JP2002514161A - ガンおよび他の細胞増殖性疾患の治療に有用なレチノイルオキシ（置換）アルキレンブチレート - Google Patents
ガンおよび他の細胞増殖性疾患の治療に有用なレチノイルオキシ（置換）アルキレンブチレートInfo
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- JP2002514161A JP2002514161A JP50440398A JP50440398A JP2002514161A JP 2002514161 A JP2002514161 A JP 2002514161A JP 50440398 A JP50440398 A JP 50440398A JP 50440398 A JP50440398 A JP 50440398A JP 2002514161 A JP2002514161 A JP 2002514161A
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Landscapes
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- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Emergency Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/674,481 US6040342A (en) | 1994-09-16 | 1996-07-02 | Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
| US08/674,481 | 1997-06-26 | ||
| US08/883,219 US6071923A (en) | 1994-09-16 | 1997-06-26 | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| US08/883,219 | 1997-06-26 | ||
| PCT/US1997/011452 WO1998000127A1 (en) | 1996-07-02 | 1997-07-01 | Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002514161A true JP2002514161A (ja) | 2002-05-14 |
Family
ID=27101163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP50440398A Pending JP2002514161A (ja) | 1996-07-02 | 1997-07-01 | ガンおよび他の細胞増殖性疾患の治療に有用なレチノイルオキシ（置換）アルキレンブチレート |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0927033A1 (enrdf_load_stackoverflow) |
| JP (1) | JP2002514161A (enrdf_load_stackoverflow) |
| AU (1) | AU3588097A (enrdf_load_stackoverflow) |
| CA (1) | CA2258593A1 (enrdf_load_stackoverflow) |
| IL (1) | IL127739A0 (enrdf_load_stackoverflow) |
| WO (1) | WO1998000127A1 (enrdf_load_stackoverflow) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530487A (ja) * | 2004-03-26 | 2007-11-01 | ディーエスエム アイピー アセッツ ビー．ブイ． | レチノイドと組み合せたｈｄａｃインヒビターを含む組成物 |
| JP2008529966A (ja) * | 2003-06-25 | 2008-08-07 | トポターゲット ジャーマニー アーゲー | 遺伝病素因状態の抑制療法のためのヒストンデアセチラーゼ阻害剤の使用 |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6124495A (en) * | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| US6110970A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
| CA2693296C (en) | 1997-12-08 | 2013-09-10 | Merck Patent Gmbh | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
| BR9909583A (pt) * | 1998-04-15 | 2002-01-15 | Lexigen Pharm Corp | Aumento da resposta imune mediado por uma proteìna de fusão anticorpo-citocina por co-administração com inibidor de angiogênese |
| EP1071469A2 (en) * | 1998-04-17 | 2001-01-31 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| ES2256027T3 (es) | 1999-08-09 | 2006-07-16 | Emd Lexigen Research Center Corp. | Complejos de anticuerpos que contienen multiples citoquinas. |
| AU2154401A (en) | 1999-11-12 | 2001-05-30 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| MXPA02007733A (es) | 2000-02-11 | 2004-09-10 | Merck Patent Gmbh | Mejoramiento de la vida media circulante de proteinas de fusion basadas en anticuerpos. |
| PL358582A1 (en) | 2000-06-29 | 2004-08-09 | Merck Patent Gmbh | Enhancement of antibody-cytokine fusion protein mediated immune responses by combined treatment with immunocytokine uptake enhancing agents |
| US6720445B2 (en) | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
| AU2002248571B2 (en) | 2001-03-07 | 2007-01-18 | Merck Patent Gmbh | Expression technology for proteins containing a hybrid isotype antibody moiety |
| WO2002079415A2 (en) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reducing the immunogenicity of fusion proteins |
| MXPA03009924A (es) | 2001-05-03 | 2004-01-29 | Merck Patent Gmbh | Anticuerpo recombinante especifico de tumor y uso del mismo. |
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| US7186804B2 (en) | 2001-12-04 | 2007-03-06 | Emd Lexigen Research Center Corp. | IL-2 fusion proteins with modulated selectivity |
| US8946295B2 (en) * | 2002-07-25 | 2015-02-03 | Sunny Pharmtech Inc. | Histone hyperacetylating agents for promoting wound healing and preventing scar formation |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| DE60333121D1 (de) | 2002-12-17 | 2010-08-05 | Merck Patent Gmbh | Pers 14.18, der gd2 bindet und seine fusion mit il-2 |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| DK1699822T3 (da) | 2003-12-30 | 2008-08-04 | Merck Patent Gmbh | IL-7-fusionsproteiner med antistofdele, fremstilling deraf og anvendelse deraf |
| CN1902222A (zh) | 2003-12-31 | 2007-01-24 | 默克专利有限公司 | 具有改善药物代谢动力学的Fc－促红细胞生成素融合蛋白质 |
| EA011859B9 (ru) | 2004-01-05 | 2013-07-30 | Емд Лексиген Ресерч Сентер Корп. | Соединения для адресной доставки препарата к ткани или органу-мишени |
| US7589179B2 (en) | 2004-12-09 | 2009-09-15 | Merck Patent Gmbh | IL-7 variants with reduced immunogenicity |
| EP1824831A2 (en) | 2004-12-16 | 2007-08-29 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1896436A2 (en) | 2005-05-11 | 2008-03-12 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| CN101263121A (zh) | 2005-07-14 | 2008-09-10 | 塔克达圣地亚哥公司 | 组蛋白脱乙酰基酶抑制剂 |
| BRPI1016204A2 (pt) | 2009-04-22 | 2016-04-19 | Merck Patent Gmbh | proteínas de fusão de anticorpos com sítios de ligação fcrn modificados |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677120A (en) * | 1985-07-31 | 1987-06-30 | Molecular Design International | Topical prodrugs for treatment of acne and skin diseases |
| DK498487A (da) * | 1986-10-06 | 1988-04-07 | Hoffmann La Roche | Hidtil ukendte retinoider |
| US4885311A (en) * | 1987-06-29 | 1989-12-05 | Molecular Design International | Topical transretinoids for treatment of acne and skin diseases |
| US4994491A (en) * | 1988-12-14 | 1991-02-19 | Molecular Design International | Dermal uses of trans-retinoids for the treatment of cancer |
| CA2037150C (en) * | 1990-03-27 | 1999-12-28 | Guenter Gross | Retinoids |
| US5710176A (en) * | 1994-09-16 | 1998-01-20 | Bar-Ilan University | Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
-
1997
- 1997-07-01 EP EP97932417A patent/EP0927033A1/en not_active Withdrawn
- 1997-07-01 AU AU35880/97A patent/AU3588097A/en not_active Abandoned
- 1997-07-01 IL IL12773997A patent/IL127739A0/xx unknown
- 1997-07-01 WO PCT/US1997/011452 patent/WO1998000127A1/en not_active Application Discontinuation
- 1997-07-01 CA CA002258593A patent/CA2258593A1/en not_active Abandoned
- 1997-07-01 JP JP50440398A patent/JP2002514161A/ja active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008529966A (ja) * | 2003-06-25 | 2008-08-07 | トポターゲット ジャーマニー アーゲー | 遺伝病素因状態の抑制療法のためのヒストンデアセチラーゼ阻害剤の使用 |
| JP2007530487A (ja) * | 2004-03-26 | 2007-11-01 | ディーエスエム アイピー アセッツ ビー．ブイ． | レチノイドと組み合せたｈｄａｃインヒビターを含む組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU3588097A (en) | 1998-01-21 |
| WO1998000127A1 (en) | 1998-01-08 |
| EP0927033A4 (enrdf_load_stackoverflow) | 1999-07-07 |
| EP0927033A1 (en) | 1999-07-07 |
| CA2258593A1 (en) | 1998-01-08 |
| IL127739A0 (en) | 1999-10-28 |
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