JP4271735B2 - 新規のｌｄｌ−レセプター - Google Patents
新規のｌｄｌ−レセプター Download PDFInfo
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- JP4271735B2 JP4271735B2 JP54363598A JP54363598A JP4271735B2 JP 4271735 B2 JP4271735 B2 JP 4271735B2 JP 54363598 A JP54363598 A JP 54363598A JP 54363598 A JP54363598 A JP 54363598A JP 4271735 B2 JP4271735 B2 JP 4271735B2
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- lrp5
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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| US7244577B2 (en) * | 1997-04-15 | 2007-07-17 | Merck & Co., Inc. | Method of screening for modulator of LRP5 activity |
| US6780609B1 (en) | 1998-10-23 | 2004-08-24 | Genome Therapeutics Corporation | High bone mass gene of 1.1q13.3 |
| US6770461B1 (en) | 1998-10-23 | 2004-08-03 | Genome Therapeutics Corporation | High bone mass gene of 11q13.3 |
| US6699466B1 (en) * | 1999-08-05 | 2004-03-02 | Research Corporation Technologies, Inc. | IL-16 antagonist peptides and DNA encoding the peptides |
| FR2798138B1 (fr) * | 1999-09-03 | 2004-05-21 | Centre Nat Rech Scient | Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante |
| BR0017197A (pt) * | 2000-04-05 | 2003-01-14 | Genome Therapeutics Corp | Sequência de ácido nucleico, sequência de aminoácido, vetor de clonagem replicativo, célula hospedeira isolada vetor de expressão, métodos para testar uma substância como um agente terapêutico para modulação óssea em um hospedeiro, para identificar uma molécula e uma proteìna candidata envolvidas na modulação óssea, para testar quanto a atividade de hbm, para desenvolvimento farmacêutico para o tratamento de distúrbios do desenvolvimento ósseo, para tratar um distúrbio do desenvolvimento ósseo em um animal, para alterar o desenvolvimento ósseo em um hospedeiro, para tratar a osteoporose, para avaliar diagnóstico para uma predisposição genética a um distúrbio do desenvolvimento ósseo, para identificar uma predisposição genética para distúrbios do desenvolvimento ósseo, para expressar a proteìna de hbm em tecido ósseo, para amplificar um polimorfismo de nucleotìdeo, para identificar um elemento regulador de um gene de hbm e para modular densidade óssea em um paciente, ensaio de diagnóstico para distúrbios do desenvolvimento ósseo, cromossoma artificial bacteriano, segmento de ácido nucleico isolado, ácido nucleico, e, polipeptìdeo. |
| ES2290155T3 (es) * | 2000-05-26 | 2008-02-16 | Oscient Pharmaceuticals Corporation | Regulacion de las tasas lipidicas por mediacion del gen zmax1 y del gen hbm. |
| WO2001091787A1 (en) | 2000-06-02 | 2001-12-06 | University Of Connecticut Health Center | Complexes of alpha (2) macroglobulin and antigenic molecules for immunotherapy |
| US7186515B1 (en) | 2000-06-02 | 2007-03-06 | University Of Connecticut Health Center | Alpha(2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
| US7179462B2 (en) | 2000-06-02 | 2007-02-20 | University Of Connecticut Health Center | α (2) macroglobulin receptor as a heat shock protein receptor and uses thereof |
| IL154473A0 (en) * | 2000-08-18 | 2003-09-17 | Proskelia | Regulator gene and system useful for the diagnosis and therapy of osteoporosis |
| EP1434783A4 (en) * | 2001-03-16 | 2006-06-07 | Lilly Co Eli | LP-mammalian proteins; RELATED REAGENTS |
| US7514594B2 (en) * | 2001-05-11 | 2009-04-07 | Wyeth | Transgenic animal model of bone mass modulation |
| US20040221326A1 (en) * | 2001-05-11 | 2004-11-04 | Philip Babij | Transgenic animal model of bone mass modulation |
| EP1483288A4 (en) * | 2001-05-11 | 2005-09-21 | Genome Therapeutics Corp | HBM VARIANTS MODULATING BONE MASS AND LIPID LEVELS |
| EP1395285A4 (en) * | 2001-05-17 | 2005-06-01 | Genome Therapeutics Corp | REAGENTS AND METHODS FOR MODULATING DKK-MEDIATED INTERACTIONS |
| US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
| WO2003015712A2 (en) | 2001-08-20 | 2003-02-27 | University Of Connecticut Health Center | Methods for preparing compositions comprising heat shock proteins or alpha-2-macroglobulin |
| GB2381790A (en) * | 2001-09-26 | 2003-05-14 | Glaxo Group Ltd | LDL-receptor polypeptides |
| JP2005220022A (ja) * | 2002-03-08 | 2005-08-18 | Anges Mg Inc | Ｗｎｔの新規作用、及び、疾患治療への応用 |
| US7169559B2 (en) * | 2002-05-13 | 2007-01-30 | Fonterra Corporate Research and Development Ltd. | LDL receptor-related proteins 1 and 2 and treatment of bone or cartilage conditions |
| US20030219793A1 (en) * | 2002-10-04 | 2003-11-27 | Carulli John P. | High bone mass gene of 11q13.3 |
| WO2005049640A2 (en) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Rhesus monkey dickkopf-1, nucleotides encoding same, and uses thereof |
| US7473770B2 (en) | 2003-11-17 | 2009-01-06 | Merck & Co., Inc. | Cynomolgus monkey dickkopf-4, nucleotides encoding same, and uses thereof |
| EP1692167A2 (en) * | 2003-11-24 | 2006-08-23 | Gunnar Westin | Mutant lrp5/6 wnt-signaling receptors in cancer diagnosis, prognosis and treatment |
| CA2798390A1 (en) | 2010-05-06 | 2011-11-10 | Novartis Ag | Compositions and methods of use for therapeutic low density lipoprotein - related protein 6 (lrp6) multivalent antibodies |
| EP2566892B1 (en) | 2010-05-06 | 2017-12-20 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| EP3290442A1 (en) | 2011-11-04 | 2018-03-07 | Novartis AG | Low density lipoprotein-related protein 6 (lrp6) half-life extender constructs |
| MA48760A (fr) | 2017-05-31 | 2020-04-08 | Boehringer Ingelheim Int | Polypeptides ayant un effet antagoniste sur la signalisation wnt dans des cellules tumorales |
Family Cites Families (6)
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| US5474796A (en) * | 1991-09-04 | 1995-12-12 | Protogene Laboratories, Inc. | Method and apparatus for conducting an array of chemical reactions on a support surface |
| US5635177A (en) * | 1992-01-22 | 1997-06-03 | Genentech, Inc. | Protein tyrosine kinase agonist antibodies |
| AU1173995A (en) * | 1993-11-10 | 1995-05-29 | Arch Development Corporation | Ubiquitous nuclear receptor: compositions and methods |
| EP0758403B1 (en) * | 1994-05-05 | 1998-06-24 | Beckman Instruments, Inc. | Oligonucleotide repeat arrays |
| JPH11508263A (ja) * | 1995-06-23 | 1999-07-21 | ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ，アズ リプレゼンテッド バイ ザ セクレタリー デパートメント オブ ヘルス アンド ヒューマン サービシーズ | アグーチシグナルタンパク質およびそのペプチドの脱色活性 |
| BR0017197A (pt) | 2000-04-05 | 2003-01-14 | Genome Therapeutics Corp | Sequência de ácido nucleico, sequência de aminoácido, vetor de clonagem replicativo, célula hospedeira isolada vetor de expressão, métodos para testar uma substância como um agente terapêutico para modulação óssea em um hospedeiro, para identificar uma molécula e uma proteìna candidata envolvidas na modulação óssea, para testar quanto a atividade de hbm, para desenvolvimento farmacêutico para o tratamento de distúrbios do desenvolvimento ósseo, para tratar um distúrbio do desenvolvimento ósseo em um animal, para alterar o desenvolvimento ósseo em um hospedeiro, para tratar a osteoporose, para avaliar diagnóstico para uma predisposição genética a um distúrbio do desenvolvimento ósseo, para identificar uma predisposição genética para distúrbios do desenvolvimento ósseo, para expressar a proteìna de hbm em tecido ósseo, para amplificar um polimorfismo de nucleotìdeo, para identificar um elemento regulador de um gene de hbm e para modular densidade óssea em um paciente, ensaio de diagnóstico para distúrbios do desenvolvimento ósseo, cromossoma artificial bacteriano, segmento de ácido nucleico isolado, ácido nucleico, e, polipeptìdeo. |
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| EP0988379A1 (en) | 2000-03-29 |
| WO1998046743A1 (en) | 1998-10-22 |
| US6545137B1 (en) | 2003-04-08 |
| JP2002501376A (ja) | 2002-01-15 |
| EP0988379B1 (en) | 2007-04-11 |
| ES2285767T3 (es) | 2007-11-16 |
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