JP2002501885A - 微粒子吸入用製剤 - Google Patents
微粒子吸入用製剤Info
- Publication number
- JP2002501885A JP2002501885A JP2000529227A JP2000529227A JP2002501885A JP 2002501885 A JP2002501885 A JP 2002501885A JP 2000529227 A JP2000529227 A JP 2000529227A JP 2000529227 A JP2000529227 A JP 2000529227A JP 2002501885 A JP2002501885 A JP 2002501885A
- Authority
- JP
- Japan
- Prior art keywords
- drug
- surfactant
- formulation
- aerosol
- propellant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
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- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/797—Lipid particle
- Y10S977/798—Lipid particle having internalized material
- Y10S977/799—Containing biological material
- Y10S977/801—Drug
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/016,265 | 1998-01-30 | ||
| US09/016,265 US6086376A (en) | 1998-01-30 | 1998-01-30 | Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant |
| PCT/US1998/027922 WO1999038493A1 (en) | 1998-01-30 | 1998-12-30 | Microparticle inhalation formulations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010128713A Division JP2010248206A (ja) | 1998-01-30 | 2010-06-04 | 微粒子吸入用製剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002501885A true JP2002501885A (ja) | 2002-01-22 |
| JP2002501885A5 JP2002501885A5 (cg-RX-API-DMAC7.html) | 2006-02-23 |
Family
ID=21776235
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000529227A Withdrawn JP2002501885A (ja) | 1998-01-30 | 1998-12-30 | 微粒子吸入用製剤 |
| JP2010128713A Pending JP2010248206A (ja) | 1998-01-30 | 2010-06-04 | 微粒子吸入用製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010128713A Pending JP2010248206A (ja) | 1998-01-30 | 2010-06-04 | 微粒子吸入用製剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6086376A (cg-RX-API-DMAC7.html) |
| EP (1) | EP1051154A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2002501885A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20010040402A (cg-RX-API-DMAC7.html) |
| CN (1) | CN1155367C (cg-RX-API-DMAC7.html) |
| AU (1) | AU756464B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2319100C (cg-RX-API-DMAC7.html) |
| IL (1) | IL137472A (cg-RX-API-DMAC7.html) |
| SE (1) | SE0002643L (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999038493A1 (cg-RX-API-DMAC7.html) |
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| US6465016B2 (en) * | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20020017295A1 (en) * | 2000-07-07 | 2002-02-14 | Weers Jeffry G. | Phospholipid-based powders for inhalation |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| WO1999061001A1 (en) | 1998-05-29 | 1999-12-02 | Rtp Pharma Inc. | Thermoprotected microparticle compositions and process for terminal steam sterilization thereof |
| ES2211151T3 (es) | 1998-08-19 | 2004-07-01 | Skyepharma Canada Inc. | Dispersiones acuosas inyectables de propofol. |
| MA25590A1 (fr) * | 1998-09-14 | 2002-12-31 | Inhale Therapeutic Syst | Agent actif de delivraison de poudre seche |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| SK288117B6 (sk) | 1998-11-20 | 2013-09-03 | Skyepharma Canada Inc. | Rapidly dispersing solid dry therapeutic dosage form |
| US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
| WO2001021154A2 (en) * | 1999-09-21 | 2001-03-29 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
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| US20030096013A1 (en) * | 2000-12-22 | 2003-05-22 | Jane Werling | Preparation of submicron sized particles with polymorph control |
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| US10874683B2 (en) * | 2016-03-10 | 2020-12-29 | Emory University | N4-hydroxycytidine and derivatives and anti-viral uses related thereto |
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| US10315836B2 (en) * | 2017-10-19 | 2019-06-11 | Matthew James ZABLOSKI | Methods, uses, and apparatus for presenting and storing objects |
| ES2995458T3 (en) | 2017-12-07 | 2025-02-10 | Univ Emory | N4-hydroxycytidine derivative and anti-viral uses related thereto |
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- 1998-12-30 AU AU20244/99A patent/AU756464B2/en not_active Ceased
- 1998-12-30 CA CA002319100A patent/CA2319100C/en not_active Expired - Fee Related
- 1998-12-30 CN CNB988133849A patent/CN1155367C/zh not_active Expired - Fee Related
- 1998-12-30 WO PCT/US1998/027922 patent/WO1999038493A1/en not_active Ceased
- 1998-12-30 IL IL13747298A patent/IL137472A/xx not_active IP Right Cessation
- 1998-12-30 EP EP98965051A patent/EP1051154A1/en not_active Ceased
- 1998-12-30 KR KR1020007008094A patent/KR20010040402A/ko not_active Ceased
-
2000
- 2000-07-13 SE SE0002643A patent/SE0002643L/xx not_active Application Discontinuation
-
2010
- 2010-06-04 JP JP2010128713A patent/JP2010248206A/ja active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1991004011A1 (en) * | 1989-09-20 | 1991-04-04 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| WO1991011495A1 (de) * | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| EP0535567A1 (de) * | 1991-10-01 | 1993-04-07 | B. Braun Melsungen AG | Flüchtige Inhalationsnarkotika enthaltende Liposomen, ihre Herstellung und Verwendung |
| WO1993015741A1 (en) * | 1992-02-06 | 1993-08-19 | Glaxo Group Limited | Medicaments |
| US5492688A (en) * | 1993-04-28 | 1996-02-20 | The Center For Innovative Technology | Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent |
| EP0634166A1 (de) * | 1993-07-15 | 1995-01-18 | Hoechst Aktiengesellschaft | Arzneistoffzubereitungen aus umhüllten, schwerstwasserlöslichen Arzneistoffen für Inhalationsarzneiformen und Verfahren zu ihrer Herstellung |
| WO1996018384A1 (en) * | 1994-12-10 | 1996-06-20 | Glaxo Group Limited | Propellant mixture for aerosol formulation |
| WO1996019198A1 (en) * | 1994-12-22 | 1996-06-27 | Astra Aktiebolag | Aerosol drug formulations |
| WO1996019197A1 (en) * | 1994-12-22 | 1996-06-27 | Astra Aktiebolag | Aerosol formulations of peptides and proteins |
| WO1997044012A1 (en) * | 1996-05-17 | 1997-11-27 | Andaris Limited | Formulation comprising microparticles, for inhalation |
Also Published As
| Publication number | Publication date |
|---|---|
| IL137472A (en) | 2005-08-31 |
| WO1999038493A1 (en) | 1999-08-05 |
| IL137472A0 (en) | 2001-07-24 |
| KR20010040402A (ko) | 2001-05-15 |
| CN1155367C (zh) | 2004-06-30 |
| SE0002643L (sv) | 2000-09-04 |
| JP2010248206A (ja) | 2010-11-04 |
| US6086376A (en) | 2000-07-11 |
| AU2024499A (en) | 1999-08-16 |
| CA2319100A1 (en) | 1999-08-05 |
| EP1051154A1 (en) | 2000-11-15 |
| AU756464B2 (en) | 2003-01-16 |
| SE0002643D0 (sv) | 2000-07-13 |
| CN1283989A (zh) | 2001-02-14 |
| CA2319100C (en) | 2008-05-27 |
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