CA2258593A1 - Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases - Google Patents
Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases Download PDFInfo
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- CA2258593A1 CA2258593A1 CA002258593A CA2258593A CA2258593A1 CA 2258593 A1 CA2258593 A1 CA 2258593A1 CA 002258593 A CA002258593 A CA 002258593A CA 2258593 A CA2258593 A CA 2258593A CA 2258593 A1 CA2258593 A1 CA 2258593A1
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- cancer
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- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/232—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having three or more double bonds, e.g. etretinate
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- C07C403/20—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by carboxyl groups or halides, anhydrides, or (thio)esters thereof
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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Landscapes
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- Molecular Biology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/674,481 | 1996-07-02 | ||
| US08/674,481 US6040342A (en) | 1994-09-16 | 1996-07-02 | Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
| US08/883,219 | 1997-06-26 | ||
| US08/883,219 US6071923A (en) | 1994-09-16 | 1997-06-26 | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2258593A1 true CA2258593A1 (en) | 1998-01-08 |
Family
ID=27101163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002258593A Abandoned CA2258593A1 (en) | 1996-07-02 | 1997-07-01 | Retinoyloxy(substituted)alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0927033A1 (enrdf_load_stackoverflow) |
| JP (1) | JP2002514161A (enrdf_load_stackoverflow) |
| AU (1) | AU3588097A (enrdf_load_stackoverflow) |
| CA (1) | CA2258593A1 (enrdf_load_stackoverflow) |
| IL (1) | IL127739A0 (enrdf_load_stackoverflow) |
| WO (1) | WO1998000127A1 (enrdf_load_stackoverflow) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5939455A (en) * | 1997-03-11 | 1999-08-17 | Beacon Laboratories, Inc. | Therapeutic augmentation of oxyalkylene diesters and butyric acid derivatives |
| US6124495A (en) | 1997-03-11 | 2000-09-26 | Beacon Laboratories, Inc. | Unsaturated oxyalkylene esters and uses thereof |
| US6110970A (en) * | 1997-03-11 | 2000-08-29 | Beacon Laboratories, Inc. | Nitrogen-containing oxyalkylene esters and uses thereof |
| ES2221717T3 (es) | 1997-12-08 | 2005-01-01 | Emd Lexigen Research Center Corp. | Proteinas de fusion heterodimeras utiles para inmunoterapia dirigida e inmunoestimulacion general. |
| MXPA00010070A (es) * | 1998-04-15 | 2004-03-10 | Lexigen Pharm Corp | Mejora de respuestas inmunes medidas de proteina de fusion anticuerpo-citoquina por co-administracion con inhibidor de angiogenesis. |
| WO1999053958A2 (en) * | 1998-04-17 | 1999-10-28 | Lexigen Pharmaceuticals Corporation | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with prostaglandin inhibitor |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| JP4793971B2 (ja) | 1999-08-09 | 2011-10-12 | メルク パテント ゲーエムベーハー | 複合サイトカイン−抗体複合体 |
| WO2001036489A2 (en) | 1999-11-12 | 2001-05-25 | Merck Patent Gmbh | Erythropoietin forms with improved properties |
| MXPA02007733A (es) | 2000-02-11 | 2004-09-10 | Merck Patent Gmbh | Mejoramiento de la vida media circulante de proteinas de fusion basadas en anticuerpos. |
| BR0112111A (pt) | 2000-06-29 | 2003-05-06 | Merck Patent Gmbh | Realce de respostas imunes mediadas por proteìna de fusão de anticorpo-citocina por tratamento combinado com agentes de realce de captação de imunocitocina |
| US6720445B2 (en) * | 2000-12-21 | 2004-04-13 | Beacon Laboratories, Inc. | Acetyloxymethyl esters and methods for using the same |
| US7148321B2 (en) | 2001-03-07 | 2006-12-12 | Emd Lexigen Research Center Corp. | Expression technology for proteins containing a hybrid isotype antibody moiety |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| EP1383785B1 (en) | 2001-05-03 | 2011-03-16 | Merck Patent GmbH | Recombinant tumor specific antibody and use thereof |
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
| US8946295B2 (en) * | 2002-07-25 | 2015-02-03 | Sunny Pharmtech Inc. | Histone hyperacetylating agents for promoting wound healing and preventing scar formation |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| BRPI0317376B8 (pt) | 2002-12-17 | 2021-05-25 | Merck Patent Gmbh | proteína de fusão de anticorpo-il2 designada como hu14.18-il2, usos da mesma, vetor e composição farmacêutica |
| CA2518318A1 (en) | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| JP2008502317A (ja) | 2003-12-30 | 2008-01-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Ｉｌ−７融合タンパク質 |
| RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
| WO2005066348A2 (en) | 2004-01-05 | 2005-07-21 | Emd Lexigen Research Center Corp. | Interleukin-12 targeted to oncofoetal fibronectin |
| KR20070012380A (ko) * | 2004-03-26 | 2007-01-25 | 디에스엠 아이피 어셋츠 비.브이. | Ｈｄａｃ 저해제를 레티노이드와 함께 포함하는 조성물 |
| CA2591297C (en) | 2004-12-09 | 2015-01-13 | Stephen D. Gillies | Il-7 variants with reduced immunogenicity |
| US7642275B2 (en) | 2004-12-16 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7642253B2 (en) | 2005-05-11 | 2010-01-05 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| KR20080032188A (ko) | 2005-07-14 | 2008-04-14 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| CA2759333A1 (en) | 2009-04-22 | 2010-10-28 | Merck Patent Gmbh | Antibody fusion proteins with modified fcrn binding sites |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4677120A (en) * | 1985-07-31 | 1987-06-30 | Molecular Design International | Topical prodrugs for treatment of acne and skin diseases |
| DK498487A (da) * | 1986-10-06 | 1988-04-07 | Hoffmann La Roche | Hidtil ukendte retinoider |
| US4994491A (en) * | 1988-12-14 | 1991-02-19 | Molecular Design International | Dermal uses of trans-retinoids for the treatment of cancer |
| US4885311A (en) * | 1987-06-29 | 1989-12-05 | Molecular Design International | Topical transretinoids for treatment of acne and skin diseases |
| CA2037150C (en) * | 1990-03-27 | 1999-12-28 | Guenter Gross | Retinoids |
| US5710176A (en) * | 1994-09-16 | 1998-01-20 | Bar-Ilan University | Retinoyloxy (substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases |
-
1997
- 1997-07-01 CA CA002258593A patent/CA2258593A1/en not_active Abandoned
- 1997-07-01 IL IL12773997A patent/IL127739A0/xx unknown
- 1997-07-01 AU AU35880/97A patent/AU3588097A/en not_active Abandoned
- 1997-07-01 WO PCT/US1997/011452 patent/WO1998000127A1/en not_active Application Discontinuation
- 1997-07-01 JP JP50440398A patent/JP2002514161A/ja active Pending
- 1997-07-01 EP EP97932417A patent/EP0927033A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1998000127A1 (en) | 1998-01-08 |
| EP0927033A4 (enrdf_load_stackoverflow) | 1999-07-07 |
| AU3588097A (en) | 1998-01-21 |
| EP0927033A1 (en) | 1999-07-07 |
| JP2002514161A (ja) | 2002-05-14 |
| IL127739A0 (en) | 1999-10-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |