|
US7244577B2
(en)
*
|
1997-04-15 |
2007-07-17 |
Merck & Co., Inc. |
Method of screening for modulator of LRP5 activity
|
|
US6770461B1
(en)
|
1998-10-23 |
2004-08-03 |
Genome Therapeutics Corporation |
High bone mass gene of 11q13.3
|
|
US6780609B1
(en)
*
|
1998-10-23 |
2004-08-24 |
Genome Therapeutics Corporation |
High bone mass gene of 1.1q13.3
|
|
US6699466B1
(en)
*
|
1999-08-05 |
2004-03-02 |
Research Corporation Technologies, Inc. |
IL-16 antagonist peptides and DNA encoding the peptides
|
|
FR2798138B1
(fr)
*
|
1999-09-03 |
2004-05-21 |
Centre Nat Rech Scient |
Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante
|
|
JP2004515209A
(ja)
*
|
2000-04-05 |
2004-05-27 |
ゲノム セラピューティックス コーポレーション |
１１ｑ１３．３の高骨量遺伝子
|
|
NZ522600A
(en)
*
|
2000-05-26 |
2004-09-24 |
Genome Therapeutics Corp |
Regulating lipid levels via the Zmax1 or HBM gene
|
|
US7179462B2
(en)
|
2000-06-02 |
2007-02-20 |
University Of Connecticut Health Center |
α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof
|
|
US7449557B2
(en)
|
2000-06-02 |
2008-11-11 |
University Of Connecticut Health Center |
Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy
|
|
US7186515B1
(en)
|
2000-06-02 |
2007-03-06 |
University Of Connecticut Health Center |
Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof
|
|
JP2004507236A
(ja)
*
|
2000-08-18 |
2004-03-11 |
プロスケリア |
骨粗鬆症の診断および治療に有用な調節遺伝子および系
|
|
AU2002250143A1
(en)
*
|
2001-03-16 |
2002-10-03 |
Eli Lilly And Company |
Lp mammalian proteins; related reagents
|
|
BR0209563A
(pt)
*
|
2001-05-11 |
2004-12-07 |
Genome Theraupeutics Corp |
ácido nucleico, polipeptìdeo, vetor, célula, anticorpo, métodos de diagnosticar um fenótipo e um paciente como expressando um ácido nucleico e de identificar agentes que modulam a atividade de um ácido nucleico e de uma proteìna e lrp5, lrp6, ou hbm e compostos que modulam a interação de dkk com o caminho de sinalização wnt, composição para modular a massa óssea e/ou os nìveis de lipìdeo em um paciente, animal transgênico, embrião e modelo de animal, e, agente
|
|
US7514594B2
(en)
|
2001-05-11 |
2009-04-07 |
Wyeth |
Transgenic animal model of bone mass modulation
|
|
US20040221326A1
(en)
*
|
2001-05-11 |
2004-11-04 |
Philip Babij |
Transgenic animal model of bone mass modulation
|
|
EP1395285A4
(en)
*
|
2001-05-17 |
2005-06-01 |
Genome Therapeutics Corp |
REAGENTS AND METHODS FOR MODULATING DKK-MEDIATED INTERACTIONS
|
|
US20040038860A1
(en)
|
2002-05-17 |
2004-02-26 |
Allen Kristina M. |
Reagents and methods for modulating dkk-mediated interactions
|
|
HK1079705A1
(zh)
|
2001-08-20 |
2006-04-13 |
University Of Connecticut Health Center |
包含用於治疗癌症及感染性疾病的热休克蛋白或α2-巨球蛋白的组合物制备方法
|
|
GB2381790A
(en)
*
|
2001-09-26 |
2003-05-14 |
Glaxo Group Ltd |
LDL-receptor polypeptides
|
|
JP2005220022A
(ja)
*
|
2002-03-08 |
2005-08-18 |
Anges Mg Inc |
Ｗｎｔの新規作用、及び、疾患治療への応用
|
|
US7169559B2
(en)
*
|
2002-05-13 |
2007-01-30 |
Fonterra Corporate Research and Development Ltd. |
LDL receptor-related proteins 1 and 2 and treatment of bone or cartilage conditions
|
|
US20030219793A1
(en)
*
|
2002-10-04 |
2003-11-27 |
Carulli John P. |
High bone mass gene of 11q13.3
|
|
US7622553B2
(en)
|
2003-11-17 |
2009-11-24 |
Merck & Co., Inc. |
Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof
|
|
US7473770B2
(en)
|
2003-11-17 |
2009-01-06 |
Merck & Co., Inc. |
Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof
|
|
WO2005048913A2
(en)
*
|
2003-11-24 |
2005-06-02 |
Gunnar Westin |
Mutant lrp5/6 wnt-signaling receptors in cancer diagnosis, prognosis and treatment
|
|
SG185416A1
(en)
|
2010-05-06 |
2012-12-28 |
Novartis Ag |
Compositions and methods of use for therapeutic low density lipoprotein -related protein 6 (lrp6) antibodies
|
|
MX2012012927A
(es)
|
2010-05-06 |
2013-05-01 |
Novartis Ag |
Composiciones y metodos de uso para anticuerpos multivalentes terapeuticos de proteina relacionada con lipoproteina de baja densidad 6 (lrp6).
|
|
US8883735B2
(en)
|
2011-11-04 |
2014-11-11 |
Novartis Ag |
Low density lipoprotein-related protein 6 (LRP6)-half life extender constructs
|
|
US11033636B2
(en)
|
2017-05-31 |
2021-06-15 |
Boehringer Ingelheim International Gmbh |
Polypeptides antagonizing Wnt signaling in tumor cells
|