JP2002512951A5 - - Google Patents
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- Publication number
- JP2002512951A5 JP2002512951A5 JP2000545514A JP2000545514A JP2002512951A5 JP 2002512951 A5 JP2002512951 A5 JP 2002512951A5 JP 2000545514 A JP2000545514 A JP 2000545514A JP 2000545514 A JP2000545514 A JP 2000545514A JP 2002512951 A5 JP2002512951 A5 JP 2002512951A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical ingredient
- matrix material
- pharmaceutical
- surgical
- product according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004615 ingredient Substances 0.000 description 22
- 239000011159 matrix material Substances 0.000 description 21
- 150000007523 nucleic acids Chemical class 0.000 description 9
- 108020004707 nucleic acids Proteins 0.000 description 9
- 102000039446 nucleic acids Human genes 0.000 description 9
- 210000004204 blood vessel Anatomy 0.000 description 8
- 102000008186 Collagen Human genes 0.000 description 7
- 108010035532 Collagen Proteins 0.000 description 7
- 229920001436 collagen Polymers 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- 108090000623 proteins and genes Proteins 0.000 description 6
- 239000013598 vector Substances 0.000 description 6
- 239000000306 component Substances 0.000 description 5
- 210000003137 popliteal artery Anatomy 0.000 description 4
- 238000001356 surgical procedure Methods 0.000 description 4
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 206010020718 hyperplasia Diseases 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000005036 nerve Anatomy 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 239000000565 sealant Substances 0.000 description 3
- 238000007789 sealing Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 239000003106 tissue adhesive Substances 0.000 description 3
- 206010020772 Hypertension Diseases 0.000 description 2
- 208000031481 Pathologic Constriction Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 238000001415 gene therapy Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000005426 pharmaceutical component Substances 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000001177 retroviral effect Effects 0.000 description 2
- 239000003566 sealing material Substances 0.000 description 2
- 208000037804 stenosis Diseases 0.000 description 2
- 230000036262 stenosis Effects 0.000 description 2
- 239000013603 viral vector Substances 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 201000006306 Cor pulmonale Diseases 0.000 description 1
- 208000007530 Essential hypertension Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 101000808011 Homo sapiens Vascular endothelial growth factor A Proteins 0.000 description 1
- 208000018262 Peripheral vascular disease Diseases 0.000 description 1
- 208000004186 Pulmonary Heart Disease Diseases 0.000 description 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
- 206010072810 Vascular wall hypertrophy Diseases 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 239000000556 agonist Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000001668 ameliorated effect Effects 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 238000002266 amputation Methods 0.000 description 1
- 238000002399 angioplasty Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003409 anti-rejection Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 208000007474 aortic aneurysm Diseases 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 230000003881 arterial anastomosis Effects 0.000 description 1
- 238000005452 bending Methods 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- ZXTYDZYHMVIHLP-UHFFFAOYSA-N cyano 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OC#N ZXTYDZYHMVIHLP-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- KAQKFAOMNZTLHT-VVUHWYTRSA-N epoprostenol Chemical compound O1C(=CCCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C[C@@H]21 KAQKFAOMNZTLHT-VVUHWYTRSA-N 0.000 description 1
- 229960001123 epoprostenol Drugs 0.000 description 1
- 239000003337 fertilizer Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960002897 heparin Drugs 0.000 description 1
- 229920000669 heparin Polymers 0.000 description 1
- 102000058223 human VEGFA Human genes 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 210000003101 oviduct Anatomy 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 208000037803 restenosis Diseases 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003874 surgical anastomosis Effects 0.000 description 1
- 239000003894 surgical glue Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9809082.2 | 1998-04-28 | ||
| GBGB9809082.2A GB9809082D0 (en) | 1998-04-28 | 1998-04-28 | Delivery device |
| GB9810429.2 | 1998-05-14 | ||
| GBGB9810429.2A GB9810429D0 (en) | 1998-04-28 | 1998-05-14 | Delivery service |
| PCT/GB1999/001310 WO1999055315A1 (en) | 1998-04-28 | 1999-04-28 | Periadventitial delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002512951A JP2002512951A (ja) | 2002-05-08 |
| JP2002512951A5 true JP2002512951A5 (https=) | 2006-06-22 |
Family
ID=26313555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000545514A Withdrawn JP2002512951A (ja) | 1998-04-28 | 1999-04-28 | 血管外膜周囲送達用装置 |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1073427B1 (https=) |
| JP (1) | JP2002512951A (https=) |
| KR (1) | KR100588714B1 (https=) |
| CN (1) | CN1195502C (https=) |
| AT (1) | ATE282408T1 (https=) |
| AU (1) | AU738514B2 (https=) |
| CA (1) | CA2326114A1 (https=) |
| DE (1) | DE69921980T2 (https=) |
| DK (1) | DK1073427T3 (https=) |
| ES (1) | ES2232133T3 (https=) |
| GB (2) | GB9809082D0 (https=) |
| HU (1) | HUP0101631A3 (https=) |
| NO (1) | NO20005398L (https=) |
| PL (1) | PL194265B1 (https=) |
| PT (1) | PT1073427E (https=) |
| WO (1) | WO1999055315A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596699B2 (en) | 1998-09-22 | 2003-07-22 | Biosurface Engineering Technologies, Inc. | Nucleic acid coating compositions and methods |
| SE0000285D0 (sv) * | 1999-12-07 | 2000-01-31 | Mika Lahtinen | Medical implant |
| EP1919944B1 (en) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modified vegf and pdgf with improved angiogenic properties |
| KR101241059B1 (ko) * | 2011-03-04 | 2013-03-11 | 연세대학교 산학협력단 | 마이크로 니들을 이용한 혈관외벽 장착 약물 전달장치 및 약물 전달방법 |
| JP7283808B2 (ja) * | 2018-10-02 | 2023-05-30 | ティーエムディー ラブ カンパニー，リミテッド | 形状記憶高分子を含む血管吻合用部材 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797485A (en) | 1971-03-26 | 1974-03-19 | Alza Corp | Novel drug delivery device for administering drug into blood circulation in blood vessel |
| US5540928A (en) | 1991-02-27 | 1996-07-30 | President And Fellows Of Harvard College | Extraluminal regulation of the growth and repair of tubular structures in vivo |
| US5399352A (en) | 1993-04-14 | 1995-03-21 | Emory University | Device for local drug delivery and methods for using the same |
| GB2298577B (en) | 1995-03-09 | 1999-02-17 | Univ Bristol | Arteriovenous bypass grafting |
| US5766584A (en) * | 1995-06-02 | 1998-06-16 | Massachusetts Institute Of Technology | Inhibition of vascular smooth muscle cell proliferation with implanted matrix containing vascular endothelial cells |
| EP0941116B1 (en) | 1996-11-01 | 2005-01-19 | Ark Therapeutics Limited | Use of vegf for the manufacture of a medicament for the treatment or prevention of intimal hyperplasia and delivery device |
-
1998
- 1998-04-28 GB GBGB9809082.2A patent/GB9809082D0/en not_active Ceased
- 1998-05-14 GB GBGB9810429.2A patent/GB9810429D0/en not_active Ceased
-
1999
- 1999-04-28 WO PCT/GB1999/001310 patent/WO1999055315A1/en not_active Ceased
- 1999-04-28 CN CNB998055336A patent/CN1195502C/zh not_active Expired - Fee Related
- 1999-04-28 DK DK99919391T patent/DK1073427T3/da active
- 1999-04-28 AT AT99919391T patent/ATE282408T1/de not_active IP Right Cessation
- 1999-04-28 PT PT99919391T patent/PT1073427E/pt unknown
- 1999-04-28 CA CA002326114A patent/CA2326114A1/en not_active Abandoned
- 1999-04-28 DE DE69921980T patent/DE69921980T2/de not_active Expired - Fee Related
- 1999-04-28 AU AU37193/99A patent/AU738514B2/en not_active Ceased
- 1999-04-28 KR KR1020007011341A patent/KR100588714B1/ko not_active Expired - Fee Related
- 1999-04-28 EP EP99919391A patent/EP1073427B1/en not_active Expired - Lifetime
- 1999-04-28 ES ES99919391T patent/ES2232133T3/es not_active Expired - Lifetime
- 1999-04-28 HU HU0101631A patent/HUP0101631A3/hu unknown
- 1999-04-28 PL PL99343725A patent/PL194265B1/pl unknown
- 1999-04-28 JP JP2000545514A patent/JP2002512951A/ja not_active Withdrawn
-
2000
- 2000-10-26 NO NO20005398A patent/NO20005398L/no not_active Application Discontinuation
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