JP2002513587A - 染色体異常を検出するための方法およびプローブ - Google Patents
染色体異常を検出するための方法およびプローブInfo
- Publication number
- JP2002513587A JP2002513587A JP2000547260A JP2000547260A JP2002513587A JP 2002513587 A JP2002513587 A JP 2002513587A JP 2000547260 A JP2000547260 A JP 2000547260A JP 2000547260 A JP2000547260 A JP 2000547260A JP 2002513587 A JP2002513587 A JP 2002513587A
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- peptide nucleic
- probes
- acid sequence
- hybridization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6841—In situ hybridisation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK61598 | 1998-05-04 | ||
DK0615/98 | 1998-05-04 | ||
PCT/DK1999/000245 WO1999057309A1 (en) | 1998-05-04 | 1999-05-04 | Method and probes for the detection of chromosome aberrations |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2002513587A true JP2002513587A (ja) | 2002-05-14 |
Family
ID=8095582
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000547260A Pending JP2002513587A (ja) | 1998-05-04 | 1999-05-04 | 染色体異常を検出するための方法およびプローブ |
Country Status (6)
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0878552A1 (en) * | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
WO1999057309A1 (en) * | 1998-05-04 | 1999-11-11 | Dako A/S | Method and probes for the detection of chromosome aberrations |
US6613567B1 (en) * | 2000-09-15 | 2003-09-02 | Isis Pharmaceuticals, Inc. | Antisense inhibition of Her-2 expression |
US20030129626A1 (en) | 2001-09-24 | 2003-07-10 | Nielsen Kirsten Vang | Methods, kits and compositions pertaining to the suppression of detectable probe binding to randomly distributed repeat sequences in genomic nucleic acid |
US7648678B2 (en) | 2002-12-20 | 2010-01-19 | Dako Denmark A/S | Method and system for pretreatment of tissue slides |
CA2724638C (en) | 2008-05-27 | 2020-02-18 | Dako Denmark A/S | Hybridization compositions and methods comprising a polar aprotic solvent |
US8352194B1 (en) | 2008-06-17 | 2013-01-08 | University Of South Florida | Method to identify cancer fusion genes |
US20100068701A1 (en) * | 2008-09-12 | 2010-03-18 | Yamada N Alice | Chromosome labeling method |
EP2401395A1 (en) | 2009-02-26 | 2012-01-04 | Dako Denmark A/S | Compositions and methods for rna hybridization applications |
US20130040294A1 (en) | 2009-12-02 | 2013-02-14 | Steen H. Matthiesen | Compositions and methods for performing hybridizations with no denaturation |
WO2011134474A1 (en) * | 2010-04-30 | 2011-11-03 | Exiqon A/S | In situ hybridization method and buffer |
EP2458365B1 (en) * | 2010-11-24 | 2019-04-10 | Milestone S.r.l. | A two-step method and system for cold formalin fixation of organic tissue samples |
US10662465B2 (en) | 2011-09-30 | 2020-05-26 | Agilent Technologies, Inc. | Hybridization compositions and methods using formamide |
US11118226B2 (en) | 2011-10-21 | 2021-09-14 | Agilent Technologies, Inc. | Hybridization compositions and methods |
KR20170007181A (ko) | 2015-07-10 | 2017-01-18 | 3스캔 인크. | 조직학적 염색제의 공간 다중화 |
DK3350343T3 (da) | 2015-09-16 | 2020-07-20 | Petaomics Inc | Fremgangsmåder og sammensætninger til genommålberigelse og selektiv dna-sekventering |
WO2021207062A1 (en) * | 2020-04-07 | 2021-10-14 | Advanced Cell Diagnostics, Inc. | Methods for detecting target nucleic acids by in situ hybridization and a kit thereof |
Family Cites Families (129)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5260433A (en) | 1982-06-23 | 1993-11-09 | Enzo Diagnostics, Inc. | Saccharide specific binding system labeled nucleotides |
US5241060A (en) | 1982-06-23 | 1993-08-31 | Enzo Diagnostics, Inc. | Base moiety-labeled detectable nucleatide |
USRE35491E (en) | 1982-11-04 | 1997-04-08 | The Regents Of The University Of California | Methods and compositions for detecting human tumors |
US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
US4681840A (en) | 1984-01-18 | 1987-07-21 | The United States Of America As Represented By The Secretary Of Commerce | Deoxyribonucleic acid molecules useful as probes for detecting oncogenes incorporated into chromosomal DNA |
US5175269A (en) | 1984-01-30 | 1992-12-29 | Enzo Diagnostics, Inc. | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group |
US4849505A (en) | 1984-01-30 | 1989-07-18 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4707440A (en) | 1984-01-30 | 1987-11-17 | Enzo Biochem, Inc. | Nucleic acid hybridization assay and detectable molecules useful in such assay |
US4943523A (en) | 1984-01-30 | 1990-07-24 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4843122A (en) | 1984-01-30 | 1989-06-27 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4952685A (en) | 1984-01-30 | 1990-08-28 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US5013831A (en) | 1984-01-30 | 1991-05-07 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4849208A (en) | 1984-01-30 | 1989-07-18 | Enzo Biochem, Inc. | Detectable molecules, method of preparation and use |
US4755458A (en) | 1984-08-30 | 1988-07-05 | Enzo Biochem, Inc. | Composition and method for the detection of the presence of a polynucleotide sequence of interest |
US4785086A (en) | 1985-01-17 | 1988-11-15 | Integrated Genetics, Inc. | Test for Campylobacter |
US6083709A (en) | 1985-08-21 | 2000-07-04 | Osi Pharmaceuticals, Inc. | Immunoassay for detection of mutant P53 polypeptide in serum |
GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
US5756696A (en) | 1986-01-16 | 1998-05-26 | Regents Of The University Of California | Compositions for chromosome-specific staining |
US6872817B1 (en) * | 1986-01-16 | 2005-03-29 | The Regents Of The Univ. Of California | Method of staining target interphase chromosomal DNA |
US6344315B1 (en) * | 1986-01-16 | 2002-02-05 | The Regents Of The University Of California | Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17 |
US5447841A (en) * | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
US5721098A (en) | 1986-01-16 | 1998-02-24 | The Regents Of The University Of California | Comparative genomic hybridization |
US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
US5015568A (en) | 1986-07-09 | 1991-05-14 | The Wistar Institute | Diagnostic methods for detecting lymphomas in humans |
US4968603A (en) | 1986-12-31 | 1990-11-06 | The Regents Of The University Of California | Determination of status in neoplastic disease |
US4912034A (en) | 1987-09-21 | 1990-03-27 | Biogenex Laboratories | Immunoassay test device and method |
US4892817A (en) | 1987-09-21 | 1990-01-09 | Biogenex Laboratories | Stable phosphatase substrate composition |
US6203977B1 (en) * | 1988-11-15 | 2001-03-20 | Yale University | Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization |
US5998135A (en) | 1989-02-24 | 1999-12-07 | Enzo Diagnostics, Inc. | Energy transfer hybridization assay using intercalators and lanthanide metals |
US5079147A (en) | 1989-03-13 | 1992-01-07 | The Wistar Institute Of Anatomy And Biology | Diagnostic probes and methods for using same to detect breast cancer |
US5198338A (en) | 1989-05-31 | 1993-03-30 | Temple University | Molecular probing for human t-cell leukemia and lymphoma |
US5242795A (en) | 1989-07-03 | 1993-09-07 | Temple University | TCL-5 gene rearrangement involved in T-cell leukemia and melanoma |
US8592155B2 (en) * | 1989-07-19 | 2013-11-26 | The Regents Of The University Of California | Method of detecting genetic deletions identified with chromosomal abnormalities |
US5149628A (en) | 1989-11-15 | 1992-09-22 | Temple University | Methods for detecting bcl-3 gene in human leukemias |
US5695976A (en) | 1989-12-18 | 1997-12-09 | Novo Nordisk A/S | Stable integration of DNA in bacterial genomes |
US5955367A (en) | 1989-12-18 | 1999-09-21 | Abbott Laboratories | Production of bacillus thuringiensis integrants |
CA2037349C (en) | 1990-03-26 | 2008-06-17 | James G. Wetmur | Branch migration of nucleotides |
US5491224A (en) | 1990-09-20 | 1996-02-13 | Bittner; Michael L. | Direct label transaminated DNA probe compositions for chromosome identification and methods for their manufacture |
US5506350A (en) | 1990-09-20 | 1996-04-09 | Bittner; Michael L. | Production of chromosome region specific DNA sequences and transamination |
US6277569B1 (en) * | 1990-09-20 | 2001-08-21 | Vysis, Inc. | Methods for multiple direct label probe detection of multiple chromosomes or regions thereof by in situ hybridization |
US5789161A (en) | 1990-09-20 | 1998-08-04 | Amoco Corporation | Methods for genome identification using direct label probe composition |
US5258507A (en) | 1990-11-08 | 1993-11-02 | Amoco Corporation | Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes |
US5512433A (en) | 1990-11-08 | 1996-04-30 | Vysis, Inc. | Methods and compounds for labeling DNA with xanthine and lower alkyl substituted xanthine derivatives and reagents for the in situ detection of chromosomes |
JP3122821B2 (ja) | 1990-11-21 | 2001-01-09 | ピカー インターナショナル インコーポレイテッド | 垂直格納コリメーターを備えた核医学カメラ用ガントリ装置 |
US5538869A (en) | 1990-12-13 | 1996-07-23 | Board Of Regents, The University Of Texas System | In-situ hybridization probes for identification and banding of specific human chromosomes and regions |
US5244787A (en) | 1991-01-31 | 1993-09-14 | Biogenex Laboratories | Antigen retrieval in formalin-fixed tissues using microwave energy |
JPH06507785A (ja) | 1991-03-20 | 1994-09-08 | ザ ソールク インスチチュート フォア バイオロジカル スタディズ | 染色体異常を確認する分析方法 |
WO1992021032A1 (en) | 1991-05-24 | 1992-11-26 | The Regents Of The University Of California | Methods for the detection of bcr-abl and abnormal abl proteins in leukemia patients |
ATE191512T1 (de) | 1991-07-31 | 2000-04-15 | Vysis Inc | Nukleinsäure sonden welche bei nachweis von shigellabakterien verwendbar sind |
US6025126A (en) | 1991-10-28 | 2000-02-15 | Arch Development Corporation | Methods and compositions for the detection of chromosomal aberrations |
WO1993012136A1 (en) | 1991-12-11 | 1993-06-24 | Thomas Jefferson University | Detection and treatment of acute leukemias resulting from chromosome abnormalities in the all-1 region |
US6040140A (en) | 1991-12-11 | 2000-03-21 | Thomas Jefferson University | Methods for screening and treating leukemias resulting from all-1 region chromosome abnormalities |
US5633135A (en) | 1991-12-11 | 1997-05-27 | Thomas Jefferson University | Chimeric nucleic acids and proteins resulting from ALL-1 region chromosome abnormalities |
ATE205542T1 (de) | 1992-03-04 | 2001-09-15 | Univ California | Vergleichende genomhybridisierung |
US5965362A (en) * | 1992-03-04 | 1999-10-12 | The Regents Of The University Of California | Comparative genomic hybridization (CGH) |
FR2691475B1 (fr) | 1992-05-20 | 1995-03-24 | Centre Nat Rech Scient | Séquence d'ADN des produits de fusion résultant de la translocation chromosomique récurrente t(11;22) (q24;q12) associée au développement d'un groupe de tumeurs cancéreuses. |
DE4216949C2 (de) | 1992-05-22 | 1997-07-24 | Christoph Prof Dr Dr Cremer | Nichtenzymatisches Verfahren zur In-situ-Hybridisierung bei spezifischen Proben |
US6121419A (en) | 1992-06-17 | 2000-09-19 | Arch Development Corp. | Compositions and methods for detecting gene rearrangements and translocations |
US5487970A (en) | 1992-06-17 | 1996-01-30 | Arch Development Corp. | Compositions and methods for detecting gene rearrangements and translocations |
US5538846A (en) | 1992-09-17 | 1996-07-23 | Meeker; Timothy C. | BCL-1 locus nucleic acid probes and assay methods |
US5547838A (en) | 1992-10-01 | 1996-08-20 | Life Technologies, Inc. | Method for the rapid and ultra-sensitive detection of leukemic cells |
WO1994009022A1 (en) | 1992-10-09 | 1994-04-28 | Oncor, Inc. | Methods for the detection of chromosome structural abnormalities by in situ hybridization to fixed tissue |
US5492837A (en) | 1993-08-27 | 1996-02-20 | Biogenex Laboratories | Mounting medium for microscope slide preparations |
US5439649A (en) | 1993-09-29 | 1995-08-08 | Biogenex Laboratories | Automated staining apparatus |
US5472842A (en) | 1993-10-06 | 1995-12-05 | The Regents Of The University Of California | Detection of amplified or deleted chromosomal regions |
US6136540A (en) * | 1994-10-03 | 2000-10-24 | Ikonisys Inc. | Automated fluorescence in situ hybridization detection of genetic abnormalities |
WO1995011313A1 (en) | 1993-10-18 | 1995-04-27 | Amoco Corporation | Control compositions for determination of molecular cytogenetic abnormalities with dna probes |
WO1995013398A1 (en) * | 1993-11-12 | 1995-05-18 | Oncor, Inc. | Detection of bladder cancer |
US5529925A (en) * | 1993-12-03 | 1996-06-25 | St. Jude Children's Research Hospital | Nucleic acid sequences and fusion proteins present in human t(2;5) lymphoma |
US5622829A (en) | 1993-12-08 | 1997-04-22 | The Regents Of The University Of California | Genetic markers for breast, ovarian, and prostatic cancer |
US5846749A (en) | 1994-10-12 | 1998-12-08 | The Regents Of The University Of California | Quantitative measurement of tissue protein identified by immunohistochemistry and standardized protein determination |
GB9501386D0 (en) | 1995-01-23 | 1995-03-15 | Hsc Res Dev Lp | Sequence of a af1q cdna |
US5731153A (en) | 1996-08-26 | 1998-03-24 | The Regents Of The University Of California | Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chromosome regions |
EP0727487A1 (en) * | 1995-02-17 | 1996-08-21 | K.U. Leuven Research & Development | Multiple-tumor aberrant growth genes |
IT1275862B1 (it) | 1995-03-03 | 1997-10-24 | Consiglio Nazionale Ricerche | Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento |
US5567586A (en) | 1995-05-18 | 1996-10-22 | Thomas Jefferson University | Methods of indentifying solid tumors with chromosome abnormalities in the ALL-1 region |
US5684142A (en) | 1995-06-07 | 1997-11-04 | Oncor, Inc. | Modified nucleotides for nucleic acid labeling |
US6218529B1 (en) * | 1995-07-31 | 2001-04-17 | Urocor, Inc. | Biomarkers and targets for diagnosis, prognosis and management of prostate, breast and bladder cancer |
US5801032A (en) | 1995-08-03 | 1998-09-01 | Abbott Laboratories | Vectors and process for producing high purity 6,12-dideoxyerythromycin A by fermentation |
US5756294A (en) | 1995-09-25 | 1998-05-26 | Oncormed, Inc. | Susceptibility mutation for breast and ovarian cancer |
EP0870055B1 (en) * | 1995-10-12 | 2007-05-16 | LANSDORP, Peter, M. | Method for detecting multiple copies of a repeat sequence in a nucleic acid molecule |
US5801021A (en) * | 1995-10-20 | 1998-09-01 | The Regents Of The University Of California | Amplifications of chromosomal region 20q13 as a prognostic indicator in breast cancer |
US5892010A (en) | 1996-07-15 | 1999-04-06 | The Regents Of The University Of California | Genes from the 20Q13 amplicon and their uses |
AU7210196A (en) * | 1995-11-16 | 1997-06-05 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
US5888733A (en) | 1995-11-16 | 1999-03-30 | Dako A/S | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples |
US5700921A (en) | 1995-11-27 | 1997-12-23 | Vector Laboratories | Labeling nucleic acids |
US6007994A (en) * | 1995-12-22 | 1999-12-28 | Yale University | Multiparametric fluorescence in situ hybridization |
US5759781A (en) | 1995-12-22 | 1998-06-02 | Yale University | Multiparametric fluorescence in situ hybridization |
US5654155A (en) | 1996-02-12 | 1997-08-05 | Oncormed, Inc. | Consensus sequence of the human BRCA1 gene |
DE19610255B4 (de) | 1996-03-15 | 2004-11-04 | Universität Heidelberg | Verfahren zur Herstellung von Nukleinsäuresequenzen und Verfahren zum Nachweis von Translokationen zwischen Chromosomen |
US5824478A (en) | 1996-04-30 | 1998-10-20 | Vysis, Inc. | Diagnostic methods and probes |
US5925519A (en) * | 1996-06-03 | 1999-07-20 | The Regents Of The University Of California | Genetic alterations associated with prostate cancer |
US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
EP0825198A1 (en) * | 1996-08-22 | 1998-02-25 | K.U. Leuven Research & Development | Plag gene family and tumorigenesis |
WO1998020143A1 (en) | 1996-11-05 | 1998-05-14 | Abbott Laboratories | Reagents and methods useful for detecting diseases of the lung |
US5804384A (en) | 1996-12-06 | 1998-09-08 | Vysis, Inc. | Devices and methods for detecting multiple analytes in samples |
GB9626074D0 (en) * | 1996-12-16 | 1997-02-05 | Cytocell Ltd | Nucleic acids amplification assay |
US5837466A (en) | 1996-12-16 | 1998-11-17 | Vysis, Inc. | Devices and methods for detecting nucleic acid analytes in samples |
US20030096255A1 (en) * | 1997-02-19 | 2003-05-22 | Felix Carolyn A. | Methods and kits for analysis of chromosomal rearrangements associated with cancer |
US6368791B1 (en) * | 1997-02-19 | 2002-04-09 | The Children's Hospital Of Philadelphia | Methods and kits for analysis of chromosomal rearrangements associated with leukemia |
GB9704054D0 (en) * | 1997-02-27 | 1997-04-16 | Univ Cambridge Tech | Assay |
US5994071A (en) | 1997-04-04 | 1999-11-30 | Albany Medical College | Assessment of prostate cancer |
EP0878552A1 (en) * | 1997-05-13 | 1998-11-18 | Erasmus Universiteit Rotterdam | Molecular detection of chromosome aberrations |
US6686165B2 (en) * | 1997-05-20 | 2004-02-03 | Erasmus Universiteit Rotterdam | Recognition of tumor-specific gene products in cancer |
US6352829B1 (en) * | 1997-05-21 | 2002-03-05 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
US5994076A (en) | 1997-05-21 | 1999-11-30 | Clontech Laboratories, Inc. | Methods of assaying differential expression |
US6358682B1 (en) * | 1998-01-26 | 2002-03-19 | Ventana Medical Systems, Inc. | Method and kit for the prognostication of breast cancer |
WO1999057309A1 (en) * | 1998-05-04 | 1999-11-11 | Dako A/S | Method and probes for the detection of chromosome aberrations |
US6037129A (en) | 1998-05-28 | 2000-03-14 | Medical University Of South Carolina | Multi-marker RT-PCR panel for detecting metastatic breast cancer |
US6573043B1 (en) * | 1998-10-07 | 2003-06-03 | Genentech, Inc. | Tissue analysis and kits therefor |
US6414133B1 (en) * | 1998-10-13 | 2002-07-02 | Ventana Medical Systems, Inc. | Multiple fusion probes |
US6251601B1 (en) * | 1999-02-02 | 2001-06-26 | Vysis, Inc. | Simultaneous measurement of gene expression and genomic abnormalities using nucleic acid microarrays |
US6174681B1 (en) * | 1999-03-05 | 2001-01-16 | Mayo Foundation For Medical Education And Research | Method and probe set for detecting cancer |
WO2000062804A2 (en) * | 1999-04-15 | 2000-10-26 | The Regents Of The University Of California | Identification of sortase gene |
US6689875B1 (en) * | 1999-06-09 | 2004-02-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Molecular characterization of chromosome translocation t(11;18)(q21;q21) and its correlation to carcinogenesis |
US20030021813A1 (en) * | 1999-08-04 | 2003-01-30 | Chovan Linda E. | Essential bacteria genes and genome scanning in Haemophilus influenzae for the identification of 'essential genes' |
EP1218547A4 (en) * | 1999-10-15 | 2005-04-20 | Ventana Med Syst Inc | METHOD FOR DETECTING UNIQUE GENE IN SITU COPIES |
DE10002803A1 (de) * | 2000-01-24 | 2001-08-02 | Conbio Lizenzverwertungsgesell | System zur internen qualitativen und quantitativen Validierung von Markerindices |
JP2004512012A (ja) * | 2000-04-04 | 2004-04-22 | メディカル リサーチ カウンシル | 細胞検出法 |
AU2001266915A1 (en) * | 2000-06-14 | 2001-12-24 | Case Western Reserve University | Probes for chondrogenesis |
US6903187B1 (en) * | 2000-07-21 | 2005-06-07 | Allergan, Inc. | Leucine-based motif and clostridial neurotoxins |
US20030039658A1 (en) * | 2000-08-18 | 2003-02-27 | Mario Estable | MCEF, a novel transcription factor |
UA83458C2 (uk) * | 2000-09-18 | 2008-07-25 | Байоджен Айдек Ма Інк. | Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf) |
US6391592B1 (en) * | 2000-12-14 | 2002-05-21 | Affymetrix, Inc. | Blocker-aided target amplification of nucleic acids |
EP1362124B1 (en) * | 2001-02-20 | 2011-07-06 | Vysis, Inc. | Methods and probes for the detection of cancer |
EP1417297A4 (en) * | 2001-07-13 | 2007-08-22 | Whitehead Biomedical Inst | LEUCEMIGENES TRANSCRIPTION FACTORS |
EP1451318A4 (en) * | 2001-10-12 | 2007-06-27 | Perkinelmer Las Inc | NUCLEIC ACID COMPILATIONS, NETWORKS AND METHODS OF USE THEREOF |
US20040029142A1 (en) * | 2002-02-11 | 2004-02-12 | Schon Eric A. | Concatenation-based nucleic acid detection compositions and methods |
US20040110227A1 (en) * | 2002-03-19 | 2004-06-10 | Erez Levanon | Methods and systems for identifying putative fusion transcripts, polypeptides encoded therefrom and polynucleotide sequences related thereto and methods and kits utilizing same |
-
1999
- 1999-05-04 WO PCT/DK1999/000245 patent/WO1999057309A1/en active Application Filing
- 1999-05-04 JP JP2000547260A patent/JP2002513587A/ja active Pending
- 1999-05-04 CA CA2327542A patent/CA2327542C/en not_active Expired - Lifetime
- 1999-05-04 AU AU35168/99A patent/AU3516899A/en not_active Abandoned
- 1999-05-04 EP EP99916814A patent/EP1078098A1/en not_active Withdrawn
-
2002
- 2002-08-27 US US10/229,110 patent/US7105294B2/en not_active Expired - Lifetime
-
2005
- 2005-09-08 US US11/220,718 patent/US7368245B2/en not_active Expired - Fee Related
-
2008
- 2008-02-19 US US12/071,268 patent/US7642057B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US7642057B2 (en) | 2010-01-05 |
CA2327542C (en) | 2011-11-22 |
US20060160106A1 (en) | 2006-07-20 |
CA2327542A1 (en) | 1999-11-11 |
US7105294B2 (en) | 2006-09-12 |
US7368245B2 (en) | 2008-05-06 |
US20080187934A1 (en) | 2008-08-07 |
WO1999057309A1 (en) | 1999-11-11 |
US20040043383A1 (en) | 2004-03-04 |
EP1078098A1 (en) | 2001-02-28 |
AU3516899A (en) | 1999-11-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7642057B2 (en) | Method and probes for the detection of chromosome aberrations | |
US5888733A (en) | In situ hybridization to detect specific nucleic acid sequences in eucaryotic samples | |
EP2636757B1 (en) | Compositions and methods for detection of chromosomal aberrations with novel hybridization buffers | |
AU664045B2 (en) | In situ hybridization method | |
JP2009118853A (ja) | 真核系サンプル中の特異的核酸配列を検出するためのinsituハイブリダイゼーション | |
US5658730A (en) | Methods of human prostate cancer diagnosis | |
EP0539366A1 (en) | Methods for detecting human leukemias | |
JP2005524384A (ja) | ゲノム核酸におけるランダム分布反復配列への検出可能なプローブ結合の抑制に関する方法、キットおよび組成物 | |
JP2009254378A (ja) | 多重腫瘍異常生長遺伝子 | |
JPH02501442A (ja) | ヌクレオチドプローブによるヒト乳頭腫の型の診断 | |
WO2013074601A1 (en) | Gamma-pna miniprobes for fluorescent labeling | |
CA2422440C (en) | Oligonucleotide sequence formula for labeling oligonucleotide probes and proteins for in situ analysis | |
WO1996000234A1 (en) | Centromere hybridization probes | |
Difilippantonio et al. | Technicolor genome analysis | |
WO1994002500A1 (en) | Oligonucleotide probes and primers for detecting chromosomal translocation | |
WO1995019449A1 (en) | Populations of non-adjacent hybridization probes | |
US7981599B1 (en) | Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair | |
JPH10504188A (ja) | 診断方法およびプローブ | |
JPH08256778A (ja) | ウシのy染色体特異的dnaおよび雌雄共通dnaのマーカーとしての利用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20060215 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20081007 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20081225 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090108 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090609 |