|
US7329670B1
(en)
|
1997-12-22 |
2008-02-12 |
Bayer Pharmaceuticals Corporation |
Inhibition of RAF kinase using aryl and heteroaryl substituted heterocyclic ureas
|
|
ID26328A
(id)
*
|
1997-12-22 |
2000-12-14 |
Bayer Ag |
Penghambat raf kinase menggunakan urea heterosiklik tersubstitusi aril dan heteroaril
|
|
US7517880B2
(en)
|
1997-12-22 |
2009-04-14 |
Bayer Pharmaceuticals Corporation |
Inhibition of p38 kinase using symmetrical and unsymmetrical diphenyl ureas
|
|
AU2003204708B2
(en)
*
|
1997-12-22 |
2006-05-25 |
Bayer Healthcare Llc |
Inhibition of Raf Kinase using Substituted Heterocyclic Ureas
|
|
SK286213B6
(sk)
*
|
1997-12-22 |
2008-05-06 |
Bayer Corporation |
Substituované heterocyklické močoviny, farmaceutický prípravok ich obsahujúci a ich použitie
|
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
WO2000042012A1
(en)
*
|
1999-01-13 |
2000-07-20 |
Bayer Corporation |
φ-CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS
|
|
EP1690853B1
(en)
*
|
1999-01-13 |
2010-03-10 |
Bayer HealthCare LLC |
Use of omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
US7351834B1
(en)
|
1999-01-13 |
2008-04-01 |
Bayer Pharmaceuticals Corporation |
ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
CN100522934C
(zh)
*
|
1999-01-13 |
2009-08-05 |
拜尔有限公司 |
用ω-羧基芳基取代的二苯脲作为raf激酶抑制剂
|
|
ATE538794T1
(de)
|
1999-01-13 |
2012-01-15 |
Bayer Healthcare Llc |
Gamma carboxyarylsubstituierte diphenylharnstoffverbindungen als p38 kinasehemmer
|
|
UA73492C2
(en)
|
1999-01-19 |
2005-08-15 |
|
Aromatic heterocyclic compounds as antiinflammatory agents
|
|
MXPA01008440A
(es)
|
1999-02-22 |
2002-04-24 |
Boehringer Ingelheim Pharma |
Derivados heterociclicos policiclos como agentes anti-inflamatorios..
|
|
WO2000051998A1
(en)
|
1999-03-02 |
2000-09-08 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as reversible inhibitors of cathepsin s
|
|
WO2000055152A1
(en)
|
1999-03-12 |
2000-09-21 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as anti-inflammatory agents
|
|
NZ528846A
(en)
|
1999-03-12 |
2005-05-27 |
Boehringer Ingelheim Pharma |
Compounds useful as anti-inflammatory agents
|
|
HN2000000051A
(es)
*
|
1999-05-19 |
2001-02-02 |
Pfizer Prod Inc |
Derivados heterociclicos utiles como agentes anticancerosos
|
|
US6573409B1
(en)
|
1999-07-02 |
2003-06-03 |
The Nutrasweet Company |
Process for the preparation of 3,3-dimethylbutanal
|
|
ATE312823T1
(de)
|
1999-07-09 |
2005-12-15 |
Boehringer Ingelheim Pharma |
Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen
|
|
US6420364B1
(en)
|
1999-09-13 |
2002-07-16 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compound useful as reversible inhibitors of cysteine proteases
|
|
US6525046B1
(en)
|
2000-01-18 |
2003-02-25 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Aromatic heterocyclic compounds as antiinflammatory agents
|
|
US6608052B2
(en)
|
2000-02-16 |
2003-08-19 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Compounds useful as anti-inflammatory agents
|
|
US6414013B1
(en)
|
2000-06-19 |
2002-07-02 |
Pharmacia & Upjohn S.P.A. |
Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention
|
|
DE10050492A1
(de)
*
|
2000-10-11 |
2002-04-25 |
Morphochem Ag |
Verfahren zur Herstellung von 5-Oxo-2,5-dihydro-furan-2-carbonsäureamiden und 6-Oxo-3,6-dihydro-2H-pyran-2-carbonsäureamiden
|
|
AU2002232439A1
(en)
|
2000-11-29 |
2002-06-11 |
Glaxo Group Limited |
Benzimidazole derivatives useful as tie-2 and/or vegfr-2 inhibitors
|
|
US7235576B1
(en)
|
2001-01-12 |
2007-06-26 |
Bayer Pharmaceuticals Corporation |
Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
US7371763B2
(en)
|
2001-04-20 |
2008-05-13 |
Bayer Pharmaceuticals Corporation |
Inhibition of raf kinase using quinolyl, isoquinolyl or pyridyl ureas
|
|
WO2002092576A1
(en)
|
2001-05-16 |
2002-11-21 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Diarylurea derivatives useful as anti-inflammatory agents
|
|
EP1395561A1
(en)
|
2001-05-25 |
2004-03-10 |
Boehringer Ingelheim Pharmaceuticals Inc. |
Carbamate and oxamide compounds as inhibitors of cytokine production
|
|
CN101624391A
(zh)
|
2001-06-11 |
2010-01-13 |
病毒化学医药公司 |
用作黄病毒感染抗病毒剂的噻吩衍生物
|
|
EP1709965A3
(en)
*
|
2001-07-11 |
2006-12-27 |
Boehringer Ingelheim Pharmaceuticals, Inc. |
Methods of treating cytokine mediate diseases
|
|
JP4982685B2
(ja)
*
|
2001-12-03 |
2012-07-25 |
バイエル、ファーマシューテイカルズ、コーポレイション |
ヒトがんを処置するための他の細胞毒剤又は細胞増殖抑制剤と組合わせたアリール尿素化合物
|
|
MXPA04007830A
(es)
|
2002-02-11 |
2005-07-01 |
Bayer Pharmaceuticals Corp |
Arilureas como inhibidores de cinasa.
|
|
MXPA04007832A
(es)
|
2002-02-11 |
2005-09-08 |
Bayer Pharmaceuticals Corp |
Aril-ureas con actividad inhibitoria de angiogenesis.
|
|
ATE386030T1
(de)
|
2002-02-25 |
2008-03-15 |
Boehringer Ingelheim Pharma |
1,4-disubstituierte benzokondensierte cycloalkyl- harnstoffverbindungen zur behandlung von zytokinvermittelten erkrankungen
|
|
DE60310730T2
(de)
|
2002-07-09 |
2007-05-16 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege
|
|
CA2511970C
(en)
|
2003-01-14 |
2012-06-26 |
Cytokinetics, Inc. |
Urea derivatives useful in the treatment of heart failure
|
|
MXPA05012377A
(es)
|
2003-05-15 |
2006-05-25 |
Arqule Inc |
Derivados de imidazotiazoles e imidazoxazol como inhibidores de p38.
|
|
WO2004113274A2
(en)
|
2003-05-20 |
2004-12-29 |
Bayer Pharmaceuticals Corporation |
Diaryl ureas with kinase inhibiting activity
|
|
EA010485B1
(ru)
|
2003-07-23 |
2008-10-30 |
Байер Фамэсьютиклс Копэрейшн |
Производное n,n'-дифенилмочевины, фармацевтическая композиция (варианты) и способ лечения и предупреждения заболеваний и состояний с его использованием (варианты)
|
|
DE602004017478D1
(de)
*
|
2003-08-15 |
2008-12-11 |
Astrazeneca Ab |
Substituierte thiophene und deren verwendungen
|
|
TW200530236A
(en)
|
2004-02-23 |
2005-09-16 |
Chugai Pharmaceutical Co Ltd |
Heteroaryl phenylurea
|
|
CN101010315A
(zh)
|
2004-04-30 |
2007-08-01 |
拜耳制药公司 |
用于治疗癌症的取代的吡唑基脲衍生物
|
|
JP5080970B2
(ja)
|
2004-06-17 |
2012-11-21 |
サイトキネティクス・インコーポレーテッド |
心疾患を治療するための置換尿素誘導体
|
|
WO2006010082A1
(en)
|
2004-07-08 |
2006-01-26 |
Arqule, Inc. |
1,4-disubstituted naphtalenes as inhibitors of p38 map kinase
|
|
US20060035893A1
(en)
|
2004-08-07 |
2006-02-16 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
|
|
JP2008517064A
(ja)
|
2004-10-19 |
2008-05-22 |
アークル インコーポレイテッド |
Ｐ３８ｍａｐキナーゼのイミダゾオキサゾールおよびイミダゾチアゾール阻害剤の合成
|
|
EP1824843A2
(en)
|
2004-12-07 |
2007-08-29 |
Locus Pharmaceuticals, Inc. |
Inhibitors of protein kinases
|
|
JP2008523071A
(ja)
|
2004-12-07 |
2008-07-03 |
ルーカス ファーマシューティカルズ， インコーポレイテッド |
Ｍａｐキナーゼの尿素インヒビター
|
|
GB0428082D0
(en)
|
2004-12-22 |
2005-01-26 |
Welcome Trust The Ltd |
Therapeutic compounds
|
|
PE20060777A1
(es)
|
2004-12-24 |
2006-10-06 |
Boehringer Ingelheim Int |
Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
|
|
SG160364A1
(en)
|
2005-03-07 |
2010-04-29 |
Bayer Schering Pharma Ag |
Pharmaceutical composition comprising an omega-carboxyaryl substituted diphenyl urea for the treatment of cancer
|
|
BRPI0610283A2
(pt)
|
2005-05-13 |
2010-10-19 |
Virochem Pharma Inc |
composto, uso do mesmo na preparação de um medicamento para o tratamento ou prevenção de uma infecção por vìrus de hepatite c, composição farmacêutica e combinação farmacêutica
|
|
US7538223B2
(en)
|
2005-08-04 |
2009-05-26 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
JP5072595B2
(ja)
|
2005-08-05 |
2012-11-14 |
中外製薬株式会社 |
マルチキナーゼ阻害剤
|
|
TW200808321A
(en)
|
2005-12-15 |
2008-02-16 |
Cytokinetics Inc |
Certain chemical entities, compositions and methods
|
|
US7825120B2
(en)
|
2005-12-15 |
2010-11-02 |
Cytokinetics, Inc. |
Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas
|
|
EP1959962A2
(en)
|
2005-12-16 |
2008-08-27 |
Cytokinetics, Inc. |
Certain chemical entities, compositions, and methods
|
|
EP1962852B1
(en)
|
2005-12-19 |
2017-01-25 |
Cytokinetics, Inc. |
Compounds, compositions and methods
|
|
EP1992344A1
(en)
|
2007-05-18 |
2008-11-19 |
Institut Curie |
P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
|
|
CN102627657B
(zh)
*
|
2012-03-09 |
2015-01-07 |
苏州施亚生物科技有限公司 |
3-(4-甲氧基-苄基)-1h-嘧啶-2,4-二酮衍生物的合成方法
|
|
WO2015041534A1
(en)
|
2013-09-20 |
2015-03-26 |
Stichting Het Nederlands Kanker Instituut |
P90rsk in combination with raf/erk/mek
|
|
EP3046557A1
(en)
|
2013-09-20 |
2016-07-27 |
Stichting Het Nederlands Kanker Instituut |
Rock in combination with mapk-pathway
|
|
US20170027940A1
(en)
|
2014-04-10 |
2017-02-02 |
Stichting Het Nederlands Kanker Instituut |
Method for treating cancer
|
|
ES2738693T3
(es)
|
2014-04-17 |
2020-01-24 |
Pasteur Institut Korea |
Compuestos para el tratamiento de infecciones virales
|
|
WO2015178770A1
(en)
|
2014-05-19 |
2015-11-26 |
Stichting Het Nederlands Kanker Instituut |
Compositions for cancer treatment
|
|
KR102420944B1
(ko)
*
|
2016-10-26 |
2022-07-15 |
이시하라 산교 가부시끼가이샤 |
3-메틸-2-티오펜카르복실산의 제조 방법
|