JP2002504325A5 - - Google Patents
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- Publication number
- JP2002504325A5 JP2002504325A5 JP2000532511A JP2000532511A JP2002504325A5 JP 2002504325 A5 JP2002504325 A5 JP 2002504325A5 JP 2000532511 A JP2000532511 A JP 2000532511A JP 2000532511 A JP2000532511 A JP 2000532511A JP 2002504325 A5 JP2002504325 A5 JP 2002504325A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- nucleic acid
- acid sequence
- expression
- usf1
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000007523 nucleic acids Chemical group 0.000 description 22
- 108091028043 Nucleic acid sequence Proteins 0.000 description 21
- 238000000034 method Methods 0.000 description 21
- 229920001184 polypeptide Polymers 0.000 description 16
- 102000004196 processed proteins & peptides Human genes 0.000 description 16
- 108090000765 processed proteins & peptides Proteins 0.000 description 16
- 150000001875 compounds Chemical class 0.000 description 13
- 101000671637 Homo sapiens Upstream stimulatory factor 1 Proteins 0.000 description 11
- 102000006381 STAT1 Transcription Factor Human genes 0.000 description 11
- 108010044012 STAT1 Transcription Factor Proteins 0.000 description 11
- 102100040105 Upstream stimulatory factor 1 Human genes 0.000 description 11
- 108091035710 E-box Proteins 0.000 description 10
- 102000004127 Cytokines Human genes 0.000 description 4
- 108090000695 Cytokines Proteins 0.000 description 4
- 102000008070 Interferon-gamma Human genes 0.000 description 4
- 108010074328 Interferon-gamma Proteins 0.000 description 4
- 229940044627 gamma-interferon Drugs 0.000 description 4
- 230000004913 activation Effects 0.000 description 3
- 230000001747 exhibiting effect Effects 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 108090000204 Dipeptidase 1 Proteins 0.000 description 2
- 102100021519 Hemoglobin subunit beta Human genes 0.000 description 2
- 108091005904 Hemoglobin subunit beta Proteins 0.000 description 2
- 108060001084 Luciferase Proteins 0.000 description 2
- 239000005089 Luciferase Substances 0.000 description 2
- 102100026371 MHC class II transactivator Human genes 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 102000006635 beta-lactamase Human genes 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000013604 expression vector Substances 0.000 description 2
- 108700008625 Reporter Genes Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR98/02025 | 1998-02-19 | ||
| FR9802025A FR2775003A1 (fr) | 1998-02-19 | 1998-02-19 | Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 |
| PCT/FR1999/000376 WO1999042571A1 (fr) | 1998-02-19 | 1999-02-19 | Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002504325A JP2002504325A (ja) | 2002-02-12 |
| JP2002504325A5 true JP2002504325A5 (https=) | 2006-04-13 |
Family
ID=9523151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000532511A Pending JP2002504325A (ja) | 1998-02-19 | 1999-02-19 | 転写因子ｓｔａｔ１と転写因子ｕｓｆ１の間の結合を阻害する能力をもつ化合物のスクリーニング方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6379894B1 (https=) |
| EP (1) | EP1068310B1 (https=) |
| JP (1) | JP2002504325A (https=) |
| AU (1) | AU2431299A (https=) |
| DE (1) | DE69938450T2 (https=) |
| FR (1) | FR2775003A1 (https=) |
| WO (1) | WO1999042571A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10148886A1 (de) | 2001-10-04 | 2003-04-30 | Avontec Gmbh | Inhibition von STAT-1 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5976835A (en) * | 1992-03-19 | 1999-11-02 | The Rockefeller University | Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof |
| DE69429608T2 (de) | 1993-08-26 | 2002-09-12 | Novimmune Sa, Genf/Geneve | MHC-Klasse-II Transaktivator (CIITA) und dessen Anwendungen |
| US5463023A (en) * | 1993-10-22 | 1995-10-31 | Washington University | Composition for inhibition of intracellular transcription |
| JPH09511908A (ja) * | 1994-04-14 | 1997-12-02 | リガンド・ファーマシューティカルズ・インコーポレイテッド | サイトカインに応答性のｄｎａ調節要素 |
| US5814517A (en) * | 1994-04-14 | 1998-09-29 | Ligand Pharmaceuticals, Inc. | DNA spacer regulatory elements responsive to cytokines and methods for their use |
| US5707803A (en) * | 1994-04-14 | 1998-01-13 | Ligand Pharmaceuticals, Inc. | DNA regulatory elements responsive to cytokines and methods for their use |
| AU2285995A (en) * | 1994-04-14 | 1995-11-10 | Ligand Pharmaceuticals Incorporated | Dna spacer regulatory elements responsive to cytokines and methods for their use |
| US5672473A (en) | 1994-08-24 | 1997-09-30 | President And Fellows Of Harvard College | Methods of identifying compounds useful for treating autoimmune diseases |
| US5643726A (en) * | 1994-11-10 | 1997-07-01 | The General Hospital Corporation | Methods for modulating transcription from the amyloid β-protein precursor (APP) promoter |
| US5716622A (en) * | 1995-01-06 | 1998-02-10 | The Rockefeller University | Functionally active regions of signal transducer and activators of transcription |
| US5821053A (en) * | 1995-02-10 | 1998-10-13 | Center For Blood Research, Inc. | LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents |
| GB9513342D0 (en) * | 1995-06-30 | 1995-09-06 | Medical Res Council | Complexes |
| ZA97476B (en) * | 1996-01-22 | 1998-07-21 | Res Dev Foundation | Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells. |
| FR2762327B1 (fr) * | 1997-04-22 | 1999-07-02 | Transgene Sa | Sequence d'acide nucleique de genes ciita, susceptibles d'etre impliquees dans le controle et la regulation de l'expression de genes codant pour des molecules mhc de type ii et leur utilisation, notamment comme medicament |
| US6207391B1 (en) * | 1998-03-31 | 2001-03-27 | Tularik Inc. | High-throughput screening assays for modulators of STAT4 and STAT6 activity |
| US6235873B1 (en) * | 1999-07-31 | 2001-05-22 | The Rockefeller University | Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes |
-
1998
- 1998-02-19 FR FR9802025A patent/FR2775003A1/fr active Pending
-
1999
- 1999-02-19 AU AU24312/99A patent/AU2431299A/en not_active Abandoned
- 1999-02-19 DE DE69938450T patent/DE69938450T2/de not_active Expired - Fee Related
- 1999-02-19 JP JP2000532511A patent/JP2002504325A/ja active Pending
- 1999-02-19 WO PCT/FR1999/000376 patent/WO1999042571A1/fr not_active Ceased
- 1999-02-19 EP EP99903787A patent/EP1068310B1/fr not_active Expired - Lifetime
-
2000
- 2000-08-18 US US09/641,999 patent/US6379894B1/en not_active Expired - Lifetime
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