JP2002504325A - 転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法 - Google Patents

転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法

Info

Publication number
JP2002504325A
JP2002504325A JP2000532511A JP2000532511A JP2002504325A JP 2002504325 A JP2002504325 A JP 2002504325A JP 2000532511 A JP2000532511 A JP 2000532511A JP 2000532511 A JP2000532511 A JP 2000532511A JP 2002504325 A JP2002504325 A JP 2002504325A
Authority
JP
Japan
Prior art keywords
polypeptide
expression
nucleic acid
acid sequence
stat1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2000532511A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002504325A5 (https=
Inventor
マック,ベルナール
Original Assignee
ノヴィミュンヌ・エス・アー
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ノヴィミュンヌ・エス・アー filed Critical ノヴィミュンヌ・エス・アー
Publication of JP2002504325A publication Critical patent/JP2002504325A/ja
Publication of JP2002504325A5 publication Critical patent/JP2002504325A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2000532511A 1998-02-19 1999-02-19 転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法 Pending JP2002504325A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR98/02025 1998-02-19
FR9802025A FR2775003A1 (fr) 1998-02-19 1998-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1
PCT/FR1999/000376 WO1999042571A1 (fr) 1998-02-19 1999-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1

Publications (2)

Publication Number Publication Date
JP2002504325A true JP2002504325A (ja) 2002-02-12
JP2002504325A5 JP2002504325A5 (https=) 2006-04-13

Family

ID=9523151

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000532511A Pending JP2002504325A (ja) 1998-02-19 1999-02-19 転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法

Country Status (7)

Country Link
US (1) US6379894B1 (https=)
EP (1) EP1068310B1 (https=)
JP (1) JP2002504325A (https=)
AU (1) AU2431299A (https=)
DE (1) DE69938450T2 (https=)
FR (1) FR2775003A1 (https=)
WO (1) WO1999042571A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148886A1 (de) 2001-10-04 2003-04-30 Avontec Gmbh Inhibition von STAT-1

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09500026A (ja) * 1994-04-14 1997-01-07 リガンド・ファーマシューティカルズ・インコーポレーテッド サイトカインに応答性のdnaスペーサー調節要素およびその使用方法
WO1997002354A1 (en) * 1995-06-30 1997-01-23 Medical Research Council INTERACTION OF p53 WITH TRANSCRIPTION FACTOR DP-1

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976835A (en) * 1992-03-19 1999-11-02 The Rockefeller University Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof
DE69429608T2 (de) 1993-08-26 2002-09-12 Novimmune Sa, Genf/Geneve MHC-Klasse-II Transaktivator (CIITA) und dessen Anwendungen
US5463023A (en) * 1993-10-22 1995-10-31 Washington University Composition for inhibition of intracellular transcription
JPH09511908A (ja) * 1994-04-14 1997-12-02 リガンド・ファーマシューティカルズ・インコーポレイテッド サイトカインに応答性のdna調節要素
US5814517A (en) * 1994-04-14 1998-09-29 Ligand Pharmaceuticals, Inc. DNA spacer regulatory elements responsive to cytokines and methods for their use
US5707803A (en) * 1994-04-14 1998-01-13 Ligand Pharmaceuticals, Inc. DNA regulatory elements responsive to cytokines and methods for their use
US5672473A (en) 1994-08-24 1997-09-30 President And Fellows Of Harvard College Methods of identifying compounds useful for treating autoimmune diseases
US5643726A (en) * 1994-11-10 1997-07-01 The General Hospital Corporation Methods for modulating transcription from the amyloid β-protein precursor (APP) promoter
US5716622A (en) * 1995-01-06 1998-02-10 The Rockefeller University Functionally active regions of signal transducer and activators of transcription
US5821053A (en) * 1995-02-10 1998-10-13 Center For Blood Research, Inc. LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
ZA97476B (en) * 1996-01-22 1998-07-21 Res Dev Foundation Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells.
FR2762327B1 (fr) * 1997-04-22 1999-07-02 Transgene Sa Sequence d'acide nucleique de genes ciita, susceptibles d'etre impliquees dans le controle et la regulation de l'expression de genes codant pour des molecules mhc de type ii et leur utilisation, notamment comme medicament
US6207391B1 (en) * 1998-03-31 2001-03-27 Tularik Inc. High-throughput screening assays for modulators of STAT4 and STAT6 activity
US6235873B1 (en) * 1999-07-31 2001-05-22 The Rockefeller University Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09500026A (ja) * 1994-04-14 1997-01-07 リガンド・ファーマシューティカルズ・インコーポレーテッド サイトカインに応答性のdnaスペーサー調節要素およびその使用方法
WO1997002354A1 (en) * 1995-06-30 1997-01-23 Medical Research Council INTERACTION OF p53 WITH TRANSCRIPTION FACTOR DP-1

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6009013765, Immunity, 19980201, Vol.8, p.157−166 *

Also Published As

Publication number Publication date
EP1068310B1 (fr) 2008-04-02
WO1999042571A1 (fr) 1999-08-26
DE69938450T2 (de) 2009-05-07
US6379894B1 (en) 2002-04-30
EP1068310A1 (fr) 2001-01-17
FR2775003A1 (fr) 1999-08-20
DE69938450D1 (de) 2008-05-15
WO1999042571A8 (fr) 1999-11-18
AU2431299A (en) 1999-09-06

Similar Documents

Publication Publication Date Title
Manna et al. Assessment of the role of activator protein-1 on transcription of the mouse steroidogenic acute regulatory protein gene
Cvekl et al. A Complex Array of Positive and Negative Elements Regulates the Chicken αΑ-Crystallin Gene: Involvement of Pax-6, USF, CREB and/or CREM, and AP-1 Proteins
Bayne et al. Increased expression of the FIGLA transcription factor is associated with primordial follicle formation in the human fetal ovary
Bucher et al. Expression of the troponin complex genes: transcriptional coactivation during myoblast differentiation and independent control in heart and skeletal muscles
US5866323A (en) Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
Oshima Werner syndrome
Gebara et al. Protein-DNA interactions associated with the onset of testisspecific expression of the mammalian Pgk-2 gene
Flink et al. Alternatively processed isoforms of cellular nucleic acid-binding protein interact with a suppressor region of the human β-myosin heavy chain gene
JP2001512698A (ja) 新規な老化因子遺伝子p23の単離
Abe et al. Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication
US20090023152A1 (en) Transcription factor MHC class II genes, substances capable of inhibiting this transcription factor and medical uses of these substances
Spicuglia et al. TCRα enhancer activation occurs via a conformational change of a pre‐assembled nucleo‐protein complex
US5840832A (en) Transcription factor regulating MHC expression, CDNA and genomic clones encoding same and retroviral expression constructs thereof
Hewetson et al. Identification of the RUSH consensus-binding site by cyclic amplification and selection of targets: demonstration that RUSH mediates the ability of prolactin to augment progesterone-dependent gene expression
Bruno et al. Upstream stimulatory factor but not c-Myc enhances transcription of the human polymeric immunoglobulin receptor gene
Proietti et al. Heregulin co-opts PR transcriptional action via Stat3 role as a coregulator to drive cancer growth
US5807740A (en) Regulators of UCP2 gene expression
Jiang et al. Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy
Higuchi et al. Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures
JP2002504325A (ja) 転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法
Reim et al. The RRM protein NonA from Drosophila forms a complex with the RRM proteins Hrb87F and S5 and the Zn finger protein PEP on hnRNA
Yang et al. Id1 induces apoptosis through inhibition of RORgammat expression
van Eggermond et al. Transcriptional silencing of RFXAP in MHC class II-deficiency
Maier et al. Identification of a distal tandem STAT6 element within the CCL17 locus
Yu et al. Characterization of the promoter of human leukocyte-specific transcript 1: a small gene with a complex pattern of alternative transcripts

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20060217

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20060217

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090331

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090618

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090625

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20090721

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20090728

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20091006

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091221

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20100104

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100406