JP2002506036A5 - - Google Patents
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- Publication number
- JP2002506036A5 JP2002506036A5 JP2000535350A JP2000535350A JP2002506036A5 JP 2002506036 A5 JP2002506036 A5 JP 2002506036A5 JP 2000535350 A JP2000535350 A JP 2000535350A JP 2000535350 A JP2000535350 A JP 2000535350A JP 2002506036 A5 JP2002506036 A5 JP 2002506036A5
- Authority
- JP
- Japan
- Prior art keywords
- oriented
- compound
- axial
- compound according
- adenine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 description 40
- 239000002777 nucleoside Substances 0.000 description 16
- 239000000539 dimer Substances 0.000 description 14
- 150000003833 nucleoside derivatives Chemical class 0.000 description 14
- 229930024421 Adenine Natural products 0.000 description 12
- 229960000643 adenine Drugs 0.000 description 12
- -1 adenine compound Chemical group 0.000 description 9
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 6
- UYTPUPDQBNUYGX-UHFFFAOYSA-N Guanine Natural products O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 6
- 229960002949 fluorouracil Drugs 0.000 description 6
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical group FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 4
- 150000003212 purines Chemical class 0.000 description 4
- 150000003230 pyrimidines Chemical class 0.000 description 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 239000001257 hydrogen Substances 0.000 description 3
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 3
- 150000005018 aminopurines Chemical group 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical group S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
- 125000003835 nucleoside group Chemical group 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- OIRDTQYFTABQOQ-DEGSGYPDSA-N (2S,3S,4R,5S)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound [C@H]1([C@@H](O)[C@@H](O)[C@@H](O1)CO)N1C2=NC=NC(=C2N=C1)N OIRDTQYFTABQOQ-DEGSGYPDSA-N 0.000 description 1
- VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 description 1
- NUIGWTHJDCDLPS-UHFFFAOYSA-N 2-(sulfanylamino)-3,7-dihydropurin-6-one Chemical compound N1C(NS)=NC(=O)C2=C1N=CN2 NUIGWTHJDCDLPS-UHFFFAOYSA-N 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
- 229960000212 aminophenazone Drugs 0.000 description 1
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/038,647 US5939402A (en) | 1995-09-21 | 1998-03-11 | Nucleoside analogs and uses against parasitic infection |
| US09/219,947 | 1998-12-23 | ||
| US09/038,647 | 1998-12-23 | ||
| US09/220,307 US6207649B1 (en) | 1995-09-21 | 1998-12-23 | Nucleoside analogs and uses in treating disease |
| US09/219,947 US6242428B1 (en) | 1995-09-21 | 1998-12-23 | Nucleoside analogs and uses in treating Plasmodium falciparum infection |
| US09/220,307 | 1998-12-23 | ||
| PCT/US1999/005360 WO1999045935A1 (en) | 1998-03-11 | 1999-03-11 | Novel nucleoside analogs and uses in treating disease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002506036A JP2002506036A (ja) | 2002-02-26 |
| JP2002506036A5 true JP2002506036A5 (enExample) | 2006-04-27 |
Family
ID=27365434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000535350A Pending JP2002506036A (ja) | 1998-03-11 | 1999-03-11 | 疾患を処置するにおける新規ヌクレオシドアナログおよびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1069903A1 (enExample) |
| JP (1) | JP2002506036A (enExample) |
| AU (1) | AU3080899A (enExample) |
| CA (1) | CA2322494A1 (enExample) |
| WO (1) | WO1999045935A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6444652B1 (en) | 1998-08-10 | 2002-09-03 | Novirio Pharmaceuticals Limited | β-L-2'-deoxy-nucleosides for the treatment of hepatitis B |
| AU2007216721B2 (en) * | 1998-08-10 | 2011-05-19 | Centre National De La Recherche Scientifique | Beta-L-2'-Deoxy Nucleosides for the Treatment of Hepatitis B |
| ATE313550T1 (de) * | 1998-08-10 | 2006-01-15 | Idenix Cayman Ltd | Beta-l-2'-deoxynukleoside für die behandlung von hepatitis b virus |
| AU2004201286B2 (en) * | 1998-08-10 | 2007-06-21 | Centre National De La Recherche Scientifique (Cnrs) | Beta-L-2'-Deoxy Nucleosides for the Treatment of Hepatitis B |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| EP1352910A1 (en) * | 2002-04-10 | 2003-10-15 | Grünenthal GmbH | New analogs of nitrobenzylthioinosine |
| TWI244393B (en) | 2002-08-06 | 2005-12-01 | Idenix Pharmaceuticals Inc | Crystalline and amorphous forms of beta-L-2'-deoxythymidine |
| NZ541651A (en) * | 2003-02-03 | 2009-01-31 | Cv Therapeutics Inc | Partial and full agonists of A1 adenosine receptors |
| GB0400290D0 (en) * | 2004-01-08 | 2004-02-11 | Medivir Ab | dUTPase inhibitors |
| CA2947939A1 (en) * | 2014-05-28 | 2015-12-03 | Idenix Pharmaceuticals Llc | Nucleoside derivatives for the treatment of cancer |
| CN106459127A (zh) * | 2014-05-28 | 2017-02-22 | 艾登尼克斯药业有限公司 | 用于治疗癌症的核苷衍生物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559101A (en) * | 1994-10-24 | 1996-09-24 | Genencor International, Inc. | L-ribofuranosyl nucleosides |
| US5672594A (en) * | 1994-10-24 | 1997-09-30 | Genencor International, Inc. | L-erythrosyl nucleosides |
-
1999
- 1999-03-11 AU AU30808/99A patent/AU3080899A/en not_active Abandoned
- 1999-03-11 CA CA002322494A patent/CA2322494A1/en not_active Abandoned
- 1999-03-11 WO PCT/US1999/005360 patent/WO1999045935A1/en not_active Ceased
- 1999-03-11 EP EP99912434A patent/EP1069903A1/en not_active Withdrawn
- 1999-03-11 JP JP2000535350A patent/JP2002506036A/ja active Pending
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