|
US6506798B1
(en)
|
1997-07-01 |
2003-01-14 |
Warner-Lambert Company |
4-Arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective MEK inhibitors
|
|
US7354894B2
(en)
|
1998-08-18 |
2008-04-08 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
|
US6846799B1
(en)
|
1998-08-18 |
2005-01-25 |
The Regents Of The University Of California |
Preventing airway mucus production by administration of EGF-R antagonists
|
|
HUP0104607A3
(en)
*
|
1998-12-15 |
2002-12-28 |
Warner Lambert Co |
Use of a mek inhibitor for preventing transplant rejection
|
|
EP1140067A1
(en)
*
|
1999-01-07 |
2001-10-10 |
Warner-Lambert Company |
Antiviral method using mek inhibitors
|
|
CA2348236A1
(en)
*
|
1999-01-13 |
2000-07-20 |
Stephen Douglas Barrett |
4-arylamino, 4-aryloxy, and 4-arylthio diarylamines and derivatives thereof as selective mek inhibitors
|
|
AP2001002225A0
(en)
|
1999-01-13 |
2001-09-30 |
Warner Lambert Co |
1-heterocycle substituted diarylamines.
|
|
WO2000050398A2
(en)
|
1999-02-24 |
2000-08-31 |
F. Hoffmann-La Roche Ag |
Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists
|
|
GB9910579D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
GB9910580D0
(en)
|
1999-05-08 |
1999-07-07 |
Zeneca Ltd |
Chemical compounds
|
|
JP2003504401A
(ja)
*
|
1999-07-16 |
2003-02-04 |
ワーナー−ランバート・カンパニー |
Ｍｅｋ阻害剤を用いる慢性疼痛の治療方法
|
|
AU5786000A
(en)
*
|
1999-07-16 |
2001-02-05 |
Warner-Lambert Company |
Method for treating chronic pain using mek inhibitors
|
|
HUP0202381A3
(en)
*
|
1999-07-16 |
2004-12-28 |
Warner Lambert Co |
Method for treating chronic pain using mek inhibitors
|
|
DK1255544T3
(da)
*
|
2000-01-31 |
2007-09-17 |
Genaera Corp |
Mucin-syntese-inhibitorer
|
|
US7345051B2
(en)
|
2000-01-31 |
2008-03-18 |
Genaera Corporation |
Mucin synthesis inhibitors
|
|
GB0002740D0
(en)
*
|
2000-02-07 |
2000-03-29 |
Novartis Ag |
Organic compounds
|
|
US7001905B2
(en)
|
2000-03-15 |
2006-02-21 |
Warner-Lambert Company |
Substituted diarylamines as MEK inhibitors
|
|
BR0109188A
(pt)
*
|
2000-03-15 |
2003-03-18 |
Warner Lambert Co |
Diarilaminas 5-amida substituìdas como inibidores de mex
|
|
DE10017480A1
(de)
*
|
2000-04-07 |
2001-10-11 |
Transmit Technologietransfer |
Verwendung von Substanzen, die als MEK Inhibitor wirken, zur Herstellung eines Arneimittels gegen DNA- und RNA-Viren
|
|
US6573402B1
(en)
|
2000-04-20 |
2003-06-03 |
Neurotech Co., Ltd. |
Compounds, compositions and methods for preventing neurodegeneration in acute and chronic injuries in the central nervous system
|
|
IL153817A0
(en)
|
2000-07-19 |
2003-07-31 |
Warner Lambert Co |
Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids
|
|
MXPA03001654A
(es)
*
|
2000-08-25 |
2004-09-10 |
Warner Lambert Co |
Proceso para la elaboracion del acido n-aril-antranilico y sus derivados.
|
|
US7253184B2
(en)
|
2000-11-02 |
2007-08-07 |
Astrazeneca Ab |
4-Substituted quinolines as antitumor agents
|
|
AU2002210714A1
(en)
|
2000-11-02 |
2002-06-11 |
Astrazeneca Ab |
Substituted quinolines as antitumor agents
|
|
IL149462A0
(en)
*
|
2001-05-09 |
2002-11-10 |
Warner Lambert Co |
Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
|
|
EP1467968A1
(en)
|
2002-01-23 |
2004-10-20 |
Warner-Lambert Company LLC |
N-(4-substituted phenyl)-anthranilic acid hydroxamate esters
|
|
DOP2003000556A
(es)
*
|
2002-01-23 |
2003-10-31 |
Warner Lambert Co |
Esteres hidroxamato de acido n-(4-fenil-sustituido)-antranilico.
|
|
CA2478374C
(en)
|
2002-03-13 |
2009-01-06 |
Eli M. Wallace |
N3 alkylated benzimidazole derivatives as mek inhibitors
|
|
US7235537B2
(en)
|
2002-03-13 |
2007-06-26 |
Array Biopharma, Inc. |
N3 alkylated benzimidazole derivatives as MEK inhibitors
|
|
US7012100B1
(en)
|
2002-06-04 |
2006-03-14 |
Avolix Pharmaceuticals, Inc. |
Cell migration inhibiting compositions and methods and compositions for treating cancer
|
|
CN1309703C
(zh)
|
2002-06-19 |
2007-04-11 |
纽若泰克有限公司 |
四氟苄基衍生物及含有其成分的用于治疗和预防中枢神经系统的急慢性神经变性疾病的药物组合物
|
|
AU2003272068A1
(en)
*
|
2002-10-21 |
2004-05-04 |
Ramot At Tel Aviv University Ltd. |
Derivatives of n-phenylanthranilic acid and 2-benzimidazolon as potassium channel and/or cortical neuron activity modulators
|
|
US7632866B2
(en)
|
2002-10-21 |
2009-12-15 |
Ramot At Tel Aviv University |
Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
|
|
WO2005000818A1
(en)
|
2003-06-27 |
2005-01-06 |
Warner-Lambert Company Llc |
5-substituted-4-`(substituted phenyl)!amino!-2-pyridone deviatives for use as mek inhibitors
|
|
US7144907B2
(en)
|
2003-09-03 |
2006-12-05 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
US7538120B2
(en)
|
2003-09-03 |
2009-05-26 |
Array Biopharma Inc. |
Method of treating inflammatory diseases
|
|
CN100594212C
(zh)
|
2003-10-21 |
2010-03-17 |
沃纳-兰伯特公司 |
N-[(r)-2,3-二羟基-丙氧基]-3,4-二氟-2-(2-氟-4-碘苯基氨基)-苯甲酰胺的多晶型物
|
|
US7732616B2
(en)
|
2003-11-19 |
2010-06-08 |
Array Biopharma Inc. |
Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
|
|
US7517994B2
(en)
|
2003-11-19 |
2009-04-14 |
Array Biopharma Inc. |
Heterocyclic inhibitors of MEK and methods of use thereof
|
|
JP4869075B2
(ja)
|
2003-11-19 |
2012-02-01 |
アレイ バイオファーマ、インコーポレイテッド |
Ｍｅｋの複素環阻害剤及びその使用方法
|
|
BRPI0416852A
(pt)
|
2003-11-21 |
2007-02-27 |
Array Biopharma Inc |
inibidores da quinase akt
|
|
SE0401969D0
(sv)
*
|
2004-08-02 |
2004-08-02 |
Astrazeneca Ab |
Piperidine derivatives
|
|
AR051248A1
(es)
*
|
2004-10-20 |
2007-01-03 |
Applied Research Systems |
Derivados de 3-arilamino piridina
|
|
US20070293544A1
(en)
*
|
2004-11-24 |
2007-12-20 |
Ulrich Abel |
Novel 4-Arylamino Pyridone Derivatives as Mek Inhibitors for the Treatment of Hyper-Proliferative Disorders
|
|
ATE443063T1
(de)
*
|
2004-12-01 |
2009-10-15 |
Merck Serono Sa |
Ä1,2,4ütriazoloä4,3-aüpyridin-derivative zur behandlung hyperproliferativer erkrankungen
|
|
SI1860098T1
(sl)
|
2005-03-16 |
2013-03-29 |
Toyama Chemical Co., Ltd. |
Nov derivat antranilne kisline ali sol le-tega
|
|
RU2500673C2
(ru)
|
2005-05-18 |
2013-12-10 |
Астразенека Аб |
Гетероциклические ингибиторы мек и способы их применения
|
|
US7495126B2
(en)
|
2005-05-25 |
2009-02-24 |
Choongwae Pharma Corporation |
Process of preparation of substituted tetrafluorobenzylaniline compound and its pharmaceutically approved salts
|
|
AU2013203939B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
AU2015255183C1
(en)
*
|
2005-10-07 |
2017-10-05 |
Exelixis, Inc |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
AU2012261703B2
(en)
*
|
2005-10-07 |
2015-08-13 |
Exelixis, Inc. |
Azetidines as MEK inhibitors for the treatment of proliferative diseases
|
|
EP1934174B1
(en)
*
|
2005-10-07 |
2011-04-06 |
Exelixis, Inc. |
Azetidines as mek inhibitors for the treatment of proliferative diseases
|
|
GB0601962D0
(en)
|
2006-01-31 |
2006-03-15 |
Ucb Sa |
Therapeutic agents
|
|
PL2049500T3
(pl)
|
2006-07-06 |
2012-02-29 |
Array Biopharma Inc |
Cyklopenta[d]pirymidyny jako inhibitory kinaz białkowych AKT
|
|
US8063050B2
(en)
|
2006-07-06 |
2011-11-22 |
Array Biopharma Inc. |
Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
WO2008006025A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrofuro pyrimidines as akt protein kinase inhibitors
|
|
WO2008006039A1
(en)
|
2006-07-06 |
2008-01-10 |
Array Biopharma Inc. |
Dihydrothieno pyrimidines as akt protein kinase inhibitors
|
|
ATE539752T1
(de)
*
|
2006-08-16 |
2012-01-15 |
Exelixis Inc |
Verwendung von pi3k- und mek-modulatoren bei der krebsbehandlung
|
|
KR20090071666A
(ko)
|
2006-10-23 |
2009-07-01 |
다케다 야쿠힌 고교 가부시키가이샤 |
Ｍａｐｋ／ｅｒｋ 키나아제 억제제
|
|
JP5311673B2
(ja)
|
2006-12-14 |
2013-10-09 |
エグゼリクシス， インコーポレイテッド |
Ｍｅｋ阻害剤の使用方法
|
|
BRPI0813999A2
(pt)
|
2007-07-05 |
2019-10-01 |
Array Biopharma Inc |
ciclopentanos de pirimidil como inibidores de akt proteína cinase
|
|
US9409886B2
(en)
|
2007-07-05 |
2016-08-09 |
Array Biopharma Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
US8846683B2
(en)
|
2007-07-05 |
2014-09-30 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
|
|
EP2404907B1
(en)
|
2007-07-05 |
2015-01-14 |
Array Biopharma, Inc. |
Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
|
|
WO2009037705A2
(en)
*
|
2007-09-20 |
2009-03-26 |
Ramot At Tel Aviv University Ltd. |
Esters of n-phenylanthranilic acid for use in the treatment of cancer and inflammation
|
|
CN101868443A
(zh)
|
2007-09-20 |
2010-10-20 |
特拉维夫大学拉莫特有限公司 |
N-苯基邻氨基苯甲酸衍生物及其用途
|
|
KR100852962B1
(ko)
|
2007-11-12 |
2008-08-20 |
주식회사 뉴로테크 |
2-하이드록시-5-페닐알킬아미노벤조산 유도체 및 이의 염의제조방법
|
|
AU2009204019B2
(en)
|
2008-01-09 |
2014-02-20 |
Array Biopharma Inc. |
Hydroxylated pyrimidyl cyclopentane as AKT protein kinase inhibitor
|
|
KR101624753B1
(ko)
|
2008-01-09 |
2016-05-26 |
어레이 바이오파마 인크. |
Ａｋｔ 단백질 키나제 저해물질로서의 수산화된 피리미딜 시클로펜탄
|
|
GB0813403D0
(en)
*
|
2008-07-22 |
2008-08-27 |
Lectus Therapeutics Ltd |
Potassium ion channel modulators & uses thereof
|
|
DK2307376T3
(en)
|
2008-08-04 |
2016-01-11 |
Merck Patent Gmbh |
NOVEL phenylamino ISONIKOTINAMIDFORBINDELSER
|
|
WO2010051933A2
(en)
|
2008-11-10 |
2010-05-14 |
Bayer Schering Pharma Aktiengesellschaft |
Substituted sulphonamido phenoxybenzamides
|
|
WO2010068738A1
(en)
|
2008-12-10 |
2010-06-17 |
Dana-Farber Cancer Institute, Inc. |
Mek mutations conferring resistance to mek inhibitors
|
|
CA2777071A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted halophenoxybenzamide derivatives
|
|
US8962606B2
(en)
|
2009-10-21 |
2015-02-24 |
Bayer Intellectual Property Gmbh |
Substituted benzosulphonamides
|
|
CA2777430A1
(en)
|
2009-10-21 |
2011-04-28 |
Bayer Pharma Aktiengesellschaft |
Substituted benzosulphonamides
|
|
WO2011106298A1
(en)
|
2010-02-25 |
2011-09-01 |
Dana-Farber Cancer Institute, Inc. |
Braf mutations conferring resistance to braf inhibitors
|
|
AU2011224410B2
(en)
|
2010-03-09 |
2015-05-28 |
Dana-Farber Cancer Institute, Inc. |
Methods of diagnosing and treating cancer in patients having or developing resistance to a first cancer therapy
|
|
US9045429B2
(en)
|
2010-10-29 |
2015-06-02 |
Bayer Intellectual Property Gmbh |
Substituted phenoxypyridines
|
|
BR112013025397A2
(pt)
|
2011-04-01 |
2019-09-24 |
Deepak Sampath |
combinação de um composto, composto de fórmula i ou um sal farmaceuticamente aceitável do mesmo, uso, kit, produto, método para tratamento de um distúrbio hiperproliferativo e método para tratamento de uma doença ou afecção modulada por quinase akt em um mamífero
|
|
CA2831922C
(en)
|
2011-04-01 |
2019-12-31 |
Genentech, Inc. |
Combinations of akt inhibitor compounds and vemurafenib, and methods of use
|
|
CN103204827B
(zh)
|
2012-01-17 |
2014-12-03 |
上海科州药物研发有限公司 |
作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途
|
|
CN102617383A
(zh)
*
|
2012-03-20 |
2012-08-01 |
横店集团家园化工有限公司 |
索法地尔晶型、制备方法及包含索法地尔晶体的无菌粉末
|
|
US20150141470A1
(en)
|
2012-05-08 |
2015-05-21 |
The Broad Institute, Inc. |
Diagnostic and treatment methods in patients having or at risk of developing resistance to cancer therapy
|
|
AU2013269994B2
(en)
*
|
2012-05-30 |
2017-04-20 |
Merck Patent Gmbh |
Solid state forms of N-((S)-2,3-Dihydroxy-propyl)-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide
|
|
HRP20180670T1
(hr)
|
2012-10-12 |
2018-07-13 |
Exelixis Inc. |
Novi postupak dobivanja spojeva namijenjenih upotrebi u liječenju raka
|
|
US11465978B2
(en)
|
2013-09-11 |
2022-10-11 |
The Administrators Of The Tulane Educational Fund |
Anthranilic amides and the use thereof
|
|
EP3094736A4
(en)
|
2014-01-14 |
2017-10-25 |
Dana-Farber Cancer Institute, Inc. |
Compositions and methods for identification, assessment, prevention, and treatment of melanoma using pd-l1 isoforms
|
|
AU2015328411C1
(en)
|
2014-10-06 |
2022-03-03 |
Dana-Farber Cancer Institute, Inc. |
Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response
|
|
MA41866A
(fr)
|
2015-03-31 |
2018-02-06 |
Massachusetts Gen Hospital |
Molécules à auto-assemblage pour l'administration ciblée de médicaments
|
|
JP7576799B2
(ja)
*
|
2018-11-20 |
2024-11-01 |
エヌフレクション セラピューティクス インコーポレイテッド |
皮膚癌の処置のためのアリールアニリンおよびヘテロアリールアニリン化合物
|
|
MA55144A
(fr)
|
2018-11-20 |
2021-09-29 |
Nflection Therapeutics Inc |
Composés naphthyridinone-aniline destinés au traitement d'affections de la peau
|
|
WO2020106305A1
(en)
|
2018-11-20 |
2020-05-28 |
Nflection Therapeutics, Inc. |
Thienyl-aniline compounds for treatment of dermal disorders
|
|
EP3883552B1
(en)
|
2018-11-20 |
2025-04-09 |
NFlection Therapeutics, Inc. |
Cyanoaryl-aniline compounds for treatment of dermal disorders
|
|
CN118591373A
(zh)
|
2021-11-23 |
2024-09-03 |
恩福莱克逊治疗有限公司 |
吡咯并吡啶-苯胺化合物的制剂
|
|
TW202342018A
(zh)
|
2022-03-04 |
2023-11-01 |
美商奇奈特生物製藥公司 |
Mek激酶抑制劑
|