JP2002503228A5 - - Google Patents

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Publication number
JP2002503228A5
JP2002503228A5 JP1998550697A JP55069798A JP2002503228A5 JP 2002503228 A5 JP2002503228 A5 JP 2002503228A5 JP 1998550697 A JP1998550697 A JP 1998550697A JP 55069798 A JP55069798 A JP 55069798A JP 2002503228 A5 JP2002503228 A5 JP 2002503228A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1998550697A
Other languages
English (en)
Japanese (ja)
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JP2002503228A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US1998/010535 external-priority patent/WO1998052925A1/en
Publication of JP2002503228A publication Critical patent/JP2002503228A/ja
Publication of JP2002503228A5 publication Critical patent/JP2002503228A5/ja
Ceased legal-status Critical Current

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JP55069798A 1997-05-22 1998-05-22 デュオカルマイシンおよびcc−1065の類似体 Ceased JP2002503228A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4850597P 1997-05-22 1997-05-22
US60/048,505 1997-05-22
PCT/US1998/010535 WO1998052925A1 (en) 1997-05-22 1998-05-22 Analogs of duocarmycin and cc-1065

Publications (2)

Publication Number Publication Date
JP2002503228A JP2002503228A (ja) 2002-01-29
JP2002503228A5 true JP2002503228A5 (cg-RX-API-DMAC7.html) 2005-12-08

Family

ID=21954939

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55069798A Ceased JP2002503228A (ja) 1997-05-22 1998-05-22 デュオカルマイシンおよびcc−1065の類似体

Country Status (9)

Country Link
US (1) US6281354B1 (cg-RX-API-DMAC7.html)
EP (1) EP0983248B1 (cg-RX-API-DMAC7.html)
JP (1) JP2002503228A (cg-RX-API-DMAC7.html)
AT (1) ATE271041T1 (cg-RX-API-DMAC7.html)
AU (1) AU754083B2 (cg-RX-API-DMAC7.html)
CA (1) CA2290789A1 (cg-RX-API-DMAC7.html)
DE (1) DE69825048D1 (cg-RX-API-DMAC7.html)
NZ (1) NZ500789A (cg-RX-API-DMAC7.html)
WO (1) WO1998052925A1 (cg-RX-API-DMAC7.html)

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MXPA03011094A (es) 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
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WO2004035571A1 (en) * 2002-10-15 2004-04-29 Rigel Pharmaceuticals, Inc. Substituted indoles and their use as hcv inhibitors
AU2003287270A1 (en) * 2002-11-14 2004-06-03 The Scripps Research Institute PURIFIED COMPOUNDS THAT INHIBIT INTRACELLULAR Alpha4/PAXILLIN BINDING
CN100519555C (zh) * 2004-03-13 2009-07-29 Tmrc株式会社 将dna的特定碱基序列烷基化的新吲哚衍生物和使用其的烷基化剂以及药剂
CA2564076C (en) 2004-05-19 2014-02-18 Medarex, Inc. Chemical linkers and conjugates thereof
RU2402548C2 (ru) * 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
US7714016B2 (en) * 2005-04-08 2010-05-11 Medarex, Inc. Cytotoxic compounds and conjugates with cleavable substrates
CN101312748A (zh) * 2005-09-26 2008-11-26 梅达莱克斯公司 抗体-药物轭合物和使用方法
NZ566395A (en) 2005-09-26 2012-03-30 Medarex Inc Human monoclonal antibodies to CD70
PT1940789E (pt) 2005-10-26 2012-02-01 Medarex Inc Métodos e compostos para preparar análogos cc-1065
CA2627190A1 (en) 2005-11-10 2007-05-24 Medarex, Inc. Duocarmycin derivatives as novel cytotoxic compounds and conjugates
WO2007067992A2 (en) 2005-12-08 2007-06-14 Medarex, Inc. Human monoclonal antibodies to fucosyl-gm1 and methods for using anti-fucosyl-gm1
WO2007067730A2 (en) 2005-12-08 2007-06-14 Medarex, Inc. Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use
US20090175886A1 (en) 2006-01-17 2009-07-09 Medarex, Inc. Monoclonal antibodies against cd30 lacking in fucosyl and xylosyl residues
AU2007292890A1 (en) 2006-09-05 2008-03-13 Medarex, Inc. Antibodies to bone morphogenic proteins and receptors therefor and methods for their use
CA2671457C (en) 2006-12-01 2017-09-26 Medarex, Inc. Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
WO2008074004A2 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
US9090693B2 (en) 2007-01-25 2015-07-28 Dana-Farber Cancer Institute Use of anti-EGFR antibodies in treatment of EGFR mutant mediated disease
CA2678514A1 (en) 2007-02-21 2008-08-28 Medarex, Inc. Chemical linkers with single amino acids and conjugates thereof
CN101688229B (zh) 2007-03-15 2013-06-12 路德维格癌症研究所 包含egfr抗体和src抑制剂的组合物及其在制备用于治疗哺乳动物癌症的药物中的用途
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
CN101896503B (zh) 2007-08-14 2018-05-22 路德维格癌症研究所有限公司 靶向egf受体的单克隆抗体175及其衍生物和用途
RU2562232C2 (ru) 2008-11-03 2015-09-10 Синтарга Б.В. Новые аналоги сс-1065 и их конъюгаты
AU2010221186B2 (en) 2009-03-05 2013-08-22 E. R. Squibb & Sons, L.L.C. Fully human antibodies specific to CADM1
NZ616382A (en) 2009-04-20 2015-04-24 Oxford Biotherapeutics Ltd Antibodies specific to cadherin-17
EP2470569A1 (en) 2009-10-13 2012-07-04 Oxford Biotherapeutics Ltd. Antibodies against epha10
CN102933231B (zh) 2010-02-10 2015-07-29 伊缪诺金公司 Cd20抗体及其用途
PT3056203T (pt) 2010-04-21 2018-02-15 Syntarga Bv Conjugados de análogos de cc-1065 e ligantes bifuncionais
CN103649121B (zh) 2011-06-28 2016-10-19 牛津生物疗法有限公司 针对adp-核糖基环化酶2的抗体
EP2922818B1 (en) 2012-11-24 2018-09-05 Hangzhou Dac Biotech Co., Ltd Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
RU2015129800A (ru) 2012-12-21 2017-01-30 Биоэллаенс К. В. Гидрофильные саморазрушающиеся линкеры и их конъюгаты
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
JP6419844B2 (ja) 2014-01-10 2018-11-07 シントン・バイオファーマシューティカルズ・ビー.ブイ.Synthon Biopharmaceuticals B.V. Cys連結された抗体−薬物コンジュゲートの精製方法
WO2015127685A1 (en) 2014-02-28 2015-09-03 Hangzhou Dac Biotech Co., Ltd Charged linkers and their uses for conjugation
US9950077B2 (en) 2014-06-20 2018-04-24 Bioalliance C.V. Anti-folate receptor alpha (FRA) antibody-drug conjugates and methods of using thereof
CA2991973C (en) 2015-07-12 2021-12-07 Suzhou M-Conj Biotech Co., Ltd. Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
MX395252B (es) 2016-01-08 2025-03-25 Altrubio Inc Anticuerpos tetravalentes anti ligando-1 de glicoproteina p-selectina (psgl-1) y usos de estos.
EP3500574B1 (en) 2016-08-19 2021-11-24 Bristol-Myers Squibb Company Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use
WO2018064094A1 (en) 2016-09-28 2018-04-05 Bristol-Myers Squibb Company Enantioselective synthesis of pyrroloindole compounds
KR102345175B1 (ko) 2016-11-14 2021-12-31 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
AU2021362997A1 (en) 2021-11-03 2024-05-16 Hangzhou Dac Biotech Co., Ltd. Specific conjugation of an antibody

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CA1238907A (en) * 1984-02-21 1988-07-05 Robert C. Kelly 1,2,8,8a-tetrahydrocyclopropa¬c|pyrrolo(3,2-e)- indol-4(5h)-ones and related compounds
US5084468A (en) * 1988-08-11 1992-01-28 Kyowa Hakko Kogyo Co., Ltd. Dc-88a derivatives
US5008271A (en) * 1988-10-21 1991-04-16 Kyowa Hakko Kogyo Co., Ltd. DC-88A derivatives
US5214065A (en) * 1990-06-11 1993-05-25 Kyowa Hakko Kogyo Co., Ltd. Dc-89 derivatives
AU3217897A (en) * 1996-05-31 1998-01-05 Scripps Research Institute, The Analogs of cc-1065 and the duocarmycins

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