JP2002500042A - 非同一遺伝子ならびに改良された分子アジュバントにおけるそれらの適用 - Google Patents
非同一遺伝子ならびに改良された分子アジュバントにおけるそれらの適用Info
- Publication number
- JP2002500042A JP2002500042A JP2000527645A JP2000527645A JP2002500042A JP 2002500042 A JP2002500042 A JP 2002500042A JP 2000527645 A JP2000527645 A JP 2000527645A JP 2000527645 A JP2000527645 A JP 2000527645A JP 2002500042 A JP2002500042 A JP 2002500042A
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- Prior art keywords
- polypeptide
- concatemer
- dna
- sequence
- encoding
- Prior art date
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- Pending
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 1
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- 230000000899 immune system response Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
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- PGSADBUBUOPOJS-UHFFFAOYSA-N neutral red Chemical compound Cl.C1=C(C)C(N)=CC2=NC3=CC(N(C)C)=CC=C3N=C21 PGSADBUBUOPOJS-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
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- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 150000008300 phosphoramidites Chemical class 0.000 description 1
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- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 239000013600 plasmid vector Substances 0.000 description 1
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- 238000007694 polyacrylamide gel isoelectric focusing Methods 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
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- 210000001236 prokaryotic cell Anatomy 0.000 description 1
- 235000019419 proteases Nutrition 0.000 description 1
- 230000012846 protein folding Effects 0.000 description 1
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- 230000016434 protein splicing Effects 0.000 description 1
- 239000012264 purified product Substances 0.000 description 1
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- WHMDPDGBKYUEMW-UHFFFAOYSA-N pyridine-2-thiol Chemical compound SC1=CC=CC=N1 WHMDPDGBKYUEMW-UHFFFAOYSA-N 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 1
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- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
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- 235000011178 triphosphate Nutrition 0.000 description 1
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- 241000712461 unidentified influenza virus Species 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/033—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the internal surface of the plasma membrane, e.g. containing a myristoylation motif
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
- C07K2319/42—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a HA(hemagglutinin)-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
- C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/90—Fusion polypeptide containing a motif for post-translational modification
- C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9727512.7 | 1997-12-31 | ||
| GBGB9727512.7A GB9727512D0 (en) | 1997-12-31 | 1997-12-31 | Fuzzy genes and their application in molecular adjuvants |
| PCT/GB1998/003918 WO1999035260A1 (en) | 1997-12-31 | 1998-12-30 | Non-identical genes and their application in improved molec ular adjuvants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002500042A true JP2002500042A (ja) | 2002-01-08 |
| JP2002500042A5 JP2002500042A5 (cg-RX-API-DMAC7.html) | 2006-03-09 |
Family
ID=10824333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000527645A Pending JP2002500042A (ja) | 1997-12-31 | 1998-12-30 | 非同一遺伝子ならびに改良された分子アジュバントにおけるそれらの適用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6770631B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1042467B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2002500042A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE403721T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU757021B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2317020A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE69839848D1 (cg-RX-API-DMAC7.html) |
| GB (1) | GB9727512D0 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ505827A (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999035260A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0008582D0 (en) * | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
| WO2001092295A2 (en) * | 2000-05-30 | 2001-12-06 | University Of Toronto | Ligands for cd21 and compositions thereof for modulating immune responses |
| GB0025229D0 (en) * | 2000-10-14 | 2000-11-29 | Adprotech Ltd | Veterinary immunisation vectors |
| WO2002059297A2 (en) | 2001-01-25 | 2002-08-01 | Evolva Biotech A/S | A library of a collection of cells |
| US8008459B2 (en) | 2001-01-25 | 2011-08-30 | Evolva Sa | Concatemers of differentially expressed multiple genes |
| KR100453877B1 (ko) | 2001-07-26 | 2004-10-20 | 메덱스젠 주식회사 | 연쇄체화에 의한 면역 글로블린 융합 단백질의 제조 방법 및 이 방법에 의해 제조된 ＴＮＦＲ/Ｆｃ 융합 단백질, 상기 단백질을 코딩하는 ＤＮＡ, 상기 ＤＮＡ를 포함하는벡터, 및 상기 벡터에 의한 형질전환체 |
| GB0204154D0 (en) * | 2002-02-22 | 2002-04-10 | Adprotech Ltd | Cat immunisation vectors |
| WO2004016283A2 (en) * | 2002-08-14 | 2004-02-26 | Avidis Sa | Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use |
| US7664748B2 (en) * | 2004-07-12 | 2010-02-16 | John Eric Harrity | Systems and methods for changing symbol sequences in documents |
| JP5241012B2 (ja) * | 2005-07-15 | 2013-07-17 | ノバルティス アーゲー | Ｐａｍｐｓ、病原体関連分子パターン |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU612340B2 (en) | 1986-11-04 | 1991-07-11 | Protein Polymers Technologies, Inc. | Construction of synthetic dna and its use in large polypeptide synthesis |
| US6018030A (en) * | 1986-11-04 | 2000-01-25 | Protein Polymer Technologies, Inc. | Peptides comprising repetitive units of amino acids and DNA sequences encoding the same |
| US5641648A (en) * | 1986-11-04 | 1997-06-24 | Protein Polymer Technologies, Inc. | Methods for preparing synthetic repetitive DNA |
| JPH0829098B2 (ja) * | 1988-01-05 | 1996-03-27 | 寳酒造株式会社 | 細胞接着活性ポリペプチド |
| WO1993012257A1 (en) * | 1991-12-12 | 1993-06-24 | Hybritech Incorporated | Enzymatic inverse polymerase chain reaction library mutagenesis |
| US5861285A (en) * | 1994-09-16 | 1999-01-19 | Tdk Corporation | Fusion protein-bound magnetic particles for recombinant production and magnetic separation of polypeptides of interest |
| US5763733A (en) * | 1994-10-13 | 1998-06-09 | Enzon, Inc. | Antigen-binding fusion proteins |
| GB9424631D0 (en) | 1994-12-06 | 1995-01-25 | Lynxvale Ltd | Modulating the immune response |
| DE19756975A1 (de) * | 1997-12-20 | 1999-06-24 | Hoechst Marion Roussel De Gmbh | Bindungspartner für Inhibitoren von cyclinabhängigen Kinasen und ihre Verwendung zur Suche nach Inhibitoren, zur Diagnose oder zur Therapie einer Erkrankung |
-
1997
- 1997-12-31 GB GBGB9727512.7A patent/GB9727512D0/en not_active Ceased
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1998
- 1998-12-30 US US09/582,761 patent/US6770631B1/en not_active Expired - Fee Related
- 1998-12-30 AU AU17762/99A patent/AU757021B2/en not_active Ceased
- 1998-12-30 NZ NZ505827A patent/NZ505827A/xx unknown
- 1998-12-30 JP JP2000527645A patent/JP2002500042A/ja active Pending
- 1998-12-30 AT AT98962638T patent/ATE403721T1/de not_active IP Right Cessation
- 1998-12-30 CA CA002317020A patent/CA2317020A1/en not_active Abandoned
- 1998-12-30 EP EP98962638A patent/EP1042467B1/en not_active Expired - Lifetime
- 1998-12-30 DE DE69839848T patent/DE69839848D1/de not_active Expired - Fee Related
- 1998-12-30 WO PCT/GB1998/003918 patent/WO1999035260A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US6770631B1 (en) | 2004-08-03 |
| CA2317020A1 (en) | 1999-07-15 |
| AU757021B2 (en) | 2003-01-30 |
| EP1042467A1 (en) | 2000-10-11 |
| NZ505827A (en) | 2003-03-28 |
| DE69839848D1 (de) | 2008-09-18 |
| AU1776299A (en) | 1999-07-26 |
| WO1999035260A1 (en) | 1999-07-15 |
| EP1042467B1 (en) | 2008-08-06 |
| GB9727512D0 (en) | 1998-02-25 |
| ATE403721T1 (de) | 2008-08-15 |
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