FR2775003A1 - Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 - Google Patents

Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 Download PDF

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Publication number
FR2775003A1
FR2775003A1 FR9802025A FR9802025A FR2775003A1 FR 2775003 A1 FR2775003 A1 FR 2775003A1 FR 9802025 A FR9802025 A FR 9802025A FR 9802025 A FR9802025 A FR 9802025A FR 2775003 A1 FR2775003 A1 FR 2775003A1
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FR
France
Prior art keywords
expression
nucleic acid
polypeptide
acid sequence
stat1
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
FR9802025A
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English (en)
French (fr)
Inventor
Bernard Mach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Priority to FR9802025A priority Critical patent/FR2775003A1/fr
Priority to EP99903787A priority patent/EP1068310B1/fr
Priority to DE69938450T priority patent/DE69938450T2/de
Priority to AU24312/99A priority patent/AU2431299A/en
Priority to JP2000532511A priority patent/JP2002504325A/ja
Priority to PCT/FR1999/000376 priority patent/WO1999042571A1/fr
Publication of FR2775003A1 publication Critical patent/FR2775003A1/fr
Priority to US09/641,999 priority patent/US6379894B1/en
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
FR9802025A 1998-02-19 1998-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1 Pending FR2775003A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR9802025A FR2775003A1 (fr) 1998-02-19 1998-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1
EP99903787A EP1068310B1 (fr) 1998-02-19 1999-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1
DE69938450T DE69938450T2 (de) 1998-02-19 1999-02-19 Verfahren zum auffinden von verbindungen, die die bindung zwischen den transkriptionsfaktoren stat1 und usf1 hemmen
AU24312/99A AU2431299A (en) 1998-02-19 1999-02-19 Method for screening compounds capable of inhibiting fixing between the transcription factor of stat1 and the transcription factor of usf1
JP2000532511A JP2002504325A (ja) 1998-02-19 1999-02-19 転写因子stat1と転写因子usf1の間の結合を阻害する能力をもつ化合物のスクリーニング方法
PCT/FR1999/000376 WO1999042571A1 (fr) 1998-02-19 1999-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1
US09/641,999 US6379894B1 (en) 1998-02-19 2000-08-18 Method for screening compounds capable of inhibiting binding between the transcription factor of STAT1 and the transcription factor of USF1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9802025A FR2775003A1 (fr) 1998-02-19 1998-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1

Publications (1)

Publication Number Publication Date
FR2775003A1 true FR2775003A1 (fr) 1999-08-20

Family

ID=9523151

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9802025A Pending FR2775003A1 (fr) 1998-02-19 1998-02-19 Methode de criblage de composes capables d'inhiber la fixation entre le facteur de transcription stat1 et le facteur de transcription usf1

Country Status (7)

Country Link
US (1) US6379894B1 (https=)
EP (1) EP1068310B1 (https=)
JP (1) JP2002504325A (https=)
AU (1) AU2431299A (https=)
DE (1) DE69938450T2 (https=)
FR (1) FR2775003A1 (https=)
WO (1) WO1999042571A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10148886A1 (de) 2001-10-04 2003-04-30 Avontec Gmbh Inhibition von STAT-1

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028492A1 (en) * 1994-04-14 1995-10-26 Ligand Pharmaceuticals Incorporated Dna regulatory elements responsive to cytokines
WO1995028482A2 (en) * 1994-04-14 1995-10-26 Ligand Pharmaceuticals Incorporated Dna spacer regulatory elements responsive to cytokines and methods for their use
WO1996015265A1 (en) * 1994-11-10 1996-05-23 The General Hospital Corporation METHODS FOR MODULATING TRANSCRIPTION FROM THE AMYLOID β-PROTEIN PRECURSOR (APP) PROMOTER
EP0874049A1 (fr) * 1997-04-22 1998-10-28 Transgene S.A. Sequences d'acide nucléique de genes CIITA

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5976835A (en) * 1992-03-19 1999-11-02 The Rockefeller University Nucleic acids encoding receptor recognition factor Stat1α and Stat1β, and methods of use thereof
DE69429608T2 (de) 1993-08-26 2002-09-12 Novimmune Sa, Genf/Geneve MHC-Klasse-II Transaktivator (CIITA) und dessen Anwendungen
US5463023A (en) * 1993-10-22 1995-10-31 Washington University Composition for inhibition of intracellular transcription
US5814517A (en) * 1994-04-14 1998-09-29 Ligand Pharmaceuticals, Inc. DNA spacer regulatory elements responsive to cytokines and methods for their use
US5707803A (en) * 1994-04-14 1998-01-13 Ligand Pharmaceuticals, Inc. DNA regulatory elements responsive to cytokines and methods for their use
US5672473A (en) 1994-08-24 1997-09-30 President And Fellows Of Harvard College Methods of identifying compounds useful for treating autoimmune diseases
US5716622A (en) * 1995-01-06 1998-02-10 The Rockefeller University Functionally active regions of signal transducer and activators of transcription
US5821053A (en) * 1995-02-10 1998-10-13 Center For Blood Research, Inc. LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents
GB9513342D0 (en) * 1995-06-30 1995-09-06 Medical Res Council Complexes
ZA97476B (en) * 1996-01-22 1998-07-21 Res Dev Foundation Novel methods for the characterization of compounds which stimulate STF-1 expression in pancreatic islet cells.
US6207391B1 (en) * 1998-03-31 2001-03-27 Tularik Inc. High-throughput screening assays for modulators of STAT4 and STAT6 activity
US6235873B1 (en) * 1999-07-31 2001-05-22 The Rockefeller University Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995028492A1 (en) * 1994-04-14 1995-10-26 Ligand Pharmaceuticals Incorporated Dna regulatory elements responsive to cytokines
WO1995028482A2 (en) * 1994-04-14 1995-10-26 Ligand Pharmaceuticals Incorporated Dna spacer regulatory elements responsive to cytokines and methods for their use
WO1996015265A1 (en) * 1994-11-10 1996-05-23 The General Hospital Corporation METHODS FOR MODULATING TRANSCRIPTION FROM THE AMYLOID β-PROTEIN PRECURSOR (APP) PROMOTER
EP0874049A1 (fr) * 1997-04-22 1998-10-28 Transgene S.A. Sequences d'acide nucléique de genes CIITA

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
LENNON A -M ET AL: "ISOLATION OF A B-CELL-SPECIFIC PROMOTER FOR THE HUMAN CLASS II TRANSACTIVATOR", IMMUNOGENETICS, vol. 45, no. 4, 1997, pages 266 - 273, XP002051562 *
MUHLETHALER-MOTTET A ET AL: "Activation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF -1.", IMMUNITY, (1998 FEB) 8 (2) 157-66., XP002083358 *
MUHLETHALER-MOTTET A ET AL: "EXPRESSION OF MHC CLASS II MOLECULES IN DIFFERENT CELLULAR AND FUNCTIONAL COMPARTMENTS IS CONTROLLED BY DIFFERENTIAL USAGE OF MULTIPLE PROMOTORS OF THE TRANSACTIVATOR CIITA", EMBO JOURNAL, vol. 16, no. 10, 15 May 1997 (1997-05-15), pages 2851 - 2860, XP002051561 *
PISKURICH J F ET AL: "IDENTIFICATION OF DINSTINCT REGIONS OF 5' FLANKING DNA THAT MEDIATE CONSTITUTIVE, IFN-GAMMA, STAT1, AND TNF-BETA-REGULATED EXPRESSION OF THE CLASS II TRANSACTIVATOR GENE", JOURNAL OF IMMUNOLOGY, vol. 160, no. 1, January 1998 (1998-01-01), pages 233 - 240, XP002073465 *

Also Published As

Publication number Publication date
EP1068310B1 (fr) 2008-04-02
WO1999042571A1 (fr) 1999-08-26
DE69938450T2 (de) 2009-05-07
US6379894B1 (en) 2002-04-30
JP2002504325A (ja) 2002-02-12
EP1068310A1 (fr) 2001-01-17
DE69938450D1 (de) 2008-05-15
WO1999042571A8 (fr) 1999-11-18
AU2431299A (en) 1999-09-06

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