | Epimmune Inc. | Pan-dr binding polypeptides and uses thereof |
EP2646459B1 (en) | 2010-12-02 | 2020-01-08 | Bionor Immuno AS | Peptide scaffold design |
JP6294076B2 (ja) | 2011-01-06 | 2018-03-14 | ビオノール イミュノ エーエスBionor Immuno As | 多量体ペプチド |
CA2874923C (en) | 2012-06-06 | 2021-08-31 | Bionor Immuno As | Peptides derived from viral proteins for use as immunogens and dosage reactants |
EP2745845A1 (en) | 2012-12-19 | 2014-06-25 | Centre Hospitalier Universitaire de Bordeaux | A method for preventing or treating an HIV infection |
CN105200010B (zh) * | 2015-10-15 | 2019-02-12 | 首都医科大学附属北京佑安医院 | 艾滋病感染者hla-a2特异性ctl细胞的体外培养方法及其专用培养基 |
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WO1991000912A1 (en) * | 1989-07-07 | 1991-01-24 | Massachusetts Institute Of Technology | Production and use of hybrid protease inhibitors |
EP0703783B1 (en) * | 1993-03-05 | 2010-05-05 | Epimmune Inc. | Methods of making immunogenic hla-a2.1 binding peptides |
US5709995A (en) * | 1994-03-17 | 1998-01-20 | The Scripps Research Institute | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses |
WO1995028958A1 (en) * | 1994-04-22 | 1995-11-02 | Sloan-Kettering Institute For Cancer Research | Induction of cytotoxic t lymphocytes (ctl) using antigenic peptides and a suitable adjuvant |
JPH10510988A (ja) * | 1994-12-14 | 1998-10-27 | ザ スクリップス リサーチ インスティテュート | 腫瘍−特異的細胞毒性t細胞のインビボ活性化 |
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- 1997-03-21 AU AU26588/97A patent/AU2658897A/en not_active Abandoned
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JP4210735B2 (ja) | 2009-01-21 |
WO1997034621A1 (en) | 1997-09-25 |
CN1218406A (zh) | 1999-06-02 |
BR9708220A (pt) | 2000-01-04 |
AU2658897A (en) | 1997-10-10 |
EP0907370B1 (en) | 2005-05-25 |
EP0907370A1 (en) | 1999-04-14 |
DE69733352D1 (de) | 2005-06-30 |
ATE296313T1 (de) | 2005-06-15 |
CA2248667C (en) | 2012-06-05 |
DE69733352T2 (de) | 2006-04-27 |
EP0907370A4 (en) | 1999-10-20 |
CA2248667A1 (en) | 1997-09-25 |
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