JP2002513291A - 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 - Google Patents

神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

Info

Publication number
JP2002513291A
JP2002513291A JP54858198A JP54858198A JP2002513291A JP 2002513291 A JP2002513291 A JP 2002513291A JP 54858198 A JP54858198 A JP 54858198A JP 54858198 A JP54858198 A JP 54858198A JP 2002513291 A JP2002513291 A JP 2002513291A
Authority
JP
Japan
Prior art keywords
cells
population
stem cells
cns
nep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP54858198A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002513291A5 (OSRAM
Inventor
ラオ,マヘンドラ,エス.
メイヤー−プロッシェル,マーゴット
ムジタバ,ターミナ
Original Assignee
ユニバーシティー オブ ユタ リサーチ ファンデーション
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユニバーシティー オブ ユタ リサーチ ファンデーション filed Critical ユニバーシティー オブ ユタ リサーチ ファンデーション
Publication of JP2002513291A publication Critical patent/JP2002513291A/ja
Publication of JP2002513291A5 publication Critical patent/JP2002513291A5/ja
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0661—Smooth muscle cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/113—Acidic fibroblast growth factor (aFGF, FGF-1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/135—Platelet-derived growth factor [PDGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Rheumatology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP54858198A 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離 Ceased JP2002513291A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US08/852,744 1997-05-07
US08/852,744 US6361996B1 (en) 1997-05-07 1997-05-07 Neuroepithelial stem cells and glial-restricted intermediate precursors
US09/073,881 US6830927B2 (en) 1997-05-07 1998-05-06 Common neural progenitor for the CNS and PNS
US09/073,881 1998-05-06
PCT/US1998/009630 WO1998050526A1 (en) 1997-05-07 1998-05-07 Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor
US10/025,333 US7037720B2 (en) 1997-05-07 2001-12-19 Neuroepithelial stem cells and glial-restricted intermediate precursors

Publications (2)

Publication Number Publication Date
JP2002513291A true JP2002513291A (ja) 2002-05-08
JP2002513291A5 JP2002513291A5 (OSRAM) 2005-12-02

Family

ID=37057261

Family Applications (1)

Application Number Title Priority Date Filing Date
JP54858198A Ceased JP2002513291A (ja) 1997-05-07 1998-05-07 神経上皮幹細胞及び系譜限定中間前駆体の産生、特性決定及び単離

Country Status (7)

Country Link
US (5) US6361996B1 (OSRAM)
EP (1) EP0983344A4 (OSRAM)
JP (1) JP2002513291A (OSRAM)
AU (1) AU751581C (OSRAM)
CA (1) CA2289021C (OSRAM)
IL (1) IL132584A0 (OSRAM)
WO (1) WO1998050526A1 (OSRAM)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263402B1 (en) * 1998-10-19 2012-09-11 Cornell Research Foundation, Inc. Method for isolating and purifying oligodendrocytes and oligodendrocyte progenitor cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US20050042749A1 (en) 2001-05-16 2005-02-24 Carpenter Melissa K. Dopaminergic neurons and proliferation-competent precursor cells for treating Parkinson's disease
IL152741A0 (en) 2000-05-17 2003-06-24 Geron Corp Neural progenitor cell populations
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
US6897061B1 (en) * 2000-06-16 2005-05-24 Spinal Cord Society Transdifferentiation of glial cells
WO2003070171A2 (en) 2002-02-15 2003-08-28 Cornell Research Foundation, Inc. Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells
US7207743B2 (en) * 2002-05-28 2007-04-24 Polivka Parking Solutions Llc Method and apparatus for constructing an automotive vehicle parking lot
US7285415B2 (en) 2002-07-11 2007-10-23 The Regents Of The University Of California Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
US20050101014A1 (en) 2002-07-11 2005-05-12 Keirstead Hans S. Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
AR046076A1 (es) * 2003-07-18 2005-11-23 Otsuka Pharma Co Ltd Procedimiento para obtener una poblacion homogenea de celulas precursoras de oligodendrocitos y poblacion obtenida
EP1682075A4 (en) * 2003-11-07 2009-12-09 Univ Florida BREEDING AND DIFFERENTIATION OF NEURAL CREATOR CELLS
ES2491891T3 (es) 2004-01-16 2014-09-08 Carnegie Mellon University Marcaje celular para técnicas de resonancia magnética nuclear
GB2414995B (en) 2004-06-09 2006-11-15 Univ Edinburgh Neural stem cells
JP2008526916A (ja) * 2005-01-19 2008-07-24 フィディア アドバンスド バイオポリマーズ ソシエタ ア レスポンサビリタ リミタータ Sciおよびpnt再生のためのヒアルロン酸誘導体および神経幹細胞
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
WO2008054509A2 (en) * 2006-04-14 2008-05-08 Celsense, Inc. Methods for assessing cell labeling
CA2649333C (en) * 2006-04-14 2016-10-04 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
JP2010500047A (ja) 2006-08-15 2010-01-07 エージェンシー フォー サイエンス,テクノロジー アンド リサーチ 間葉系幹細胞馴化培地
US8163075B2 (en) 2006-10-31 2012-04-24 Sensient Colors Llc Inks comprising modified pigments and methods for making and using the same
AU2008242987A1 (en) * 2007-04-17 2008-10-30 University Of Rochester Telencephalic glial-restricted cell populations and related compositions and methods
AU2008275578B2 (en) * 2007-07-10 2014-04-10 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
EP3483222A3 (en) 2007-08-23 2019-08-07 Sensient Colors LLC Self-dispersed pigments and methods for making and using the same
US8513009B2 (en) 2008-01-30 2013-08-20 Geron Corporation Synthetic surfaces for culturing stem cell derived oligodendrocyte progenitor cells
SG188918A1 (OSRAM) 2008-03-17 2013-04-30 Agency Science Tech & Res
AU2009241762B2 (en) * 2008-05-02 2015-07-16 Celsense Inc. Compositions and methods for producing emulsions for nuclear magnetic resonance techniques and other applications
US9709553B2 (en) 2008-05-08 2017-07-18 University Of Rochester Treating myelin diseases with optimized cell preparations
US9688956B2 (en) 2008-06-05 2017-06-27 National Cheng Kung University Method for preserving proliferation and differentiation potential of mesenchymal stem cells
WO2010008486A2 (en) 2008-06-24 2010-01-21 Parkinsons Institute Pluripotent cell lines and methods of use thereof
WO2010068946A1 (en) * 2008-12-12 2010-06-17 Nova Southeastern University Methods of isolating and using stem cells
CN102325878A (zh) 2008-12-23 2012-01-18 斯特姆塞尔思加利福尼亚有限公司 少突胶质前体细胞的靶向细胞群及制备与使用方法
JP2012523479A (ja) 2009-04-07 2012-10-04 センシエント カラーズ エルエルシー 自己分散性粒子並びにその製造方法及び使用方法
EP2456853B1 (en) 2009-07-21 2020-10-28 ABT Holding Company Use of stem cells to reduce leukocyte extravasation
US20110020292A1 (en) 2009-07-21 2011-01-27 Abt Holding Company Use of Stem Cells to Reduce Leukocyte Extravasation
NZ602174A (en) * 2010-02-05 2014-10-31 Auckland Uniservices Ltd Cell programming
SG183497A1 (en) 2010-02-25 2012-09-27 Abt Holding Co Modulation of macrophage activation
US8895291B2 (en) 2010-10-08 2014-11-25 Terumo Bct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
US8433419B2 (en) 2010-10-13 2013-04-30 Cardiac Pacemakers, Inc. Method and apparatus for controlling neurostimulation according to physical state
WO2012168295A1 (en) 2011-06-06 2012-12-13 ReGenesys BVBA Expansion of stem cells in hollow fiber bioreactors
WO2014124087A1 (en) 2013-02-06 2014-08-14 University Of Rochester Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders
US9896656B2 (en) 2013-03-15 2018-02-20 Wake Forest University Health Sciences Neural progenitor cell differentiation
PT2983680T (pt) 2013-04-12 2020-10-29 Abt Holding Co Melhoria de órgãos para transplante
ES2753323T3 (es) 2013-04-30 2020-04-08 Univ Leuven Kath Terapia celular para síndromes mielodisplásicos
JP6612227B2 (ja) 2013-11-16 2019-11-27 テルモ ビーシーティー、インコーポレーテッド バイオリアクターにおける細胞増殖
US9724432B2 (en) 2015-04-30 2017-08-08 University Of Rochester Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder
WO2017147212A1 (en) 2016-02-22 2017-08-31 The Regents Of The University Of California Compositions and methods for imaging cell populations
CN109219657A (zh) 2016-03-30 2019-01-15 阿斯特利亚斯生物治疗股份公司 少突胶质细胞祖细胞组合物
EP4549457A3 (en) * 2017-01-31 2025-05-28 Osaka University Differentiation control method for pluripotent stem cells
JP7457505B2 (ja) 2017-05-10 2024-03-28 ユニバーシティー オブ ロチェスター 神経精神障害を処置する方法
IL281628B2 (en) 2018-09-19 2025-06-01 Lineage Cell Therapeutics Inc Methods for differentiating pluripotent stem cells in dynamic suspension culture
US11603518B2 (en) * 2019-01-23 2023-03-14 Asterias Biotherapeutics, Inc. Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells
JP7728747B2 (ja) 2019-08-23 2025-08-25 サナ バイオテクノロジー,インコーポレイテッド Cd24発現細胞およびそれらの用途
BR112022019060A2 (pt) 2020-03-25 2022-11-29 Sana Biotechnology Inc Células neurais hipoimunogênicas para o tratamento de distúrbios e condições neurológicas
IL300516A (en) 2020-08-13 2023-04-01 Sana Biotechnology Inc Methods for treating susceptible patients with hypoimmunogenic cells, and related methods and compounds
BR112023024434A2 (pt) 2021-05-27 2024-02-20 Sana Biotechnology Inc Células hipoimunogênicas que compreendem hla-e ou hla-g geneticamente modificadas
EP4370544A2 (en) 2021-07-14 2024-05-22 Sana Biotechnology, Inc. Altered expression of y chromosome-linked antigens in hypoimmunogenic cells
AU2022325955A1 (en) 2021-08-11 2024-02-08 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy to reduce instant blood mediated inflammatory reactions
WO2023019226A1 (en) 2021-08-11 2023-02-16 Sana Biotechnology, Inc. Genetically modified cells for allogeneic cell therapy
MX2024001443A (es) 2021-08-11 2024-05-15 Sana Biotechnology Inc Sistemas inducibles para alterar la expresión génica en células hipoinmunógenas.
JP2024534771A (ja) 2021-08-11 2024-09-26 サナ バイオテクノロジー,インコーポレイテッド 補体媒介性炎症反応を低減するための同種異系細胞療法のための遺伝子改変細胞
WO2023183313A1 (en) 2022-03-22 2023-09-28 Sana Biotechnology, Inc. Engineering cells with a transgene in b2m or ciita locus and associated compositions and methods
WO2025054202A1 (en) 2023-09-05 2025-03-13 Sana Biotechnology, Inc. Method of screening a sample comprising a transgene with a unique barcode
WO2025151838A1 (en) 2024-01-12 2025-07-17 Sana Biotechnology, Inc. Safety switches to control in vitro and in vivo proliferation of cell therapy products

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5411883A (en) * 1989-12-26 1995-05-02 Somatix Therapy Corporation Proliferated neuron progenitor cell product and process
US5589376A (en) 1992-07-27 1996-12-31 California Institute Of Technology Mammalian neural crest stem cells
US5753506A (en) * 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500245A (ja) * 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞

Non-Patent Citations (17)

* Cited by examiner, † Cited by third party
Title
JPN4007016138, Society for Neuroscience,1996,Vol.22,p.527,215.12 *
JPN4007016139, The Journal of Neuroscience,1995,Vol.15,No.5,p.3653−3661 *
JPN4007016140, Genes & Development,1996,Vol.10,No.24,p.3129−3140 *
JPN4007016480, Developmental Biology,1998,Vol.200,p.1−15 *
JPN6008050264, Society for Neuroscience,1996,Vol.22,p.527,215.12 *
JPN6008050266, The Journal of Neuroscience,1995,Vol.15,No.5,p.3653−3661 *
JPN6008050269, Genes & Development,1996,Vol.10,No.24,p.3129−3140 *
JPN6008050271, Journal of Neurocytology,1992,Vol.21,No.9,p.635−647 *
JPN6008050273, Developmental Biology,1998,Vol.200,p.1−15 *
JPN6008050275, Developmental Biology,1997,Vol.188,p.48−63 *
JPN6009049890, Developmental Biology,1992,Vol.152,p.363−372 *
JPN6009049892, Cell Biology,1992,Vol.3,p.413−422 *
JPN6009049894, Neuron,1990,Vol.5,p.615−625 *
JPN6009049895, The Journal of Neuroscience,1992,Vol.12,No.7,p.2751−2764 *
JPN6009049898, Develpomental Brain Research,1990,Vol.54,p.235−248 *
JPN6009049899, Neuroscience Letters,1993,Vol.163,p.227−230 *
JPN6009049901, GLIA,1996,Vol.16,p.27−39 *

Also Published As

Publication number Publication date
US6361996B1 (en) 2002-03-26
US20060199264A1 (en) 2006-09-07
AU751581C (en) 2003-06-19
US20100015702A1 (en) 2010-01-21
WO1998050526A1 (en) 1998-11-12
CA2289021A1 (en) 1998-11-12
EP0983344A1 (en) 2000-03-08
AU7481198A (en) 1998-11-27
US7595194B2 (en) 2009-09-29
AU751581B2 (en) 2002-08-22
EP0983344A4 (en) 2000-09-27
US20020142460A1 (en) 2002-10-03
US7037720B2 (en) 2006-05-02
IL132584A0 (en) 2001-03-19
CA2289021C (en) 2013-07-09
US6830927B2 (en) 2004-12-14
US20020045251A1 (en) 2002-04-18

Similar Documents

Publication Publication Date Title
CA2289021C (en) Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor
JP4371179B2 (ja) 系列限定ニューロン前駆体
Kilpatrick et al. Cloning and growth of multipotential neural precursors: requirements for proliferation and differentiation
US6949380B1 (en) Transdifferentiation of epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
Izrael et al. Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo
Rao et al. Immortalization and controlled in vitro differentiation of murine multipotent neural crest stem cells
US20130017179A1 (en) Lineage-Restricted Neuronal Precursors
JPH10509319A (ja) ドーパミン作動性細胞のインビトロ誘導
JP2002511246A (ja) 系列特異性細胞および前駆体細胞
JP2013063080A (ja) 神経前駆細胞の集団
WO2004007700A1 (ja) 神経系細胞の製造方法
Zhang et al. Increased myelinating capacity of embryonic stem cell derived oligodendrocyte precursors after treatment by interleukin-6/soluble interleukin-6 receptor fusion protein
Donaldson et al. Human amniotic fluid stem cells do not differentiate into dopamine neurons in vitro or after transplantation in vivo
JP2007520207A (ja) 胚性幹細胞由来のgaba作動性ニューロンのインビトロ生成および神経疾患の処置におけるその使用
Qu et al. Bromodeoxyuridine increases multipotency of human bone marrow-derived stem cells
Li et al. Engraftable neural crest stem cells derived from cynomolgus monkey embryonic stem cells
Lin et al. New mouse oligodendrocyte precursor (mOP) cells for studies on oligodendrocyte maturation and function
US7041507B1 (en) Transdiffentiation of transfected epidermal basal cells into neural progenitor cells, neuronal cells and/or glial cells
KR20040079669A (ko) Nurr1 과발현에 의한 도파민성 신경세포의 분화방법
AU2002309073B2 (en) Generation, characterization, and isolation of neuroepithelial stem cells and lineage restricted intermediate precursor
EP1179046B1 (en) Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells
AU765517B2 (en) Lineage-restricted precursor cells isolated from mouse neural tube and mouse embryonic stem cells

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050509

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050509

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20070821

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20071016

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20071126

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080221

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081007

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090107

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090209

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090929

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091216

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100201

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20100108

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100222

A313 Final decision of rejection without a dissenting response from the applicant

Free format text: JAPANESE INTERMEDIATE CODE: A313

Effective date: 20100419

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100525