JP2002512029A - ヒトｋ＋イオンチャンネルおよびその治療的適用 - Google Patents
ヒトｋ＋イオンチャンネルおよびその治療的適用Info
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- JP2002512029A JP2002512029A JP2000544795A JP2000544795A JP2002512029A JP 2002512029 A JP2002512029 A JP 2002512029A JP 2000544795 A JP2000544795 A JP 2000544795A JP 2000544795 A JP2000544795 A JP 2000544795A JP 2002512029 A JP2002512029 A JP 2002512029A
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- 230000002992 thymic effect Effects 0.000 description 1
- 238000012090 tissue culture technique Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000005026 transcription initiation Effects 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
- 238000003146 transient transfection Methods 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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- 230000005748 tumor development Effects 0.000 description 1
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- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 238000002255 vaccination Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98107268.9 | 1998-04-21 | ||
| EP98107268 | 1998-04-21 | ||
| PCT/EP1999/002695 WO1999054463A2 (en) | 1998-04-21 | 1999-04-21 | Human k+ ion channel and therapeutic applications thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009160236A Division JP2009235091A (ja) | 1998-04-21 | 2009-07-06 | ヒトｋ＋イオンチャンネルおよびその治療的適用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002512029A true JP2002512029A (ja) | 2002-04-23 |
| JP2002512029A5 JP2002512029A5 (enExample) | 2006-06-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000544795A Withdrawn JP2002512029A (ja) | 1998-04-21 | 1999-04-21 | ヒトｋ＋イオンチャンネルおよびその治療的適用 |
| JP2009160236A Pending JP2009235091A (ja) | 1998-04-21 | 2009-07-06 | ヒトｋ＋イオンチャンネルおよびその治療的適用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009160236A Pending JP2009235091A (ja) | 1998-04-21 | 2009-07-06 | ヒトｋ＋イオンチャンネルおよびその治療的適用 |
Country Status (10)
| Country | Link |
|---|---|
| US (7) | US6638736B1 (enExample) |
| EP (1) | EP1073738B1 (enExample) |
| JP (2) | JP2002512029A (enExample) |
| AT (1) | ATE278017T1 (enExample) |
| CA (1) | CA2323571A1 (enExample) |
| DE (1) | DE69920681T2 (enExample) |
| DK (1) | DK1073738T3 (enExample) |
| ES (1) | ES2230852T3 (enExample) |
| PT (1) | PT1073738E (enExample) |
| WO (1) | WO1999054463A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008520186A (ja) * | 2004-10-01 | 2008-06-19 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 哺乳類ｅａｇ１イオンチャネルタンパク質に対する新規の抗体 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69920681T2 (de) * | 1998-04-21 | 2005-09-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Humaner k+ ionenkanal und therapeutische verwendungen davon |
| DE10025620A1 (de) * | 2000-05-24 | 2001-12-06 | Forschungsgesellschaft Genion | Verfahren zur Herstellung von Chimären zwischen bakteriellen und eukaryotischen Kaliumkanälen auf festen Trägern und deren Verwendung zur Identifizierung von Kaliumkanalagonisten und -antagonisten |
| DE10224534A1 (de) | 2002-05-31 | 2003-12-11 | Juergen Dolderer | Verfahren zum Diagnostizieren des colorektaien Karzinoms in einer Gewebeprobe und Mittel zur Behandlung |
| MX2007003865A (es) * | 2004-10-01 | 2009-06-17 | Ct Investig Y Estudios Del Ipn | Métodos para el diagnóstico temprano de infecciones virales y enfermedades inflamatorias o de la predisposición de un individuo a desórdenes proliferativos o hiperplasia. |
| AU2013201604B2 (en) * | 2007-04-13 | 2014-08-14 | Southern Research Institute | Anti-angiogenic agents and methods of use |
| ES2334084B1 (es) * | 2007-12-21 | 2011-01-24 | Inst Cientifico Tecnol Navarra | Marcadores geneticos para el pronostico de la esclerosis multiple. |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| TWI570415B (zh) * | 2015-10-02 | 2017-02-11 | A spring probe having an outer sleeve and a probe device having the spring probe | |
| EP3195727A1 (en) | 2016-01-22 | 2017-07-26 | Forschungsinstitut Fur Biologischen Landbau (FiBL) | Duddingtonia flagrans strain and feed additive formulation for biological pest control |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998000168A1 (en) * | 1996-07-02 | 1998-01-08 | Novartis Consumer Health S.A. | Topical composition comprising a combination of antihistaminic compounds with terpenoid compounds |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4394448A (en) * | 1978-02-24 | 1983-07-19 | Szoka Jr Francis C | Method of inserting DNA into living cells |
| US5703055A (en) * | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| GB9303210D0 (en) | 1993-02-17 | 1993-03-31 | Univ Manitoba | Cancer treatment |
| AU665341B2 (en) | 1990-12-18 | 1996-01-04 | Wellcome Foundation Limited, The | Agents for potentiating the effects of antitumor agents and combating multiple drug resistance |
| US6610827B1 (en) * | 1997-10-29 | 2003-08-26 | Elan Pharmaceuticals, Inc. | Potassium channel subunit polypeptide and polynucleotide compositions and uses therefor |
| DE69920681T2 (de) * | 1998-04-21 | 2005-09-08 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Humaner k+ ionenkanal und therapeutische verwendungen davon |
-
1999
- 1999-04-21 DE DE69920681T patent/DE69920681T2/de not_active Expired - Lifetime
- 1999-04-21 DK DK99920731T patent/DK1073738T3/da active
- 1999-04-21 AT AT99920731T patent/ATE278017T1/de not_active IP Right Cessation
- 1999-04-21 PT PT99920731T patent/PT1073738E/pt unknown
- 1999-04-21 ES ES99920731T patent/ES2230852T3/es not_active Expired - Lifetime
- 1999-04-21 JP JP2000544795A patent/JP2002512029A/ja not_active Withdrawn
- 1999-04-21 WO PCT/EP1999/002695 patent/WO1999054463A2/en not_active Ceased
- 1999-04-21 EP EP99920731A patent/EP1073738B1/en not_active Expired - Lifetime
- 1999-04-21 CA CA002323571A patent/CA2323571A1/en not_active Abandoned
-
2000
- 2000-10-23 US US09/694,777 patent/US6638736B1/en not_active Expired - Fee Related
-
2002
- 2002-07-01 US US10/188,308 patent/US7364730B2/en not_active Expired - Fee Related
- 2002-07-01 US US10/188,296 patent/US7364845B2/en not_active Expired - Fee Related
- 2002-07-01 US US10/188,297 patent/US7314914B2/en not_active Expired - Fee Related
- 2002-07-01 US US10/188,341 patent/US7129207B2/en not_active Expired - Fee Related
-
2006
- 2006-11-30 US US11/633,085 patent/US20080020406A1/en not_active Abandoned
-
2009
- 2009-06-09 US US12/480,913 patent/US20100021467A1/en not_active Abandoned
- 2009-07-06 JP JP2009160236A patent/JP2009235091A/ja active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998000168A1 (en) * | 1996-07-02 | 1998-01-08 | Novartis Consumer Health S.A. | Topical composition comprising a combination of antihistaminic compounds with terpenoid compounds |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008520186A (ja) * | 2004-10-01 | 2008-06-19 | マックス−プランク−ゲゼルシャフト・ツア・フェルデルング・デア・ヴィッセンシャフテン・エー・ファオ | 哺乳類ｅａｇ１イオンチャネルタンパク質に対する新規の抗体 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20030077735A1 (en) | 2003-04-24 |
| US20030087378A1 (en) | 2003-05-08 |
| DK1073738T3 (da) | 2005-01-24 |
| EP1073738A2 (en) | 2001-02-07 |
| PT1073738E (pt) | 2005-01-31 |
| ATE278017T1 (de) | 2004-10-15 |
| WO1999054463A3 (en) | 2000-04-20 |
| US7129207B2 (en) | 2006-10-31 |
| US7314914B2 (en) | 2008-01-01 |
| EP1073738B1 (en) | 2004-09-29 |
| US7364730B2 (en) | 2008-04-29 |
| DE69920681T2 (de) | 2005-09-08 |
| WO1999054463A2 (en) | 1999-10-28 |
| DE69920681D1 (de) | 2004-11-04 |
| US7364845B2 (en) | 2008-04-29 |
| CA2323571A1 (en) | 1999-10-28 |
| US20100021467A1 (en) | 2010-01-28 |
| US20030092120A1 (en) | 2003-05-15 |
| US20030087377A1 (en) | 2003-05-08 |
| ES2230852T3 (es) | 2005-05-01 |
| US6638736B1 (en) | 2003-10-28 |
| JP2009235091A (ja) | 2009-10-15 |
| US20080020406A1 (en) | 2008-01-24 |
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