JP2002501085A5 - - Google Patents
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- Publication number
- JP2002501085A5 JP2002501085A5 JP2000528602A JP2000528602A JP2002501085A5 JP 2002501085 A5 JP2002501085 A5 JP 2002501085A5 JP 2000528602 A JP2000528602 A JP 2000528602A JP 2000528602 A JP2000528602 A JP 2000528602A JP 2002501085 A5 JP2002501085 A5 JP 2002501085A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- human
- heterodimer
- subunit
- hybridoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000833 heterodimer Substances 0.000 description 8
- 210000004408 hybridoma Anatomy 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 241000124008 Mammalia Species 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000011231 Crohn disease Diseases 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 241000282560 Macaca mulatta Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 210000000628 antibody-producing cell Anatomy 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002443 helper t lymphocyte Anatomy 0.000 description 1
- 230000008076 immune mechanism Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7233398P | 1998-01-23 | 1998-01-23 | |
| US60/072,333 | 1998-01-23 | ||
| PCT/EP1999/000202 WO1999037682A2 (en) | 1998-01-23 | 1999-01-15 | Antibodies against human il-12 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009098976A Division JP2009197008A (ja) | 1998-01-23 | 2009-04-15 | ヒトｉｌ−１２に対する抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002501085A JP2002501085A (ja) | 2002-01-15 |
| JP2002501085A5 true JP2002501085A5 (https=) | 2006-03-02 |
| JP4481489B2 JP4481489B2 (ja) | 2010-06-16 |
Family
ID=22106938
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000528602A Expired - Fee Related JP4481489B2 (ja) | 1998-01-23 | 1999-01-15 | ヒトｉｌ−１２に対する抗体 |
| JP2009098976A Withdrawn JP2009197008A (ja) | 1998-01-23 | 2009-04-15 | ヒトｉｌ−１２に対する抗体 |
| JP2013029936A Pending JP2013139458A (ja) | 1998-01-23 | 2013-02-19 | ヒトｉｌ−１２に対する抗体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009098976A Withdrawn JP2009197008A (ja) | 1998-01-23 | 2009-04-15 | ヒトｉｌ−１２に対する抗体 |
| JP2013029936A Pending JP2013139458A (ja) | 1998-01-23 | 2013-02-19 | ヒトｉｌ−１２に対する抗体 |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6225117B1 (https=) |
| EP (2) | EP1049717B1 (https=) |
| JP (3) | JP4481489B2 (https=) |
| KR (1) | KR100764256B1 (https=) |
| CN (2) | CN101274962A (https=) |
| AR (2) | AR014459A1 (https=) |
| AT (2) | ATE553129T1 (https=) |
| AU (1) | AU759624B2 (https=) |
| BR (1) | BR9907743A (https=) |
| CA (1) | CA2318052C (https=) |
| CY (2) | CY1106594T1 (https=) |
| DE (1) | DE69935574T2 (https=) |
| DK (2) | DK1049717T3 (https=) |
| ES (2) | ES2284242T3 (https=) |
| PT (2) | PT1818343E (https=) |
| TR (1) | TR200002145T2 (https=) |
| WO (1) | WO1999037682A2 (https=) |
| ZA (1) | ZA99452B (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003104495A1 (en) * | 2002-06-11 | 2003-12-18 | Isis Pharmaceuticals, Inc. | METHODS FOR BLOCKING ADIPOCYTE DIFFERENTIATION AND TRIGLYCERIDE ACCUMULATION WITH INTERLEUKIN 12 p35 INHIBITORS |
| US6399379B1 (en) | 1992-09-29 | 2002-06-04 | Isis Pharmaceuticals, Inc. | Antisense modulation of interleukin 12 p35 subunit expression |
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| US6706264B1 (en) | 1994-03-14 | 2004-03-16 | Genetics Institute, Llc | Use of IL-12 antagonists in the treatment of conditions promoted by an increase in levels of IFN-y |
| US7026456B1 (en) | 1998-01-23 | 2006-04-11 | Hoffman-La Roche, Inc. | Antibodies against human IL-12 |
| US6448081B1 (en) | 2001-05-07 | 2002-09-10 | Isis Pharmaceuticals, Inc. | Antisense modulation of interleukin 12 p40 subunit expression |
| DE69927520T2 (de) | 1998-12-09 | 2006-06-22 | Protein Design Labs, Inc., Fremont | Verwendung von il-12 antikörpern zur behandlung von psoriasis |
| US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
| US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
| US6939545B2 (en) | 1999-04-28 | 2005-09-06 | Genetics Institute, Llc | Composition and method for treating inflammatory disorders |
| CA2897626C (en) * | 2000-02-11 | 2020-03-24 | Biogen Ma Inc. | Heterologous polypeptide of the tnf family |
| US6348316B1 (en) | 2000-04-12 | 2002-02-19 | Cedars-Sinai Medical Center | Genetic testing for determining the risk of pouchitis development |
| US6902734B2 (en) * | 2000-08-07 | 2005-06-07 | Centocor, Inc. | Anti-IL-12 antibodies and compositions thereof |
| US7638604B2 (en) * | 2001-02-23 | 2009-12-29 | Genetics Institute, Llc | Monoclonal antibodies against interleukin-22 |
| AU2002314825A1 (en) * | 2001-05-30 | 2002-12-09 | Centocor, Inc. | Anti-p40 immunoglobulin derived proteins, compositions, methods and uses |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| EP2025345A1 (en) * | 2002-12-30 | 2009-02-18 | Biogen Idec MA Inc. | KIM-1 antagonists and use to modulate immune system |
| WO2005058251A2 (en) * | 2003-12-15 | 2005-06-30 | Dendreon Corporation | Hla-dr-specific antibodies, compositions and methods |
| GB0329146D0 (en) * | 2003-12-16 | 2004-01-21 | Glaxosmithkline Biolog Sa | Vaccine |
| MY157915A (en) | 2004-12-21 | 2016-08-15 | Centocor Inc | Anti-il-12 antibodies, epitopes, compositions, methods and uses. |
| KR101213894B1 (ko) | 2005-03-02 | 2012-12-20 | 바이오겐 아이덱 엠에이 인코포레이티드 | Ｔｈ2 매개성 병태를 치료하기 위한 ｋｉｍ-1 항체 |
| CN103145842A (zh) * | 2005-06-30 | 2013-06-12 | Abbvie公司 | Il-12/p40结合蛋白 |
| TWI417301B (zh) | 2006-02-21 | 2013-12-01 | Wyeth Corp | 對抗人類介白素-２２（ｉｌ-２２）之抗體及其用途 |
| TW200744634A (en) * | 2006-02-21 | 2007-12-16 | Wyeth Corp | Methods of using antibodies against human IL-22 |
| KR20090100461A (ko) | 2007-01-16 | 2009-09-23 | 아보트 러보러터리즈 | 건선의 치료방법 |
| RU2476442C2 (ru) | 2007-03-29 | 2013-02-27 | Эббот Лэборетриз | Кристаллические антитела против il-12 человека |
| WO2009117289A2 (en) | 2008-03-18 | 2009-09-24 | Abbott Laboratories | Methods for treating psoriasis |
| KR20160116056A (ko) | 2008-08-14 | 2016-10-06 | 테바 파마슈티컬즈 오스트레일리아 피티와이 엘티디 | 항-ｉｌ-12/ｉｌ-23 항체 |
| RU2011126338A (ru) * | 2008-11-28 | 2013-01-10 | Эбботт Лэборетриз | Стабильные композиции антител и способы их стабилизации |
| SG179135A1 (en) * | 2009-09-14 | 2012-05-30 | Abbott Lab | Methods for treating psoriasis |
| CN103275222B (zh) * | 2013-05-15 | 2014-04-16 | 中山康方生物医药有限公司 | 一种阻断白介素12 p40功能的单克隆抗体及其编码基因和应用 |
| CN109071653A (zh) | 2016-03-29 | 2018-12-21 | 詹森生物科技公司 | 用增加的抗-il12和/或-23抗体给药间隔治疗牛皮癣 |
| TW201922780A (zh) * | 2017-09-25 | 2019-06-16 | 美商健生生物科技公司 | 以抗ｉｌ１２／ｉｌ２３抗體治療狼瘡之安全且有效之方法 |
| EP3793521A4 (en) | 2018-05-18 | 2022-02-23 | Janssen Biotech, Inc. | SAFE AND EFFECTIVE METHOD OF TREATING LUPUS WITH AN ANTI-IL12/IL23 ANTIBODY |
| IL326284A (en) | 2018-09-24 | 2026-04-01 | Janssen Biotech Inc | A safe and effective method for treating ulcerative colitis with an anti-IL12/IL23 antibody |
| JP7805788B2 (ja) | 2019-05-23 | 2026-01-26 | ヤンセン バイオテツク，インコーポレーテツド | Ｉｌ－２３及びｔｎｆアルファに対する抗体の併用療法による炎症性腸疾患の治療方法 |
| IL298389A (en) | 2020-05-21 | 2023-01-01 | Janssen Biotech Inc | Method of treating inflammatory bowel disease with a combination therapy of antibodies to il-23 and tnf alpha |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811523A (en) | 1988-11-10 | 1998-09-22 | Trinchieri; Giorgio | Antibodies to natural killer stimulatory factor |
| US5780597A (en) | 1989-12-22 | 1998-07-14 | Hoffmann-La Roche Inc. | Monoclonal antibodies to cytotoxic lymphocyte maturation factor |
| CA2125763C (en) * | 1993-07-02 | 2007-08-28 | Maurice Kent Gately | P40 homodimer of interleukin-12 |
| US5536657A (en) | 1993-07-19 | 1996-07-16 | Hoffmann-La Roche Inc. | Recombinant DNA encoding human receptor for interleukin-12 |
| ZA95960B (en) * | 1994-03-14 | 1995-10-10 | Genetics Inst | Use of interleukin-12 antagonists in the treatment of autoimmune diseases |
| US7119248B1 (en) * | 1994-04-12 | 2006-10-10 | Miltenyi Biotec Gmbh | Antibodies against epitopes with homology to self antigens, methods of preparation and applications thereof |
| US5853721A (en) * | 1995-01-31 | 1998-12-29 | Hoffmann-La Roche Inc. | Antibody to interleukin-12 receptor |
| US5853697A (en) * | 1995-10-25 | 1998-12-29 | The United States Of America, As Represented By The Department Of Health & Human Services | Methods of treating established colitis using antibodies against IL-12 |
| US5809360A (en) * | 1996-08-07 | 1998-09-15 | Agfa Division - Bayer Corporation | Cassette for storing and accessing plates within an automated plate handler |
| IL123888A0 (en) * | 1997-04-01 | 1998-10-30 | Sankyo Co | Anti-fas antibodies |
-
1999
- 1999-01-15 CN CNA2008100016288A patent/CN101274962A/zh active Pending
- 1999-01-15 EP EP99904780A patent/EP1049717B1/en not_active Expired - Lifetime
- 1999-01-15 PT PT07005606T patent/PT1818343E/pt unknown
- 1999-01-15 BR BR9907743-4A patent/BR9907743A/pt not_active IP Right Cessation
- 1999-01-15 EP EP07005606A patent/EP1818343B1/en not_active Revoked
- 1999-01-15 DK DK99904780T patent/DK1049717T3/da active
- 1999-01-15 ES ES99904780T patent/ES2284242T3/es not_active Expired - Lifetime
- 1999-01-15 CA CA2318052A patent/CA2318052C/en not_active Expired - Lifetime
- 1999-01-15 ES ES07005606T patent/ES2386262T3/es not_active Expired - Lifetime
- 1999-01-15 AT AT07005606T patent/ATE553129T1/de active
- 1999-01-15 DK DK07005606.4T patent/DK1818343T3/da active
- 1999-01-15 KR KR1020007008036A patent/KR100764256B1/ko not_active Expired - Fee Related
- 1999-01-15 DE DE69935574T patent/DE69935574T2/de not_active Expired - Lifetime
- 1999-01-15 PT PT99904780T patent/PT1049717E/pt unknown
- 1999-01-15 TR TR2000/02145T patent/TR200002145T2/xx unknown
- 1999-01-15 JP JP2000528602A patent/JP4481489B2/ja not_active Expired - Fee Related
- 1999-01-15 AT AT99904780T patent/ATE357459T1/de active
- 1999-01-15 CN CNB998023108A patent/CN100374466C/zh not_active Expired - Lifetime
- 1999-01-15 AU AU25177/99A patent/AU759624B2/en not_active Expired
- 1999-01-15 WO PCT/EP1999/000202 patent/WO1999037682A2/en not_active Ceased
- 1999-01-19 US US09/232,522 patent/US6225117B1/en not_active Expired - Lifetime
- 1999-01-21 ZA ZA9900452A patent/ZA99452B/xx unknown
- 1999-01-22 AR ARP990100251A patent/AR014459A1/es active IP Right Grant
-
2007
- 2007-05-15 CY CY20071100657T patent/CY1106594T1/el unknown
- 2007-07-03 AR ARP070102968A patent/AR061801A2/es unknown
-
2009
- 2009-04-15 JP JP2009098976A patent/JP2009197008A/ja not_active Withdrawn
-
2012
- 2012-06-29 CY CY20121100589T patent/CY1112927T1/el unknown
-
2013
- 2013-02-19 JP JP2013029936A patent/JP2013139458A/ja active Pending
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