JP2002371070A - Ｎ−無水カルボン酸の製造方法 - Google Patents
Ｎ−無水カルボン酸の製造方法Info
- Publication number
- JP2002371070A JP2002371070A JP2002157840A JP2002157840A JP2002371070A JP 2002371070 A JP2002371070 A JP 2002371070A JP 2002157840 A JP2002157840 A JP 2002157840A JP 2002157840 A JP2002157840 A JP 2002157840A JP 2002371070 A JP2002371070 A JP 2002371070A
- Authority
- JP
- Japan
- Prior art keywords
- reaction
- amino acid
- phosgene
- group
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
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- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/44—Two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0107140A FR2828195B1 (fr) | 2001-05-31 | 2001-05-31 | Procede de preparation des n-carboxyanhydrides |
| FR0107140 | 2001-05-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2002371070A true JP2002371070A (ja) | 2002-12-26 |
Family
ID=8863816
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002157840A Ceased JP2002371070A (ja) | 2001-05-31 | 2002-05-30 | Ｎ−無水カルボン酸の製造方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6603016B2 (enExample) |
| EP (1) | EP1262480B2 (enExample) |
| JP (1) | JP2002371070A (enExample) |
| AT (1) | ATE304000T1 (enExample) |
| CA (1) | CA2387464C (enExample) |
| DE (1) | DE60205985T3 (enExample) |
| ES (1) | ES2246381T5 (enExample) |
| FR (1) | FR2828195B1 (enExample) |
| HU (1) | HUP0201837A3 (enExample) |
| IL (1) | IL149625A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008518032A (ja) * | 2004-10-26 | 2008-05-29 | シグマ−アルドリッチ・カンパニー | アミノ酸ｎ−カルボキシ無水物の合成 |
| WO2012132991A1 (ja) | 2011-03-25 | 2012-10-04 | 日本曹達株式会社 | グルタミン酸ベンジルエステルn－無水カルボン酸 |
| JP2012214450A (ja) * | 2011-03-25 | 2012-11-08 | Nippon Soda Co Ltd | グルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶多形 |
| EP3572408A1 (en) | 2018-05-25 | 2019-11-27 | Shin-Etsu Chemical Co., Ltd. | Method for purifying an amino acid-n-carboxy anhydride |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7317070B1 (en) | 2004-03-12 | 2008-01-08 | Sigma-Aldrich Co. | Process for the preparation of polyamino acids |
| WO2006027788A1 (en) * | 2004-09-06 | 2006-03-16 | Biocon Limited | Process for the preparation of n-carboxyanhydrides |
| FR2928372B1 (fr) * | 2008-03-10 | 2010-12-31 | Solvay | Procede de synthese peptidique |
| US8399600B2 (en) * | 2008-08-07 | 2013-03-19 | Sigma-Aldrich Co. Llc | Preparation of low molecular weight polylysine and polyornithine in high yield |
| EP2406300B1 (en) | 2009-03-10 | 2016-11-16 | Sigma-Aldrich Co. LLC | Method for the production of polyamino acid random copolymers |
| US12435048B2 (en) | 2018-09-28 | 2025-10-07 | Lonza Ltd | Method for preparation of n-carboxyanhydrides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1038913A (en) * | 1962-11-16 | 1966-08-10 | Asahi Chemical Ind | A process for producing n-carboxy anhydrides of alpha-amino acids |
| JPS4924958A (enExample) † | 1972-06-28 | 1974-03-05 | ||
| US5135754A (en) † | 1988-01-06 | 1992-08-04 | Delalande S.A. | Method of preparing a copolymer of two α-amino acids and a copolymer thus obtained |
| FR2815962B1 (fr) * | 2000-10-30 | 2003-03-07 | Isochem Sa | Procede de preparation des n-carboxyanhydrides |
-
2001
- 2001-05-31 FR FR0107140A patent/FR2828195B1/fr not_active Expired - Fee Related
-
2002
- 2002-05-14 IL IL149625A patent/IL149625A/en not_active IP Right Cessation
- 2002-05-17 EP EP02291225A patent/EP1262480B2/fr not_active Expired - Lifetime
- 2002-05-17 DE DE60205985T patent/DE60205985T3/de not_active Expired - Lifetime
- 2002-05-17 AT AT02291225T patent/ATE304000T1/de active
- 2002-05-17 ES ES02291225T patent/ES2246381T5/es not_active Expired - Lifetime
- 2002-05-24 CA CA002387464A patent/CA2387464C/fr not_active Expired - Fee Related
- 2002-05-30 HU HU0201837A patent/HUP0201837A3/hu unknown
- 2002-05-30 JP JP2002157840A patent/JP2002371070A/ja not_active Ceased
- 2002-05-30 US US10/158,712 patent/US6603016B2/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008518032A (ja) * | 2004-10-26 | 2008-05-29 | シグマ−アルドリッチ・カンパニー | アミノ酸ｎ−カルボキシ無水物の合成 |
| WO2012132991A1 (ja) | 2011-03-25 | 2012-10-04 | 日本曹達株式会社 | グルタミン酸ベンジルエステルn－無水カルボン酸 |
| JP2012214450A (ja) * | 2011-03-25 | 2012-11-08 | Nippon Soda Co Ltd | グルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶多形 |
| JP5833635B2 (ja) * | 2011-03-25 | 2015-12-16 | 日本曹達株式会社 | グルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶、及びグルタミン酸ベンジルエステルｎ−無水カルボン酸の結晶化方法。 |
| EP3572408A1 (en) | 2018-05-25 | 2019-11-27 | Shin-Etsu Chemical Co., Ltd. | Method for purifying an amino acid-n-carboxy anhydride |
| KR20190134500A (ko) | 2018-05-25 | 2019-12-04 | 신에쓰 가가꾸 고교 가부시끼가이샤 | 아미노산 n-카르복시 무수물의 정제 방법 |
| US10975042B2 (en) | 2018-05-25 | 2021-04-13 | Shin-Etsu Chemical Co., Ltd. | Method for purifying an amino acid-n-carboxy anhydride |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60205985T2 (de) | 2006-07-13 |
| HUP0201837A3 (en) | 2013-07-29 |
| US6603016B2 (en) | 2003-08-05 |
| ES2246381T5 (es) | 2011-01-18 |
| HUP0201837A2 (hu) | 2002-12-28 |
| IL149625A (en) | 2007-12-03 |
| EP1262480B2 (fr) | 2010-08-04 |
| DE60205985D1 (de) | 2005-10-13 |
| EP1262480B1 (fr) | 2005-09-07 |
| FR2828195B1 (fr) | 2003-12-26 |
| CA2387464C (fr) | 2009-11-17 |
| FR2828195A1 (en) | 2003-02-07 |
| ES2246381T3 (es) | 2006-02-16 |
| EP1262480A1 (fr) | 2002-12-04 |
| CA2387464A1 (fr) | 2002-11-30 |
| US20020183551A1 (en) | 2002-12-05 |
| IL149625A0 (en) | 2002-11-10 |
| HU0201837D0 (enExample) | 2002-07-29 |
| ATE304000T1 (de) | 2005-09-15 |
| DE60205985T3 (de) | 2011-03-03 |
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